scholarly journals IE-Map: A novel in-vivo atlas template of the human inner ear

2019 ◽  
Author(s):  
Seyed-Ahmad Ahmadi ◽  
Theresa Raiser ◽  
Ria Maxine Rühl ◽  
Virginia L. Flanagin ◽  
Peter zu Eulenburg
Keyword(s):  
Inner Ear ◽  
Normal Subjects ◽  
Intracranial Volume ◽  
Imaging Data ◽  
Magnetic Resonance Imaging Data ◽  
Non Invasive ◽  
Substructure Analysis ◽  
Auditory Organ ◽  
Human Inner Ear

AbstractBrain atlases and templates are core tools in scientific research with increasing importance also in clinical applications. Advances in neuroimaging now allowed us to expand the atlas domain to the vestibular and auditory organ, the inner ear. In this study, we present IE-Map, an in-vivo template and atlas of all known substructures of the human labyrinth derived from multi-modal high-resolution magnetic resonance imaging data in a non-invasive manner (no contrast agent or radiation). We reconstructed a common template from 126 inner ears (63 normal subjects) and annotated it with 94 established landmarks and semi-automatic segmentations. Quantitative substructure analysis revealed a correlation of labyrinth parameters with total intracranial volume. No effects of gender or laterality were found. We provide the validated templates, atlas segmentations, surface meshes and landmark annotations as open-access material, to provide neuroscience researchers and clinicians in neurology, neurosurgery, and otorhinolaryngology with a widely applicable tool for computational neurootology.

scholarly journals IE-Map: a novel in-vivo atlas and template of the human inner ear

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Seyed-Ahmad Ahmadi ◽  
Theresa Marie Raiser ◽  
Ria Maxine Rühl ◽  
Virginia Lee Flanagin ◽  
Peter zu Eulenburg
Keyword(s):  
Inner Ear ◽  
Normal Subjects ◽  
Intracranial Volume ◽  
Micro Ct ◽  
Bony Labyrinth ◽  
Non Invasive ◽  
Auditory Organ ◽  
Magnetic Resonance Imaging Mri ◽  
Human Inner Ear

AbstractBrain atlases and templates are core tools in scientific research with increasing importance also in clinical applications. Advances in neuroimaging now allowed us to expand the atlas domain to the vestibular and auditory organ, the inner ear. In this study, we present IE-Map, an in-vivo template and atlas of the human labyrinth derived from multi-modal high-resolution magnetic resonance imaging (MRI) data, in a fully non-invasive manner without any contrast agent or radiation. We reconstructed a common template from 126 inner ears (63 normal subjects) and annotated it with 94 established landmarks and semi-automatic segmentations of all relevant macroscopic vestibular and auditory substructures. We validated the atlas by comparing MRI templates to a novel CT/micro-CT atlas, which we reconstructed from 21 publicly available post-mortem images of the bony labyrinth. Templates in MRI and micro-CT have a high overlap, and several key anatomical measures of the bony labyrinth in IE-Map are in line with micro-CT literature of the inner ear. A quantitative substructural analysis based on the new template, revealed a correlation of labyrinth parameters with total intracranial volume. No effects of gender or laterality were found. We provide the validated templates, atlas segmentations, surface meshes and landmark annotations as open-access material, to provide neuroscience researchers and clinicians in neurology, neurosurgery, and otorhinolaryngology with a widely applicable tool for computational neuro-otology.

scholarly journals Head models of healthy and depressed adults for simulating the effects of non-invasive brain stimulation

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 704 ◽  
Author(s):  
Nya Mehnwolo Boayue ◽  
Gábor Csifcsák ◽  
Oula Puonti ◽  
Axel Thielscher ◽  
Matthias Mittner
Keyword(s):  
Electric Fields ◽  
Brain Stimulation ◽  
Brain Anatomy ◽  
Imaging Data ◽  
Magnetic Resonance Imaging Data ◽  
Structural Variations ◽  
Major Depressive ◽  
Non Invasive ◽  
The Past ◽  
Dorsolateral Prefrontal

During the past decade, it became clear that the effects of non-invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are substantially influenced by variations in individual head and brain anatomy. In addition to structural variations in the healthy, several psychiatric disorders are characterized by anatomical alterations that are likely to further constrain the intracerebral effects of NIBS. Here, we present high-resolution realistic head models derived from structural magnetic resonance imaging data of 19 healthy adults and 19 patients diagnosed with major depressive disorder (MDD). By using a freely available software package for modelling the effects of different NIBS protocols, we show that our head models are well-suited for assessing inter-individual and between-group variability in the magnitude and focality of tDCS-induced electric fields for two protocols targeting the left dorsolateral prefrontal cortex.

