scholarly journals Reconstructing the human genetic history of mainland Southeast Asia: insights from genome-wide data from Thailand and Laos

2020 ◽  
Author(s):  
Wibhu Kutanan ◽  
Dang Liu ◽  
Jatupol Kampuansai ◽  
Metawee Srikummool ◽  
Suparat Srithawong ◽  
...  
Keyword(s):  
Genetic Structure ◽  
Southeast Asia ◽  
Geographic Region ◽  
Whole Genome Sequence ◽  
Genetic History ◽  
Asian Populations ◽  
Genome Wide ◽  
Population Interactions ◽  
Hill Tribes ◽  
Mainland Southeast Asia

AbstractThailand and Laos, located in the center of Mainland Southeast Asia (MSEA), harbor diverse ethnolinguistic groups encompassing all five language families of MSEA: Tai-Kadai (TK), Austroasiatic (AA), Sino-Tibetan (ST), Hmong-Mien (HM) and Austronesian (AN). Previous genetic studies of Thai/Lao populations have focused almost exclusively on uniparental markers and there is a paucity of genome-wide studies. We therefore generated genome-wide SNP data for 33 ethnolinguistic groups, belonging to the five MSEA language families from Thailand and Laos, and analysed these together with data from modern Asian populations and SEA ancient samples. Overall, we find genetic structure according to language family, albeit with heterogeneity in the AA-, HM- and ST-speaking groups, and in the hill tribes, that reflects both population interactions and genetic drift. For the TK speaking groups, we find localized genetic structure that is driven by different levels of interaction with other groups in the same geographic region. Several Thai groups exhibit admixture from South Asia, which we date to ∼600-1000 years ago, corresponding to a time of intensive international trade networks that had a major cultural impact on Thailand. An AN group from Southern Thailand shows both South Asian admixture as well as overall affinities with AA-speaking groups in the region, suggesting an impact of cultural diffusion. Overall, we provide the first detailed insights into the genetic profiles of Thai/Lao ethnolinguistic groups, which should be helpful for reconstructing human genetic history in MSEA and selecting populations for participation in ongoing whole genome sequence and biomedical studies.

scholarly journals Autosomal Microsatellite Investigation Reveals Multiple Genetic Components of the Highlanders from Thailand

Genes ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 383
Author(s):  
Aornpriya Mawan ◽  
Nonglak Prakhun ◽  
Kanha Muisuk ◽  
Suparat Srithawong ◽  
Metawee Srikummool ◽  
...  
Keyword(s):  
Genetic Structure ◽  
Genetic Relationships ◽  
Forensic Investigation ◽  
Northern Thailand ◽  
Hill Tribe ◽  
Genetic Components ◽  
Large Populations ◽  
Population Interactions ◽  
Hill Tribes ◽  
The Hill

The hill tribes of northern Thailand comprise nine officially recognized groups: the Austroasiatic-speaking (AA) Khmu, Htin and Lawa; the Hmong-Mien-speaking (HM) IuMien and Hmong; and the Sino-Tibetan-speaking (ST) Akha, Karen, Lahu and Lisu. Except the Lawa, the rest of the hill tribes migrated into their present habitats only very recently. The Thai hill tribes were of much interest to research groups focusing on study of cultural and genetic variation because of their unique languages and cultures. So far, there have been several genetic studies of the Thai hill tribes. However, complete forensic microsatellite database of the Thai hill tribes is still lacking. To construct such database, we newly generated 654 genotypes of 15 microsatellites commonly used in forensic investigation that belong to all the nine hill tribes and also non-hill tribe highlanders from northern Thailand. We also combined 329 genotypes from previous studies of northern Thai populations bringing to a total of 983 genotypes, which were then subjected to genetic structure and population relationships analyses. Our overall results indicated homogenous genetic structure within the HM- and Tai-Kadai (TK)-speaking groups, large genetic divergence of the HM-speaking Hmong but not IuMien from the other Thai groups, and genetic heterogeneity within the ST- and AA-speaking groups, reflecting different population interactions and admixtures. In addition to establishing genetic relationships within and among these populations, our finding, which provides a more complete picture of the forensic microsatellite database of the multiple Thai highland dwellers, would not only serve to expand and strengthen forensic investigation in Thailand, but would also benefit its neighboring countries of Laos and Myanmar, from which many of the Thai hill tribes originated and where large populations of these ethnic groups still reside.

scholarly journals Insight into the Peopling of Mainland Southeast Asia from Thai Population Genetic Structure

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e79522 ◽  
Author(s):  
Pongsakorn Wangkumhang ◽  
Philip James Shaw ◽  
Kridsadakorn Chaichoompu ◽  
Chumpol Ngamphiw ◽  
Anunchai Assawamakin ◽  
...  
Keyword(s):  
Genetic Structure ◽  
Southeast Asia ◽  
Population Genetic Structure ◽  
Population Genetic ◽  
Thai Population ◽  
Insight Into ◽  
Mainland Southeast Asia

scholarly journals Extensive Ethnolinguistic Diversity in Vietnam Reflects Multiple Sources of Genetic Diversity

