scholarly journals DNA Compass: a secure, client-side site for navigating personal genetic information

2016 ◽  
Author(s):  
Charles Curnin ◽  
Assaf Gordon ◽  
Yaniv Erlich
Keyword(s):  
Large Scale ◽  
Genomic Data ◽  
Personal Genomic ◽  
The Public ◽  
Direct To Consumer ◽  
The Status ◽  
And Performance ◽  
Precision Medicine Initiative ◽  
Client Side ◽  
Number Of Individuals

AbstractMotivationMillions of individuals have access to raw genomic data using direct-to-consumer companies. The advent of large-scale sequencing projects, such as the Precision Medicine Initiative, will further increase the number of individuals with access to their own genomic information. However, querying genomic data requires a computer terminal – an impediment for the general public.ResultsDNA Compass is a website designed to empower the public by enabling simple navigation of personal genomic data. Users can query the status of their genomic variants for over 400 conditions or tens of millions of documented SNPs. DNA Compass presents the relevant genotypes of the user side-by-side with explanatory scientific resources. The genotypes data never leaves the user’s computer, a feature that provides improved security and performance. Nearly 2500 unique users have used our tool, mainly from the general genetic genealogy community, demonstrating its utility.AvailabilityDNA Compass is freely available on https://[email protected]

scholarly journals DUPLICITY IN REGULATION AND PERFORMANCE OF THE FINANCIAL SECTOR IN KENYA

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Dr.Agnes Ogada
Keyword(s):  
Large Scale ◽  
Developing Economies ◽  
Financial Sector ◽  
The United States ◽  
Empirical Literature ◽  
Unique Contribution ◽  
Regulatory Structure ◽  
The Public ◽  
And Performance ◽  
The Uk

Purpose: The objective of the study was to investigate the duplicity in regulation and its effect on performance of the financial sector in Kenya. The specific objectives were; to review and identify regulation duplication/competition in existing regulatory framework for the financial sector in Kenya; to describe how regulatory effectiveness has been measured in empirical literature; to assess whether the current regulatory structure has affected the performance of the financial sector in Kenya and lastly to suggest potential ways of enhancing regulatory effectiveness in Kenya. Methodology: The paper used a desk study review methodology where relevant empirical literature was reviewed to identify main themes and to extract knowledge gaps. Findings: The study found out that financial sector in Kenya and other developing economies have reported losses on a large scale due to under regulation and regulator duplicity. Some of these have become insolvent, or have had to be taken over or rescued by their governments. A single market regulator clearly has its own advantages over multiple regulators. But it is more suitable for well-developed and mature markets which are smaller in size, like the UK. The study also found out that Kenya’s economy and political arena are not mature enough to handle a single financial market regulator. In this light it can be asserted that even mature economies such as the United States still have multiple regulators. Unique contribution to theory, practice and policy: Adherence to principles of open government, including transparency and participation in the regulatory process to ensure that regulation serves the public interest and is informed by the legitimate needs of those interested in and affected by regulation. Governments should ensure that regulations are comprehensible and clear and that parties can easily understand their rights and obligations. Organizations should create personalized technology systems that create a demand adaptation of ICT at every level of the organizational operations

scholarly journals DNA.Land: A digital biobank using a massive crowdsourcing approach

2017 ◽  
Author(s):  
Jie Yuan ◽  
Assaf Gordon ◽  
Daniel Speyer ◽  
Richard Aufrichtig ◽  
Dina Zielinski ◽  
...  
Keyword(s):  
Large Scale ◽  
Lessons Learned ◽  
Return Of Results ◽  
Crowd Sourcing ◽  
Direct To Consumer ◽  
Genomic Technologies ◽  
Daunting Task ◽  
Types Of Information ◽  
Number Of Individuals ◽  
Technical Framework

AbstractPrecision medicine necessitates large scale collections of genomes and phenomes. Despite decreases in the costs of genomic technologies, collecting these types of information at scale is still a daunting task that poses logistical challenges and requires consortium-scale resources. Here, we describe DNA.Land, a digital biobank to collect genome and phenomes with a fraction of the resources of traditional studies at the same scale. Our approach relies on crowd-sourcing data from the rapidly growing number of individuals that have access to their own genomic datasets through Direct-to-Consumer (DTC) companies. To recruit participants, we developed a series of automatic return-of-results features in DNA.Land that increase users’ engagement while stratifying human subject research protection. So far, DNA.Land has collected over 43,000 genomes in 20 months of operation, orders of magnitude higher than previous digital attempts by academic groups. We report lessons learned in running a digital biobank, our technical framework, and our approach regarding ethical, legal, and social implications.

