scholarly journals Control of polyunsaturated fatty acids desaturation by Sting regulates inflammatory responses

2020 ◽  
Author(s):  
Isabelle K. Vila ◽  
Hanane Chamma ◽  
Alizée Steer ◽  
Clara Taffoni ◽  
Line S. Reinert ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Metabolic Pathways ◽  
Acid Metabolism ◽  
Inflammatory Responses ◽  
Fatty Acid Desaturase ◽  
Health Issues ◽  
Major Health ◽  
Rate Limiting ◽  
Fatty Acid Desaturase 2

AbstractInflammatory disorders are major health issues in which immune function and metabolic homeostasis are concertedly altered. Yet, how innate and metabolic pathways are coordinated, in homeostatic conditions, is poorly understood. Here, we demonstrate that the Stimulator of interferon genes (Sting) inhibits the Fatty acid desaturase 2 (Fads2) rate limiting enzyme in polyunsaturated Fatty acid desaturation, thereby controlling both Fatty acid (FA) metabolism and innate immunity. Indeed, we show that Sting activation increased Fads2 activity, while decreasing Fads2 levels enhanced Sting activation, establishing an anti-viral state. Remarkably, the cross-regulation between Sting and Fads2 is mediated by the cyclic GMP-AMP (cGAMP) Sting agonist and PUFAs. Indeed, PUFAs inhibit Sting activation, while cGAMP binds Fads2 and promotes its degradation. Thus, our study identifies Sting as a master regulator of the interplay between FA metabolism and inflammation.One Sentence SummarySting inhibits polyunsaturated fatty acid metabolism.

scholarly journals STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

2022 ◽  
Vol 34 (1) ◽  
pp. 125-139.e8
Author(s):  
Isabelle K. Vila ◽  
Hanane Chamma ◽  
Alizée Steer ◽  
Mathilde Saccas ◽  
Clara Taffoni ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Inflammatory Responses

scholarly journals Association between the Polymorphisms of fads2a and fads2b and Poly-Unsaturated Fatty Acids in Common Carp (Cyprinus carpio)

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1780
Author(s):  
Yan Zhang ◽  
Xiao-Qing Sun ◽  
Yu-Qing Ye ◽  
Qi Wang ◽  
Qing-Song Li ◽  
...  
Keyword(s):  
Common Carp ◽  
Unsaturated Fatty Acids ◽  
Major Gene ◽  
Fatty Acid Desaturase ◽  
Mixed Linear Model ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Food Fish ◽  
Rate Limiting ◽  
Fatty Acid Desaturase 2

Fatty acid desaturase 2 (fads2) is one of the rate-limiting enzymes in PUFAs biosynthesis. Compared with the diploid fish encoding one fads2, the allo-tetraploid common carp, one most important food fish, encodes two fads2 genes (fads2a and fads2b). The associations between the contents of different PUFAs and the polymorphisms of fads2a and fads2b have not been studied. The contents of 12 PUFAs in common carp individuals were measured, and the polymorphisms in the coding sequences of fads2a and fads2b were screened. We identified five coding single nucleotide polymorphisms (cSNPs) in fads2a and eleven cSNPs in fads2b. Using the mixed linear model and analysis of variance, a synonymous fads2a cSNP was significantly associated with the content of C20:3n-6. One non-synonymous fads2b cSNP (fads2b.751) and one synonymous fads2b cSNP (fads2b.1197) were associated with the contents of seven PUFAs and the contents of six PUFAs, respectively. The heterozygous genotypes in both loci were associated with higher contents than the homozygous genotypes. The fads2b.751 genotype explained more phenotype variation than the fads2b.1197 genotype. These two SNPs were distributed in one haplotype block and associated with the contents of five common PUFAs. These results suggested that fads2b might be the major gene responding to common carp PUFA contents and that fads.751 might be the main effect SNP. These cSNPs would be potential markers for future selection to improve the PUFA contents in common carp.

