scholarly journals Emerging and Continuing Trends in Opioid Overdose Decedent Characteristics during COVID-19

Author(s):  
Gian-Gabriel P. Garcia ◽  
Erin Stringfellow ◽  
Catherine DiGennaro ◽  
Nicole Poellinger ◽  
Jaden Wood ◽  
...  

Background: Since COVID-19 erupted in the United States, little is known about how state-level opioid overdose trends and decedent characteristics have varied throughout the country. Objective: Investigate changes in annual overdose death rates, substances involved, and decedent demographics in opioid overdose deaths across nine states; assess whether 2019-2020 trends were emerging (i.e., change from 2019-2020 was non-existent from 2018-2019) or continuing (i.e., change from 2019-2020 existed from 2018-2019). Design: Cross-sectional study using vital statistics data to conduct a retrospective analysis comparing 2020 to 2019 and 2019 to 2018 across nine states. Setting: Alaska, Colorado, Connecticut, Indiana, Massachusetts, North Carolina, Rhode Island, Utah, and Wyoming. Participants: Opioid-related overdose deaths in 2018, 2019, and 2020. Measurements: Annual overdose death rate, proportion of overdose deaths involving specific substances, and decedent demographics (age, sex, race, and ethnicity). Results: We find emerging increases in annual opioid-related overdose death rates in Alaska (55.3% [P=0.020]), Colorado (80.2% [P<0.001]), Indiana (40.1% [P=0.038]), North Carolina (30.5% [P<0.001]), and Rhode Island (29.6% [P=0.011]). Decreased heroin-involved overdose deaths were emerging in Alaska (-49.5% [P=0.001]) and Indiana (-58.8% [P<0.001]), and continuing in Colorado (-33.3% [P<0.001]), Connecticut (-48.2% [P<0.001]), Massachusetts (39.9% [P<0.001]), and North Carolina (-34.8% [P<0.001]). Increases in synthetic opioid presence were emerging in Alaska (136.5% [P=0.019]) and Indiana (27.6% [P<0.001]), and continuing in Colorado (44.4% [P<0.001]), Connecticut (3.6% [P<0.05]), and North Carolina (14.6% [P<0.001]). We find emerging increases in the proportion of male decedents in Colorado (15.2% [P=0.008]) and Indiana (12.0% [P=0.013]). Limitations: Delays from state-specific death certification processes resulted in varying analysis periods across states. Conclusion: These findings highlight emerging changes in opioid overdose dynamics across different states, which can inform state-specific public health interventions.

2019 ◽  
Vol 34 (s1) ◽  
pp. s53-s53
Author(s):  
Sasha Rihter ◽  
Nathan Menke

Introduction:The opioid epidemic is overwhelming communities across the United States. West Virginia (WV) has been devastated, heralding a 86% increase in deaths from 2012-2016, and over 1,000 deaths last year as per WV Health Statistics Center. Treatment centers and providers have emerged throughout the state to provide medication-assisted treatment (MAT). The impact of these clinics on the opioid abusing population is not yet fully understood.Aim:Utilizing Geographic Information System (GIS), a comparison of MAT provider locations versus regions of historical overdoses can indicate areas of deficiency. If no providers emerge in underserved counties, overdose deaths in those areas will continue to rise.Methods:Maps were created using current DEA-X licenses in WV registered through Substance Abuse and Mental Health Services Administration (SAHMSA). Overdose death rates were taken from WV Public Health Records from 2010-2017. Two maps and corresponding data were compared for overlap or lack thereof.Results:Of the 338 locations of DEA-X licenses registered, 17.5% are in Cabell County, which led the state in overdose deaths in 2017. Only 2.5% of the total providers are currently in Wayne County, which had the second highest overdose death rate. Berkeley County, which was 3rd highest, has a mere 6.5% of total providers. Comparatively, Kanawah County, home to the state’s capital, has over twice this number of providers despite consistently having at or below the state average of overdose rates. Resources are pulled towards population-dense areas or university centers, where the epidemic is present but misses counties with higher overdose rates.Discussion:Results show a lack of MAT providers in many of WV’s devastated counties. Treatment centers exist throughout the state but are concentrated in regions with large cities or academic centers. This distribution limits accessibility to a marginalized patient population, making improvements unlikely in WV’s future opioid-overdose death rates.