scholarly journals COVID-19 and Organizational Digital Transformation of Media Workers and Its Effect

2021 ◽  
Vol 2 (1) ◽  
pp. 1-9
Keyword(s):  
Job Performance ◽  
Large Scale ◽  
Negative Influence ◽  
Employee Productivity ◽  
Company Performance ◽  
Convenience Sample ◽  
Employee Support ◽  
The Public ◽  
Overall Performance ◽  
And Performance

COVID- 19 had a negative influence on the employee's job performance and increased the risk of error. It's about exploring the link between employee support and company performance, if possible, to form on a large scale. Let's address the differences between fairness in the job and justice in the workplace. For this study, a convenience sample of 222 media personnel was identified and selected. The questionnaires were open-ended to gather the responses. It was used in the evaluation of only a portion of the answers using a Pseudo-Differential Templating Process. In cash-flow expansion, employee productivity improves since COVID-19 views as providing employees with more money rather than providing a structure for their work. Both ideas are not mutually exclusive but must all be pursued, for corporate justice is key in explaining the relation between perceived organizational assistance and employee success. Managers need to provide their employees with resources to succeed if they expect their workers to do well. When management's encouragement and fairness are interpreted as personal values, employees become motivated and do their best work. The contribution of employees to the overall performance of an organization matters even more. In the context of COVID-19, the study evaluated non-reported assistance to employees' levels of job performance; this correlation between perceptions of assistance and performance was found to be nonlinear. These days, the public expects to have to battle barriers of additional financial support from corporations.

scholarly journals Structural Distortions: Re-examining State Capture and Apprising its Persistence and Effects

2020 ◽  
Vol 73 (4) ◽  
pp. 67-93
Author(s):  
Kerry Longhurst
Keyword(s):  
Large Scale ◽  
Business Environment ◽  
The Public ◽  
Business Environments ◽  
Mass Migration ◽  
Structural Distortions ◽  
State Capture ◽  
Vested Interests ◽  
The Status ◽  
Political Economic

Moldova is a textbook-plus case of a captured state, a condition synonymous with a number of post-Soviet countries. Moldova’s state capture resulted from its post-1991 partial reform path which enabled the emergence of oligarchs able to seize core state functions and distort business environments to the detriment of the public good. Moldova is significant because of the extremity of its state capture with a single oligarchic network shaping the rules of the game in political, economic, social and to a degree foreign policy terms. This situation created a vicious circle, which hindered Moldova’s development, reinforced poverty and the hollowing out of the state through mass migration. 2021 offers a vantage point to consider whether Moldova can shed its capture via the anti-corruption reform programme set out by president Maia Sandu or whether prospects for change are more likely to be impeded by persistent vested interests keen to keep the status quo. Future remedies for Moldova hinge on there being palpable socio-economic improvements to people’s lives, twinned with successful prosecutions of those responsible for large-scale acts of corruption and embezzlement. Aside from this, reforms need to hone in on improving the business environment, the weaving in of women’s empowerment and providing solutions to stem outwards migration.

scholarly journals An Appraisal of the Market for Agricultural Economists - - Structure and Performance

1969 ◽  
Vol 1 (1) ◽  
pp. 139-144 ◽  
Author(s):  
Harold F. Breimyer
Keyword(s):  
Economic Policy ◽  
New Deal ◽  
Public Interest ◽  
Performing Arts ◽  
Great Society ◽  
Recent Issue ◽  
The Public ◽  
The Status ◽  
And Performance ◽  
The New Deal

“The Great Society is the ‘age of the economist.’ One finds economists not only at the center of economic policy, in the Council of Economic Advisers, but also as important formulators of policy in the Departments of Defense, HEW, and HUD, and even as analysts of the status of the performing arts.” (USDA could have been added.)Despite the contemporary accuracy of these lines from a recent issue of The Public Interest, any inference that the Great Society was the first “age of the economist” is patently wrong. That label belongs to the New Deal era.

scholarly journals rmvPFBAM: Removing Primers from BAM Files Based on Amplicon-Based Next-Generation Sequencing and Cloud Computing When Analyzing Personal Genome Data

