scholarly journals A survey of Chinese pig farms and human healthcare isolates reveals separate human and animal MRSA populations

2021 ◽  
Author(s):  
Geng Zou ◽  
Marta MATUSZEWSKA ◽  
Ming Jia ◽  
Jianwei ZHOU ◽  
Xiaoliang Ba ◽  
...  
Keyword(s):  
North America ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Human Infection ◽  
Central China ◽  
Livestock Farming ◽  
Pig Farms ◽  
Pig Farm ◽  
Human Immune ◽  
Mrsa St398 ◽  
Human Healthcare

There has been increasing concern that the overuse of antibiotics in livestock farming is contributing to the burden of antimicrobial resistance in people. Farmed animals in Europe and North America, particularly pigs, provide a reservoir for livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA, ST398) found in people. This study was designed to investigate the contribution of MRSA from Chinese pig farms to human infection and carriage. A collection of 603 S. aureus were isolated from 55 pig farms and 4 hospitals (MRSA= 285, 198; MSSA= 50, 70) in central China, a high pig farming density area, during 2017-2018. CC9 MRSA accounting for 93% of all farm MRSA isolates, while no was found in hospitals. ST398 isolates were found on three farms (n = 23) and three hospitals (n = 12). None of the ST398 from this study belong to the livestock clade of the LA-MRSA commonly found in Europe and North America. The hospital ST398 MRSA isolates formed a clade that was clearly separate from the farm ST398 MRSA and MSSA isolates, and all possessed human immune evasion cluster genes which were absent from all the pig farm ST398 isolates. Despite the presence of high levels of MRSA found on Chinese pig farms we found no evidence of them spilling over to the human population. Nevertheless, the ST398 MRSA obtained from human samples appear to be part of a widely distributed lineage in China. And the new animal adapted ST398 lineage that emerged in China should also be alarmed.

scholarly journals Evidence for the Dissemination to Humans of Methicillin-Resistant Staphylococcus aureus ST398 through the Pork Production Chain: A Study in a Portuguese Slaughterhouse

2020 ◽  
Vol 8 (12) ◽  
pp. 1892 ◽  
Author(s):  
Ons Bouchami ◽  
Maria João Fraqueza ◽  
Nuno Alexandre Faria ◽  
Valquíria Alves ◽  
Opeyemi Uwangbaoje Lawal ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Virulence Gene ◽  
Multidrug Resistant ◽  
Human Infection ◽  
Production Chain ◽  
Methicillin Resistant ◽  
Pork Production ◽  
Clonal Type ◽  
Mrsa St398

Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) ST398 was recovered from infections in humans exposed to animals, raising public health concerns. However, contact with food producing chain as a means of transmission of LA-MRSA to humans remains poorly understood. We aimed to assess if pork production chain is a source of MRSA ST398 for human colonization and infection. MRSA from live pigs, meat, the environment, and slaughterhouse workers were analyzed by Pulsed-Field Gel Electrophoresis (PFGE), spa, MLST typing, SNPs and for antibiotic resistance and virulence gene profiles. We compared core and accessory genomes of MRSA ST398 isolated from slaughterhouse and hospital. We detected MRSA ST398 (t011, t108, t1451) along the entire pork production chain (live pigs: 60%; equipment: 38%; meat: 23%) and in workers (40%). All MRSA ST398 were multidrug resistant, and the majority carried genes encoding biocide resistance and enterotoxins. We found 23 cross-transmission events between live pigs, meat, and workers (6–55 SNPs). MRSA ST398 from infection and slaughterhouse environment belonged to the same clonal type (ST398, t011, SCCmec V), but differed in 321–378 SNPs. Pork production chain can be a source of MRSA ST398 for colonization of human slaughterhouse workers, which can represent a risk of subsequent meat contamination and human infection.

scholarly journals Dynamics of Livestock-Associated Methicillin Resistant Staphylococcus aureus in pig farms networks: insight from mathematical modeling and French data

2019 ◽  
Author(s):  
Jonathan Bastard ◽  
Mathieu Andraud ◽  
Claire Chauvin ◽  
Philippe Glaser ◽  
Lulla Opatowski ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Epidemiological Data ◽  
Control Measures ◽  
Methicillin Resistant ◽  
Spreading Dynamics ◽  
Pig Farms ◽  
Pig Farm ◽  
Severe Infections ◽  
Spreading Potential

AbstractLivestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA) colonizes livestock animals worldwide, especially pigs and calves. Although frequently carried asymptomatically, LA-MRSA can cause severe infections in humans. It is therefore important to better understand LA-MRSA spreading dynamics within pig farms and over pig farms networks, and to compare different strategies of control and surveillance. For this purpose, we propose a stochastic meta-population model of LA-MRSA spread along the French pig-farm network (n=10,542 farms), combining within- and between-farms dynamics, based on detailed data on breeding practices and pig exchanges between holdings. We calibrate the model using French epidemiological data. We then identify farm-level factors associated with the spreading potential of LA-MRSA in the network. We also show that, assuming control measures applied in a limited (n=100) number of farms, targeting farms depending on their centrality in the network is the only way to significantly reduce LA-MRSA global prevalence. Finally, we investigate the scenario of emergence of a new LA-MRSA strain, and find that the farms with the highest indegree would be the best sentinels for a targeted surveillance of such a strain’s introduction.

PROBLEMS CAUSED BY SMALL PIG FARM ODOR AROUND THE WESTERN SONGKHLA LAKE BASIN

2017 ◽  
Vol 2 (1) ◽  
pp. 1-13
Author(s):  
Papontee Teeraphan
Keyword(s):  
Air Pollution ◽  
Lake Basin ◽  
Urgent Problem ◽  
The Public ◽  
Pig Farms ◽  
Pig Farm ◽  
The Government ◽  
The Moment ◽  
Source Of Information ◽  
Proper Solutions

Pollution is currently a significant issue arising awareness throughout the world. In Thailand, pollution can often be seen in any part of the country. Air pollution is pointed as an urgent problem. This pollution has not damaged only to human health and lives, it has destroyed environment, and possibly leading to violence. In Phattalung, air pollution is affecting to the residents’ lives. Especially, when the residents who are mostly agriculturists have not managed the waste resulted from the farm. In Phattalung, at the moment, there are many pig farms, big and small. Some of them are only for consuming for a family, some, however, are being consumed for the business which pigs will be later purchased by big business companies. Therefore, concerning pollution, the researcher and the fund giver were keen to focus on the points of the air pollution of the small pig farms. This is because it has been said that those farms have not been aware on the pollution issue caused by the farms. Farm odor is very interesting which can probably lead to following problems. The researcher also hopes that this research can be used as a source of information by the government offices in order to be made even as a policy or a proper legal measurement. As the results, the study shows that, first, more than half of the samples had smelled the farm odor located nearby their communities, though it had not caused many offenses. Second, the majority had decided not to act or response in order to solve the odor problem, but some of them had informed the officers. The proper solutions in reducing offenses caused by pig farm odor were negotiation and mediation. Last, the majority does not perceive about the process under the Public Health Act B.E. 2535.

scholarly journals Tularemia as a Mosquito-Borne Disease

2020 ◽  
Vol 9 (1) ◽  
pp. 26
Author(s):  
Zakaria Abdellahoum ◽  
Max Maurin ◽  
Idir Bitam
Keyword(s):  
North America ◽  
Northern Hemisphere ◽  
Francisella Tularensis ◽  
Research Work ◽  
Warm Season ◽  
Epidemiological Data ◽  
Human Infection ◽  
Etiological Agent ◽  
Etiologic Agents

Francisella tularensis (Ft) is the etiological agent of tularemia, a disease known for over 100 years in the northern hemisphere. Ft includes four subspecies, of which two are the etiologic agents of tularemia: Ft subsp. tularensis (Ftt) and Ft subsp. holarctica (Fth), mainly distributed in North America and the whole northern hemisphere, respectively. Several routes of human infection with these bacteria exist, notably through bites of Ixodidae ticks. However, mosquitoes represent the main vectors of Fth in Scandinavia, where large tularemia outbreaks have occurred, usually during the warm season. The mechanisms making mosquitoes vectors of Fth are still unclear. This review covers the inventory of research work and epidemiological data linking tularemia to mosquitoes in Scandinavia and highlights the gaps in understanding mosquitoes and Ft interactions.

scholarly journals KAJIAN KRITERIA INVESTASI KONVENSIONAL DAN LINGKUNGAN PETERNAKAN BABI DI KOTA TOMOHON

ZOOTEC ◽  
2019 ◽  
Vol 39 (1) ◽  
pp. 171
Author(s):  
Franky N.S Oroh ◽  
S A.E Moningkey ◽  
I D.R Lumenta
Keyword(s):  
Net Present Value ◽  
Economic Feasibility ◽  
Cost Ratio ◽  
Internal Rate Of Return ◽  
Benefit Cost Ratio ◽  
Investment Plan ◽  
Investment Companies ◽  
Pig Farms ◽  
Pig Farm ◽  
Benefit Cost

