scholarly journals The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus entry inhibitor

2021 ◽  
Author(s):  
Emmanuelle V. LeBlanc ◽  
Che C. Colpitts
Keyword(s):  
Green Tea ◽  
Vaccine Development ◽  
Epigallocatechin Gallate ◽  
Proof Of Concept ◽  
Case Scenario ◽  
Human Coronavirus ◽  
Highly Pathogenic ◽  
Egcg Treatment ◽  
Green Tea Catechin ◽  
Coronavirus Infection

The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emphasized the serious threat to human health posed by emerging coronaviruses. Effective antiviral countermeasures are urgently needed as vaccine development against an emerging coronavirus takes time, even in the best-case scenario. The green tea catechin, epigallocatechin gallate (EGCG), has broad spectrum antiviral activity. We demonstrate here that EGCG prevents murine and human coronavirus infection and blocks the entry of lentiviral particles pseudotyped with spike proteins from bat or highly pathogenic coronaviruses. We show that EGCG treatment reduces coronavirus attachment to target cell surfaces. Our results demonstrate the potential for the development of pan-coronavirus attachment inhibitors.

Versatile Health Benefits of Catechin from Green Tea (Camellia sinensis)

2019 ◽  
Vol 15 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Satheesh Babu Natarajan ◽  
Suriyakala Perumal Chandran ◽  
Sahar Husain Khan ◽  
Packiyaraj Natarajan ◽  
Karthiyaraj Rengarajan
Keyword(s):  
Green Tea ◽  
Camellia Sinensis ◽  
Health Benefits ◽  
Epigallocatechin Gallate ◽  
Extraction Methods ◽  
Major Constituent ◽  
Epicatechin Gallate ◽  
Wide Range ◽  
Green Tea Catechin ◽  
Anti Inflammatory

Background: Tea (Camellia sinensis, Theaceae) is the second most consumed beverage in the world. Green tea is the least processed and thus contain rich antioxidant level, and believed to have most of the health benefits. </p><p> Methods: We commenced to search bibliographic collection of peer reviewed research articles and review articles to meet the objective of this study. </p><p> Results: From this study, we found that the tea beverage contains catechins are believed to have a wide range of health benefits which includes neuroprotective, anti-inflammatory, antiulcer, antiviral, antibacterial, and anti-parasitic effects. The four major catechin compounds of green tea are epigallocatechin (EGC), epicatechin (EC), epigallocatechin gallate (EGCG), and epicatechin gallate (ECG), of which EGCG is the major constituent and representing 50-80% of the total catechin content. And also contain xanthine derivatives such as caffeine, theophylline, and theobromine, and the glutamide derivative theanine. It also contains many nutritional components, such as vitamin E, vitamin C, fluoride, and potassium. We sum up the various green tea phytoconstituents, extraction methods, and its medicinal applications. </p><p> Conclusion: In this review article, we have summarized the pharmacological importance of green tea catechin which includes antioxidant potential, anti-inflammatory, antimicrobial, anticancer, antidiabetic and cosmetic application.

scholarly journals Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2588 ◽  
Author(s):  
Noriyuki Miyoshi ◽  
Hiroki Tanabe ◽  
Takuji Suzuki ◽  
Koichi Saeki ◽  
Yukihiko Hara
Keyword(s):  
Green Tea ◽  
Case Reports ◽  
Animal Experiments ◽  
Health Benefits ◽  
Epigallocatechin Gallate ◽  
Clinical Intervention ◽  
Clinical Effectiveness ◽  
Epidemiological Studies ◽  
Anogenital Warts ◽  
Green Tea Catechin

Most cell-based and animal experiments have shown that green tea catechins (GTC) exhibit various health benefits. In human experimental and epidemiological studies, there are conflicting results, and more precise investigations are required. One of the most effective ways to prove beneficial health effects in humans might be clinical intervention studies. Polyphenon®E was developed as a standardized GTC preparation, which was approved by Food and Drug Administration of US in 2006 as a medication to treat genital warts (Veregen® or sinecatechins). Positive efficacy of Polyphenon®E/sinecatechins/Veregen® (PSV) on anogenital warts has been demonstrated in several epidemiological studies and there have been several case reports to show the clinical effectiveness of PSV. In addition, several studies have provided evidence to suggest that PSV is effective in other human papillomavirus (HPV)-related diseases, although some studies failed to show such effects. Since (−)-epigallocatechin gallate (EGCG) is the major component of PSV, the mechanism of the action of PSV might be deduced from that of EGCG. The microarray analysis of the biopsy samples from the patients suggested that apoptosis induction and the downregulation of inflammation are involved in the mechanism of the action of PSV in the clearance of anogenital warts. Cell-based and animal experiments using PSV also demonstrated effects similar to those elicited by EGCG, explaining how PSV works to induce apoptosis and exert anti-inflammatory actions in HPV-related diseases. Future studies would clarify what kinds of diseases respond effectively to PSV, showing health benefits of GTC and EGCG in humans.

Mucosal Immunity Against HIV-1 Infection by the Green Tea Catechin, Epigallocatechin Gallate

2009 ◽  
Vol 123 (2) ◽  
pp. S208-S208
Author(s):  
C.L. Nance ◽  
E. Siwak ◽  
M. D'Souza ◽  
A. McMullen ◽  
S. Sanga ◽  
...  
Keyword(s):  
Green Tea ◽  
Mucosal Immunity ◽  
Epigallocatechin Gallate ◽  
Green Tea Catechin ◽  
Hiv 1

T.75. Inhibition of Dendritic Cell HIV-1 Infection by the Green Tea Catechin, Epigallocatechin Gallate

2009 ◽  
Vol 131 ◽  
pp. S72
Author(s):  
Christina Nance ◽  
Edward Siwak ◽  
Andrew Victores ◽  
Melinda D'Souza ◽  
Ashley McMullen ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Green Tea ◽  
Epigallocatechin Gallate ◽  
Green Tea Catechin ◽  
Hiv 1

HIV-1 Infectivity Inhibited by Binding of the Green Tea Catechin, Epigallocatechin Gallate, to CD4

2007 ◽  
Vol 123 ◽  
pp. S13
Author(s):  
Christina Nance ◽  
Edward Siwak ◽  
Aarthi Ram ◽  
Van Willis ◽  
Susan Westerfield ◽  
...  
Keyword(s):  
Green Tea ◽  
Epigallocatechin Gallate ◽  
Green Tea Catechin ◽  
Hiv 1
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