scholarly journals Low case numbers enable long-term stable pandemic control without lockdowns

Author(s):  
Sebastian Contreras ◽  
Jonas Dehning ◽  
Sebastian B Mohr ◽  
F. Paul Spitzner ◽  
Viola Priesemann

The traditional long-term solutions for epidemic control involve eradication or herd immunity. Neither of them will be attained within a few months for the COVID-19 pandemic. Here, we analytically derive the existence of a third, viable solution: a stable equilibrium at low case numbers, where test-trace-and-isolate policies partially compensate for local spreading events, and only moderate contact restrictions remain necessary. Across wide parameter ranges of our complementary compartmental model, the equilibrium is reached at or below 10 daily new cases per million people. Such low levels had been maintained over months in most European countries. However, this equilibrium is endangered (i) if contact restrictions are relaxed, or (ii) if case numbers grow too high. The latter destabilisation marks a novel tipping point beyond which the spread self-accelerates because test-trace-and-isolate capacities are overwhelmed. To reestablish control quickly, a lockdown is required. We show that a lockdown is either effective within a few weeks, or tends to fail its aim. If effective, recurring lockdowns are not necessary --- contrary to the oscillating dynamics previously presented in the context of circuit breakers, and contrary to a regime with high case numbers --- if moderate contact reductions are maintained. Hence, at low case numbers, the control is easier, and more freedom can be granted. We demonstrate that this strategy reduces case numbers and fatalities by a factor of 5 compared to a strategy focused only on avoiding major congestion of hospitals. Furthermore, our solution minimises lockdown duration, and hence economic impact. In the long term, control will successively become easier due to immunity through vaccination or large scale testing programmes. International coordination would facilitate even more the implementation of this solution.

2000 ◽  
Vol 1696 (1) ◽  
pp. 118-123 ◽  
Author(s):  
J. W. Gillespie ◽  
D. A. Eckel ◽  
W. M. Edberg ◽  
S. A. Sabol ◽  
D. R. Mertz ◽  
...  

Bridge 1.351 on Business Route 896 in Glasgow, Delaware, was replaced with one of the first state-owned all-composite bridges in the nation. Composites are lightweight construction materials that do not corrode, which results in benefits such as ease of construction and reduced maintenance costs. A summary of the design, large-scale testing, fabrication, erection, and monitoring of this bridge is presented. The bridge was designed to AASHTO load and resistance factor design specifications. A methodology was developed to incorporate the engineering properties of these unique composite materials into the design. The bridge consists of two 13 × 32 ft (3.96 × 9.75 m) sections joined by a unique longitudinal joint. The sections have sandwich construction consisting of a core [28 in. (71.12 cm) deep] and facesheets [0.4 to 0.6 in. (10.16 to 15.24 mm) thick] that provide shear and flexural rigidity, respectively. The composite bridge was fabricated with E-glass preforms and vinyl-ester resin, which offers excellent structural performance and long-term durability. Each of the sections was fabricated to near-net shape in a single step by a vacuum-assisted resin transfer molding process. The overall structural behavior has been accurately predicted with simple design equations based on sandwich theory for anisotropic materials. Large-scale testing of full-sized subcomponents was conducted to prove that the design satisfied deflection, fatigue, and strength limit states. A redundant longitudinal joint was designed that consisted of both an adhesively bonded vertical joint between sections and splice plates. Assembly procedures were developed, and transverse testing of the full-sized joint was conducted. Final bridge sections were proof-tested to the strength limit state. The construction phase included section positioning, joint assembly, and application of a latex-modified concrete wear surface. The bridge was reopened to traffic on November 20, 1998. Results from the long-term monitoring effort will be documented.


Subject Asteroid mining. Significance The US firm Planetary Resources in April completed successful tests in orbit of technology it plans to use to prospect for natural resources on asteroids from 2020. Separately, the China Academy of Launch Vehicle Technology late last year announced long-term plans for large-scale asteroid mining. Meanwhile, US legislators have begun laying the legal foundations for a space mining industry. Significant technological challenges remain, but key technologies have already been demonstrated, making the industry a serious prospect. Impacts An investment bubble could follow dramatic early successes or technological breakthroughs. There may be international tension over ownership or priority of access unless new international legal frameworks are agreed in advance. Asteroid mining will not be a viable solution to terrestrial resource depletion for the foreseeable future.


