scholarly journals Investigating the interaction between inter-locus and intra-locus sexual conflict using hemiclonal analysis in Drosophila melanogaster

2021 ◽  
Author(s):  
Manas Geeta Arun ◽  
Tejinder Singh Chechi ◽  
Rakesh Meena ◽  
Shradha Dattaraya Bhosle ◽  
Srishti ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Sex Ratio ◽  
Genetic Correlation ◽  
Empirical Evidence ◽  
Sexual Conflict ◽  
Genetic Basis ◽  
Operational Sex Ratio ◽  
Female Fitness ◽  
Male And Female ◽  
Males And Females

Divergence in the evolutionary interests of males and females leads to sexual conflict. Traditionally, sexual conflict has been classified into two types: inter-locus sexual conflict (IeSC) and intra-locus sexual conflict (IaSC). IeSC is modeled as a conflict over outcomes of intersexual reproductive interactions mediated by loci that are sex-limited in their effects. IaSC is thought to be a product of selection acting in opposite directions in males and females on traits with a common underlying genetic basis. While in their canonical formalisms IaSC and IeSC are mutually exclusive, there is growing support for the idea that the two may interact. Empirical evidence for such interactions, however, is limited. Here, we investigated the interaction between IeSC and IaSC in Drosophila melanogaster. Using hemiclonal analysis, we sampled 39 hemigenomes from a laboratory-adapted population of D. melanogaster. We measured the contribution of each hemigenome to adult male and female fitness at three different intensities of IeSC, obtained by varying the operational sex-ratio. Subsequently, we estimated the intensity of IaSC at each sex-ratio by calculating the intersexual genetic correlation for fitness and the proportion of sexually antagonistic fitness-variation. Our results indicate a statistically non-significant trend suggesting that increasing the strength of IeSC ameliorates IaSC in the population.

scholarly journals Sex determination in crayfish: are intersex Cherax quadricarinatus (Decapoda, Parastacidae) genetically females?

2003 ◽  
Vol 82 (2) ◽  
pp. 107-116 ◽  
Author(s):  
S. PARNES ◽  
I. KHALAILA ◽  
G. HULATA ◽  
A. SAGI
Keyword(s):  
Sex Ratio ◽  
Sex Determination ◽  
Genetic Basis ◽  
Male And Female ◽  
Cherax Quadricarinatus ◽  
Male Ratio ◽  
Males And Females ◽  
Normal Males ◽  
Red Claw Crayfish ◽  
Female Genital

In the Australian red-claw crayfish Cherax quadricarinatus (von Martens) (Decapoda, Parastacidae), a gonochoristic species, seven different combinations of intersex individuals (with both male and female genital openings) have been described. However, to date, the genetic basis for this phenomenon has not been investigated. This study was designed to test a simple chromosome-based sex-determination model for C. quadricarinatus that assumes the male to be the homogametic (ZZ) sex. According to our model, intersex individuals that are functionally males are genetically females (WZ). Individual crosses were performed between intersex and female crayfish, with control crosses being performed between normal males and females. The control crosses yielded, in most cases, the expected 1[ratio ]1 sex ratio in the F1 progeny. Crosses between intersex individuals and females yielded a 1[ratio ]3 (male[ratio ]female) sex ratio in most crosses. According to our hypothesis, one-third of the females produced in a cross of a female with an intersex animal should be WW females. The hypothesis was tested by crossing normal males with F1 females, which were progeny of intersex fathers. These crosses yielded almost 100% females, a finding that conforms to the above-suggested sex determination model for C. quadricarinatus and the female WZ genotype of intersex individuals.

scholarly journals Adaptations to sexual selection and sexual conflict: insights from experimental evolution and artificial selection

2010 ◽  
Vol 365 (1552) ◽  
pp. 2541-2548 ◽  
Author(s):  
Dominic A. Edward ◽  
Claudia Fricke ◽  
Tracey Chapman
Keyword(s):  
Sexual Selection ◽  
Sex Ratio ◽  
Sexual Conflict ◽  
Artificial Selection ◽  
Experimental Evolution ◽  
Genetic Basis ◽  
Mating Behaviour ◽  
Evolutionary Change ◽  
Operational Sex Ratio ◽  
Adult Sex Ratio

