α-Cyclodextrin decreases cholera toxin binding to GM1-gangliosides
2013 ◽
Vol 62
(7)
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pp. 1011-1014
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Keyword(s):
Cholera toxin (CT), the principal virulence factor secreted by Vibrio cholerae, is an A-B5 type exotoxin that binds to host cell GM1-gangliosides and is responsible for cholera diarrhoea. We tested the hypothesis that the cyclic hexasaccharide α-cyclodextrin (α-CD), but not the cyclic heptasaccharides methyl-β-cyclodextrin (MD-β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) inhibit binding of CT to GM1-gangliosides. We report that α-CD decreases CT binding to GM1-ganglioside-coated microtitre plate wells and on the surface of fixed HeLa cells in a concentration-dependent manner, suggesting that this may be a promising lead for the development of compounds with therapeutic properties.
2006 ◽
Vol 74
(5)
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pp. 2937-2946
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Keyword(s):
2011 ◽
Vol 345
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pp. 393-398
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2021 ◽
Vol 2021
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pp. 1-14
1981 ◽
Vol 241
(3)
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pp. G248-G252
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2015 ◽
Vol 2015
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pp. 1-10
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2019 ◽
Vol 5
(3)
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pp. 231-236
2017 ◽
Vol 8
(2)
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pp. 51
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1987 ◽
Vol 253
(1)
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pp. C105-C112
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