scholarly journals Regaining perspective on SARS-CoV-2 molecular tracing and its implications

2020 ◽  
Author(s):  
Carla Mavian ◽  
Simone Marini ◽  
Costanza Manes ◽  
Ilaria Capua ◽  
Mattia Prosperi ◽  
...  
Keyword(s):  
Genetic Heterogeneity ◽  
Partial Information ◽  
Sufficient Information ◽  
Scientific Journals ◽  
Full Genome ◽  
Genome Sequences ◽  
The Past ◽  
Viral Sequences

AbstractDuring the past three months, a new coronavirus (SARS-CoV-2) epidemic has been growing exponentially, affecting over 100 thousand people worldwide, and causing enormous distress to economies and societies of affected countries. A plethora of analyses based on viral sequences has already been published, in scientific journals as well as through non-peer reviewed channels, to investigate SARS-CoV-2 genetic heterogeneity and spatiotemporal dissemination. We examined all full genome sequences currently available to assess the presence of sufficient information for reliable phylogenetic and phylogeographic studies. Our analysis clearly shows severe limitations in the present data, in light of which any finding should be considered, at the very best, preliminary and hypothesis-generating. Hence the need for avoiding stigmatization based on partial information, and for continuing concerted efforts to increase number and quality of the sequences required for robust tracing of the epidemic.

scholarly journals A snapshot of SARS-CoV-2 genome availability up to 30th March, 2020 and its implications

2020 ◽  
Author(s):  
Carla Mavian ◽  
Simone Marini ◽  
Mattia Prosperi ◽  
Marco Salemi
Keyword(s):  
Sufficient Information ◽  
Scientific Journals ◽  
Full Genome ◽  
Genome Sequences ◽  
Phylogenetic Information ◽  
Specific Data ◽  
Full Dataset ◽  
Viral Sequences ◽  
Country Specific

AbstractThe SARS-CoV-2 pandemic has been growing exponentially, affecting nearly 900 thousand people and causing enormous distress to economies and societies worldwide. A plethora of analyses based on viral sequences has already been published, in scientific journals as well as through non-peer reviewed channels, to investigate SARS-CoV-2 genetic heterogeneity and spatiotemporal dissemination. We examined full genome sequences currently available to assess the presence of sufficient information for reliable phylogenetic and phylogeographic studies in countries with the highest toll of confirmed cases. Although number of-available full-genomes is growing daily, and the full dataset contains sufficient phylogenetic information that would allow reliable inference of phylogenetic relationships, country-specific SARS-CoV-2 datasets still present severe limitations. Studies assessing within country spread or transmission clusters should be considered preliminary at best, or hypothesis generating. Hence the need for continuing concerted efforts to increase number and quality of the sequences required for robust tracing of the epidemic.Significance StatementAlthough genome sequences of SARS-CoV-2 are growing daily and contain sufficient phylogenetic information, country-specific data still present severe limitations and should be interpreted with caution.

scholarly journals Multi-Method END Study in the Search for 'Defects' in an Aeronautical Radar Element

2020 ◽  
Vol 14 (11) ◽  
pp. 19
Author(s):  
Gaston Sanglier ◽  
Jose Miguel ◽  
Jose Antonio Penaranda ◽  
y Gabriel Del Ojo
Keyword(s):  
Partial Information ◽  
Non Destructive Testing ◽  
Destructive Testing ◽  
The Past ◽  
New Methods ◽  
New Concepts ◽  
Indispensable Tool ◽  
Inspection Techniques ◽  
Non Destructive

Non-Destructive Testing (NDT) has gone from being a simple laboratory curiosity to an indispensable tool in the industry to determine the level of quality achieved in its products. The new concepts of Integrated Manufacturing (CIM) bring a more universal concept of quality compared to the past philosophy based on Quality Control as a group specialized in checking whether production works within certain specifications. Even so, NDTs have not lost interest, but have seen their interest increased due to automated inspection techniques. It has become a contribution to the structuring of quality as it allows to move from purely empirical criteria to other more objective and that constitute the link between design and evaluation (Ramirez et al, 1996). The work presented, although it does not propose new methods or techniques of NDT, has the interest of converging into a single object five conventional methods each of which provides partial information about their quality of manufacture and must synthesize the results in order to evaluate it. Furthermore, it shows a situation of the application of NDT in which these must be applied in the absence of reference standards, as they do not exist. This peculiar situation is completely different from the usual situation in the use of NDT in the industry, both in manufacturing processes and in maintenance inspections.

scholarly journals The Prevalence of Inappropriate Image Duplication in Biomedical Research Publications

mBio ◽  
2016 ◽  
Vol 7 (3) ◽  
Author(s):  
Elisabeth M. Bik ◽  
Arturo Casadevall ◽  
Ferric C. Fang
Keyword(s):  
Biomedical Research ◽  
Scientific Literature ◽  
Scientific Journals ◽  
Marked Variation ◽  
The Past ◽  
Inaccurate Data ◽  
Research Publications ◽  
Scientific Papers ◽  
Actual Prevalence