Artificial selection and experimental evolution document natural selection under controlled conditions. Collectively, these techniques are continuing to provide fresh and important insights into the genetic basis of evolutionary change, and are now being employed to investigate mating behaviour. Here, we focus on how selection techniques can reveal the genetic basis of post-mating adaptations to sexual selection and sexual conflict. Alteration of the operational sex ratio of adult Drosophila over just a few tens of generations can lead to altered ejaculate allocation patterns and the evolution of resistance in females to the costly effects of elevated mating rates. We provide new data to show how male responses to the presence of rivals can evolve. For several traits, the way in which males responded to rivals was opposite in lines selected for male-biased, as opposed to female-biased, adult sex ratio. This shows that the manipulation of the relative intensity of intra- and inter-sexual selection can lead to replicable and repeatable effects on mating systems, and reveals the potential for significant contemporary evolutionary change. Such studies, with important safeguards, have potential utility for understanding sexual selection and sexual conflict across many taxa. We discuss how artificial selection studies combined with genomics will continue to deepen our knowledge of the evolutionary principles first laid down by Darwin 150 years ago.

scholarly journals Rapid evolution of the inter-sexual genetic correlation for fitness in Drosophila melanogaster

2015 ◽  
Author(s):  
Julie M Collet ◽  
Sara Fuentes ◽  
Jack Hesketh ◽  
Mark S Hill ◽  
Paolo Innocenti ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Correlation ◽  
Rapid Evolution ◽  
Population Divergence ◽  
Female Fitness ◽  
Sexual Antagonism ◽  
Male And Female ◽  
Phenotypic Differences ◽  
Frequency Changes ◽  
Large Frequency

Sexual antagonism (SA) arises when male and female phenotypes are under opposing selection, yet genetically correlated. Until resolved, antagonism limits evolution towards optimal sex-specific phenotypes. Despite its importance for sex-specific adaptation and existing theory, the dynamics of SA resolution are not well understood empirically. Here, we present data from Drosophila melanogaster, compatible with a resolution of SA. We compared two independent replicates of the 'LHM' population in which SA had previously been described. Both had been maintained under identical, controlled conditions, and separated for <250 generations. Although heritabilities of male and female fitness were similar, the inter-sexual genetic correlation differed significantly, being negative in one replicate (indicating SA) but close to zero in the other. Using population sequencing, we show that phenotypic differences were associated with population divergence in allele frequencies at non-random loci across the genome. Large frequency changes were more prevalent in the population without SA and were enriched at loci mapping to genes previously shown to have a sexually antagonistic relationships between expression and fitness. Our data suggest that rapid evolution towards SA resolution has occurred in one of the populations and open avenues towards studying the genetics of SA and its resolution.

scholarly journals Sex-dependent dominance maintains migration supergene in rainbow trout

2018 ◽  
Author(s):  
Devon E. Pearse ◽  
Nicola J. Barson ◽  
Torfinn Nome ◽  
Guangtu Gao ◽  
Matthew A. Campbell ◽  
...  
Keyword(s):  
Rainbow Trout ◽  
Sex Chromosomes ◽  
Sexual Conflict ◽  
Genetic Basis ◽  
Deleterious Mutation ◽  
Deleterious Mutations ◽  
Heteromorphic Sex Chromosomes ◽  
Males And Females ◽  
Shared Genetic ◽  
Environmental Dependence

AbstractTraits with different fitness optima in males and females cause sexual conflict when they have a shared genetic basis. Heteromorphic sex chromosomes can resolve this conflict and protect sexually antagonistic polymorphisms but accumulate deleterious mutations. However, many taxa lack differentiated sex chromosomes, and how sexual conflict is resolved in these species is largely unknown. Here we present a chromosome-anchored genome assembly for rainbow trout (Oncorhynchus mykiss) and characterize a 56 Mb double-inversion supergene that mediates sex-specific migration through sex-dependent dominance, a mechanism that reduces sexual conflict. The double-inversion contains key photosensory, circadian rhythm, adiposity, and sexual differentiation genes and displays frequency clines associated with latitude and temperature, revealing environmental dependence. Our results constitute the first example of sex-dependent dominance across a large autosomal supergene, a novel mechanism for sexual conflict resolution capable of protecting polygenic sexually antagonistic variation while avoiding the homozygous lethality and deleterious mutation load of heteromorphic sex chromosomes.

