Monitoring S. pombe genome stress by visualizing end-binding protein Ku
Keyword(s):
AbstractStudies of genome stability have exploited visualization of fluorescently tagged proteins in live cells to characterize DNA damage, checkpoint, and repair responses. In this report, we describe a new tool for fission yeast, a tagged version of the end-binding protein Pku70 which is part of the KU protein complex. We compare Pku70 localization to other markers upon treatment to various genotoxins, and identify a unique pattern of distribution. Pku70 provides a new tool to define and characterize DNA lesions and the repair response.
Keyword(s):
2005 ◽
Vol 25
(17)
◽
pp. 7889-7899
◽
Keyword(s):
2018 ◽
Vol 115
(8)
◽
pp. E1759-E1768
◽
Keyword(s):
Keyword(s):
2000 ◽
Vol 65
(0)
◽
pp. 353-360
◽
Keyword(s):
2006 ◽
Vol 26
(1)
◽
pp. 39-49
◽
Keyword(s):