Brain I3 Binding Protein regulates K-Ras4B membrane localization and signaling
Keyword(s):
Membrane localization of Ras proteins is necessary for their biological functions and oncogenic activity. We report here on the identification of Brain I3 Binding Protein (BRI3BP) as a novel binding partner for Ras. We show that K-Ras4B plasma membrane localization and biological function are reduced in the absence of BRI3BP. BRI3BP interacts with K-Ras4B and K-Ras4A and our data suggest that BRI3BP operates within the recycling endosomal compartment to regulate K-Ras localization to the plasma membrane. This study uncovers a new regulatory protein for Ras membrane localization.
2003 ◽
Vol 23
(18)
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pp. 6574-6584
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2019 ◽
Vol 19
(23)
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pp. 2114-2127
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2002 ◽
Vol 277
(51)
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pp. 49352-49359
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1992 ◽
Vol 119
(3)
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pp. 617-627
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Keyword(s):
Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis
2005 ◽
Vol 169
(2)
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pp. 285-295
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1992 ◽
Vol 267
(19)
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pp. 13480-13487