scholarly journals An Artificial Intelligence-Assisted Diagnostic Platform for Rapid Near-Patient Hematology

2021 ◽  
Author(s):  
Neta Bachar ◽  
Dana Benbassat ◽  
David Brailovsky ◽  
Yochay Eshel ◽  
Dan Glück ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Blood Count ◽  
Clinical Laboratory ◽  
Complete Blood Count ◽  
Point Of Care ◽  
Finger Prick ◽  
Repeatability And Reproducibility ◽  
Current Point ◽  
High Repeatability ◽  
Hematology Analyzers

Hematology analyzers capable of performing complete blood count (CBC) have lagged in their prevalence at the point-of-care. Sight OLO® (Sight Diagnostics, Israel) is a novel hematological platform which provides a 19 parameter, five-part differential CBC, and is designed to address the limitations in current point-of-care hematology analyzers using recent advances in artificial intelligence (AI) and computer vision. Accuracy, repeatability, and flagging capabilities of OLO were compared with the Sysmex XN-Series System (Sysmex, Japan). Matrix studies compared performance using venous, capillary and direct-from-finger-prick blood samples. Regression analysis shows strong concordance between OLO and the Sysmex XN, demonstrating that OLO performs with high accuracy for all CBC parameters. High repeatability and reproducibility were demonstrated for most of the testing parameters. The analytical performance of the OLO hematology analyzer was validated in a multicenter clinical laboratory setting, demonstrating its accuracy and comparability to clinical laboratory-based hematology analyzers. Furthermore, the study demonstrated the validity of CBC analysis of samples collected directly from fingerpricks.One Sentence SummaryWe present a novel diagnostic platform based on artificial intelligence-assisted image analysis that is capable of performing rapid complete blood count from venous, capillary, and finger-prick samples in near-patient settings.

scholarly journals 332: Can a point-of-care hemoglobin device replace complete blood count for fetal blood sampling during intrauterine transfusion?

2018 ◽  
Vol 218 (1) ◽  
pp. S207-S208
Author(s):  
Cathy Monteith ◽  
Jahan Jadauji ◽  
Hala Abu ◽  
Ann M. McHugh ◽  
Jennifer C. Donnelly ◽  
...  
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Point Of Care ◽  
Blood Sampling ◽  
Fetal Blood ◽  
Fetal Blood Sampling ◽  
Intrauterine Transfusion

Coagulopathy in Cardiac Surgery: Etiology and Treatment Options

2020 ◽  
pp. 313-322
Author(s):  
Dana Teodorescu ◽  
Caroline Larkin
Keyword(s):  
Cardiac Surgery ◽  
Laboratory Testing ◽  
Blood Count ◽  
Complete Blood Count ◽  
Point Of Care ◽  
Treatment Options ◽  
Coagulation Factors ◽  
Bleeding Diathesis ◽  
Standard Laboratory ◽  
Post Cardiac Surgery

This chapter reviews the causes and outlines an approach to the management of coagulopathy following cardiac surgery. Bleeding after cardiac surgery is common and expected up to a rate of 2 mL/kg/h for the first 6 hours. A more significant hemorrhage needs to be investigated and treated. Causes are often multifactorial. It is imperative that surgical causes be excluded early concomitant to providing resuscitation, investigating other medical causes for bleeding, and treating coagulopathy empirically until laboratory testing becomes available. The most frequent causes for coagulopathy post–cardiac surgery are excess heparinization, prolonged cardiopulmonary bypass time, hypothermia, acidosis, and preexisting bleeding diathesis. The management of coagulopathy implies maintenance of the normal physiological conditions for coagulation, reversal of excess heparinization, treatment of hyperfibrinolysis, maintaining normal levels of coagulation factors, and transfusion of platelets if thrombocytopenia or platelet dysfunction occurs. The chapter reviews what is involved in standard laboratory testing (complete blood count, prothrombin time, activated partial thromboplastin time, fibrinogen level, etc.) for coagulopathy. Also discussed is point-of-care testing and how the results from these tests should be interpreted. The chapter details the various blood products that are required in this scenario and suggests doses and transfusion thresholds.

scholarly journals Point-of-care versus central testing of hemoglobin during large volume blood transfusion

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Justin Herman ◽  
Brian Park ◽  
Bharat Awsare ◽  
Frances West ◽  
Denine Crittendon ◽  
...  
Keyword(s):  
Massive Transfusion ◽  
Clinical Laboratory ◽  
Complete Blood Count ◽  
Point Of Care ◽  
Tertiary Care ◽  
Absolute Difference ◽  
Care Hospital ◽  
Specific Patient ◽  
Paired Samples ◽  
Clinically Significant

