scholarly journals Tissue Registration and Exploration User Interfaces in support of a Human Reference Atlas

2021 ◽  
Author(s):  
Katy Borner ◽  
Andreas Bueckle ◽  
Bruce W. Herr ◽  
Leonard E Cross ◽  
Ellen M. Quardokus ◽  
...  

Several international consortia are collaborating to construct a human reference atlas, which is a comprehensive, high-resolution, three-dimensional atlas of all the cells in the healthy human body. Laboratories around the world are collecting tissue specimens from donors varying in sex, age, ethnicity, and body mass index. However, integrating and harmonizing tissue data across 20+ organs and more than 15 bulk and spatial single-cell assay types poses diverse challenges. Here we present the software tools and user interfaces developed to annotate ("register") and explore the collected tissue data. A key part of these tools is a common coordinate framework, which provides standard terminologies and data structures for describing specimens, biological structures, and spatial positions linked to existing ontologies. As of December 2021, the "registration" user interface has been used to harmonize and make publicly available data on 6,178 tissue sections from 2,698 tissue blocks collected by the Human Biomolecular Atlas Program, the Stimulating Peripheral Activity to Relieve Conditions program, the Human Cell Atlas, the Kidney Precision Medicine Project, and the Genotype Tissue Expression project. The second "exploration" user interface enables consortia to evaluate data quality and coverage, explore tissue data in the context of the human body, and guide data acquisition.

2001 ◽  
Vol 10 (1) ◽  
pp. 96-108 ◽  
Author(s):  
Doug A. Bowman ◽  
Ernst Kruijff ◽  
Joseph J. LaViola ◽  
Ivan Poupyrev

Three-dimensional user interface design is a critical component of any virtual environment (VE) application. In this paper, we present a broad overview of 3-D interaction and user interfaces. We discuss the effect of common VE hardware devices on user interaction, as well as interaction techniques for generic 3-D tasks and the use of traditional 2-D interaction styles in 3-D environments. We divide most user-interaction tasks into three categories: navigation, selection/manipulation, and system control. Throughout the paper, our focus is on presenting not only the available techniques but also practical guidelines for 3-D interaction design and widely held myths. Finally, we briefly discuss two approaches to 3-D interaction design and some example applications with complex 3-D interaction requirements. We also present an annotated online bibliography as a reference companion to this article.


2012 ◽  
Vol 198-199 ◽  
pp. 1016-1020
Author(s):  
Xiao Jie Li ◽  
Bao Zhen Ge

This paper studies three-dimensional laser scanning system of human body, and make adjustments according to the world coordinate error correction based on the point cloud obtained. This paper also analyzed the cause and characteristics of three-dimensional laser scanning system’s world coordinates error, and established the world coordinate correction model on the condition that vertical column coordinate error is not included in the calibration plane and the error is minimum relative to other highly cross-section. With a standard rectangular timber as the scan objects, correction factor is fitted and the effectiveness of this method is proved through experiments in which point cloud’s world coordinate error is significantly reduced.


Author(s):  
Giovanni Mosiello ◽  
Andrey Kiselev ◽  
Amy Loutfi

AbstractMobile Robotic Telepresence (MRP) helps people to communicate in natural ways despite being physically located in different parts of the world. User interfaces of such systems are as critical as the design and functionality of the robot itself for creating conditions for natural interaction. This article presents an exploratory study analysing different robot teleoperation interfaces. The goals of this paper are to investigate the possible effect of using augmented reality as the means to drive a robot, to identify key factors of the user interface in order to improve the user experience through a driving interface, and to minimize interface familiarization time for non-experienced users. The study involved 23 participants whose robot driving attempts via different user interfaces were analysed. The results show that a user interface with an augmented reality interface resulted in better driving experience.


2002 ◽  
Vol 11 (2) ◽  
pp. 119-133 ◽  
Author(s):  
Nicholas R. Hedley ◽  
Mark Billinghurst ◽  
Lori Postner ◽  
Richard May ◽  
Hirokazu Kato

In this paper, we describe two explorations in the use of hybrid user interfaces for collaborative geographic data visualization. Our first interface combines three technologies: augmented reality (AR), immersive virtual reality (VR), and computer vision-based hand and object tracking. Wearing a lightweight display with an attached camera, users can look at a real map and see three-dimensional virtual terrain models overlaid on the map. From this AR interface, they can fly in and experience the model immersively, or use free hand gestures or physical markers to change the data representation. Building on this work, our second interface explores alternative interface techniques, including a zoomable user interface, paddle interactions, and pen annotations. We describe the system hardware and software and the implications for GIS and spatial science applications.


