scholarly journals Polycomb Group Ring Finger Protein 6 suppresses Myc-induced lymphomagenesis

2021 ◽  
Author(s):  
Nina Tanaskovic ◽  
Mattia Dalsass ◽  
Giorgia Ceccotti ◽  
Marco Filipuzzi ◽  
Alessandro Verrecchia ◽  
...  
Keyword(s):  
Transcription Factors ◽  
B Cells ◽  
Tumor Suppressor ◽  
Transgenic Mice ◽  
Ring Finger ◽  
Polycomb Group ◽  
Ring Finger Protein ◽  
Suppressor Activity ◽  
Finger Protein ◽  
Tumor Suppressor Activity

AbstractMax is an obligate dimerization partner for the Myc transcription factors and for several repressors, such as Mnt, Mxd1-4 and Mga, collectively thought to antagonize Myc function in transcription and oncogenesis. Mga, in particular, is part of the variant Polycomb group repressive complex PRC1.6. Here, we show that ablation of the distinct PRC1.6 subunit Pcgf6 – but not Mga – accelerates Myc-induced lymphomagenesis in Eµ-myc transgenic mice. Unexpectedly, however, Pcgf6 loss shows no significant impact on transcriptional profiles, in neither pre-tumoral B-cells, nor lymphomas. Altogether, these data unravel an unforeseen, Mga- and PRC1.6-independent tumor suppressor activity of Pcgf6.

scholarly journals Mutated Rnf43 Aggravates Helicobacter Pylori-Induced Gastric Pathology

Cancers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 372 ◽  
Author(s):  
Victoria Neumeyer ◽  
Michael Vieth ◽  
Markus Gerhard ◽  
Raquel Mejías-Luque
Keyword(s):  
Helicobacter Pylori ◽  
Tumor Suppressor ◽  
Point Mutations ◽  
Ring Finger ◽  
Stem Cell Marker ◽  
Ring Finger Protein ◽  
Functional Studies ◽  
Finger Protein ◽  
H Pylori ◽  
Key Events

The E3 ubiquitin ligase ring finger protein 43 (RNF43) is frequently mutated in gastric tumors and loss of RNF43 expression was suggested to be one of the key events during the transition from adenoma to gastric carcinoma. Functional studies on RNF43 have shown that it acts as a tumor suppressor by negatively regulating Wnt signaling. Interestingly, we observed that RNF43H292R/H295R mice bearing two point mutations in the ring domain displayed thickening of the mucosa at early age but did not develop neoplasia. In this study, we infected these mice for 6 months with Helicobacter pylori, which has been described as one of the major risk factors for gastric cancer. Mice bearing mutant RNF43H292R/H295R showed higher gastritis scores upon H. pylori infection compared to wild-type mice, accompanied by increased lymphocyte infiltration and Ifng levels. Furthermore, infected Rnf43 mutant mice developed atrophy, hyperplasia and MUC2 expressing metaplasia and displayed higher levels of the gastric stem cell marker CD44 and canonical NF-κB signaling. In summary, our results show that transactivating mutations in the tumor suppressor Rnf43 can worsen H. pylori induced pathology.

scholarly journals The ER-Bound RING Finger Protein 5 (RNF5/RMA1) Causes Degenerative Myopathy in Transgenic Mice and Is Deregulated in Inclusion Body Myositis

PLoS ONE ◽  
2008 ◽  
Vol 3 (2) ◽  
pp. e1609 ◽  
Author(s):  
Agnès Delaunay ◽  
Kenneth D. Bromberg ◽  
Yukiko Hayashi ◽  
Massimiliano Mirabella ◽  
Denise Burch ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Inclusion Body ◽  
Inclusion Body Myositis ◽  
Ring Finger ◽  
Ring Finger Protein ◽  
Finger Protein

Targeting the p53 tumor suppressor activity in glioblastomas using small molecule MDM2-inhibitor

2011 ◽  
Vol 42 (01) ◽  
Author(s):  
P. Monfared ◽  
T. Viel ◽  
G. Schneider ◽  
Y. Waerzeggers ◽  
S. Rapic ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Small Molecule ◽  
Suppressor Activity ◽  
P53 Tumor Suppressor ◽  
Tumor Suppressor Activity ◽  
Mdm2 Inhibitor
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