Climatic-niche evolution of SARS-CoV-2
AbstractCOVID-19 pandemic is studied by several field experts. However, it is still unclear why it was restricted to higher latitudes during the initial days & later cascaded in the tropics. Here, we analyzed 176 SARS-CoV-2 genomes across different latitudes & climate (Koppen’s climate) that provided insights about within species virus evolution & its relation to abiotic factors. Two genetically variant groups, named as G1 & G2 were identified, well defined by four mutations. The G1 group (ancestor), is mainly restricted to warm & moist, temperate climate (Koppen’s C climate) while its descendent G2 group surpasses the climatic restrictions of G1, initially cascading into neighboring cold climate (D) of higher latitudes & later into hot climate of the tropics (A). It appears that the gradation of temperate climate (Cfa-Cfb) to “cold climate” (Dfa-Dfb) climate drives the evolution of G1 into G2 variant group which later adapted to tropical climate (A) as well. It seems this virus follows inverse latitudinal gradient in the beginning due to its preference towards temperate (C) & cold climate (D). Nevertheless, due to the uncertainty of COVID-19 data, the results must be cautiously interpreted & should not be extrapolated to climate types and climatic conditions other than those analyzed here for the early evolution period. Our work elucidates virus evolutionary studies combined with climatic studies can provide crucial information about the pathogenesis & natural spreading pathways in such outbreaks which is hard to achieve through individual studies.Graphical AbstractIn BriefThe authors elucidate adaptation of SARS-CoV-2 to different climates by studying phylogenetics & the distribution of strains on Koppen’s climate map.HighlightsSARS-CoV-2 follows inverse latitudinal gradient during initial days.Phylogenetic network divides SARS-CoV-2 strains into two variant groups, G1 & G2.G1 strains is restricted to Koppen’s “temperate” climate (mainly Cfa-Cfb).G2 strains has evolved from G1 to sustain in mainly “humid-continental” (Dfa-Dfb) & “tropical-savannah” (Aw) climate.