ABSTRACT Inaccurate data in scientific papers can result from honest error or intentional falsification. This study attempted to determine the percentage of published papers that contain inappropriate image duplication, a specific type of inaccurate data. The images from a total of 20,621 papers published in 40 scientific journals from 1995 to 2014 were visually screened. Overall, 3.8% of published papers contained problematic figures, with at least half exhibiting features suggestive of deliberate manipulation. The prevalence of papers with problematic images has risen markedly during the past decade. Additional papers written by authors of papers with problematic images had an increased likelihood of containing problematic images as well. As this analysis focused only on one type of data, it is likely that the actual prevalence of inaccurate data in the published literature is higher. The marked variation in the frequency of problematic images among journals suggests that journal practices, such as prepublication image screening, influence the quality of the scientific literature.

scholarly journals The Prevalence of Inappropriate Image Duplication in Biomedical Research Publications

2016 ◽  
Author(s):  
Elisabeth M. Bik ◽  
Arturo Casadevall ◽  
Ferric C. Fang
Keyword(s):  
Biomedical Research ◽  
Scientific Literature ◽  
Scientific Journals ◽  
Marked Variation ◽  
The Past ◽  
Inaccurate Data ◽  
Research Publications ◽  
Scientific Papers ◽  
Actual Prevalence

ABSTRACTInaccurate data in scientific papers can result from honest error or intentional falsification. This study attempted to determine the percentage of published papers containing inappropriate image duplication, a specific type of inaccurate data. The images from a total of 20,621 papers in 40 scientific journals from 1995-2014 were visually screened. Overall, 3.8% of published papers contained problematic figures, with at least half exhibiting features suggestive of deliberate manipulation. The prevalence of papers with problematic images rose markedly during the past decade. Additional papers written by authors of papers with problematic images had an increased likelihood of containing problematic images as well. As this analysis focused only on one type of data, it is likely that the actual prevalence of inaccurate data in the published literature is higher. The marked variation in the frequency of problematic images among journals suggest that journal practices, such as pre-publication image screening, influence the quality of the scientific literature.

Publication process

2016 ◽  
Keyword(s):  
Impact Factor ◽  
Research Process ◽  
Research Field ◽  
Scientific Journals ◽  
Final Phase ◽  
The Past ◽  
Research Findings ◽  
The Impact ◽  
Objective Indicators

The final phase in the research process is the publication of research findings in a paper in scientific journals. Authors who contributed to the developed work are reported in the manuscript. There are now rules and guidelines to help in improving the transparency for the reporting of authorship and contributorship in papers which are discussed in this chapter The appraisal of the quality of scientific and medical can be difficult. Criteria that had been used in the past included journal prestige, the reputation of authors and institution and prestige and estimated importance and relevance of the research field. However, these factors are both qualitative and subjective. Consequently, there is demand for quatitative and objective indicators for evaluating research that is related to published science. The impact factor is perhaps the most widely used indicator that measures and quantifies a journal’s quality.

scholarly journals An Analysis of SARS-CoV-2 Using ViReport

2020 ◽  
Author(s):  
Miranda Song ◽  
Niema Moshiri
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Phylogenetic Analyses ◽  
Full Genome ◽  
Genome Sequences ◽  
Link Type ◽  
Preventative Intervention ◽  
Viral Sequences

AbstractThe ongoing outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in millions of cases and hundreds of thousands of deaths. Given the current lack of treatments or vaccines available, it may be useful to trace the evolu-tion and spread of the virus to better develop methods of preventative intervention. In this study, we analyzed over 4,000 full genome sequences of human SARS-CoV-2 using novel tool ViReport [13], an automated workflow for performing phylogenetic analyses on viral sequences and generating comprehensive molecular epidemiologi-cal reports. The complete ViReport output can be found at https://github.com/mirandajsong/ViReport-SARS-CoV-2.

Immunoferritin localization of intracellular antigens in positively stained frozen sections

1978 ◽  
Vol 36 (2) ◽  
pp. 168-169
Author(s):  
K. T. Tokuyasu
Keyword(s):  
Surface Tension ◽  
Water Surface ◽  
Thin Layers ◽  
The Other ◽  
Positive Staining ◽  
Frozen Sections ◽  
The Past ◽  
Ultrathin Frozen Sections ◽  
Definition Of

During the past investigations of immunoferritin localization of intracellular antigens in ultrathin frozen sections, we found that the degree of negative staining required to delineate u1trastructural details was often too dense for the recognition of ferritin particles. The quality of positive staining of ultrathin frozen sections, on the other hand, has generally been far inferior to that attainable in conventional plastic embedded sections, particularly in the definition of membranes. As we discussed before, a main cause of this difficulty seemed to be the vulnerability of frozen sections to the damaging effects of air-water surface tension at the time of drying of the sections.Indeed, we found that the quality of positive staining is greatly improved when positively stained frozen sections are protected against the effects of surface tension by embedding them in thin layers of mechanically stable materials at the time of drying (unpublished).