Novel polymorphisms in Stearoyl‐CoA Desaturase (SCD) and Fatty Acid Desaturase 2 (FADS2) in channel catfish ( Ictalurus punctatus, Rafinesque, 1818 )

2021 ◽  
Author(s):  
Oliva Mendoza‐Pacheco ◽  
Gaspar Manuel Parra‐Bracamonte ◽  
Xochitl Fabiola De la Rosa‐Reyna ◽  
Ana María Sifuentes‐Rincón ◽  
Isidro Otoniel Montelongo‐Alfaro ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Ictalurus Punctatus ◽  
Channel Catfish ◽  
Fatty Acid Desaturase ◽  
Stearoyl Coa Desaturase ◽  
Fatty Acid Desaturase 2

scholarly journals Delta-6-desaturase Links Polyunsaturated Fatty Acid Metabolism With Phospholipid Remodeling and Disease Progression in Heart Failure

2014 ◽  
Vol 7 (1) ◽  
pp. 172-183 ◽  
Author(s):  
Catherine H. Le ◽  
Christopher M. Mulligan ◽  
Melissa A. Routh ◽  
Gerrit J. Bouma ◽  
Melinda A. Frye ◽  
...  
Keyword(s):  
Heart Failure ◽  
Fatty Acid ◽  
Disease Progression ◽  
Polyunsaturated Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Delta 6 Desaturase

scholarly journals Redox, amino acid, and fatty acid metabolism intersect with bacterial virulence in the gut

2018 ◽  
Vol 115 (45) ◽  
pp. E10712-E10719 ◽  
Author(s):  
Reed Pifer ◽  
Regan M. Russell ◽  
Aman Kumar ◽  
Meredith M. Curtis ◽  
Vanessa Sperandio
Keyword(s):  
Fatty Acid ◽  
High Throughput ◽  
Fatty Acid Metabolism ◽  
Metabolic Pathways ◽  
Virulence Genes ◽  
Acid Metabolism ◽  
Feedback Mechanism ◽  
Regulatory Pathways ◽  
Successful Infection ◽  
Cellular Circuits

The gut metabolic landscape is complex and is influenced by the microbiota, host physiology, and enteric pathogens. Pathogens have to exquisitely monitor the biogeography of the gastrointestinal tract to find a suitable niche for colonization. To dissect the important metabolic pathways that influence virulence of enterohemorrhagicEscherichia coli(EHEC), we conducted a high-throughput screen. We generated a dataset of regulatory pathways that control EHEC virulence expression under anaerobic conditions. This unraveled that the cysteine-responsive regulator, CutR, converges with the YhaO serine import pump and the fatty acid metabolism regulator FadR to optimally control virulence expression in EHEC. CutR activates expression of YhaO to increase activity of the YhaJ transcription factor that has been previously shown to directly activate the EHEC virulence genes. CutR enhances FadL, which is a pump for fatty acids that represses inhibition of virulence expression by FadR, unmasking a feedback mechanism responsive to metabolite fluctuations. Moreover, CutR and FadR also augment murine infection byCitrobacter rodentium, which is a murine pathogen extensively employed as a surrogate animal model for EHEC. This high-throughput approach proved to be a powerful tool to map the web of cellular circuits that allows an enteric pathogen to monitor the gut environment and adjust the levels of expression of its virulence repertoire toward successful infection of the host.

Polyunsaturated fatty acid metabolism in enterocyte models: T84 cell line vs. Caco-2 cell line

2013 ◽  
Vol 50 (2) ◽  
pp. 111-120 ◽  
Author(s):  
Pauline Beguin ◽  
Anne-Catherine Schneider ◽  
Eric Mignolet ◽  
Yves-Jacques Schneider ◽  
Yvan Larondelle
Keyword(s):  
Fatty Acid ◽  
Cell Line ◽  
Polyunsaturated Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
T84 Cell Line
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