2020 ◽  
Vol 37 (9) ◽  
pp. 2503-2519 ◽  
Author(s):  
Dang Liu ◽  
Nguyen Thuy Duong ◽  
Nguyen Dang Ton ◽  
Nguyen Van Phong ◽  
Brigitte Pakendorf ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Southeast Asia ◽  
Linguistic Diversity ◽  
Published Data ◽  
Multiple Sources ◽  
Austronesian Languages ◽  
Genome Wide ◽  
Genome Wide Data ◽  
History Of ◽  
Mainland Southeast Asia

Abstract Vietnam features extensive ethnolinguistic diversity and occupies a key position in Mainland Southeast Asia. Yet, the genetic diversity of Vietnam remains relatively unexplored, especially with genome-wide data, because previous studies have focused mainly on the majority Kinh group. Here, we analyze newly generated genome-wide single-nucleotide polymorphism data for the Kinh and 21 additional ethnic groups in Vietnam, encompassing all five major language families in Mainland Southeast Asia. In addition to analyzing the allele and haplotype sharing within the Vietnamese groups, we incorporate published data from both nearby modern populations and ancient samples for comparison. In contrast to previous studies that suggested a largely indigenous origin for Vietnamese genetic diversity, we find that Vietnamese ethnolinguistic groups harbor multiple sources of genetic diversity that likely reflect different sources for the ancestry associated with each language family. However, linguistic diversity does not completely match genetic diversity: There have been extensive interactions between the Hmong-Mien and Tai-Kadai groups; different Austro-Asiatic groups show different affinities with other ethnolinguistic groups; and we identified a likely case of cultural diffusion in which some Austro-Asiatic groups shifted to Austronesian languages during the past 2,500 years. Overall, our results highlight the importance of genome-wide data from dense sampling of ethnolinguistic groups in providing new insights into the genetic diversity and history of an ethnolinguistically diverse region, such as Vietnam.

scholarly journals Reconstructing Austronesian population history in Island Southeast Asia

2014 ◽  
Author(s):  
Mark Lipson ◽  
Po-Ru Loh ◽  
Nick Patterson ◽  
Priya Moorjani ◽  
Ying-Chin Ko ◽  
...  
Keyword(s):  
Southeast Asia ◽  
Population History ◽  
Austronesian Languages ◽  
Ancestral Gene ◽  
Mainland Population ◽  
Island Southeast Asia ◽  
New Methods ◽  
Asian Populations ◽  
Genome Wide ◽  
Genome Wide Data

Austronesian languages are spread across half the globe, from Easter Island to Madagascar. Evidence from linguistics and archaeology indicates that the "Austronesian expansion," which began 4-5 thousand years ago, likely had roots in Taiwan, but the ancestry of present-day Austronesian-speaking populations remains controversial. Here, focusing primarily on Island Southeast Asia, we analyze genome-wide data from 56 populations using new methods for tracing ancestral gene flow. We show that all sampled Austronesian groups harbor ancestry that is more closely related to aboriginal Taiwanese than to any present-day mainland population. Surprisingly, western Island Southeast Asian populations have also inherited ancestry from a source nested within the variation of present-day populations speaking Austro-Asiatic languages, which have historically been nearly exclusive to the mainland. Thus, either there was once a substantial Austro-Asiatic presence in Island Southeast Asia, or Austronesian speakers migrated to and through the mainland, admixing there before continuing to western Indonesia.

scholarly journals New insights from Thailand into the maternal genetic history of Mainland Southeast Asia

2018 ◽  
Vol 26 (6) ◽  
pp. 898-911 ◽  
Author(s):  
Wibhu Kutanan ◽  
Jatupol Kampuansai ◽  
Andrea Brunelli ◽  
Silvia Ghirotto ◽  
Pittayawat Pittayaporn ◽  
...  
Keyword(s):  
Southeast Asia ◽  
Genetic History ◽  
History Of ◽  
Mainland Southeast Asia

Genetic structure of the ethnic Lao groups from mainland Southeast Asia revealed by forensic microsatellites

2020 ◽  
Vol 84 (5) ◽  
pp. 357-369 ◽  
Author(s):  
Suparat Srithawong ◽  
Kanha Muisuk ◽  
Metawee Srikummool ◽  
Narongdet Mahasirikul ◽  
Saksuriya Triyarach ◽  
...  
Keyword(s):  
Genetic Structure ◽  
Southeast Asia ◽  
Mainland Southeast Asia

scholarly journals Indian genetic heritage in Southeast Asian populations

2021 ◽  
Author(s):  
Piya Changmai ◽  
Kitipong Jaisamut ◽  
Jatupol Kampuansai ◽  
Wibhu Kutanan ◽  
N. Ezgi Altınışık ◽  
...  
Keyword(s):  
Southeast Asia ◽  
Ethnic Groups ◽  
South Asian ◽  
Southeast Asian ◽  
Population History ◽  
Published Data ◽  
Indian Culture ◽  
Asian Populations ◽  
Snp Data ◽  
Mainland Southeast Asia