ABSTRACTSTUDY OF CONVENTIONAL INVESTMENT CRITERIA AND ENVIRONMENTAL OF PIG FARMING IN TOMOHON CITY. This study aims to analyze the feasibility of conventional (private) and environment (externalities) investment criteria, which determine the extent of the economic feasibility of the externalities investment criteria taking into account the private costs (conventional costs) and externalities costs (environmental costs) in the pig farm agribusiness. This research was conducted in Tomohon, where the sample pig farms that have business scale criterion of <1,000, 1,000-5,000, and > 5,000 heads. The analysis used the analysis of investment criteria to look at the externalities economic feasibility of the pig farms, with the calculation of Net Present Value (NPV), Benefit Cost Ratio (BCR) and Internal Rate of Return (IRR). NPV of conventionally and externalities was greater than zero or positive, these results suggest that the companies have been conventionally sampled financially feasibility, as well as the investment plan of externalities. IRR conventional and externalities is greater than one, these results indicate that the samples with conventional and externalities investment companies are still profitable, especially if the investment is viewed in the environment, it would be beneficial as it will reduce the environmental impact. BC ratio values conventionally and externalities is greater than one, these results suggest that the externalities investment is feasible for conducting.Keywords :Economy, Environment, Pig Farms, Tomohon

scholarly journals Livestock-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) as Causes of Human Infection and Colonization in Germany

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e55040 ◽  
Author(s):  
Robin Köck ◽  
Frieder Schaumburg ◽  
Alexander Mellmann ◽  
Mahir Köksal ◽  
Annette Jurke ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Human Infection ◽  
Methicillin Resistant

Methicillin-ResistantStaphylococcus aureus(MRSA) ST398 in Pig Farms and Multispecies Farms

2012 ◽  
Vol 60 (5) ◽  
pp. 366-374 ◽  
Author(s):  
M. Verhegghe ◽  
L. J. Pletinckx ◽  
F. Crombé ◽  
T. Vandersmissen ◽  
F. Haesebrouck ◽  
...  
Keyword(s):  
Pig Farms ◽  
Mrsa St398

Whole-Genome Analysis of Livestock-Associated Methicillin-Resistant Staphylococcus aureus Sequence Type 398 Strains Isolated From Patients With Bacteremia in China

2020 ◽  
Vol 221 (Supplement_2) ◽  
pp. S220-S228 ◽  
Author(s):  
Hongbin Chen ◽  
Yuyao Yin ◽  
Xiaohua Li ◽  
Shuguang Li ◽  
Hua Gao ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Sequence Type ◽  
Teaching Hospitals ◽  
Molecular Characteristics ◽  
Whole Genome Analysis ◽  
Methicillin Resistant ◽  
Severe Infections ◽  
Type V ◽  
Mrsa St398

Abstract Sequence type (ST) 398 is the most prevalent clone of livestock-associated methicillin-resistant Staphylococcus aureus (MRSA). To evaluate the molecular characteristics and phylogeny of Chinese ST398 isolates, 4 MRSA ST398 strains and 4 methicillin-susceptible S. aureus (MSSA) ST398 strains were collected from patients with bacteremia at 6 teaching hospitals in China between 1999 and 2016. Moreover, 689 ST398 genome sequences were downloaded from the GenBank database for comparison. The 4 MRSA ST398 strains were resistant to β-lactam antibiotics, and 2 strains were also resistant to erythromycin. Among the 4 MSSA ST398 strains, 2 strains displayed multidrug resistance (MDR) and were resistant to penicillin, erythromycin, tetracycline, and gentamicin. The accessory genome of MSSA ST398 was more diverse than that of MRSA ST398. All 4 MRSA ST398 strains carried type V staphylococcal cassette chromosome mec elements; however, MSSA ST398 carried more resistance genes than MRSA ST398. These 4 MRSA ST398 strains carried hemolysin, along with virulence genes associated with immune invasion and protease. Phylogenic analysis showed that the 4 MRSA ST398 strains clustered in 1 clade. The global ST398 phylogeny showed that ST398 was divided into an animal clade and a human clade, and the ST398 strains of this study clustered in the human clade. A small number of human strains were also present in the animal clade and vice versa, suggesting transmission of ST398 between animals and humans. In conclusion, livestock-associated MRSA ST398 has caused severe infections in Chinese hospitals, and it should therefore be paid more attention to and monitored.

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