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Yanjun Ma
Keyword(s):  
Next Generation Sequencing ◽  
False Positive ◽  
Large Scale ◽  
Genomic Data ◽  
Next Generation Sequencing Data ◽  
Personal Genome ◽  
Next Generation ◽  
Sequencing Data ◽  
Personal Genomic ◽  
Generation Sequencing

Personal genomic data constitute one important part of personal health data. However, due to the large amount of personal genomic data obtained by the next-generation sequencing technology, special tools are needed to analyze these data. In this article, we will explore a tool analyzing cloud-based large-scale genome sequencing data. Analyzing and identifying genomic variations from amplicon-based next-generation sequencing data are necessary for the clinical diagnosis and treatment of cancer patients. When processing the amplicon-based next-generation sequencing data, one essential step is removing primer sequences from the reads to avoid detecting false-positive mutations introduced by nonspecific primer binding and primer extension reactions. At present, the removing primer tools usually discard primer sequences from the FASTQ file instead of BAM file, but this method could cause some downstream analysis problems. Only one tool (BAMClipper) removes primer sequences from BAM files, but it only modified the CIGAR value of the BAM file, and false-positive mutations falling in the primer region could still be detected based on its processed BAM file. So, we developed one cutting primer tool (rmvPFBAM) removing primer sequences from the BAM file, and the mutations detected based on the processed BAM file by rmvPFBAM are highly credible. Besides that, rmvPFBAM runs faster than other tools, such as cutPrimers and BAMClipper.

scholarly journals State of Technology and Productivity in Pakistan’s Manufacturing Industries: Some Strategic Directions to Build Technological Competence

2000 ◽  
Vol 39 (1) ◽  
pp. 1-21 ◽  
Author(s):  
Zafar Mahmood ◽  
Rehana Siddiqui
Keyword(s):  
Total Factor Productivity ◽  
Large Scale ◽  
Slow Growth ◽  
Manufacturing Sector ◽  
Careful Analysis ◽  
Manufacturing Industries ◽  
Factor Productivity ◽  
Technology System ◽  
The Public ◽  
The Status

Historically, Pakistan’s economic growth record, especially of the manufacturing sector, has been quite satisfactory. However, since the late 1980s Pakistan has been facing a slow growth of manufacturing industries, particularly of the large-scale manufacturing units. This has led some economists to express the apprehension that perhaps de-industrialisation is taking place in the country. A careful analysis of the causes of this sluggish growth suggests that one of the main contributory factors is the slow growth in total factor productivity (TFP)—the best overall measure of competitiveness. What has caused this productivity slow-down? For Pakistan there is clear evidence of a relationship between the growth in total factor productivity and the ailing S & T apparatus. The results presented in the study also lend support to the hypothesis that knowledge capital, human capital, openness, and government policies are crucial determinants of total factor productivity growth. Given a liberal economic environment in the country, which is essential to improve efficiency and productivity, the paper offers four strategic directions in order to improve the status of the S & T system in Pakistan: (1) augment the public sector S & T apparatus with the private sector funding and oversight; (2) take measures to upgrade scientific research institutions to the international standard; (3) streamline the technology creation, absorption, and diffusion system; and (4) enhance the demand for S & T in industries. These strategic directions are designed in such a manner that they work together towards a series of phased reforms, which can create incentives and market-based mechanisms to enhance the technology system without relying on a radical shift in the governance element of the bureaucracy.

scholarly journals Low budget analysis of Direct-To-Consumer genomic testing familial data

F1000Research ◽  
2012 ◽  
Vol 1 ◽  
pp. 3 ◽  
Author(s):  
Gustavo Glusman ◽  
Mike Cariaso ◽  
Rafael Jimenez ◽  
Daniel Swan ◽  
Bastian Greshake ◽  
...  
Keyword(s):  
Genomic Data ◽  
Systematic Research ◽  
Personal Genome ◽  
Personal Genomic ◽  
Familial Data ◽  
Direct To Consumer ◽  
Budget Analysis ◽  
Snp Data ◽  
Whole Exome ◽  
Genetic Risks

