scholarly journals The rhesus monkey hippocampus critically contributes to scene memory retrieval, but not new learning

2018 ◽  
Author(s):  
Sean Froudist-Walsh ◽  
Philip G. F. Browning ◽  
Paula L. Croxson ◽  
Kathy L. Murphy ◽  
Jul Lea Shamy ◽  
...  
Keyword(s):  
Anterograde Amnesia ◽  
Visual Object ◽  
Anatomical Structures ◽  
Memory Impairments ◽  
New Learning ◽  
Hippocampal Lesions ◽  
The Rich ◽  
Neurotoxic Lesions ◽  
Cortical Regions ◽  
And Storage

AbstractHumans can recall a large number of memories years after the events that triggered them. Early studies of humans with amnesia led to the hippocampus being viewed as the critical structure for episodic memory, but human lesions are imprecise, making it difficult to identify the anatomical structures underlying memory impairments. Rodent studies enable great temporal and anatomical precision in hippocampal manipulations, but not investigation of the rich assortment of interleaved memories that occurs in humans. Thus it is not known how lesions restricted to the hippocampus affect the retrieval of multiple sequentially encoded memories. Furthermore, disagreement exists as to whether hippocampal inactivations lead to a temporally graded, or ungraded amnesia, which could be a consequence of different types hippocampal disruption observed in rodent and human studies. In the current study, four rhesus monkeys received bilateral neurotoxic lesions of the hippocampus, and were compared to thirteen unoperated controls on recognition and new learning of visual object-in-place scenes. Monkeys with hippocampal lesions were significantly impaired compared to controls at remembering scenes that were encoded before the lesion. We did not observe any temporal gradient effect of the lesion on memory recognition, with recent and remote memories being equally affected by the lesion. Monkeys with hippocampal lesions showed no deficits in learning and later recognising new scenes. Thus, the hippocampus, like other cortical regions, may be engaged in the acquisition and storage of new memories, but its role can be taken over by spared regions following a lesion. These findings illustrate the utility of experimental paradigms for studying retrograde and anterograde amnesia that make use of the capacity of nonhuman primates to rapidly acquire many distinct visual memories.

scholarly journals Alteraciones de memoria en daño cerebral

2012 ◽  
Vol 4 (3) ◽  
pp. 73
Author(s):  
David De Noreña ◽  
Irene De la Vega Rodríguez
Keyword(s):  
Free Recall ◽  
Frontal Cortex ◽  
Medial Temporal Lobe ◽  
Anterograde Amnesia ◽  
Memory Encoding ◽  
Specific Group ◽  
Memory Impairments ◽  
Strategic Processes ◽  
Memory Acquisition ◽  
Per Se

Frontal cortex is involved in important memory processes but its role is different from that associated with structures in the medial temporal lobe and diencephalon. While damage in the latter structures produces profound and global anterograde amnesia, damage to the frontal cortex is manifested by an specific group of memory impairments and distortions like confabulations, source amnesia, prospective memory and metamemory deficit, or impaired free recall. Frontal lobes is less involved in memory acquisition per se than it is in leading the strategic processes that support memory encoding, retrieval and monitoring.

scholarly journals Computer Games in Art History. Traditional architecture and painting presented in virtual reality

E-methodology ◽  
2019 ◽  
Vol 5 (5) ◽  
pp. 84-99
Author(s):  
Michał Szymański
Keyword(s):  
Computer Games ◽  
Visual Analysis ◽  
Complex Structure ◽  
Visual Complexity ◽  
Historical Context ◽  
Visual Object ◽  
History Of Art ◽  
History Of ◽  
The Rich ◽  
Game Developers

Aim. The aim of the research is to show the applications of art reception in computer games. Moreover  it is important  to show  the game as a visual object worth to analysis for art historian, because of complex structure and relations with traditional artistic media like architecture and painting. Many disciplines, like ludology, narratology and culture study research computer games, but we can see a  large lack in the  state of research in visual aspects of games, which should be supplemented.  Methods. The subject of study are five games belonging to different game genres. The first, Assasin’s Creed II is set in a  historical context, the next Witcher III and Dark Souls embedded in the realities of fantasy and finally, two games  in an  independent games category. The basic method is iconographic identification of  the object and comparative difference and similarity between original source of inspiration and transposition of  this in computer media. Therefore basic tools gained from history of art are used, which are necessary for visual analysis of a  piece of art. Also important is notion of  a commonplace forming a frame for images from different media.  Results. Indicated examples show that classic art has a strong influence on numerous computer games. The citations and allusions from art brings an additional narration completing the story in the game. Objects of architecture or paintings  also give  symbolic meanings, influencing the interpretation of the whole game. Game developers oscillate between education in the history of art and the use of these references to create your own world.  Conclusion. The examples presented in the article are only part of the rich area of art inspirations that can be found in many games. This should become a contribution to further research, not only taking into account the indicated types of references, but also the visuality of the games themselves The visual complexity of the games would require separate, more extensive research that would bring a lot into the perception of games and researching them