Measurement of the Human Cochlear Spiral Curvature In Vivo

2013 ◽  
Vol 284-287 ◽  
pp. 1552-1558
Author(s):  
Jen Fang Yu ◽  
Kun Che Lee
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Inner Ear ◽  
Cochlear Implantation ◽  
Resonance Imaging ◽  
Basal Turn ◽  
Magnetic Resonance Imaging Mri ◽  
Human Inner Ear

This research aims to characterize the geometry of the human cochlear spiral in vivo by measuring curvature and length. Magnetic resonance imaging (MRI) was used to visualise the human inner ear in vivo. The inner ear was imaged in 12 ears in 7 subjects recruited. Visualisation of the cochlear spiral was enhanced by T2 weighting and further processing of the raw images. The spirals were divided into 3 segments: the basal turn segment, the middle turn segment and the apex turn segment. The length and curvature of each segment were measured. The measured lengths of cochlear spiral are consistent with data in the literature derived from anatomical dissections. Overall, the apex turn segment of the cochlear had the greatest degree of curvature. A detailed description of the cochlear spiral is provided, using measurements of curvature and length. This data will provide a valuable reference in the development of cochlear implantation procedures.

Volumetric Rendering of Human Inner Ear by MR Imaging

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P103-P103
Author(s):  
Jen-Fang Yu ◽  
Wei-Chung Chin ◽  
Che-Ming Wu ◽  
Shu-Hang Ng
Keyword(s):  
Mr Imaging ◽  
Inner Ear ◽  
3D Model ◽  
Semicircular Canals ◽  
Vestibular Aqueduct ◽  
3D Geometry ◽  
Large Vestibular Aqueduct Syndrome ◽  
Volumetric Rendering ◽  
Human Inner Ear

Problem To non-invasively measure in-vivo human inner ear by MRI and measure the geometry of vestibule by the reconstructed 3D model of inner ear for further diagnosis of large vestibular aqueduct syndrome (LVAS). Methods 3-T MR scanner, MAGNETOM Trio made by Siemens, was utilized. The TR/TE for MR imaging of 7 patients was 5.65/2.6 ms and the voxel size was 0.5 mm X 0.5 mm X 0.5 mm for single slice of 48 slices. The configuration of semicircular canals, vestibule and cochlea could be detected by threshold. The 3D geometry of inner ear was then computed based on the thickness of slice. Results The surface area and volume of semicircular canals for 7 normal ears were 217.85 square mm and 63.56 cubic mm; of vestibule were 105.88 square mm and 56.36 cubic mm; of cochlea were 171.84 square mm and 81.29 cubic mm respectively. The variation of volumes of vestibule and cochlea could be quantified non-invasively. The correlation between the volume and the level of LVAS will be analyzed once the number of volunteer reaches a statistically significant level. Conclusion The variation for the geometry of vestibule could be measured non-invasively. The grade of LVAS can be assessed by the obtained 3D model of semi-circular canal, vestibule and cochlea. Significance According to the 3D model, the geometry of inner ear can be measured, and the syndrome can be revealed directly to help clinical diagnosis of LVAS more accurately.

scholarly journals Three-dimensional movements of the lumbar spine facet joints and segmental movements: in vivo examinations of normal subjects with a new non-invasive method

2011 ◽  
Vol 21 (4) ◽  
pp. 599-605 ◽  
Author(s):  
P. Svedmark ◽  
T. Tullberg ◽  
M. E. Noz ◽  
G. Q. Maguire ◽  
M. P. Zeleznik ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Three Dimensional ◽  
Normal Subjects ◽  
Facet Joints ◽  
Non Invasive ◽  
Invasive Method

scholarly journals I034 Mechanical modeling of in vivo human carotid arteries from non-invasive clinical data. application to normal subjects