2010 ◽  
Vol 17 (5) ◽  
pp. 840-847 ◽  
Author(s):  
Helen Campbell ◽  
Nick Andrews ◽  
Ray Borrow ◽  
Caroline Trotter ◽  
Elizabeth Miller

ABSTRACT Meningococcal serogroup C conjugate (MCC) vaccines were licensed in the United Kingdom more than 10 years ago based on correlates of protection that had previously been established for serogroup C-containing polysaccharide vaccines by using the serum bactericidal antibody (SBA) assay. These correlates of protection were subsequently validated against postlicensure estimates of observed vaccine effectiveness up to 7 to 9 months after the administration of the MCC vaccine. Vaccine effectiveness was, however, shown to fall significantly more than 1 year after the administration of a 3-dose course in infancy. Despite this finding, the marked impact on serogroup C disease has been sustained, with the lowest recorded incidence (0.02 case per 100,000 population) in the 2008-2009 epidemiological year, mainly due to the indirect herd immunity effect of the vaccine in reducing carriage. Updated estimates of vaccine effectiveness through 30 June 2009 confirmed high short-term protection after vaccination in infancy, at 97% (95% confidence interval [CI], 91% to 99%), falling to 68% (95% CI, −63% to 90%) more than a year after vaccination. The observed vaccine effectiveness more than 12 months postvaccination was consistent with measured declining SBA levels, but confidence intervals were imprecise; vaccine effectiveness estimates were consistent with SBA titers of 1:4 or 1:8 as correlates of long-term protection after a primary course in infants. Modeling suggested that protection against carriage persists for at least 3 years and predicted the stabilization of serogroup C disease at low levels (fewer than 50 cases per year) up to 2015-2016.


Author(s):  
M. Ammar Luthfi Kurniawan ◽  
Litania Leona Hidayat ◽  
Jihan Natra Shafira ◽  
Iche Andriyani Liberty

Social distancing includes strategies to ban public gatherings and advise individuals to stay at their home or maintain distance to one another by at least 1-2 meters. This study aims to intend to assess all the available evidence of social distancing in decreasing COVID-19 transmission in the general population. We conducted an electronic search of published literature using MEDLINE/Pubmed, Science direct, PMC, Wiley, and Google Scholar and we use Joanna Briggs Institute (JBI) critical appraisal checklist to assess methodological qualities. A total of 7 articles were decided to be included in this study. Social distancing has curb down the number and saved approximately 10 thousand Brazilian lives. A study by VoPham et al on the association of social distancing and COVID-19 incidence found higher social distancing was associated with a 29% reduction of COVID-19 incidence (adjusted IRR 0.71;95% CI (0,57-0,87) and 35% reduction of COVID-19 mortality (adjusted IRR 0,65; 95% CI 0,55-0,76). Social distancing is one of the major policies implemented for long-term behavioral adjustment in managing the COVID-19 pandemic. Passive social distancing is not enough to drag down the number, there needs to be large scale testing, isolation, and contact tracing. However, we believe we have illuminated the impact of social distancing on the COVID-19 pandemic and add to the available literature the basis of social distancing in reducing transmission of COVID-19.


1994 ◽  
Vol 144 ◽  
pp. 29-33
Author(s):  
P. Ambrož

AbstractThe large-scale coronal structures observed during the sporadically visible solar eclipses were compared with the numerically extrapolated field-line structures of coronal magnetic field. A characteristic relationship between the observed structures of coronal plasma and the magnetic field line configurations was determined. The long-term evolution of large scale coronal structures inferred from photospheric magnetic observations in the course of 11- and 22-year solar cycles is described.Some known parameters, such as the source surface radius, or coronal rotation rate are discussed and actually interpreted. A relation between the large-scale photospheric magnetic field evolution and the coronal structure rearrangement is demonstrated.


1967 ◽  
Vol 06 (01) ◽  
pp. 8-14 ◽  
Author(s):  
M. F. Collen

The utilization of an automated multitest laboratory as a data acquisition center and of a computer for trie data processing and analysis permits large scale preventive medical research previously not feasible. Normal test values are easily generated for the particular population studied. Long-term epidemiological research on large numbers of persons becomes practical. It is our belief that the advent of automation and computers has introduced a new era of preventive medicine.


2014 ◽  
pp. 124-129
Author(s):  
Z. V. Karamysheva

The review contains detailed description of the «Atlas of especially protected natural areas of Saint Petersburg» published in 2013. This publication presents the results of long-term studies of 12 natural protected areas made by a large research team in the years from 2002 to 2013 (see References). The Atlas contains a large number of the historical maps, new satellite images, the original illustrations, detailed texts on the nature of protected areas, summary tables of rare species of vascular plants, fungi and vertebrates recorded in these areas. Special attention is paid to the principles of thematic large-scale mapping. The landscape maps, the vegetation maps as well as the maps of natural processes in landscapes are included. Reviewed Atlas deserves the highest praise.


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