scholarly journals Estimating the time since admixture from phased and unphased molecular data

2020 ◽  
Author(s):  
Thijs Janzen ◽  
Verónica Miró Pina
Keyword(s):  
Case Studies ◽  
Molecular Clock ◽  
Simulated Data ◽  
Molecular Data ◽  
Recent Past ◽  
Ancestral Recombination Graph ◽  
Expected Number ◽  
Swordtail Fish ◽  
New Framework ◽  
Better Than

AbstractAfter admixture, recombination breaks down genomic blocks of contiguous ancestry. The break down of these blocks forms a new ‘molecular’ clock, that ticks at a much faster rate than the mutation clock, enabling accurate dating of admixture events in the recent past. However, existing theory on the break down of these blocks, or the accumulation of delineations between blocks, so called ‘junctions’, has been limited to using regularly spaced markers on phased data. Here, we present an extension to the theory of junctions using the Ancestral Recombination Graph that describes the expected number of junctions for any distribution of markers along the genome. Furthermore, we provide a new framework to infer the time since admixture using unphased data. We demonstrate both the phased and unphased methods on simulated data and show that our new extensions perform much better than previous methods, especially for more ancient admixture times. Lastly, we demonstrate the applicability of our method on an empirical dataset of labcrosses of yeast (Saccharomyces cerevisae) and on two case studies of hybridization in swordtail fish and Populus trees.

A novel GNSS deformation feature extraction method based on ensemble improved LMD threshold denoising

2020 ◽  
Vol 14 (4) ◽  
pp. 445-453
Author(s):  
Qian Fan ◽  
Yiqun Zhu
Keyword(s):  
Feature Extraction ◽  
Spline Interpolation ◽  
Simulated Data ◽  
Mining Area ◽  
Deformation Monitoring ◽  
Denoising Method ◽  
Feature Extraction Method ◽  
Deformation Feature ◽  
Mode Decomposition ◽  
Better Than

AbstractIn order to solve the problem that the moving span of basic local mean decomposition (LMD) method is difficult to choose reasonably, an improved LMD method (ILMD), which uses three cubic spline interpolation to replace the sliding average, is proposed. On this basis, with the help of noise aided calculation, an ensemble improved LMD method (EILMD) is proposed to effectively solve the modal aliasing problem in original LMD. On the basis of using EILMD to effectively decompose the data of GNSS deformation monitoring series, GNSS deformation feature extraction model based on EILMD threshold denoising is given by means of wavelet soft threshold processing mode and threshold setting method in empirical mode decomposition denoising. Through the analysis of simulated data and the actual GNSS monitoring data in the mining area, the results show that denoising effect of the proposed method is better than EILMD, ILMD and LMD direct coercive denoising methods. It is also better than wavelet analysis denoising method, and has good adaptability. This fully demonstrates the feasibility and effectiveness of the proposed method in GNSS feature extraction.

Bounded Elastic Moduli Multiplier Technique for Limit Loads: Part 2 - Case Studies

2021 ◽  
Author(s):  
Sathya Prasad Mangalaramanan
Keyword(s):  
Lower Bound ◽  
Case Studies ◽  
Power Law ◽  
Elastic Moduli ◽  
New Method ◽  
Stress Distributions ◽  
Limit Loads ◽  
Elastic Plastic ◽  
Thick Cylinder ◽  
Better Than

Abstract An accompanying paper provides the theoretical underpinnings of a new method to determine statically admissible stress distributions in a structure, called Bounded elastic moduli multiplier technique (BEMMT). It has been shown that, for textbook cases such as thick cylinder, beam, etc., the proposed method offers statically admissible stress distributions better than the power law and closer to elastic-plastic solutions. This paper offers several examples to demonstrate the robustness of this method. Upper and lower bound limit loads are calculated using iterative elastic analyses using both power law and BEMMT. These results are compared with the ones obtained from elastic-plastic FEA. Consistently BEMMT has outperformed power law when it comes to estimating lower bound limit loads.

scholarly journals Tail-Heaviness, Asymmetry, and Profitability Forecasting by Quantile Regression

2020 ◽  
Author(s):  
Hui Tian ◽  
Andrew Yim ◽  
David P. Newton
Keyword(s):  
Quantile Regression ◽  
Forecast Error ◽  
Simulated Data ◽  
Ordinary Least Squares ◽  
Shape Effect ◽  
Forecasting Accuracy ◽  
Forecasting Performance ◽  
Cash Flow Forecasting ◽  
Positive Effect ◽  
Better Than

We show that quantile regression is better than ordinary-least-squares (OLS) regression in forecasting profitability for a range of profitability measures following the conventional setup of the accounting literature, including the mean absolute forecast error (MAFE) evaluation criterion. Moreover, we perform both a simulated-data and an archival-data analysis to examine how the forecasting performance of quantile regression against OLS changes with the shape of the profitability distribution. Considering the MAFE and mean squared forecast error (MSFE) criteria together, we see that the quantile regression is more accurate relative to OLS when the profitability to be forecast has a heavier-tailed distribution. In addition, the asymmetry of the profitability distribution has either a U-shape or an inverted-U-shape effect on the forecasting accuracy of quantile regression. An application of the distributional shape analysis framework to cash flow forecasting demonstrates the usefulness of the framework beyond profitability forecasting, providing additional empirical evidence on the positive effect of tail-heaviness and supporting the notion of an inverted-U-shape effect of asymmetry. This paper was accepted by Shiva Rajgopal, accounting.

