scholarly journals Synthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Disposable E-cigarettes: Chemical Analysis and Risk Assessment.

2021 ◽  
Author(s):  
Sairam V. Jabba ◽  
Hanno C. Erythropel ◽  
Deyri G. Torres ◽  
Lauren A Delgado ◽  
Paul T Anastas ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Chemical Analysis ◽  
Health Risks ◽  
Tobacco Product ◽  
Cooling Effect ◽  
Regulatory Agencies ◽  
Cigarette Use ◽  
Sensory Effects ◽  
Cigarette Brand ◽  
Almost All

Background: Menthol, through its cooling sensory effects, facilitates smoking and tobacco product initiation, which is reflected by the high popularity of mint/menthol-flavored E cigarettes. More recently, E cigarette vendors started marketing synthetic cooling agents as additives that impart a cooling effect but lack a characteristic minty odor. Knowledge about content of synthetic coolants in US-marketed E cigarette products and associated health risks is limited. Methods: E-liquid vendor sites were searched with the terms koolada, kool / cool, ice or WS 3 / WS 23, denoting individual cooling agents. Ice flavor varieties of Puffbar, the popular disposable E cigarette brand, were compared with non-Ice varieties. GC/MS and GC/FID were used for detection of synthetic coolants. Margin of exposure (MOE), a risk assessment parameter, was calculated to assess the risk associated with synthetic coolant exposure from E cigarette use. Results: WS 3 was widely present in refill E liquids. Almost all liquids in Puffbar-branded disposable E cigarettes contained WS 23 (13/14 varieties), and some WS 3 (5/14), in both Ice- and non-Ice varieties. Modeling consumption of WS 3 from vaped E liquids resulted in MOEs below the safe margin of 100 for most daily use scenarios (3-mL:14/25 E liquids; 5-mL:18/25; 10-mL:20/25 ). MOEs for WS 23 from 11/13 Puffbar products were ≤100 in all use scenarios. Conclusions: Manufacturers add synthetic cooling agents (WS 3, WS 23) to US-marketed E cigarettes, at levels that may result in consumer exposures exceeding safety thresholds set by regulatory agencies. Synthetic cooling agents are not only found in mint-or menthol-flavored products, but also in fruit- and candy-flavored products, including popular disposable E cigarette products such as Puffbar.

scholarly journals Origins of Risk Assessment in Food Safety Decision Making

1988 ◽  
Vol 7 (4) ◽  
pp. 539-542 ◽  
Author(s):  
Joseph V. Rodricks
Keyword(s):  
Risk Assessment ◽  
Decision Making ◽  
Human Exposure ◽  
Driving Forces ◽  
Quantitative Risk Assessment ◽  
Regulatory Agencies ◽  
Decision Making Process ◽  
Commercially Important ◽  
Exposure Levels ◽  
Almost All

FDA's efforts during the early 1970s to establish acceptable food exposure levels for carcinogenic animal drugs such as diethylstilbestrol (DES) led the agency to incorporate quantitative risk assessment into its decision-making process. During the nearly two decades since FDA first introduced risk assessment as a regulatory tool, its uses have been expanded to almost all areas of chemical regulation. The major driving forces behind this expansion have been (1) the need to deal systematically with the large number of commercially important chemicals that have been identified as animal carcinogens and that have been found to occur widely in the environment and (2) the large number of laws that now require regulatory agencies to establish limits on human exposure to these substances.

An Estimation of Endogenous Formaldehyde Exposure due to Consumption of Indonesian Opah Fish (Lampris guttatus) in Three Major Export Destination Countries

2019 ◽  
Vol 14 (1) ◽  
pp. 1 ◽  
Author(s):  
Umi Anissah ◽  
Ajeng Kurniasari Putri ◽  
Giri Rohmad Barokah
Keyword(s):  
Risk Assessment ◽  
Health Risks ◽  
Health Problem ◽  
International Market ◽  
Formaldehyde Content ◽  
Export Volume ◽  
Formaldehyde Exposure ◽  
Export Destination ◽  
Export Product ◽  
Over Time