Direct-to-consumer (DTC) genetic testing is a recent commercial endeavor that allows the general public to access personal genomic data. The growing availability of personal genomic data has in turn stimulated the development of non-commercial tools for DTC data analysis. Despite this new wealth of public resources, no systematic research has been carried out to assess these tools for interpretation of DTC data. Here, we provide an initial analysis benchmark in the context of a whole family, using single nucleotide polymorphism (SNP) data. Five blood-related DTC SNP chip data tests were analyzed in conjunction with one whole exome sequence. We report findings related to genomic similarity between individuals, genetic risks and an overall assessment of data quality; thus providing an evaluation of the current potential of public domain analysis tools for personal genomics. We envisage that as the use of personal genome tests spreads to the general population, publicly available tools will have a more prominent role in the interpretation of genomic data in the context of health risks and ancestry.

scholarly journals Subsidy/Donation and Performance of Microfinance Institutions

2019 ◽  
pp. 1-12
Author(s):  
Emengini Steve, Emeka ◽  
Onyeanu, Edith, Ogoegbunam ◽  
Anisiuba Chika, Anastasia ◽  
P. Ojiakor, Ijeoma ◽  
S. Ugwuegbe, Ugochukwu
Keyword(s):  
Stock Exchange ◽  
Tax Incentives ◽  
Secondary Source ◽  
Microfinance Institutions ◽  
The Public ◽  
Effective Performance ◽  
The Status ◽  
The Face ◽  
Microfinance Institution ◽  
And Performance

Subsidies and Donations are veritable tools that are supposed to engender effective performance in Microfinance institutions. On the face value, subsidies seem to be very positive but they can be counterproductive when related to their effects on performance, efficiency and self-sustainability of the Microfinance institutions. This paper therefore focuses on the assessment and review of issues relating to Subsidy/Donation and their effect on Performance of Microfinance Institutions (MFIs) in Nigeria. The methodology adopted is descriptive in nature and secondary source of data were made use of. Our review revealed mix results on the empirical findings of effect of subsidies/donations on performance of Microfinance institutions. This review shows that Subsidies can disincentive workers and managers, thereby creating moral hazard problems (Corruption and Financial impropriety). However, when applied to effect low borrowing costs and Tax incentives/concessions, it affects performance positively. The review also shows that subsidies ought to be used only in the startup phases of the life cycle and to be withdrawn when the Microfinance institution improves. Overall, to achieve the double bottom lines of social and financial sustainability obligations, funding structure in Microfinance should de-emphasise subsidy dependence and encourage market based principles and commercialisation. For effective corporate governance, big Microfinance institutions at the status of Banks and big NGOs should be mandated to disclose their accounts to the public and not just mere annual returns to the Central bank of Nigeria (This may involve quoting them in Nigeria Stock Exchange).

Motivasi dan kepuasan kerja pegawai puskesmas BLUD dan non-BLUD Kabupaten Semarang

2018 ◽  
Vol 2 (3) ◽  
pp. 111
Author(s):  
Aswindar Adhi Gumilang ◽  
Tri Pitara Mahanggoro ◽  
Qurrotul Aini
Keyword(s):  
Public Health ◽  
Job Satisfaction ◽  
Financial Management ◽  
Work Motivation ◽  
P Value ◽  
The Public ◽  
The Status ◽  
The Difference ◽  
Demand For Health ◽  
Public Demand

The public demand for health service professionalism and transparent financial management made some Puskesmas in Semarang regency changed the status of public health center to BLUD. The implementation of Puskesmas BLUD and non-BLUD requires resources that it can work well in order to meet the expectations of the community. The aim of this study is to know the difference of work motivation and job satisfaction of employees in Puskesmas BLUD and non-BLUD. Method of this research is a comparative descriptive with a quantitative approach. The object of this research are work motivation and job satisfaction of employees in Puskesmas BLUD and non-BLUD Semarang regency. This Research showed that Sig value. (P-value) work motivation variable was 0.019 smaller than α value (0.05). It showed that there was a difference of work motivation of employees in Puskemas BLUD and non-BLUD. Sig value (P-value) variable of job satisfaction was 0.020 smaller than α value (0.05). It showed that there was a difference of job satisfaction of BLUD and non-BLUD. The average of non-BLUD employees motivation were 76.59 smaller than the average of BLUD employees were 78.25. The average of job satisfaction of BLUD employees were 129.20 bigger than the average of non-BLUD employee were 124.26. Job satisfaction of employees in Puskesmas BLUD was higher than non-BLUD employees.

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