Region-Specific PSD-95 Interactomes Contribute to Functional Diversity of Excitatory Synapses in Human Brain
Keyword(s):
The overarching goal of this exploratory study is to link subcellular microdomain specific protein-protein interactomes with big data analytics. We isolated postsynaptic density-95 (PSD-95) complexes from four human brain regions and compared their protein interactomes using multiple bioinformatics techniques. We demonstrate that human brain regions have unique postsynaptic protein signatures that may be used to interrogate perturbagen databases. Assessment of our hippocampal signature using the iLINCS database yielded several compounds with recently characterized “off target” effects on protein-protein interactions in the posynaptic density compartment.
Keyword(s):
2018 ◽
Vol 25
(1)
◽
pp. 5-21
◽
Keyword(s):
2018 ◽
Vol 46
(6)
◽
pp. 1593-1603
◽
2021 ◽
2012 ◽
Vol 58
(11)
◽
pp. 1241-1257
◽
1997 ◽
Vol 379
(1)
◽
pp. S22
Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactions
1998 ◽
Vol 95
(18)
◽
pp. 10972-10977
◽
Keyword(s):