AbstractThe great ethnolinguistic diversity found today in mainland Southeast Asia (MSEA) reflects multiple migration waves of people in the past. Deeply divergent East Eurasian hunter-gatherers were the first anatomically modern human population known to migrate to the region. Agriculturalists from South China migrated to the region and admixed with the local hunter-gatherers during the Neolithic period. During the Bronze and Iron Ages, the genetic makeup of people in MSEA changed again, indicating an additional influx of populations from South China. Maritime trading between MSEA and India was established at the latest 300 BCE, and the formation of early states in Southeast Asia during the first millennium CE was strongly influenced by Indian culture, and this cultural influence is still prominent today. Several ancient Indian-influenced states were located in present-day Thailand, and various populations in the country are likely to be descendants of people from those states. To systematically explore Indian genetic heritage in MSEA, we generated genome-wide SNP data (the HumanOrigins array) for 119 present-day individuals belonging to 10 ethnic groups from Thailand and co-analyzed them with published data from MSEA using the PCA, ADMIXTURE, f3-statistics, qpAdm, and qpGraph methods. We found South Asian low-level admixture in various MSEA populations which are probably descendants of people from the ancient Indian-influenced states, but failed to find a South Asian genetic component in present-day hunter-gatherer groups and relatively isolated groups from highlands in Northern Thailand. Our results also support close genetic affinity between Kra-Dai-speaking (also known as Tai-Kadai) and Austronesian-speaking populations, which fits a linguistic hypothesis suggesting cladality of the two language families.Author SummaryMainland Southeast Asia is a region with great ethnolinguistic diversity and complex population history. We studied genetic population history of present-day mainland Southeast Asian populations using genome-wide SNP data (the HumanOrigins array). We generated new data for 10 present-day ethnic groups from Thailand, which we further combined with published data from mainland and island Southeast Asians and worldwide populations. We revealed South Asian genetic admixture in various mainland Southeast Asian ethnic groups which are highly influenced by Indian culture, but failed to find it in groups who remained culturally isolated until recently. Our finding suggests that a massive migration of Indian people in the past was responsible for the spread of Indian culture in mainland Southeast Asia. We also found support for a close genetic affinity between Kra-Dai- and Austronesianspeaking populations, which fits a linguistic hypothesis suggesting cladality of the two language families.

scholarly journals Spatial genetic structure of Aedes aegypti mosquitoes in mainland Southeast Asia

2010 ◽  
Vol 3 (4) ◽  
pp. 319-339 ◽  
Author(s):  
Thaung Hlaing ◽  
Willoughby Tun-Lin ◽  
Pradya Somboon ◽  
Duong Socheat ◽  
To Setha ◽  
...  
Keyword(s):  
Genetic Structure ◽  
Aedes Aegypti ◽  
Southeast Asia ◽  
Spatial Genetic Structure ◽  
Mainland Southeast Asia

scholarly journals Genomic variation in the American pika: signatures of geographic isolation and implications for conservation

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kelly B. Klingler ◽  
Joshua P. Jahner ◽  
Thomas L. Parchman ◽  
Chris Ray ◽  
Mary M. Peacock
Keyword(s):  
Genetic Variation ◽  
Genetic Structure ◽  
Sierra Nevada ◽  
Spatial Genetic Structure ◽  
Spatial Scales ◽  
Thermal Sensitivity ◽  
Genomic Variation ◽  
Genome Wide ◽  
A Genome ◽  
American Pika

Abstract Background Distributional responses by alpine taxa to repeated, glacial-interglacial cycles throughout the last two million years have significantly influenced the spatial genetic structure of populations. These effects have been exacerbated for the American pika (Ochotona princeps), a small alpine lagomorph constrained by thermal sensitivity and a limited dispersal capacity. As a species of conservation concern, long-term lack of gene flow has important consequences for landscape genetic structure and levels of diversity within populations. Here, we use reduced representation sequencing (ddRADseq) to provide a genome-wide perspective on patterns of genetic variation across pika populations representing distinct subspecies. To investigate how landscape and environmental features shape genetic variation, we collected genetic samples from distinct geographic regions as well as across finer spatial scales in two geographically proximate mountain ranges of eastern Nevada. Results Our genome-wide analyses corroborate range-wide, mitochondrial subspecific designations and reveal pronounced fine-scale population structure between the Ruby Mountains and East Humboldt Range of eastern Nevada. Populations in Nevada were characterized by low genetic diversity (π = 0.0006–0.0009; θW = 0.0005–0.0007) relative to populations in California (π = 0.0014–0.0019; θW = 0.0011–0.0017) and the Rocky Mountains (π = 0.0025–0.0027; θW = 0.0021–0.0024), indicating substantial genetic drift in these isolated populations. Tajima’s D was positive for all sites (D = 0.240–0.811), consistent with recent contraction in population sizes range-wide. Conclusions Substantial influences of geography, elevation and climate variables on genetic differentiation were also detected and may interact with the regional effects of anthropogenic climate change to force the loss of unique genetic lineages through continued population extirpations in the Great Basin and Sierra Nevada.

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