Author(s):  
Bernd Wollschlaeger

In reviewing the elements of opioid overdose education, prevention, and management, this chapter focuses particularly on practical interventions that are available and deserve advocacy; e.g., provision of naloxone to those with opioid use disorder and to possible first responders. It moves from a discussion of the epidemiology of opioid deaths to the more individual topic of patient risk for overdose. Prophylactic interventions in the form of education of the patient’s family and friends, and agreements for treatment with informed consent are described. There follows a discussion of management of the opioid poisoning itself, including use/distribution of naloxone injection. Two figures are included: drug overdose death rates in the United States (2014); a map describing the current states with naloxone or “good Samaritan” laws impacting opioid overdose management. A text box with resources includes directions for initiation of community overdose prevention and intervention schemes.


2020 ◽  
Vol 37 (8) ◽  
pp. 624-631
Author(s):  
James Gerhart ◽  
Paul Duberstein ◽  
Danielle Paull ◽  
Sean O’Mahony ◽  
John Burns ◽  
...  

Background: Opioid overdoses have reached epidemic levels in the United States and have clustered in Northeastern and “Rust Belt” states. Five Factor Model (FFM) personality traits also vary at the state level, with anger-prone traits clustered in the Northeast region. This study tested the hypothesis that state-level anger proneness would be associated with a greater increase in rates of opioid overdose death. Methods: This was a secondary analysis of state-level data on FFM traits, opioid overdose deaths, and other classes of preventable death. Robust mixed models tested whether change in rates of opioid overdose death from 2008 to 2016 was moderated by state-level anger proneness. Results: State-level anger proneness was significantly associated with greater increases in rates of opioid overdose deaths (B = 1.01, standard error = 0.19, P < .001, 95% confidence interval: 0.63-1.39). The slope of increase in opioid overdose death rates was 380% greater in anger-prone states and held after adjustment for potential confounders such as state-level prevalence of major depressive disorder, number of mental health facilities, and historical patterns of manufacturing decline. A similar pattern was observed between state-level anger proneness and benzodiazepine overdose deaths but was not significant for the latter after adjustment for potential confounders. Conclusion: These findings suggest that states characterized as more anger prone have experienced greater increases in opioid overdose deaths.


2020 ◽  
pp. 003335492096917
Author(s):  
Joel E. Segel ◽  
Tyler N.A. Winkelman

Objectives Although trends in opioid-related death rates in the United States have been described, the association between state-level opioid overdose death rates in early waves and substance-related overdose death rates in later waves has not been characterized. We examined the relationship between state-level opioid overdose death rates at the beginning of the crisis (1999-2004) and overdose death rates for opioids and other substances in later years. Methods Using 1999-2018 multiple cause of death data from the Centers for Disease Control and Prevention, we first categorized each state by quartile of baseline (1999-2004) opioid overdose death rates. By baseline opioid overdose death rates, we then compared states’ annual overdose death rates from any opioid, heroin, synthetic opioids, sedatives, stimulants/methamphetamine, and cocaine from 2005 through 2018. To test the association between baseline opioid overdose death rates and subsequent substance-related overdose death rates for all 6 substances, we estimated unadjusted and adjusted linear models controlling for annual state-level unemployment, median household income, age, sex, and race/ethnicity. Results Our results suggest 2 characteristics of the opioid crisis: persistence and pervasiveness. In adjusted analyses, we found that for each additional opioid overdose death per 100 000 population at baseline, states had 23.5 more opioid deaths, 4.4 more heroin deaths, 8.0 more synthetic opioid deaths, 9.2 more sedative deaths, 3.3 more stimulant deaths, and 4.6 more cocaine deaths per 100 000 population from 2005 to 2018. Conclusion These findings have important implications for continued surveillance to assist policy makers in deciding how to deploy resources to combat not just opioid use disorder but also polysubstance use disorder and broader problems of substance use disorder.