Abstract Background Point-of-care (POC) hemoglobin testing has the potential to revolutionize massive transfusion strategies. No prior studies have compared POC and central laboratory testing of hemoglobin in patients undergoing massive transfusions. Methods We retrospectively compared the results of our point-of-care hemoglobin test (EPOC®) to our core laboratory complete blood count (CBC) hemoglobin test (Sysmex XE-5000™) in patients undergoing massive transfusion protocols (MTP) for hemorrhage. One hundred seventy paired samples from 90 patients for whom MTP was activated were collected at a single, tertiary care hospital between 10/2011 and 10/2017. Patients had both an EPOC® and CBC hemoglobin performed within 30 min of each other during the MTP. We assessed the accuracy of EPOC® hemoglobin testing using two variables: interchangeability and clinically significant differences from the CBC. The Clinical Laboratory Improvement Amendments (CLIA) proficiency testing criteria defined interchangeability for measurements. Clinically significant differences between the tests were defined by an expert panel. We examined whether these relationships changed as a function of the hemoglobin measured by the EPOC® and specific patient characteristics. Results Fifty one percent (86 of 170) of paired samples’ hemoglobin results had an absolute difference of ≤7 and 73% (124 of 170) fell within ±1 g/dL of each other. The mean difference between EPOC® and CBC hemoglobin had a bias of − 0.268 g/dL (p = 0.002). When the EPOC® hemoglobin was < 7 g/dL, 30% of the hemoglobin values were within ±7, and 57% were within ±1 g/dL. When the measured EPOC® hemoglobin was ≥7 g/dL, 55% of the EPOC® and CBC hemoglobin values were within ±7, and 76% were within ±1 g/dL. EPOC® and CBC hemoglobin values that were within ±1 g/dL varied by patient population: 77% for cardiac surgery, 58% for general surgery, and 72% for non-surgical patients. Conclusions The EPOC® device had minor negative bias, was not interchangeable with the CBC hemoglobin, and was less reliable when the EPOC® value was < 7 g/dL. Clinicians must consider speed versus accuracy, and should check a CBC within 30 min as confirmation when the EPOC® hemoglobin is < 7 g/dL until further prospective trials are performed in this population.

scholarly journals Determination of Hemoglobin Level Among 9-Month-Old Infants Visiting Well Child Clinic

2021 ◽  
Vol 8 ◽  
pp. 2333794X2110366
Author(s):  
Pongtong Puranitee ◽  
Sajee Fuangfu ◽  
Oraporn Dumrongwongsiri
Keyword(s):  
Infant Formula ◽  
Associated Factors ◽  
Blood Count ◽  
Complete Blood Count ◽  
Point Of Care ◽  
Hemoglobin Level ◽  
Breastfed Infants ◽  
Confident Interval ◽  
Prevalence Of Anemia

Screening for anemia is recommended among infants aged 9 to 12 months. This study was conducted to determine the prevalence of anemia among 9-month-old infants at Well Child Clinic, and associated factors with anemia. Well Child record of all visits during January to December 2018 were reviewed. Hemoglobin (Hb) was determined by complete blood count (CBC) or point-of-care Hb (POC-Hb). Anemia was found in 99 from 145 infants (68.3%). The prevalence of anemia was 33.3% and 72.8% when tested by CBC and POC-Hb, respectively. Breastfed Infants had significantly lower mean Hb than formula-fed infants. The odd ratio [95% confident interval] of having anemia among infants who were fed with infant formula were 0.37 [0.14-0.94]; P = .038 when compared to breastfed infants. There was a high proportion of anemia among 9-month-old infants in Rama-WCC and breastfeeding was associated with anemia in infants. The use of POC-Hb may overestimate the prevalence of anemia.

scholarly journals An Artificial Intelligence powered Digital Inline Holographic Microscopy and Characterization Scheme

2020 ◽  
Author(s):  
Rajkumar Vaghashiya ◽  
Varun Chauhan ◽  
Kaushal Kapadiya ◽  
Smit Sanghavi ◽  
Ishita Nandwani ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Blood Cell ◽  
Blood Count ◽  
Complete Blood Count ◽  
Cell Types ◽  
Performance Comparison ◽  
Characterization Technique ◽  
Size Characterization ◽  
Increase In Accuracy

Abstract Digital Inline Holography (DIH) based microscopy is a well-established technique for the characterization of nano and microparticles, such as biological cells, artificial microparticles, quantum dots, etc. Due to its simplicity and cost-effectiveness, various practical solutions such as auto characterization of complete blood count (CBC), cell viability test, and 3D cell tomography have been developed. In our previous work, we demonstrated the feasibility of this system to perform complete blood count along with the auto characterization of cell-lines as well as shape and size characterization of the microparticles. However, its performance suffered due to the weak signals from some of the cells owing to their poor signatures and the presence of background noise. The auto characterization technique therein was based on the parameters determined from our empirical findings, which limit the system in terms of its cellline recognition power. In this work, we try to address these issues by leveraging an artificial intelligence-powered auto signal enhancing scheme as well as adaptive cell characterization technique. The performance comparison of our proposed method with the existing analytical model shows an increase in accuracy to >98% along with the signal enhancement of >5 dB for most cell types like Red Blood Cell (RBC) and White Blood Cell (WBC), except the cancer cells (HepG2 and MCF-7) for which the accuracy is about 84%.

