scholarly journals An MRI-Derived Neuroanatomical Atlas of the Fischer 344 Rat Brain

2019 ◽  
Author(s):  
Dana Goerzen ◽  
Caitlin Fowler ◽  
Gabriel A. Devenyi ◽  
Jurgen Germann ◽  
Dan Madularu ◽  
...  
Keyword(s):  
Sex Differences ◽  
Rat Brain ◽  
Brain Atlas ◽  
Fischer 344 Rats ◽  
Brain Volumes ◽  
Male And Female ◽  
Brain Image ◽  
Fischer 344 ◽  
Regional Brain ◽  
Fischer 344 Rat

AbstractThis paper reports the development of a high-resolution 3-D MRI atlas of the Fischer 344 adult rat brain. The atlas is a 60 μm isotropic image volume composed of 256 coronal slices with 71 manually delineated structures and substructures. The atlas was developed using Pydpiper image registration pipeline to create an average brain image of 41 four-month-old male and female Fischer 344 rats. Slices in the average brain image were then manually segmented, individually and bilaterally, on the basis of image contrast in conjunction with Paxinos and Watson’s (2007) stereotaxic rat brain atlas. Summary statistics (mean and standard deviation of regional volumes) are reported for each brain region across the sample used to generate the atlas, and a statistical comparison of a chosen subset of regional brain volumes between male and female rats is presented. On average, the coefficient of variation of regional brain volumes across all rats in our sample was 4%, with no individual brain region having a coefficient of variation greater than 13%. A full description of methods used, as well as the atlas, the template that the atlas was derived from, and a masking file, can be found at Zenodo at https://doi.org/10.5281/zenodo.3555556. To our knowledge, this is the first MRI atlas created using Fischer 344 rats and will thus provide an appropriate neuroanatomical model for researchers working with this strain.HIGHLIGHTS⍰ Open-access high-resolution anatomical MRI template for Fischer 344 rat brain.⍰ Segmented atlas of 71 regions for use as a tool in Fischer 344 preclinical research paradigms.⍰ Analysis of population variability of regional brain volumes.⍰ Analysis of sex-differences in regional brain volumesKEYWORDS: Fischer 344; Structural MRI; Segmentation; Rat brain template; Digital brain atlas; Sex-differences;

Induction of c-jun and TGF-β1 in Fischer 344 rats during amiodarone-induced pulmonary fibrosis

2001 ◽  
Vol 281 (5) ◽  
pp. L1180-L1188 ◽  
Author(s):  
William H. Chung ◽  
Brian M. Bennett ◽  
William J. Racz ◽  
James F. Brien ◽  
Thomas E. Massey
Keyword(s):  
Pulmonary Fibrosis ◽  
Protein Expression ◽  
Pulmonary Toxicity ◽  
Transforming Growth Factor ◽  
Fischer 344 Rats ◽  
Intratracheal Administration ◽  
Fischer 344 ◽  
Fischer 344 Rat ◽  
Mrna And Protein Expression ◽  
Tgf Β1

Amiodarone (AM) is an antidysrhythmic agent with a propensity to cause pulmonary toxicity, including potentially fatal fibrosis. In the present study, the potential roles of c-Jun and transforming growth factor (TGF)-β1 in AM-induced inflammation and fibrogenesis were examined after intratracheal administration of AM (1.83 μmol/day on days 0 and 2) or an equivalent volume (0.4 ml) of distilled water to male Fischer 344 rats. Northern and immunoblot analyses demonstrated that lung TGF-β1 (mRNA and protein) expression was increased 1.5- to 1.8-fold relative to control during the early inflammation period and 1 day, 1 wk, and 2 wk post-AM treatment. Lung c-Jun protein expression was increased concomitantly with evidence of AM-induced fibrosis; at 5 wk post-AM treatment, c-Jun protein was increased 3.3-fold relative to control. The results indicate a role for induction of c- jun and TGF-β1 expression in the development of AM-induced pulmonary fibrosis in the Fischer 344 rat and provide potential targets for therapeutic intervention.

scholarly journals LONGITUDINAL CHARACTERIZATION OF NEUROANATOMICAL CHANGES IN THE FISCHER 344 RAT BRAIN DURING NORMAL AGING AND BETWEEN SEXES

2021 ◽  
Author(s):  
Caitlin Fowler ◽  
Dana Goerzen ◽  
Dan Madularu ◽  
Gabriel A. Devenyi ◽  
M. Mallar Chakravarty ◽  
...  
Keyword(s):  
Rat Brain ◽  
Normal Aging ◽  
Fischer 344 ◽  
Fischer 344 Rat

Central neurotoxicity induced by subchronic exposure to 2,4-pentanedione vapour

1995 ◽  
Vol 14 (8) ◽  
pp. 662-671 ◽  
Author(s):  
RH Garman ◽  
DE Dodd ◽  
B. Ballantyne
Keyword(s):  
Electron Microscopy ◽  
Vestibular Nuclei ◽  
Brain Lesions ◽  
Female Rats ◽  
Male Rats ◽  
Fischer 344 Rats ◽  
Male And Female ◽  
Fischer 344 ◽  
Peripheral Nerve Lesions ◽  
Microscopical Evidence