Author(s):  
Jaynia Anderson ◽  
Natalie Demeter ◽  
Mar-y-sol Pasquires ◽  
Stephen Wirtz

ObjectiveDemonstrate the use of timely, actionable data from a data visualization tool, the California Opioid Overdose Surveillance Dashboard, which integrates statewide, geographic- and demographic-specific data, by describing the changes in opioid overdose deaths in California.IntroductionCalifornia continues to face a serious public health crisis with the opioid epidemic having substantial health and economic impacts. The epidemic is dynamic and rapidly changing, involving both prescription opioids influenced by prescribing and dispensing patterns as well as illicit opioids influenced by the availability of heroin and recently, the increased availability of fentanyl. The complexity of the issue necessitates data-informed actions through multi-sector, strategic collaboration at both the state and local levels to address the problem comprehensively. With nearly 2,000 opioid overdose deaths per year and wide variation of overdose rates across counties and demographic groups, there is a need for integrated, timely, actionable data for use by state policy makers, local opioid safety coalitions, media, community stakeholders, and the public to monitor and combat this dynamic epidemic at the state and local level. Using fatality data from the California Opioid Overdose Surveillance Dashboard1, the opioid overdose epidemic is described along with the differential geographic and demographic impacts.MethodsAs part of California Department of Public Health’s Prevention for States grant funded by the Centers for Disease Control and Prevention, the California Opioid Overdose Surveillance Dashboard was developed as a data tool to provide enhanced visualization and integration of non-fatal and fatal opioid-involved overdose data and opioid prescription data. The dashboard was built on an open source RStudio server using Shiny, an R package that provides a framework for building web applications. Data incorporated on the dashboard include emergency department visits, hospitalizations, fatalities, and prescriptions related to opioid overdoses among California residents, presented in raw counts, crude rates, and age-adjusted rates at the state, county, and zip code levels, as well as by sex, age, and race/ethnicity. Overdose deaths are identified using ICD-10 (International Classification of Diseases, 10th Revision) codes X40-X44, X60-X64, X85, Y10-Y14, and T40.0-T40.6, recorded in the underlying cause of death and multiple cause of death fields on death certificates. Fentanyl overdose deaths are identified using a text search on contributing cause of death fields on death certificates. Using data from the California Opioid Overdose Surveillance Dashboard, we present one perspective of the epidemic by using 2017 death data to describe the changing trend and geographic and demographic variation of prescription drug, heroin, and fentanyl overdose deaths.ResultsOverall trends from 2011-2017 show that deaths due to opioid overdoses have increased. Prescription drug overdose death rates have slightly decreased by 6% from 3.93/100,000 in 2011 to 3.7/100,000 in 2017. Heroin overdose death rates have increased by 89% from 0.90/100,000 in 2011 to 1.70/100,000 in 2017. Fentanyl overdose death rates have increased by 320% from 0.25/100,000 in 2011 to 1.05/100,000 in 2017. The highest rates of prescription opioid overdose deaths are primarily concentrated in northern rural counties, while the highest rates of heroin and fentanyl overdose deaths are more dispersed throughout the state with many coastal counties showing higher rates of overdose deaths (Figure 1). Prescription opioid overdose deaths are concentrated among older ages showing highest rates among 55 to 59 year olds (8.27/100,000). In contrast, heroin and fentanyl overdose death rates are concentrated among younger ages with the highest rates seen among 25 to 29 year olds, 4.54/100,000 and 2.78/100,000, respectively (Figure 2). Males died from prescription opioid, heroin, and fentanyl overdoses at significantly higher rates than females. Prescription opioid and fentanyl overdose death rates (11.5/100,000 and 4.80/100,000, respectively) are significantly higher among Native Americans compared to other races/ethnicities (Table 1). Non-Hispanic whites had significantly higher prescription opioid and heroin overdose death rates (6.90/100,000 and 2.96/100,000, respectively) compared to non-Hispanic black, Hispanic, and Asian residents of California.ConclusionsFatality data from 2017 show the characteristics of the opioid overdose epidemic in California are changing. While still high, overdose deaths from prescription opioids, seen primarily in older age groups and northern rural California, are slightly declining. Concurrently, we are seeing sharp rises in heroin and fentanyl overdose death rates among younger adults throughout the state. Regardless of any change in trend, there remain clear disparities in overdose death rates by race/ethnicity; with Native Americans having the highest rates for both prescription and illicit opioids, and non-Hispanic whites have higher rates of prescription opioid and heroin overdose deaths.Given the varying demographic and geographic impacts based on the type of opioid, as demonstrated with the use of death data, there needs to be targeted data-informed interventions to address and prevent prescription and illicit opioid overdoses. Death data is just one perspective on the epidemic, other data sources (emergency department visits, hospitalizations, and prescriptions) are needed complete the picture to truly provide a robust data-informed approach. The California Opioid Overdose Surveillance dashboard integrates these multiple data sources and serves as a valuable tool in providing specific and timely data to inform approaches and interventions at the state and local level in continuing to fight California’s opioid overdose epidemic. The enhanced visualization, geographic- and demographic-specific data, and increasingly timely data allow for state and local policy makers, local opioid safety coalitions, and community stakeholders to track the dynamics and impact of the epidemic and to identify those who are most vulnerable and differentially impacted.References1 California Opioid Overdose Surveillance Dashboard https://discovery.dev.cdph.ca.gov/CDIC/ODdash/ 


