scholarly journals Remote olfactory assessment using the NIH Toolbox Odor Identification Test and the Brain Health Registry

2020 ◽  
Author(s):  
Cristina Jaen ◽  
Christopher Maute ◽  
Scott Mackin ◽  
Monica R Camacho ◽  
Diana Truran ◽  
...  
Keyword(s):  
Test Methods ◽  
Olfactory Function ◽  
Odor Identification ◽  
Brain Health ◽  
Self Administration ◽  
Identification Test ◽  
And Gender ◽  
Health Registry ◽  
The Brain ◽  
At Home

Objective: Early identification of deficits in our ability to perceive odors is important as many normal (i.e., aging) and pathological (i.e., sinusitis, viral, neurodegeneration) processes can result in diminished olfactory function. However, unlike hearing and vision, olfactory function is rarely tested outside of a research laboratory. The purpose of this study is to determine the feasibility of remotely testing olfactory performance using the National Institutes of Health's Toolbox odor identification test (NIH Toolbox Odor ID Test). Methods: Participants were recruited using the Brain Health Registry (BHR), an online assessment platform which connects participants with researchers. Interested participants were mailed the NIH Toolbox Odor ID Test along with instructions on accessing a website to record their responses. Results: Data obtained from subjects who performed the test at home was comparable to the normative data collected when the NIH Toolbox Odor ID Test was administered by a tester in a research setting. Age-dependent olfactory decline and gender-dependent sensitivity could be detected using the NIH Toolbox Odor ID Test remotely. Conclusions: The NIH Toolbox Odor ID Test is a valid instrument to measure olfactory performance via self-administration at home. This approach can be useful for longitudinal studies or as a screening tool for studies that require testing the sense of smell.

scholarly journals Cognitive Performance in Parkinson’s Disease in the Brain Health Registry

2019 ◽  
Vol 68 (3) ◽  
pp. 1029-1038 ◽  
Author(s):  
Brenna Cholerton ◽  
Michael W. Weiner ◽  
Rachel L. Nosheny ◽  
Kathleen L. Poston ◽  
R. Scott Mackin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Performance ◽  
Brain Health ◽  
Health Registry ◽  
The Brain

P1-318: Internet-based recruitment and screening of subjects for ad trials using longitudinal data from the brain health registry

2015 ◽  
Vol 11 (7S_Part_10) ◽  
pp. P478-P479
Author(s):  
Michael W. Weiner ◽  
Rachel L. Nosheny ◽  
Derek Flennkiken ◽  
Philip S. Insel ◽  
Shannon Finley ◽  
...  
Keyword(s):  
Longitudinal Data ◽  
Brain Health ◽  
Health Registry ◽  
The Brain

scholarly journals Predicting amyloid status using self‐report information from an online research and recruitment registry: The Brain Health Registry

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Miriam T. Ashford ◽  
John Neuhaus ◽  
Chengshi Jin ◽  
Monica R. Camacho ◽  
Juliet Fockler ◽  
...  
Keyword(s):  
Self Report ◽  
Online Research ◽  
Brain Health ◽  
Health Registry ◽  
The Brain

VALIDATION OF STUDY PARTNER-REPORTED OUTCOMES COLLECTED ONLINE USING THE BRAIN HEALTH REGISTRY

2017 ◽  
Vol 13 (7) ◽  
pp. P913-P914
Author(s):  
Rachel Nosheny ◽  
Monica R. Camacho ◽  
Derek Flenniken ◽  
Aaron Ulbricht ◽  
Juliet Fockler ◽  
...  
Keyword(s):  
Brain Health ◽  
Study Partner ◽  
Health Registry ◽  
The Brain

Unsupervised Performance of the CogState Brief Battery in the Brain Health Registry: Implications for Detecting Cognitive Decline

2021 ◽  
pp. 1-7
Author(s):  
T. Banh ◽  
C. Jin ◽  
J. Neuhaus ◽  
R.S. Mackin ◽  
P. Maruff ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Disease Status ◽  
Self Report ◽  
Longitudinal Change ◽  
Longitudinal Assessment ◽  
Brain Health ◽  
Cross Sectional ◽  
Participant Characteristics ◽  
Health Registry ◽  
The Brain

Introduction: The feasibility and validity of unsupervised, longitudinal brief computerized cognitive batteries is unknown. Methods: Participants aged 56-90 (N = 19476) from the Brain Health Registry (BHR) completed the CogState Brief Battery (CBB) at 6-month intervals over a period of 5 years. We used linear mixed-effects models to assess whether cross-sectional and longitudinal performance on CBB within BHR was associated with demographic and cognitive characteristics. We also defined a group of CBB decliners based on subject-specific slopes and estimated associations between decliner status and participant characteristics. Results: We found weak associations between longitudinal change in CBB and participant characteristics. Cross-sectional CBB scores were significantly associated with participant characteristics such as age, gender, ethnicity, self-reported disease status, and memory concern. CBB decliners were more likely to self-report mild cognitive impairment (MCI) and memory concerns. Discussion: Cross-sectional, remote CBB shows evidence of construct validity, but our results suggest that longitudinal assessment may not provide additional value for identifying those at risk for and with cognitive impairment.