Draw-a-Person Protocols of Male and Female College Students

1967 ◽  
Vol 25 (3) ◽  
pp. 873-879 ◽  
Author(s):  
Christina Soccolich ◽  
Boleslaw A. Wysocki
Keyword(s):  
College Students ◽  
Sexual Conflict ◽  
Female College Students ◽  
Strong Tendency ◽  
Male And Female ◽  
Female College ◽  
Opposite Sex ◽  
Males And Females

A purely male vs female differentiation of D-A-P test variables was attempted for 50 male and 50 female college students or graduates of 3 yr. or less. Analysis of sex and aggression variables revealed much emphasis and conflict in these areas in the drawings of both males and females. Sexual conflict was almost always expressed in the drawings of the opposite sex alone. A generalized psychosexual immaturity was demonstrated in the drawings of male Ss. Female Ss seemed to exhibit conflict over masculine orientation and ‘role’ inversion in their drawings. In addition, a strong tendency toward ‘evasion,’ a wish to ‘not see’ or ‘perceive vaguely,’ was heavily evidenced in the drawings of both male and, to a lesser extent, female Ss.

Variation with Age in the Susceptibility to DDT and the Respiration Rate of male and female Drosophila melanogaster Mg.

1954 ◽  
Vol 45 (2) ◽  
pp. 323-328 ◽  
Author(s):  
R. W. Kerr
Keyword(s):  
Drosophila Melanogaster ◽  
Respiration Rate ◽  
Wild Type ◽  
Male And Female ◽  
Males And Females

DDT in odourless distillate was topically applied to individual males and females of the Rothamated wild type of Drosophila melanogaster Mg. The lines for the regression of mortality in probits on log. dosage of DDT for males and females, five days old, were parallel, and males were 1·86 times as susceptible as females. Susceptibility was high in young flies, but rapidly decreased with age, to a minimum at about five days, thereafter increasing rapidly in males and not significantly in females. The need for sexing and standardising age in flies used for toxicological investigations was thus demonstrated.Respiration rate in untreated flies was measured by a modified Barcroft method. In males it increased with age up to five days, and then decreased; in females it increased with age up to nine days. Variations with age in respiration rate and susceptibility to DDT were negatively correlated.

Routine Infanticide by Married Couples? An Assessment of Baptismal Records from Seventeenth Century Parma

2011 ◽  
Vol 15 (6) ◽  
pp. 507-530 ◽  
Author(s):  
Laura Hynes
Keyword(s):  
Seventeenth Century ◽  
Sex Ratio ◽  
Economic Status ◽  
Married Couples ◽  
Sex Ratio At Birth ◽  
Male And Female ◽  
Socio Economic Status ◽  
Rural And Urban ◽  
Italian City ◽  
Males And Females

Abstract This study uses baptismal records from the Italian city of Parma from 1609 to 1637 to chart the sex ratio of male and female infants at baptism. This article measures the Parman sex ratio against the natural sex ratio at birth for live-born infants, as determined by Praven Visaria, and offers preliminary findings that indicate that married couples used infanticide as a means of controlling family size and sex in seventeenth-century Parma. The 28 years studied encompass both relatively strong economic and agricultural years as well as a variety of crises. By selecting a period with both good and bad economic years it is possible to see if parents behaved differently as their household conditions varied. Further, dividing the approximately 30,000 baptisms by rural and urban jurisdictions and familial socio-economic status makes visible parental recourse to infanticide through unnatural ratios of males and females within different segments of society.