scholarly journals An ancestral recombination graph of human, Neanderthal, and Denisovan genomes

2021 ◽  
Vol 7 (29) ◽  
pp. eabc0776
Author(s):  
Nathan K. Schaefer ◽  
Beth Shapiro ◽  
Richard E. Green
Keyword(s):  
Incomplete Lineage Sorting ◽  
Simulated Data ◽  
Modern Human ◽  
Ancestral Recombination Graph ◽  
Lineage Sorting ◽  
Human Genomes ◽  
Genome Wide ◽  
A Genome ◽  
Graph Inference ◽  
And Function

Many humans carry genes from Neanderthals, a legacy of past admixture. Existing methods detect this archaic hominin ancestry within human genomes using patterns of linkage disequilibrium or direct comparison to Neanderthal genomes. Each of these methods is limited in sensitivity and scalability. We describe a new ancestral recombination graph inference algorithm that scales to large genome-wide datasets and demonstrate its accuracy on real and simulated data. We then generate a genome-wide ancestral recombination graph including human and archaic hominin genomes. From this, we generate a map within human genomes of archaic ancestry and of genomic regions not shared with archaic hominins either by admixture or incomplete lineage sorting. We find that only 1.5 to 7% of the modern human genome is uniquely human. We also find evidence of multiple bursts of adaptive changes specific to modern humans within the past 600,000 years involving genes related to brain development and function.

scholarly journals Commission 14: Atomic and Molecular Data: (Donnees Atomiques et Moleculaires)

2000 ◽  
Vol 24 (1) ◽  
pp. 380-420
Author(s):  
F. Rostas ◽  
P. L. Smith ◽  
K. A. Berrington ◽  
N. Feautrier ◽  
N. Grevesse ◽  
...  
Keyword(s):  
Case Studies ◽  
Executive Committee ◽  
Molecular Cloud ◽  
Molecular Data ◽  
Research Community ◽  
General Assembly ◽  
Modeling Tools ◽  
New Developments ◽  
Interdisciplinary Character

In recognition of its special interdisciplinary character, IAU Commission 14 is linked directly to the Executive Committee. The Commission’s role is to inform the astronomical community of new developments in the diverse fields of research which involve atoms and molecules. Conversely it endeavors to sensitize the research community active in those fields to the specific needs of astronomy, especially concerning basic data and modeling tools. More generally, Commission 14 tries to foster long term relations and collaborations between the two communities and, when necessary, to alert funding authorities to the specific needs of ground and space based astronomy for specific atomic and molecular data. This report is one of the main contributions of Commission 14 to the information of the astronomical community. Several meetings concerned, at least in part, with the need and availability of atomic and molecular data for astrophysics were also sponsored or co-sponsored. In the last triennium, Commission 14 cosponsored IAU Symposium 194 “Astrochemistry: From Molecular Cloud to Planetary Systems” held in Sogwipo (Korea) from Aug. 23 to 27, 1999 and organized by Commission 34. A Joint Discussion: JD1 on “Atomic and Molecular Data for Astrophysics, New Developments, Case Studies and Future Needs” has been planned for the XXIVth IAU General Assembly in Manchester (Aug. 7-19, 2000) and cosponsored by Commissions 15, 16, 29, 34, 36, 40 and 44. Several other Joint Discussions to be held at the Manchester General Assembly are co-sponsored by this commission.

scholarly journals Bridging the gap between science communication practice and theory: Reflecting on a decade of practitioner experience using polar outreach case studies to develop a new framework for public engagement design

Polar Record ◽  
2019 ◽  
Vol 55 (4) ◽  
pp. 297-310 ◽  
Author(s):  
Rhian A. Salmon ◽  
Heidi A. Roop
Keyword(s):  
Case Studies ◽  
Public Engagement ◽  
Science Communication ◽  
Practical Training ◽  
Power Structures ◽  
International Polar Year ◽  
Communication Practice ◽  
Wide Range ◽  
Training Resources ◽  
New Framework

AbstractThe International Polar Year 2007–2008 stimulated a wide range of education, outreach and communication (EOC) related to polar research, and catalysed enthusiasm and networks that persist ten years on. Using a multi-method approach that incorporates case studies, auto-ethnographic interviews, and survey data, we interrogate the opportunities and limitations of polar EOC activities and propose a new framework for practical, reflexive, engagement design. Our research suggests that EOC activities are under-valued and often designed based on personal instinct rather than strategic planning, but that there is also a lack of accessible tools that support a more strategic design process. We propose three foci for increasing the professionalisation of practitioner approaches to EOC: (1) improved articulation of goals and objectives; (2) acknowledgement of different drivers, voices and power structures; and (3) increased practical training, resources and reporting structures. We respond to this by proposing a framework for planning and design of public engagement that provides an opportunity to become more transparent and explicit about the real goals of an activity and what “success” looks like. This is critical to effectively evaluate, learn from our experiences, share them with peers, and ultimately deliver more thoughtfully designed, effective engagement.