Author(s):  
O. Faroon ◽  
F. Al-Bagdadi ◽  
T. G. Snider ◽  
C. Titkemeyer

The lymphatic system is very important in the immunological activities of the body. Clinicians confirm the diagnosis of infectious diseases by palpating the involved cutaneous lymph node for changes in size, heat, and consistency. Clinical pathologists diagnose systemic diseases through biopsies of superficial lymph nodes. In many parts of the world the goat is considered as an important source of milk and meat products.The lymphatic system has been studied extensively. These studies lack precise information on the natural morphology of the lymph nodes and their vascular and cellular constituent. This is due to using improper technique for such studies. A few studies used the SEM, conducted by cutting the lymph node with a blade. The morphological data collected by this method are artificial and do not reflect the normal three dimensional surface of the examined area of the lymph node. SEM has been used to study the lymph vessels and lymph nodes of different animals. No information on the cutaneous lymph nodes of the goat has ever been collected using the scanning electron microscope.


Author(s):  
Tong Wensheng ◽  
Lu Lianhuang ◽  
Zhang Zhijun

This is a combined study of two diffirent branches, photogrammetry and morphology of blood cells. The three dimensional quantitative analysis of erythrocytes using SEMP technique, electron computation technique and photogrammetry theory has made it possible to push the study of mophology of blood cells from LM, TEM, SEM to a higher stage, that of SEM P. A new path has been broken for deeply study of morphology of blood cells.In medical view, the abnormality of the quality and quantity of erythrocytes is one of the important changes of blood disease. It shows the abnormal blood—making function of the human body. Therefore, the study of the change of shape on erythrocytes is the indispensable and important basis of reference in the clinical diagnosis and research of blood disease.The erythrocytes of one normal person, three PNH Patients and one AA patient were used in this experiment. This research determines the following items: Height;Length of two axes (long and short), ratio; Crevice in depth and width of cell membrane; Circumference of erythrocytes; Isoline map of erythrocytes; Section map of erythrocytes.


Author(s):  
Hakan Ancin

This paper presents methods for performing detailed quantitative automated three dimensional (3-D) analysis of cell populations in thick tissue sections while preserving the relative 3-D locations of cells. Specifically, the method disambiguates overlapping clusters of cells, and accurately measures the volume, 3-D location, and shape parameters for each cell. Finally, the entire population of cells is analyzed to detect patterns and groupings with respect to various combinations of cell properties. All of the above is accomplished with zero subjective bias.In this method, a laser-scanning confocal light microscope (LSCM) is used to collect optical sections through the entire thickness (100 - 500μm) of fluorescently-labelled tissue slices. The acquired stack of optical slices is first subjected to axial deblurring using the expectation maximization (EM) algorithm. The resulting isotropic 3-D image is segmented using a spatially-adaptive Poisson based image segmentation algorithm with region-dependent smoothing parameters. Extracting the voxels that were labelled as "foreground" into an active voxel data structure results in a large data reduction.


2017 ◽  
Vol 8 (1) ◽  
pp. 41-60
Author(s):  
Karen Van den Berg

"Wie kommt es, dass sich der Flagship-Store eines Technikkonzerns präsentiert wie eine öffentliche Kunsthalle, während die Dependance des Louvre in Nord-Pas-de-Calais wirkt, als würde man eine iPad-Benutzeroberfläche betreten? Der Beitrag liefert eine Analyse des Louvre Lens und beleuchtet das Projekt in Hinblick auf seine verblüffenden ästhetischen Familienähnlichkeiten in Materialsprache, Struktur und Atmosphäre zu neueren Apple Stores. Dabei wird versucht, die kulturellen und mentalitätsgeschichtlichen Codes zu entziffern und zu plausibilisieren, dass sich hier eine Epistemologie entfaltet, die die Welt als simultan präsentes Symbolsystem begreift. How is it that the flagship store of a technology company presents itself as a public arthall, while the branch of the Louvre in Nord-Pas-de-Calais looks like the user interface of an iPad? The paper provides an analysis of the Louvre Lens and illuminates the project in terms of its stunning aesthetic similarities in material language, structure and atmosphere to recent Apple Stores. Furthermore, it attempts to decipher the cultural and mental-historical codes and argues that an epistemology is developing here which comprehends the world as a simultaneous symbolic system. "


Transfers ◽  
2011 ◽  
Vol 1 (1) ◽  
pp. 73-96 ◽  
Author(s):  
Charissa N. Terranova

This essay focuses on a body of photoconceptual works from the 1960s and 1970s in which the automobile functions as a prosthetic-like aperture through which to view the world in motion. I argue that the logic of the “automotive prosthetic“ in works by Paul McCarthy, Dennis Hopper, Ed Ruscha, Jeff Wall, John Baldessari, Richard Prince, Martha Rosler, Robert Smithson, Ed Kienholz, Julian Opie, and Cory Arcangel reveals a techno-genetic understanding of conceptual art, functioning in addition and alternatively to semiotics and various philosophies of language usually associated with conceptual art. These artworks show how the automobile, movement on roads and highways, and the automotive landscape of urban sprawl have transformed the human sensorium. I surmise that the car has become a prosthetic of the human body and is a technological force in the maieusis of the posthuman subject. I offer a reading of specific works of photoconceptual art based on experience, perception, and a posthumanist subjectivity in contrast to solely understanding them according to semiotics and linguistics.


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