The demand for Indonesian opah fish as an export product is increasing in the international market. Three countries (Malaysia, Mauritius, and Taiwan) recorded as the leading export destination of Indonesian opah fish. However, as the fish kept in a frozen state during export transportation, the endogenous formaldehyde may increase over time. This research presented the health risk assessment of population in the leading export destination countries that consumed opah fish from Indonesia. The study aimed to reveal the most potential export destination country that may accept an increasing volume of opah fish supply from Indonesia. The potency was determined from current export volume, the amount of endogenous formaldehyde content, and fish consumption at each country. The data were calculated with @Risk®7.0 software. The results showed opah fish consumed by Malaysian can be categorized as safe. Increasing the number of opah fish imported by Malaysian as much as six times, 12 times, 18 times, 27 and 36 times relatively does not cause health risks related to the presence of its endogenous formaldehyde. Moreover, opah fish consumed by Taiwanese is also safe, but with increasing the number of consumptions by more than 26 times is suspected to be potentially causing a health problem. However, opah fish consumed in Mauritius was categorized as unsafe and potentially caused health risks. Based on these results, Indonesia may consider to increase the opah fish export to Malaysia and Taiwan in the future.

Exploration Health Risks: Probabalistic Risk Assessment

2006 ◽  
Author(s):  
Jennifer L. Rhatigan ◽  
John B. Charles ◽  
J. Michelle Edwards
Keyword(s):  
Risk Assessment ◽  
Health Risks

scholarly journals Polytobacco product use among current cigarette smokers in Hong Kong, China: results from population surveys (2015–17)

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
S. L. Chau ◽  
M. P. Wang ◽  
Y. Wu ◽  
D. Y. T. Cheung ◽  
A. Kong ◽  
...  
Keyword(s):  
Control Policy ◽  
Tobacco Product ◽  
Cigarette Use ◽  
Related Factors ◽  
Cigarette Smokers ◽  
Tobacco Products ◽  
Product Use ◽  
Younger Age ◽  
Current Cigarette ◽  
Age And Sex

Abstract Background Polytobacco product use is increasingly popular, but little is known about the prevalence, trend, and factors of such use particularly in non-western countries. Method A representative sample of 1139 current cigarette smokers aged 15+ (84.1% male) were telephone interviewed in Tobacco Control Policy-related Surveys in 2015–2017. Information collected included poly-tobacco use (PTU), smoking and socio-demographic characteristics. Associations of current PTU with related factors were analyzed using logistic regression with adjustment for confounders. Prevalence was weighted by age and sex of current cigarette users in the general population. Results Eighty-four point one percent (95% CI 81.4–86.6%) were exclusive cigarette smokers. Fifteen point nine percent (13.4–18.6%) were current polytobacco product users, 12.3% (10.2–14.8%) used one tobacco product and 2.52% (1.59–3.97%) used two tobacco products in addition to cigarette. Cigarette use with cigar was more common (6.28%, 4.75–8.27%), and the least used product with cigarette was e-cigarette (1.05%, 0.44–2.50%). The changes in overall prevalence of PTU by number of products use varied in 3 years. Current PTU was associated with being male (AOR 2.01, 95% CI 1.12–3.61), younger age (AORs range from 1.34–4.65, P for trend < .001) and less ready to quit (2.08, 1.09–3.97). Conclusions Prevalence of PTU increased slowly by year, one tobacco product use with cigarette was more common. The most used tobacco product with cigarette was cigar. Being male, younger and less ready to quit were associated with current PTU.

scholarly journals Frequency and Prioritization of Patient Health Risks from a Structured Health Risk Assessment

2014 ◽  
Vol 12 (6) ◽  
pp. 505-513 ◽  
Author(s):  
S. M. Phillips ◽  
R. E. Glasgow ◽  
G. Bello ◽  
M. G. Ory ◽  
B. A. Glenn ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Health Risk Assessment ◽  
Health Risks ◽  
Patient Health

scholarly journals Predicting the potential distribution of the vase tunicate Ciona intestinalis in Canadian waters: informing a risk assessment

2008 ◽  
Vol 65 (5) ◽  
pp. 788-794 ◽  
Author(s):  
Thomas W. Therriault ◽  
Leif-Matthias Herborg
Keyword(s):  
Risk Assessment ◽  
Native Species ◽  
Potential Distribution ◽  
Negative Impact ◽  
Ciona Intestinalis ◽  
Environmental Niche ◽  
Environmental Models ◽  
Introduced Range ◽  
Negative Impacts ◽  
Almost All