Robots Showing Emotions

2016 ◽  
Vol 17 (3) ◽  
pp. 408-437 ◽  
Author(s):  
Julian M. Angel-Fernandez ◽  
Andrea Bonarini
Keyword(s):  
Case Studies ◽  
Emotion Expression ◽  
The Body ◽  
Emotional Expressions ◽  
Emotional States ◽  
Special Shape ◽  
Social Agents ◽  
Angular Velocities ◽  
Better Than

Abstract Robots should be able to represent emotional states to interact with people as social agents. There are cases where robots cannot have bio-inspired bodies, for instance because the task to be performed requires a special shape, as in the case of home cleaners, package carriers, and many others. In these cases, emotional states have to be represented by exploiting movements of the body. In this paper, we present a set of case studies aimed at identifying specific values to convey emotion trough changes in linear and angular velocities, which might be applied on different non-anthropomorphic bodies. This work originates from some of the most considered emotion expression theories and from emotion coding for people. We show that people can recognize some emotional expressions better than others, and we propose some directions to express emotions exploiting only bio-neutral movement.

Frenemies

2018 ◽  
Author(s):  
Nancy Whittier
Keyword(s):  
Sexual Abuse ◽  
Child Sexual Abuse ◽  
Case Studies ◽  
Violence Against Women ◽  
Congressional Hearings ◽  
Violence Against Women Act ◽  
Reputational Risk ◽  
Collaborative Interaction ◽  
Policy Arena ◽  
New Framework

What happens when activists who usually oppose each other work to advance similar goals? This book re-conceptualizes models of social movements’ relationships with each other and develops a new framework for understanding relationships that are neither coalitions nor countermovements. Rich, empirically grounded case studies of opposition to pornography, child sexual abuse policy, and the Violence Against Women Act show how feminists and conservatives engaged with the issues and with each other, the differences between their approaches, and both their points of overlap and their power struggles. Each case illustrates a different type of relationship: an adversarial yet collaborative interaction around pornography; a narrow, issue-specific, and politically neutral opposition to child sexual abuse; and an ambivalent alliance confined to the policy arena for the Violence Against Women Act. Focusing on activism targeting the federal government from 1980 to 2013, the book draws on a unique, in-depth dataset, including transcripts of Congressional hearings and movement documents, to analyze interpretive processes within the state. Activists constructed frames that enabled cross-ideological support, dealt with the reputational risk of appearing to consort with the enemy, and sometimes compromised or de-emphasized controversial goals in favor of areas of commonality. In the end, feminists and conservatives influenced policy and culture to different degrees in the three case studies, depending on their relative power. Frenemies draws powerful lessons about both the benefits and risks of collaboration across ideological difference.

scholarly journals MONITORING OF EFFECTIVENESS OF SPIRONOLACTONE THERAPY AND ITS COMBINATIONS WITH FUROSEMIDE TO LIVER CIRRHOSIS AND ASCITES IN RSUP H. ADAM MALIK MEDAN

2018 ◽  
Vol 11 (13) ◽  
pp. 159
Author(s):  
Elliya Siswanti ◽  
Urip Harahap ◽  
Juwita Sembiring
Keyword(s):  
Liver Cirrhosis ◽  
Case Studies ◽  
Urine Sodium ◽  
Cross Sectional ◽  
Normal Value ◽  
Significant Difference ◽  
Sample Data ◽  
Better Than ◽  
Program Version

Objectives: Spironolactone and furosemide are diuretics used to treat liver cirrhosis with ascites, but not case studies have been found to distinguish the effects of spironolactone and its combination with furosemide in cases of cirrhosis accompanied by ascites. This study aims to determine the effectiveness of spironolactone therapy and its combination with furosemide to liver cirrhosis patients accompanied ascites.Methods: This research was done by cross-sectional prospective method. 26 patients in RSUP H Adam Malik Medan for 3 months were divided into two groups. The first group of nine patients, age between 39 and 65 years, was given spironolactone. The second group of 17 patients, age between 20 and 81 years, was given spironolactone combined with furosemide. The sample data were analyzed with statistics using Mann–Whitney U-test, SPSS program version 22.Result: Based on Mann–Whitney U statistic test, the value of Asymp. significance (2-tailed) 0.435 for urine Na/K at time, and Asymp. significance value (2-tailed) 0.628 24 h urine sodium examination, based on the value, it was concluded that there was no significant difference between spironolactone with its combination with furosemide. Even though the significant value were 0.628 mEq and 0.435 mEq (p>0.05).Conclusion: This study showed that the combination of spironolactone with furosemide was better than compared to spironolactone. Although there was not statistically significant difference if seen from the comparison of 24 h of urine sodium value with a normal value of 78 mEq.

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