RING finger protein TOPORS modulates the expression of tumor suppressor SMAR1 in colorectal cancer via the TLR4‐TRIF pathway

The E3 ubiquitin ligase ring finger protein 43 (RNF43) is frequently mutated in gastric tumors and loss of RNF43 expression was suggested to be one of the key events during the transition from adenoma to gastric carcinoma. Functional studies on RNF43 have shown that it acts as a tumor suppressor by negatively regulating Wnt signaling. Interestingly, we observed that RNF43H292R/H295R mice bearing two point mutations in the ring domain displayed thickening of the mucosa at early age but did not develop neoplasia. In this study, we infected these mice for 6 months with Helicobacter pylori, which has been described as one of the major risk factors for gastric cancer. Mice bearing mutant RNF43H292R/H295R showed higher gastritis scores upon H. pylori infection compared to wild-type mice, accompanied by increased lymphocyte infiltration and Ifng levels. Furthermore, infected Rnf43 mutant mice developed atrophy, hyperplasia and MUC2 expressing metaplasia and displayed higher levels of the gastric stem cell marker CD44 and canonical NF-κB signaling. In summary, our results show that transactivating mutations in the tumor suppressor Rnf43 can worsen H. pylori induced pathology.

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miR-203a suppresses cell proliferation by targeting RING-finger protein 6 in colorectal cancer

Anti-Cancer Drugs ◽

10.1097/cad.0000000000000874 ◽

2020 ◽

Vol 31 (6) ◽

pp. 583-591 ◽

Cited By ~ 3

Author(s):

Jiyu Miao ◽

Ni Hou ◽

Wanwan Yang ◽

Qiuyu Jiang ◽

Wanjuan Xue ◽

...

Keyword(s):

Colorectal Cancer ◽

Cell Proliferation ◽

Ring Finger ◽

Ring Finger Protein ◽

Finger Protein

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RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-17-2133 ◽

2017 ◽

Vol 24 (6) ◽

pp. 1473-1485 ◽

Cited By ~ 19

Author(s):

Qian Liang ◽

Dan Ma ◽

Xiaoqiang Zhu ◽

Zhenhua Wang ◽

Tian-Tian Sun ◽

...

Keyword(s):

Colorectal Cancer ◽

Ring Finger ◽

Ring Finger Protein ◽

Stat3 Pathway ◽

Poor Outcome ◽

Finger Protein

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LINC00998 functions as a novel tumor suppressor in acute myeloid leukemia via regulating the ZFP36 ring finger protein/mammalian target of rapamycin complex 2 axis

Bioengineered ◽

10.1080/21655979.2021.1996506 ◽

2021 ◽

Author(s):

Ximin Fang ◽

Xiazhen Pan ◽

Huirong Mai ◽

Xiuli Yuan ◽

Sixi Liu ◽

...

Keyword(s):

Acute Myeloid Leukemia ◽

Tumor Suppressor ◽

Myeloid Leukemia ◽

Mammalian Target Of Rapamycin ◽

Ring Finger ◽

Target Of Rapamycin ◽

Ring Finger Protein ◽

Finger Protein ◽

Acute Myeloid

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Polycomb Group Ring Finger Protein 6 suppresses Myc-induced lymphomagenesis

10.1101/2021.12.02.470967 ◽

2021 ◽

Author(s):

Nina Tanaskovic ◽

Mattia Dalsass ◽

Giorgia Ceccotti ◽

Marco Filipuzzi ◽

Alessandro Verrecchia ◽

...

Keyword(s):

Transcription Factors ◽

B Cells ◽

Tumor Suppressor ◽

Transgenic Mice ◽

Ring Finger ◽

Polycomb Group ◽

Ring Finger Protein ◽

Suppressor Activity ◽

Finger Protein ◽

Tumor Suppressor Activity

AbstractMax is an obligate dimerization partner for the Myc transcription factors and for several repressors, such as Mnt, Mxd1-4 and Mga, collectively thought to antagonize Myc function in transcription and oncogenesis. Mga, in particular, is part of the variant Polycomb group repressive complex PRC1.6. Here, we show that ablation of the distinct PRC1.6 subunit Pcgf6 – but not Mga – accelerates Myc-induced lymphomagenesis in Eµ-myc transgenic mice. Unexpectedly, however, Pcgf6 loss shows no significant impact on transcriptional profiles, in neither pre-tumoral B-cells, nor lymphomas. Altogether, these data unravel an unforeseen, Mga- and PRC1.6-independent tumor suppressor activity of Pcgf6.

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