Abstract Therriault, T. W., and Herborg, L-M. 2008. Predicting the potential distribution of the vase tunicate Ciona intestinalis in Canadian waters: informing a risk assessment. – ICES Journal of Marine Science, 65: 788–794. A crucial step in characterizing the potential risk posed by non-native species is determining whether a potential invader can establish in the introduced range and what its potential distribution could be. To this end, various environmental models ranging from simple to complex have been applied to predict the potential distribution of an invader, with varying levels of success. Recently, in marine waters, tunicates have received much attention, largely because of their negative impacts on shellfish aquaculture. One of these species is the vase tunicate Ciona intestinalis, which recently has had a negative impact on aquaculture operations in Atlantic Canada and could pose a risk in Pacific Canada. To inform the risk assessment of this species, we evaluated two different types of environmental model. Simple models based on reported temperature or salinity tolerances were relatively uninformative, because almost all waters were deemed suitable. In contrast, a more complex genetic algorithm for rule-set prediction (GARP) environmental niche model, based on documented Canadian occurrence points, provided informative projections of the potential distribution in Canadian waters. In addition to informing risk assessments, these predictions can be used to focus monitoring activities, particularly towards vectors that could transport C. intestinalis to these favourable environments.

scholarly journals Cyanobacterial Toxins and Peptides in Lake Vegoritis, Greece

Toxins ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 394
Author(s):  
Sevasti-Kiriaki Zervou ◽  
Kimon Moschandreou ◽  
Aikaterina Paraskevopoulou ◽  
Christophoros Christophoridis ◽  
Elpida Grigoriadou ◽  
...  
Keyword(s):  
Public Health ◽  
Risk Assessment ◽  
Simultaneous Determination ◽  
Aquatic Ecosystems ◽  
Human Exposure ◽  
Bioactive Metabolites ◽  
Cyanobacterial Toxins ◽  
Major Threat ◽  
Almost All

Cyanotoxins (CTs) produced by cyanobacteria in surface freshwater are a major threat for public health and aquatic ecosystems. Cyanobacteria can also produce a wide variety of other understudied bioactive metabolites such as oligopeptides microginins (MGs), aeruginosins (AERs), aeruginosamides (AEGs) and anabaenopeptins (APs). This study reports on the co-occurrence of CTs and cyanopeptides (CPs) in Lake Vegoritis, Greece and presents their variant-specific profiles obtained during 3-years of monitoring (2018–2020). Fifteen CTs (cylindrospermopsin (CYN), anatoxin (ATX), nodularin (NOD), and 12 microcystins (MCs)) and ten CPs (3 APs, 4 MGs, 2 AERs and aeruginosamide (AEG A)) were targeted using an extended and validated LC-MS/MS protocol for the simultaneous determination of multi-class CTs and CPs. Results showed the presence of MCs (MC-LR, MC-RR, MC-YR, dmMC-LR, dmMC-RR, MC-HtyR, and MC-HilR) and CYN at concentrations of <1 μg/L, with MC-LR (79%) and CYN (71%) being the most frequently occurring. Anabaenopeptins B (AP B) and F (AP F) were detected in almost all samples and microginin T1 (MG T1) was the most abundant CP, reaching 47.0 μg/L. This is the first report of the co-occurrence of CTs and CPs in Lake Vegoritis, which is used for irrigation, fishing and recreational activities. The findings support the need for further investigations of the occurrence of CTs and the less studied cyanobacterial metabolites in lakes, to promote risk assessment with relevance to human exposure.

Baby Walker Injuries

PEDIATRICS ◽  
1982 ◽  
Vol 70 (1) ◽  
pp. 106-109 ◽  
Author(s):  
Louis E. Fazen ◽  
Pamela I. Felizberto
Keyword(s):  
Child Health ◽  
Head And Neck ◽  
Health Risks ◽  
Medical Management ◽  
Regulatory Agencies ◽  
Neck Injuries ◽  
Product Labeling ◽  
Phone Interview ◽  
Baby Walker

In a study of 49 children between the ages of 8 and 14 months, parents were surveyed with a written questionnaire and a follow-up phone interview to determine the utilization of baby walkers and the frequency and severity of baby walker injuries. Most respondents (86%) placed their children in various types of baby walkers between 4 months and 1 year of age. Half of the 42 infants who used walkers experienced at least one accident involving a tip over, a fall down stairs, or finger entrapment. Two of those accidents resulted in injuries serious enough to require medical management. Both infants sustained head and neck injuries after falling down stairs in a walker. Whereas stairway and finger entrapment accidents occurred before the age of 7 months, tip overs were much more likely to occur after the age of 8 months. Injuries are more common but less severe than previously reported. Pediatricians and other child health advocates can inform parents about the health risks, encourage regulatory agencies to improve product labeling, and stimulate manufacturers to adjust the product to age and weight specifications of the growing infant.

