scholarly journals Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2

2020 ◽  
Author(s):  
Romain Gasser ◽  
Marc Cloutier ◽  
Jérémie Prévost ◽  
Corby Fink ◽  
Éric Ducas ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Immunoglobulin A ◽  
Humoral Response ◽  
Immunoglobulin M ◽  
Neutralization Activity ◽  
Immunoglobulin Isotype ◽  
Neutralizing Capacity ◽  
Increased Susceptibility

AbstractCharacterization of the humoral response to SARS-CoV-2, the etiological agent of Covid-19, is essential to help control the infection. In this regard, we and others recently reported that the neutralization activity of plasma from COVID-19 patients decreases rapidly during the first weeks after recovery. However, the specific role of each immunoglobulin isotype in the overall neutralizing capacity is still not well understood. In this study, we selected plasma from a cohort of Covid-19 convalescent patients and selectively depleted immunoglobulin A, M or G before testing the remaining neutralizing capacity of the depleted plasma. We found that depletion of immunoglobulin M was associated with the most substantial loss of virus neutralization, followed by immunoglobulin G. This observation may help design efficient antibody-based COVID-19 therapies and may also explain the increased susceptibility to SARS-CoV-2 of autoimmune patients receiving therapies that impair the production of IgM.

scholarly journals Characterization of Biofilm Formation and the Role of BCR1 in Clinical Isolates of Candida parapsilosis

2013 ◽  
Vol 13 (4) ◽  
pp. 438-451 ◽  
Author(s):  
Srisuda Pannanusorn ◽  
Bernardo Ramírez-Zavala ◽  
Heinrich Lünsdorf ◽  
Birgitta Agerberth ◽  
Joachim Morschhäuser ◽  
...  
Keyword(s):  
Biofilm Formation ◽  
Candida Parapsilosis ◽  
Clinical Isolates ◽  
Wild Type ◽  
Content Type ◽  
Initial Adhesion ◽  
High Level ◽  
Increased Susceptibility

ABSTRACT In Candida parapsilosis , biofilm formation is considered to be a major virulence factor. Previously, we determined the ability of 33 clinical isolates causing bloodstream infection to form biofilms and identified three distinct groups of biofilm-forming strains (negative, low, and high). Here, we establish two different biofilm structures among strains forming large amounts of biofilm in which strains with complex spider-like structures formed robust biofilms on different surface materials with increased resistance to fluconazole. Surprisingly, the transcription factor Bcr1, required for biofilm formation in Candida albicans and C. parapsilosis , has an essential role only in strains with low capacity for biofilm formation. Although BCR1 leads to the formation of more and longer pseudohyphae, it was not required for initial adhesion and formation of mature biofilms in strains with a high level of biofilm formation. Furthermore, an additional phenotype affected by BCR1 was the switch in colony morphology from rough to crepe, but only in strains forming high levels of biofilm. All bcr1 Δ/Δ mutants showed increased proteolytic activity and increased susceptibility to the antimicrobial peptides protamine and RP-1 compared to corresponding wild-type and complemented strains. Taken together, our results demonstrate that biofilm formation in clinical isolates of C. parapsilosis is both dependent and independent of BCR1 , but even in strains which showed a BCR1 -independent biofilm phenotype, BCR1 has alternative physiological functions.

Major Immunoglobulin Ratios in Carcinoma of the Head and Neck

1978 ◽  
Vol 87 (3) ◽  
pp. 412-415 ◽  
Author(s):  
Arnold E. Katz ◽  
John O. Nysather ◽  
Lee A. Harker
Keyword(s):  
Head And Neck ◽  
Immunoglobulin G ◽  
Immunoglobulin A ◽  
Elevated Serum ◽  
Immunoglobulin M ◽  
Serum Immunoglobulin ◽  
Control Groups ◽  
Immunoglobulin Production ◽  
Patients With Cancer ◽  
Serum Iga

— Serum immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) levels were determined on 245 patients with carcinoma of the head and neck and on 92 controls. Ratios of these levels were calculated for each subject. The patients with cancer demonstrated elevated serum IgA levels ( P <.0001) and elevated IgA/IgM and IgA/IgG ratios ( P <.05). No differences were noted when the IgM/IgG ratios were compared between the cancer and the control groups. These observations are offered as evidence that previously reported elevations of serum IgA levels in patients with carcinoma of the head and neck are not merely an index of nonspecific increased immunoglobulin production in these patients.

Characteristics of immunoglobulin A nephropathy with mesangial immunoglobulin G and immunoglobulin M deposition

Nephrology ◽  
2010 ◽  
Vol 15 (8) ◽  
pp. 747-754 ◽  
Author(s):  
TAKAHITO MORIYAMA ◽  
ARI SHIMIZU ◽  
TAKASHI TAKEI ◽  
KEIKO UCHIDA ◽  
KAZUHO HONDA ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Immunoglobulin A ◽  
Immunoglobulin M ◽  
Immunoglobulin A Nephropathy

scholarly journals Multi-Micronutrient Supplementation and Immunoglobulin Response in Well-Fed Firefighters

2020 ◽  
Vol 05 (01) ◽  
pp. E1-E7
Author(s):  
José Augusto Rodrigues Santos ◽  
Ricardo J. Fernandes ◽  
Rodrigo Zacca
Keyword(s):  
Immunoglobulin G ◽  
Physical Training ◽  
Immunoglobulin A ◽  
Immunoglobulin M ◽  
Control Group ◽  
Micronutrient Supplementation ◽  
Mean Values ◽  
Serum Immunoglobulins ◽  
Recruit Training ◽  
And Control

AbstractIntensive physical training programs can affect the immune system. This study aims to verify the multi-micronutrient supplementation effects on serum immunoglobulins levels prior to and after a five-week physical training program. Twenty-four male recruit firefighters were randomly allocated into supplemented (with Prisfar Ever-Fit Plus over 35 consecutive days) and placebo groups (n=12 each). Serum immunoglobulins G, A, and M were assessed. Supplementation effect was detected for immunoglobulin G (eta-squared, η2: 0.09; p=0.035; power: 0.56), A (η2: 0.24; p=0.001; power: 0.95), and M (η2: 0.09; p=0.036; power: 0.56). Although immunoglobulin A was different between groups at baseline (mean difference: 42.58; 95%CI: 7.00 to 78.16 mg/dL; p=0.021; d=2.48), within-group (before vs. after five weeks) showed no differences for both supplemented and control groups. In addition, even if immunoglobulin G and M were similar at baseline, immunoglobulin G decreased (mean diff.: 46.4; 95%CI: 6.7 to 86.1 mg/dL; p=0.03; d=0.74) and immunoglobulin M increased (mean diff.: −10.7; 95%CI: −15.8 to −5.5 mg/dL; p=0.001; d=−1.33) in the control group. Although mean values remained within the reference values, changes observed for immunoglobulin G and M may reflect some immune protection for firefighters engaged in recruit training.

scholarly journals Immunoglobulin G antibodies to the N-Methyl-D-aspartate receptor are distinct from immunoglobulin A and immunoglobulin M responses

2014 ◽  
Vol 77 (1) ◽  
pp. 183-183 ◽  
Author(s):  
Eric Lancaster ◽  
Frank Leypoldt ◽  
Maarten J. Titulaer ◽  
Jérôme Honnorat ◽  
Patrick J. Waters ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Immunoglobulin A ◽  
Immunoglobulin M ◽  
Aspartate Receptor
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