Cross-Cultural Application of the “Sniffin’ Sticks” Odor Identification Test

2007 ◽  
Vol 21 (5) ◽  
pp. 570-573 ◽  
Author(s):  
Chih-Hung Shu ◽  
Ben-Chih Yuan ◽  
Shih-Hsiang Lin ◽  
Ching-Zong Lin
Keyword(s):  
Age Groups ◽  
Cross Cultural ◽  
Olfactory Function ◽  
Odor Identification ◽  
Olfactory Test ◽  
Age Related ◽  
Identification Score ◽  
Identification Test ◽  
Place Of Origin ◽  
Identification Function

Background Odor identification tasks are an important tool for the clinical assessment of olfactory function. However, cultural differences prevent odor identification tests from being used in different countries, because odor identification is strongly dependent on familiarity with these odors. The “Sniffin’ Sticks” olfactory test has been developed in Europe and is used for assessment of olfactory function in many European countries. The aim of this study was to investigate the applicability of the “Sniffin’ Sticks” odor identification test in an area with a different culture compared with its place of origin. Methods The 16 odors in the “Sniffin’ Stick” odor identification test were kept the same but some descriptors were changed compared with the original version. One odor was presented for 3 seconds. Then, subjects chose an item from a list of four descriptors. Two hundred two subjectively normosmic subjects were tested. Forty-two subjects were retested 1 week after the first test. Results Mean odor identification scores of age groups 18–35 years, 36–55 years, and >55 years were 14.8, 14.7, and 13.3, respectively. The score at the 10th percentile was 13.0 in the youngest group of subjects. Age-related decrease of odor identification scores was clearly established. The decrease of the odor identification score was most obvious in subjects aged 63–67 years. The coefficient of correlation between test and retest was 0.76. Conclusion After revision of the descriptors, the “Sniffin’ Sticks” odor identification test appears to be suited for assessment of olfactory identification function in an Asian region.

Olfactory Identification among Various Subtypes of Parkinson Disease

2019 ◽  
Vol 81 (3-4) ◽  
pp. 167-173 ◽  
Author(s):  
Mir Mohammad Jalali ◽  
Seyed Ali Roudbary ◽  
Hooshang Gerami ◽  
Robabeh Soleimani ◽  
Seyed Matin Ebrahimi
Keyword(s):  
Parkinson Disease ◽  
Test Methods ◽  
Repeated Measurements ◽  
Olfactory Function ◽  
Analysis Of Covariance ◽  
Cross Sectional ◽  
Significant Difference ◽  
Identification Test ◽  
The Impact ◽  
Smell Identification

Introduction: This study is aimed at investigating the olfactory function among different subtypes of Parkinson disease (PD) and the impact of sex on smell identification test. Methods: In this cross-sectional study, we used Iran-smell identification test (Iran-SIT). PD severity was determined using a Hoehn and Yahr (H&amp;Y) scale. We used analysis of covariance (ANCOVA) to compare the olfactory function among different PD subtypes. All analyses were performed using SPSS software version 16.0. Results: In total, 66 males and 38 females participated in this study. The most common PD subtype was postural instability and gait difficulty (38.5%). Severe hyposmia and anosmia were found in 44.6 and 19.6% of participants, respectively. Women had a higher score in olfactory function than men (p = 0.44). The score of subjects with stage 1 in the H&amp;Y scale was about 3 points higher than the score with stage 4. The ANCOVA showed a statistically significant effect of subtypes PD on Iran-SIT score after controlling for the effects of covariates (p = 0.03). There is a significant difference between tremor-dominant Parkinson disease (TDPD) and other subtypes of PD (p < 0.05). However, Iran-SIT scores failed to show a significant difference between men and women (p = 0.13). Discussion/Conclusion: Our results confirmed that PD is heterogeneous and there is significant variability in odor identification ability in these patients. We observed more olfactory impairment in TDPD, and subjects with higher H&amp;Y stage. We recommended future studies with repeated measurements of different aspects of smell function to characterize the temporal relationship of olfactory dysfunction with PD.

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