E-cigarettes use behaviors among heavy users in Japan: An online survey (Preprint)

2021 ◽  
Author(s):  
Shihoko Koyama ◽  
Takahiro Tabuchi ◽  
Isao Miyashiro
Keyword(s):  
Electrical Resistance ◽  
Online Survey ◽  
Tobacco Product ◽  
Cigarette Use ◽  
Web Based ◽  
Concurrent Use ◽  
Frequency Of Use ◽  
The World ◽  
Device Type ◽  
Comprehensive Survey

BACKGROUND Electronic cigarette (e-cigarette) use has become increasingly widespread throughout the world, including Japan. However, little is known about how e-cigarettes are used in Japan, a country with heavy restrictions on nicotine-containing e-liquids, vaping products. OBJECTIVE This study comprehensively examined e-cigarette use, including e-cigarette use duration, frequency of use, device type, electrical resistance, nicotine use, favorite e-liquid flavors and concurrent use with cigarettes and/or HTPs in Japan. METHODS This study examined the detail of e-cigarette use (e-cigarette use duration, frequency of use, device type, electrical resistance, nicotine use, favorite e-liquid flavors) among users in Japan, through an online survey using a web-based self-reported questionnaire which included questions about sex, age, combustible cigarette and heated tobacco product (HTP) use behaviors. RESULTS Of 4,689 e-cigarettes users analyzed, 93.5% were men and 52.9% had been using e-cigarettes for 1-3 years. Over 80% used e-cigarettes every day; 62.4% used nicotine liquid, and half of the nicotine liquid users used nicotine salt. The most popular liquid flavor was fruit (prevalence: 68.1%), followed by tobacco (prevalence: 48.4%). While 9.0% were e-cigarette single users, 35.2% were dual users (e-cigarettes and cigarettes or HTPs) and 13.8% were triple user (e-cigarettes, cigarettes and HTPs). CONCLUSIONS This is the first comprehensive survey of Japanese e-cigarette users and our finding suggest more than half use nicotine liquid, although e-cigarettes containing nicotine liquid have been prohibited by the Pharmaceutical Affairs Act since 2010 in Japan. The study also showed 49.1% of participants used cigarettes and/or HTPs concurrently (dual or triple users).

Risk Assessment of Some Heavy Metals in Two Fish Species Oreochromis Niloticus and Clarias Gariepinus from Sharqia Province, Egypt

2021 ◽  
Vol 8 (1) ◽  
pp. 1-5
Author(s):  
Nahla S El-Shenawy ◽  
Heba N Gad EL-Hak ◽  
Mahi A Ghobashy ◽  
Maha FM Soliman ◽  
Farida A Mansour ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Risk Assessment ◽  
Human Health ◽  
Health Risks ◽  
Oreochromis Niloticus ◽  
Clarias Gariepinus ◽  
Human Health Risk ◽  
Dry Weight ◽  
Critical Problem ◽  
Potential Health

Accumulation of heavy metals in fish is considered a critical problem for human health. Therefore, the study aimed to quantify the concentrations of iron (Fe), zinc (Zn), manganese (Mn), and lead (Pb) in Oreochromis niloticus and Clarias gariepinus from two areas in Al Sharqia governorate, Egypt, from September 2017 to August 2018. A human health risk assessment was conducted to evaluate the potential hazards associated with fish consumption. Metals concentrations (mg/kg dry weight) in muscles of catfish ranged 1.88-221.26 for Fe; 1.78-19.77 for Zn; BDL-238.51 for Mn; BDL-22.75 for Pb. In muscles of tilapia fish metals concentrations ranged 7.96-149.10 for Fe; 1.20-19.77 for Zn; BDL-230.82 for Mn; BDL-25.93 for Pb. Pb had Hazard quotients (HQs) which indicated potential health risks to tilapia consumers at both study areas and catfish consumers at the Faqous area. Fishermen were at higher risk compared to the other consumers.

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