1 Male and female Fischer 344 rats were exposed to 2,4- pentanedione (2,4-PD) vapour acutely (4 h) at 1265 or 1811 ppm, or for 6 h day-1 , 5 days a week for 14 weeks to 0, 101, 307 or 650 ppm. 2 Mortality occurred during or within a few hours of the acute exposures (10% at 1265 ppm; 70% at 1811 ppm). No animal had gross or microscopic brain lesions. 3 All female rats (20) and 10 of 30 male rats exposed to 650 ppm 2,4-PD vapour died by the 38th study day (29 exposures); there were no subsequent male deaths. Twenty-five of the 30 animals that died, and seven of the 15 males that survived, had light microscopical evidence of degenerative lesions, principally within the caudate/putamen nuclei, nuclei of the cerebellar medulla, and vestibular nuclei. Less frequently involved, in animals that died, were various regions of the cerebral cortex. The early histopathological lesions, seen from the 16th study day (12 exposures) to the 38th study day (28 exposures) were characterised by malacia. When present, lesions in male rats surviving the 14-weeks of 650 ppm 2, 4-PD expo sure were characterised by malacia and gliosis. No peripheral nerve lesions were seen by light or transmis sion electron microscopy. 4 Neither mortality nor neuropathology were seen in rats subchronically exposed to 101 or 307 ppm, 2,4-PD vapour.

scholarly journals A 90-day Feeding Toxicity Study of L-Serine in Male and Female Fischer 344 Rats

2010 ◽  
Vol 23 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Yukie Tada ◽  
Norio Yano ◽  
Hiroshi Takahashi ◽  
Katsuhiro Yuzawa ◽  
Hiroshi Ando ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Fischer 344 Rats ◽  
Male And Female ◽  
Fischer 344

Spontaneous Renal Tubular Carcinoma in Fischer-344 Rat Littermates

1995 ◽  
Vol 32 (4) ◽  
pp. 419-422 ◽  
Author(s):  
J. D. Thurman ◽  
J. R. Hailey ◽  
A. Turturro ◽  
D. W. Gaylor
Keyword(s):  
Renal Tubular Cell ◽  
Fischer 344 Rats ◽  
Tubular Carcinoma ◽  
Familial Predisposition ◽  
Treatment Groups ◽  
Fischer 344 ◽  
Fischer 344 Rat ◽  
Chance Event ◽  
Renal Tubular ◽  
Ad Libitum Intake

Two of 632 Fischer-344 rats in a food restriction study had spontaneous, bilateral, multicentric renal tubular cell carcinomas. Although there were 104 litters represented in this study, both rats that developed this rare neoplasm were from the same litter. The littermates, one male and one female, were in the food-restricted treatment groups (60% of ad libitum intake) and were 550 and 447 days old, respectively, at death. The probability that the two rare bilateral renal neoplasms occurred by a chance event in littermates is approximately 0.8%. The apparent familial predisposition for development of specific types of neoplasms emphasizes the importance of randomization of individuals into treatment groups and consideration of lineage for rare tumors.

Pharmacokinetics of tertiary butyl alcohol in male and female Fischer 344 rats

1997 ◽  
Vol 92 (3) ◽  
pp. 179-186 ◽  
Author(s):  
Torka S. Poet ◽  
John L. Valentine ◽  
Susan J. Borghoff
Keyword(s):  
Butyl Alcohol ◽  
Tertiary Butyl Alcohol ◽  
Fischer 344 Rats ◽  
Tertiary Butyl ◽  
Male And Female ◽  
Fischer 344

Effects of subchronic d-fenfluramine on splenic immune functions in young and old male and female fischer 344 rats

1991 ◽  
Vol 13 (8) ◽  
pp. 1203-1212 ◽  
Author(s):  
J. Clancy ◽  
L.M. Petrovic ◽  
B.H. Gordon ◽  
R.J. Handa ◽  
D.B. Campbell ◽  
...  
Keyword(s):  
Fischer 344 Rats ◽  
Immune Functions ◽  
Male And Female ◽  
Fischer 344

scholarly journals Determination of Methylene Blue and Leucomethylene Blue in Male and Female Fischer 344 Rat Urine and B6C3F1 Mouse Urine

2005 ◽  
Vol 29 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Norman F. Gaudette ◽  
Jon W. Lodge
Keyword(s):  
Methylene Blue ◽  
Rat Urine ◽  
Male And Female ◽  
Mouse Urine ◽  
Fischer 344 ◽  
B6c3f1 Mouse ◽  
Fischer 344 Rat

Age-related alterations of enzyme activities and subunits of hepatic glutathione S-transferases in male and female Fischer-344 rats

1991 ◽  
Vol 1077 (3) ◽  
pp. 325-331 ◽  
Author(s):  
Maria-Cristina Carrillo ◽  
Munetaka Nokubo ◽  
Kenichi Kitani ◽  
Kimihiko Satoh ◽  
Kiyomi Sato
Keyword(s):  
Enzyme Activities ◽  
Fischer 344 Rats ◽  
Male And Female ◽  
Fischer 344 ◽  
Age Related ◽  
Hepatic Glutathione ◽  
Glutathione S Transferases

scholarly journals Apoptosis and Necrosis in Livers of Fischer-344 Rats and Sex Differences in Damage by Reactive Oxygen Species

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 69A-69A
Author(s):  
Charles V Smith ◽  
Sanjiv Gupta ◽  
Richard S Husser ◽  
Robert S Geske ◽  
Stephen E Welty
Keyword(s):  
Reactive Oxygen Species ◽  
Sex Differences ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Fischer 344 Rats ◽  
Fischer 344 ◽  
Apoptosis And Necrosis
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