2009 ◽  
Vol 102 ◽  
pp. S99
Author(s):  
I. Masson ◽  
H. Beaussier ◽  
P. Boutouyrie ◽  
S. Laurent ◽  
J. Humfray ◽  
...  
Keyword(s):  
Clinical Data ◽  
Carotid Arteries ◽  
Normal Subjects ◽  
Mechanical Modeling ◽  
Non Invasive ◽  
Data Application ◽  
Human Carotid

scholarly journals Current Approaches to the Management of Hemochromatosis

Hematology ◽  
2006 ◽  
Vol 2006 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Pierre Brissot ◽  
Frédéric de Bels
Keyword(s):  
Chelation Therapy ◽  
Iron Chelation ◽  
Preventive Therapy ◽  
Imaging Data ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Data ◽  
Non Invasive ◽  
Juvenile Hemochromatosis ◽  
Pathogenetic Factor ◽  
Iron Parameters

The term hemochromatosis encompasses at least four types of genetic iron overload conditions, most of them recently distinguished from one another as a result of the identification of a series of genes related to iron metabolism. At least three of these entities (HFE hemochromatosis, juvenile hemochromatosis and transferrin receptor 2 hemochromatosis) involve systemic hepcidin deficiency as a key pathogenetic factor. Major advances in the management of hemochromatosis influence the diagnostic approach to the disease, with the development of an overall non invasive strategy, mainly based on clinical, biological (iron parameters and genetic testing), and imaging (especially magnetic resonance imaging) data. Therapeutic management remains, on the curative side, dominated by phlebotomy (venesection), practical aspects of which have been recently revisited by the Guidelines Department of the French “Haute Autorité de Santé.” However, innovative treatment approaches, based on the improved pathophysiological understanding of these diseases and the progress in iron chelation therapy, are emerging. Preventive therapy, focused on family screening, remains a key part of the management of hemochromatosis.

scholarly journals Engineering Oncolytic Vaccinia Viruses for Non-Invasive Optical Imaging of Tumors

2008 ◽  
Vol 2 (1) ◽  
pp. 252-261
Author(s):  
Béla Dénes ◽  
Nadja Fodor ◽  
Andre Obenaus ◽  
István Fodor
Keyword(s):  
Fluorescent Light ◽  
Imaging Data ◽  
Promising Alternative ◽  
Non Invasive ◽  
Vaccinia Viruses ◽  
Optical Reporters ◽  
Diagnostic Agent ◽  
Virus Delivery ◽  
Oncolytic Effect

Attenuated vaccinia viruses (VV) selectively replicate in malignant cells and confer oncolytic effect in vivo. Here we demonstrate that oncolytic VV may also be used as a diagnostic agent for tumor-bearing mice. A series of recombinant vaccinia viruses has been constructed expressing optical reporters to mediate emission of bioluminescent and fluorescent light which can be visualized. Data show that following systemic virus delivery the developing tumors can be non-invasively visualized in mice in vivo. Renilla luciferase and Aquoria GFP have been effective in imaging xenografted PC-3 prostate and orthotopic MB-49 bladder tumors. Brighter reporters, Gaussia luciferase and Renilla GFP have been used for imaging TRAMP prostate cancer and C6 subcutaneous model of glioma. The C6 imaging data have been corroborated by traditional MRI. We are also developing a VV-mediated system for tumor detection in far red or near infra red fluorescent light. Results suggest that VV-mediated imaging is a promising alternative for early diagnosis of various human cancers.

Geometrical Scaling for the Measurement of In-Vivo Human Inner Ear

2012 ◽  
Vol 10 (5) ◽  
pp. 1247-1251
Author(s):  
Jen-Fang Yu ◽  
Kun-Che Lee ◽  
Wei-Chung Chin
Keyword(s):  
Inner Ear ◽  
Geometrical Scaling ◽  
Human Inner Ear
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