scholarly journals Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue

2021 ◽  
Vol 15 (8) ◽  
pp. e0009692
Author(s):  
Kantasit Wisanuvej ◽  
Kochawan Boonyawat ◽  
Chutchaiwat Savetamornkul ◽  
Sirapong Virapongsiri ◽  
Jatupon Krongvorakul ◽  
...  
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Point Of Care ◽  
Hemoglobin Concentration ◽  
Warning Signs ◽  
Adult Patients ◽  
Severe Dengue ◽  
University Hospitals ◽  
Automated Method ◽  
Indispensable Tool

Background Hematocrit measurement has been an indispensable tool for monitoring plasma leakage and bleeding in dengue patients. However, hematocrit measurement by automated methods is hampered by frequent venipunctures. Utility of point-of-care hemoglobin (POC-Hb) test for monitoring dengue patients has not been established. We evaluated the relationship between hemoglobin measured by POC-Hb testing and hematocrit measured by the automated method in adult dengue patients. Methodology and principal findings Adult dengue patients were recruited at two university hospitals in Thailand from October 2019 to December 2020. POC-Hb test was performed using capillary blood simultaneously with venipuncture to obtain whole blood for an automated complete blood count (CBC) analysis. The correlation of hemoglobin and hematocrit measurement was evaluated. A total of 44 dengue patients were enrolled. Twenty-nine patients (65.9%) were female, with a median age of 31 years (interquartile range 22–41). Of the enrolled patients, 30 (68.2%), 11 (25.0%), and 3 (6.8%) were classified as dengue without warning signs, with warning signs, and severe dengue, respectively. Seven patients (15.9%) had hemoconcentration, and five patients (11.3%) had bleeding. A total of 216 pairs of POC-Hb and CBC were evaluated. A significant positive correlation was observed between hemoglobin measured by POC-Hb testing and hematocrit measured by an automated CBC (r = 0.869, p <0.001). Bland-Altman analysis between hemoglobin measured by POC-Hb testing and an automated CBC showed a bias of -0.43 (95% limit of agreement of -1.81 and 0.95). Using the cutoff of POC-Hb ≥20% as a criteria for hemoconcentration, the sensitivity and specificity of hemoconcentration detected by POC-Hb device were 71.4% and 100.0%, respectively. Conclusions Hemoglobin measurement by POC-Hb testing has a strong correlation with hematocrit in adult patients with dengue fever. However, the sensitivity in detecting hemoconcentration is fair. The adjunct use of capillary POC-Hb testing can decrease the frequency of venipuncture. Further study in children is encouraged.

scholarly journals Publisher Correction: A cartridge based Point-of-Care device for complete blood count

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Usama Abbasi ◽  
Prasanta Chowdhury ◽  
Sasikala Subramaniam ◽  
Prakhar Jain ◽  
Nitin Muthe ◽  
...  
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Point Of Care

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Evaluation of a new point of care automated complete blood count (CBC) analyzer in various clinical settings

2008 ◽  
Vol 389 (1-2) ◽  
pp. 120-125 ◽  
Author(s):  
L.V. Rao ◽  
Björn A. Ekberg ◽  
Diane Connor ◽  
Felice Jakubiak ◽  
Guy M. Vallaro ◽  
...  
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Point Of Care ◽  
Clinical Settings

scholarly journals Volume, conductance, and scatter parameters of neoplastic and nonneoplastic lymphocytes using Coulter LH780

2018 ◽  
Vol 10 (01) ◽  
pp. 085-088
Author(s):  
Chidambharam Choccalingam
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Lymphoblastic Leukemia ◽  
Viral Disease ◽  
Lymphocytic Leukemia ◽  
Differential Count ◽  
Blood Cell Count ◽  
Differential White Blood Cell ◽  
The Right ◽  
Hematology Analyzers

Abstract PURPOSE: Automated hematology analyzers yield a complete hematological profile including a complete blood count and a differential white blood cell count. The differential count is based on analyses of three parameters, namely, volume, conductance, and scatter (VCS). We aimed to evaluate the VCS parameters, histograms, and scatterplots of neoplastic and nonneoplastic lymphocytes. MATERIAL AND METHODS: Patients were grouped into four categories, namely, acute lymphoblastic leukemia (ALL), chronic systemic disorders, chronic lymphocytic leukemia (CLL), and acute viral disease. Lymphocytes from all four groups were compared with lymphocytes from normal participants. RESULTS AND CONCLUSIONS: The histogram for acute viral disease showed a trough at T1, which was slightly obliterated, and the F1 curve mildly extended to the right. The T1 for ALL was replaced with a peak at >40% of the preset limit. The F1 peak was shifted to left for CLL. The scatterplot for viral disease showed lymphocytes extending to the variant lymphocyte window. The lymphocytes of ALL extended to the blast window, with both increase in volume and mild increase in scatter. The lymphocytes in CLL were smaller and located below the normal lymphocyte region. Mean lymphocyte volume was significantly increased in ALL and was significantly decreased in CLL. Mean lymphocyte conductance was significantly increased in CLL and significantly decreased in both acute viral disease and ALL. Mean lymphocyte scatter was significantly decreased in acute viral disease and significantly increased in ALL.

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