scholarly journals Task-related effective connectivity reveals that the cortical rich club gates cortex-wide communication

2017 ◽  
Author(s):  
Mario Senden ◽  
Niels Reuter ◽  
Martijn P. van den Heuvel ◽  
Rainer Goebel ◽  
Gustavo Deco ◽  
...  
Keyword(s):  
Information Exchange ◽  
Effective Connectivity ◽  
Functional Integration ◽  
Brain Regions ◽  
Rich Club ◽  
State Dependent ◽  
Gating Mechanism ◽  
The Rich ◽  
Cortical Regions ◽  
Peripheral Regions

AbstractHigher cognition may require the globally coordinated integration of specialized brain regions into functional networks. A collection of structural cortical hubs - referred to as the rich club - has been hypothesized to support task-specific functional integration. In the present paper, we use a whole-cortex model to estimate directed interactions between 68 cortical regions from fMRI activity for four different tasks (reflecting different cognitive domains) and resting state. We analyze the state-dependent input and output effective connectivity of the structural rich club and relate these to whole-cortex dynamics and network reconfigurations. We find that the cortical rich club exhibits an increase in outgoing effective connectivity during task performance as compared to rest while incoming connectivity remains constant. Increased outgoing connectivity targets a sparse set of peripheral regions with specific regions strongly overlapping between tasks. At the same time, community detection analyses reveal massive reorganizations of interactions among peripheral regions, including those serving as target of increased rich club output. This suggests that while peripheral regions may play a role in several tasks, their concrete interplay might nonetheless be task-specific. Furthermore, we observe that whole-cortex dynamics are faster during task as compared to rest. The decoupling effects usually accompanying faster dynamics appear to be counteracted by the increased rich club outgoing effective connectivity. Together our findings speak to a gating mechanism of the rich club that supports fast-paced information exchange among relevant peripheral regions in a task-specific and goal-directed fashion, while constantly listening to the whole network.

The Role of the Perirhinal Cortex and Hippocampus in Learning, Memory, and Perception

2005 ◽  
Vol 58 (3-4b) ◽  
pp. 246-268 ◽  
Author(s):  
Mark J. Buckley
Keyword(s):  
Medial Temporal Lobe ◽  
Memory Loss ◽  
Anterograde Amnesia ◽  
Perirhinal Cortex ◽  
Memory System ◽  
Object Identity ◽  
Temporal Relationships ◽  
New Findings ◽  
Hippocampal Lesions

One traditional and long-held view of medial temporal lobe (MTL) function is that it contains a system of structures that are exclusively involved in memory, and that the extent of memory loss following MTL damage is simply related to the amount of MTL damage sustained. Indeed, human patients with extensive MTL damage are typically profoundly amnesic whereas patients with less extensive brain lesions centred upon the hippocampus typically exhibit only moderately severe anterograde amnesia. Accordingly, the latter observations have elevated the hippocampus to a particularly prominent position within the purported MTL memory system. This article reviews recent lesion studies in macaque monkeys in which the behavioural effects of more highly circumscribed lesions (than those observed to occur in human patients with MTL lesions) to different subregions of the MTL have been examined. These studies have reported new findings that contradict this concept of a MTL memory system. First, the MTL is not exclusively involved in mnemonic processes; some MTL structures, most notably the perirhinal cortex, also contribute to perception. Second, there are some forms of memory, including recognition memory, that are not always affected by selective hippocampal lesions. Third, the data support the idea that regional functional specializations exist within the MTL. For example, the macaque perirhinal cortex appears to be specialized for processing object identity whereas the hippocampus may be specialized for processing spatial and temporal relationships.

scholarly journals Dwelling quietly in the rich club: brain network determinants of slow cortical fluctuations