2021 ◽  
pp. 002242782098684
Author(s):  
Richard Rosenfeld ◽  
Joel Wallman ◽  
Randolph Roth

Objectives: Evaluate the relationship between the opioid epidemic and homicide rates in the United States. Methods: A county-level cross-sectional analysis covering the period 1999 to 2015. The race-specific homicide rate and the race-specific opioid-related overdose death rate are regressed on demographic, social, and economic covariates. Results: The race-specific opioid-related overdose death rate is positively associated with race-specific homicide rates, net of controls. The results are generally robust across alternative samples and model specifications. Conclusions: We interpret the results as reflecting the violent dynamics of street drug markets, although more research is needed to draw definitive conclusions about the mechanisms linking opioid demand and homicide.


Author(s):  
Heather M Santa ◽  
Samira G Amirova ◽  
Daniel J Ventricelli ◽  
George E Downs ◽  
Alexandra A Nowalk ◽  
...  

Abstract Purpose Opioid misuse and overdose deaths remain a public health concern in the United States. Pennsylvania has one of the highest rates of opioid overdose deaths in the country, with Philadelphia County’s being 3 times higher than the national average. Despite several multimodal interventions, including use of SBIRT (screening, brief intervention, and referral to treatment) methods and naloxone distribution, the rate of overdose deaths remains high. Methods To gain insights on strategies for improving access to naloxone and naloxone distribution by pharmacists in Philadelphia County, a study was conducted in 11 community pharmacies (chain and independent) in Philadelphia. Twenty-four pharmacists were recruited and completed SBIRT and naloxone trainings. Each pharmacy elected to have at least 1 pharmacy champion who received additional training on and helped develop pharmacy site–specific naloxone dispensing protocols. Results Pre-post survey results showed a reduction in stigmatizing attitudes regarding naloxone dispensing and an increase in pharmacists’ understanding of the standing order and appropriate naloxone use. There was an increase in pharmacists’ self-reported confidence in their ability to appropriately identify, discuss, and dispense naloxone to patients. All pharmacies increased their average monthly dispensing rate following protocol implementation. Conclusion Pharmacists who received both trainings were more likely to change naloxone dispensing practices, leading to an overall increase in naloxone dispensing by community pharmacists. The study addressed overall gaps in pharmacists’ knowledge, reduced stigma, and prepared pharmacists to address opioid use and overdose prevention with their patients. The described pharmacist-led patient counseling and intervention service for overdose prevention may be explored as a model for other community pharmacies to adopt to improve naloxone dispensing and similar interventions to reduce overdose deaths.


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