Exercise Capacity in Chronic Heart Failure

2012 ◽  
Vol 9 (1) ◽  
pp. 57-60 ◽  
Author(s):  
Gina G Mentzer ◽  
Alex J Auseon
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Exercise Training ◽  
Exercise Capacity ◽  
Positive Impact ◽  
Pharmacologic Therapy ◽  
The Past ◽  
Diagnosis And Prognosis ◽  
Future Therapy

Heart failure (HF) affects more than 5 million people and has an increasing incidence and cost burden. Patients note symptoms of dyspnea and fatigue that result in a decreased quality of life, which has not drastically improved over the past decades despite advances in therapies. The assessment of exercise capacity can provide information regarding patient diagnosis and prognosis, while doubling as a potential future therapy. clinically, there is acceptance that exercise is safe in hf and can have a positive impact on morbidity and quality of life, although evidence for improvement in mortality is still lacking. specific prescriptions for exercise training have not been developed because many variables and confounding factors have prevented research trials from demonstrating an ideal regimen. Physicians are becoming more aware of the indices and goals for hf patients in exercise testing and therapy to provide comprehensive cardiac care. it is further postulated that a combination of exercise training and pharmacologic therapy may eventually provide the most benefits to those suffering from hf.

Bioethics In Neurospinal Patient Care

2018 ◽  
Vol 1 (2) ◽  
pp. 1
Author(s):  
Andi Asadul Islam
Keyword(s):  
Time Frame ◽  
Hippocratic Oath ◽  
Moral Vision ◽  
Human Identity ◽  
The Past ◽  
Harvey Cushing ◽  
Sharp Focus ◽  
Realistic Approach ◽  
Cord Injury

Neurosurgery is among the newest of surgical disciplines, appearing in its modern incarnation at the dawn of twentieth century with the work of Harvey Cushing and contemporaries. Neurosurgical ethics involves challenges of manipulating anatomical locus of human identity and concerns of surgeons and patients who find themselves bound together in that venture.In recent years, neurosurgery ethics has taken on greater relevance as changes in society and technology have brought novel questions into sharp focus. Change of expanded armamentarium of techniques for interfacing with the human brain and spine— demand that we use philosophical reasoning to assess merits of technical innovations.Bioethics can be defined as systematic study of moral challenges in medicine, including moral vision, decisions, conduct, and policies related to medicine. Every surgeon should still take the Hippocratic Oath seriously and consider it a basic guide to follow good medical ethics in medical practice. It is simple and embodies three of the four modern bioethics principles – Respecting autonomy, beneficence, nonmaleficence, and justice.Spinal cord injury (SCI) is a devastating condition often affecting young and healthy individuals around the world. Currently, scientists are pressured on many fronts to develop an all-encompassing “cure” for paralysis. While scientific understanding of central nervous system (CNS) regeneration has advanced greatly in the past years, there are still many unknowns with regard to inducing successful regeneration. A more realistic approach is required if we are interested in improving the quality of life of a large proportion of the paralyzed population in a more expedient time frame.

Menopausal hormone therapy and uterine cancer: the acceptability of the tandem

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (6) ◽  
pp. 42-47
Author(s):  
O V Yakushevskaya ◽  
S V Yureneva ◽  
A E Protasova ◽  
G N Khabas ◽  
M R Dumanovskaya
Keyword(s):  
Hormone Therapy ◽  
Uterine Cancer ◽  
Menopausal Hormone Therapy ◽  
Medical Rehabilitation ◽  
Cytostatic Treatment ◽  
Systematic Analysis ◽  
Strict Adherence ◽  
Patient Profile ◽  
The Past

The aim of the work is to conduct a systematic analysis of the available research results on the possibility of using menopausal hormone therapy (MHT) in patients who successfully completed the treatment of endometrial cancer (EC). Materials and methods. The review includes data from foreign articles published in PubMed and Medline, and domestic works published on elibrary.ru over the past 40 years. Results. The results obtained allow us to consider MHT as an independent method of medical rehabilitation for women who have undergone EC. A clear patient profile should be established, allowing the use of this method, with strict adherence to health monitoring. Conclusion Patients who have successfully completed the treatment of EC require the creation of special rehabilitation conditions in the interests of maintaining health and quality of life and should be under the close attention of the doctor. Argumented approaches to the appointment of MHT in such patients will avoid complications associated with estrogen deficiency after surgery, radiation with or without systemic (cytostatic) treatment methods.

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