2015 ◽  
Vol 370 (1668) ◽  
pp. 20140165 ◽  
Author(s):  
Leonardo L. Gollo ◽  
Andrew Zalesky ◽  
R. Matthew Hutchison ◽  
Martijn van den Heuvel ◽  
Michael Breakspear
Keyword(s):  
Spatial Scales ◽  
Brain Regions ◽  
Brain Network ◽  
Morphological Properties ◽  
Brain Organization ◽  
Rich Club ◽  
Guiding Principle ◽  
The Rich ◽  
Cortical Regions ◽  
The Brain

For more than a century, cerebral cartography has been driven by investigations of structural and morphological properties of the brain across spatial scales and the temporal/functional phenomena that emerge from these underlying features. The next era of brain mapping will be driven by studies that consider both of these components of brain organization simultaneously—elucidating their interactions and dependencies. Using this guiding principle, we explored the origin of slowly fluctuating patterns of synchronization within the topological core of brain regions known as the rich club, implicated in the regulation of mood and introspection. We find that a constellation of densely interconnected regions that constitute the rich club (including the anterior insula, amygdala and precuneus) play a central role in promoting a stable, dynamical core of spontaneous activity in the primate cortex. The slow timescales are well matched to the regulation of internal visceral states, corresponding to the somatic correlates of mood and anxiety. In contrast, the topology of the surrounding ‘feeder’ cortical regions shows unstable, rapidly fluctuating dynamics likely to be crucial for fast perceptual processes. We discuss these findings in relation to psychiatric disorders and the future of connectomics.

scholarly journals Network structural dependency in the human connectome across the life-span

2019 ◽  
Vol 3 (3) ◽  
pp. 792-806 ◽  
Author(s):  
Markus D. Schirmer ◽  
Ai Wern Chung ◽  
P. Ellen Grant ◽  
Natalia S. Rost
Keyword(s):  
Life Span ◽  
Age Groups ◽  
Model Fitting ◽  
Gaussian Mixture ◽  
Global Functioning ◽  
Rich Club ◽  
Network Measure ◽  
The Rich ◽  
Cortical Regions ◽  
Dependency Index

Principles of network topology have been widely studied in the human connectome. Of particular interest is the modularity of the human brain, where the connectome is divided into subnetworks from which changes with development, aging or disease can be investigated. We present a weighted network measure, the Network Dependency Index (NDI), to identify an individual region’s importance to the global functioning of the network. Importantly, we utilize NDI to differentiate four subnetworks (Tiers) in the human connectome following Gaussian mixture model fitting. We analyze the topological aspects of each subnetwork with respect to age and compare it to rich club-based subnetworks (rich club, feeder, and seeder). Our results first demonstrate the efficacy of NDI to identify more consistent, central nodes of the connectome across age groups, when compared with the rich club framework. Stratifying the connectome by NDI led to consistent subnetworks across the life-span, revealing distinct patterns associated with age where, for example, the key relay nuclei and cortical regions are contained in a subnetwork with highest NDI. The divisions of the human connectome derived from our data-driven NDI framework have the potential to reveal topological alterations described by network measures through the life-span.

scholarly journals The Carpal and Tarsal Bones of the Human Body: Arabic mnemonics

2020 ◽  
Vol 20 (2) ◽  
pp. 223
Author(s):  
Mickaël A. Joseph ◽  
Jansirani Natarajan
Keyword(s):  
Nursing Students ◽  
Human Anatomy ◽  
Learning Material ◽  
Educational Strategies ◽  
Anatomical Structures ◽  
Arabic Speakers ◽  
Tarsal Bones ◽  
Native Arabic Speakers ◽  
New Learning ◽  
English Speaking

Memorising human anatomy structures remains a challenge for nursing students. Educators endeavour to make human anatomy interesting and easy to memorise. Various instructional approaches can be used to help students enhance their memory. Mnemonics, for example, are well-established educational strategies that have proven useful in the encoding, retention and retrieval of anatomical terms. The carpal and tarsal bones are some of the anatomical structures that prove challenging to nursing students’ study of anatomy. Although available online to students, most of the accessible mnemonics are in English and non-native English-speaking students (students who are native Arabic-speakers) might find them difficult to understand. Therefore, we have created two simple Arabic mnemonics that can simplify the memorisation of the carpal and tarsal bones. We believe that Arabic mnemonics effectively enhance memorisation by linking the new learning material to familiar information.Keywords: Learning; Memory; Anatomy; Nursing; Carpal bones; Tarsal Bones; Oman.

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