scholarly journals Effect of chromosome substitution on intrinsic exercise capacity in mice

F1000Research ◽  
2014 ◽  
Vol 3 ◽  
pp. 9 ◽  
Author(s):  
Sean M. Courtney ◽  
Michael P. Massett
Keyword(s):  
Exercise Capacity ◽  
Genetic Basis ◽  
Chromosome Substitution ◽  
Chromosome 14 ◽  
Exercise Time ◽  
Male And Female ◽  
Graded Exercise ◽  
Important Regulator ◽  
Study Support ◽  
Males And Females

Previous research identified a locus on Chromosome 14 as an important regulator of endurance exercise capacity in mice. The aim of this study was to investigate the effect of chromosome substitution on intrinsic exercise capacity and identify quantitative trait loci (QTL) associated with exercise capacity in mice. Mice from a chromosome substitution strain (CSS) derived from A/J and C57Bl/6J (B6), denoted as B6.A14, were used to assess the contribution of Chromosome 14 to intrinsic exercise capacity. All mice performed a graded exercise test to exhaustion to determine exercise capacity expressed as time (min) or work (kg·m). Exercise time and work were significantly greater in B6 mice than B6.A14 and A/J mice, indicating the presence of a QTL on Chromosome 14 for exercise capacity. To localize exercise-related QTL, 155 B6.A14 x B6 F2 mice were generated for linkage analysis. Suggestive QTL for exercise time (57 cM, 1.75 LOD) and work (57 cM, 2.08 LOD) were identified in the entire B6.A14 x B6 F2 cohort. To identify putative sex-specific QTL, male and female F2 cohorts were analyzed separately.  In males, a significant QTL for exercise time (55 cM, 2.28 LOD) and a suggestive QTL for work (55 cM, 2.19 LOD) were identified.  In the female cohort, no QTL was identified for time, but a suggestive QTL for work was located at 16 cM (1.8 LOD). These data suggest that one or more QTL on Chromosome 14 regulate exercise capacity. The putative sex-specific QTL further suggest that the genetic architecture underlying exercise capacity is different in males and females.  Overall, the results of this study support the use of CSS as a model for the genetic analysis of exercise capacity. Future studies should incorporate the full panel of CSS using male and female mice to dissect the genetic basis for differences in exercise capacity.

scholarly journals Multiple Toll-Spätzle Pathways in Drosophila melanogaster Immunity

2018 ◽  
Author(s):  
Munmun Chowdhury ◽  
Chun-Feng Li ◽  
Zhen He ◽  
Yuzhen Lu ◽  
Xusheng Liu ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Drosophila Melanogaster ◽  
Candida Albicans ◽  
Systemic Infection ◽  
Defense Responses ◽  
Immune Defense ◽  
Adult Males ◽  
Male And Female ◽  
Vesicular Stomatitis ◽  
Males And Females

AbstractThe Drosophila melanogaster Toll-Spätzle pathway plays an important role in development and immunity. Drosophila genome encodes nine Toll receptors and six Spätzle (Spz) proteins, and only the canonical Toll-Spz (Toll-1-Spz-1) pathway has been well investigated. In this study, we compared the nine Drosophila Tolls and showed that similarly to Toll, Toll-7 also strongly activated drosomycin promoter. Importantly, we showed that both Toll and Toll-7 interacted with Spz, Spz-2 and Spz-5, and co-expression of Toll or Toll-7 with Spz, Spz-2 and Spz-5 activated the drosomycin promoter. Furthermore, Toll and Toll-7 both recognized vesicular stomatitis virus (VSV) by binding to the VSV glycoprotein. Septic infection in Toll and Toll-7 mutant flies suggested that Toll and Toll-7 differentially affected defense responses in adult males and females after systemic infection by Enterococcus faecalis, Pseudomonas aeruginosa, Candida albicans or VSV. Our results suggest multiple Toll family members activate the expression of antimicrobial peptides. Our results also provide evidence that Toll and Toll-7 bind multiple Spätzle proteins and differentially affect immune defense against different pathogens in adult male and female flies.

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