scholarly journals Hormonal control of motivational circuitry orchestrates the transition to sexuality in Drosophila

2019 ◽  
Author(s):  
Stephen X. Zhang ◽  
Ethan H. Glantz ◽  
Dragana Rogulja ◽  
Michael A. Crickmore
Keyword(s):  
Sexual Behavior ◽  
Juvenile Hormone ◽  
Sexual Activity ◽  
Sexual Motivation ◽  
Hormonal Control ◽  
Complete Suppression ◽  
Hormonal Changes ◽  
Inhibitory Mechanisms ◽  
Circuit Elements ◽  
And Behavior

SUMMARYNewborns and hatchlings of many species perform incredibly sophisticated behaviors, but all vertebrates and many invertebrates selectively abstain from sexual activity at the beginning of life. Hormonal changes have long been associated with adolescence, but it is not clear how these circulating factors create a new motivation and drive its associated behaviors. We show that the transition to sexuality in male Drosophila is controlled by juvenile hormone, which spikes at eclosion and declines over days as the propensity for courtship gradually increases. Juvenile hormone directly inhibits the activity of at least three courtship-motivating circuit elements, ensuring the complete suppression of sexual motivation and behavior. Blocking or overriding these inhibitory mechanisms evokes immediate and robust sexual behavior from very young and otherwise asexual males. These results provide a first example of hormonal changes gating the transition to sexuality by activating latent, but largely developed and functional, motivational circuitry.

scholarly journals Hormonal control of motivational circuitry orchestrates the transition to sexuality in Drosophila

2021 ◽  
Vol 7 (25) ◽  
pp. eabg6926
Author(s):  
Stephen X. Zhang ◽  
Ethan H. Glantz ◽  
Lauren E. Miner ◽  
Dragana Rogulja ◽  
Michael A. Crickmore
Keyword(s):  
Hormonal Control ◽  
Behavioral Changes ◽  
Complete Suppression ◽  
Hormonal Changes ◽  
Organizational Changes ◽  
Neuronal Circuitry ◽  
Young Males ◽  
Inhibitory Mechanisms ◽  
Circuit Elements ◽  
And Behavior

Newborns and hatchlings can perform incredibly sophisticated behaviors, but many animals abstain from sexual activity at the beginning of life. Hormonal changes have long been known to drive both physical and behavioral changes during adolescence, leading to the largely untested assumption that sexuality emerges from organizational changes to neuronal circuitry. We show that the transition to sexuality in male Drosophila is controlled by hormonal changes, but this regulation is functional rather than structural. In very young males, a broadly acting hormone directly inhibits the activity of three courtship-motivating circuit elements, ensuring the complete suppression of sexual motivation and behavior. Blocking or overriding these inhibitory mechanisms evokes immediate and robust sexual behavior from very young and otherwise asexual males. Similarities to mammalian adolescence suggest a general principle in which hormonal changes gate the transition to sexuality not by constructing new circuitry but by permitting activity in otherwise latent motivational circuit elements.

scholarly journals Neural and Hormonal Control of Sexual Behavior

Endocrinology ◽  
2020 ◽  
Vol 161 (10) ◽  
Author(s):  
Kimberly J Jennings ◽  
Luis de Lecea
Keyword(s):  
Sexual Behavior ◽  
Neural Circuits ◽  
Sexual Motivation ◽  
Gonadal Hormones ◽  
Hormonal Control ◽  
Sexually Dimorphic ◽  
Neural Patterning ◽  
Ideal System ◽  
Brain And Behavior ◽  
And Behavior

Abstract Gonadal hormones contribute to the sexual differentiation of brain and behavior throughout the lifespan, from initial neural patterning to “activation” of adult circuits. Sexual behavior is an ideal system in which to investigate the mechanisms underlying hormonal activation of neural circuits. Sexual behavior is a hormonally regulated, innate social behavior found across species. Although both sexes seek out and engage in sexual behavior, the specific actions involved in mating are sexually dimorphic. Thus, the neural circuits mediating sexual motivation and behavior in males and females are overlapping yet distinct. Furthermore, sexual behavior is strongly dependent on circulating gonadal hormones in both sexes. There has been significant recent progress on elucidating how gonadal hormones modulate physiological properties within sexual behavior circuits with consequences for behavior. Therefore, in this mini-review we review the neural circuits of male and female sexual motivation and behavior, from initial sensory detection of pheromones to the extended amygdala and on to medial hypothalamic nuclei and reward systems. We also discuss how gonadal hormones impact the physiology and functioning of each node within these circuits. By better understanding the myriad of ways in which gonadal hormones impact sexual behavior circuits, we can gain a richer and more complete appreciation for the neural substrates of complex behavior.

scholarly journals The olfactory secretome varies according to season in female sheep and goat

2019 ◽  
Author(s):  
Paul CANN ◽  
Malika CHABI ◽  
Aliénor DELSART ◽  
Chrystelle LE DANVIC ◽  
Jean-Michel SALIOU ◽  
...  
Keyword(s):  
Sexual Activity ◽  
Hormonal Control ◽  
Physiological Status ◽  
Sexually Active ◽  
Hormonal Changes ◽  
Seasonal Breeding ◽  
Proteomics Data ◽  
Specific Expression ◽  
Two Dimensional Gel Electrophoresis ◽  
Post Translational Modifications

Abstract Abstract: Background : Small ungulates (sheep and goat) display a seasonal breeding, characterised by two successive periods, sexual activity (SA) and sexual rest (SR). Odours emitted by a sexually active male can reactivate the ovulation of anoestrus females. The plasticity of the olfactory system under these hormonal changes has never been explored at the peripheral level of odours reception. As it was shown in pig that the olfactory secretome (proteins secreted in the nasal mucus) could be modified under hormonal control, we monitored its composition in females of both species through several reproductive seasons, thanks to a non-invasive sampling of olfactory mucus. For this purpose, two-dimensional gel electrophoresis (2D-E), western-blot with specific antibodies, MALDI-TOF and high-resolution (nano-LC-MS/MS) mass spectrometry, RACE-PCR and molecular modelling were used. Results : In both species the olfactory secretome is composed of isoforms of OBP-like proteins, generated by post-translational modifications, as phosphorylation, N-glycosylation and O -GlcNAcylation. Important changes were observed in the olfactory secretome between the sexual rest and the sexual activity periods, characterised in ewe by the specific expression of SAL-like proteins and the emergence of OBPs O- GlcNAcylation. In goat, the differences between SA and SR did not come from new proteins expression, but from different post-translational modifications, the main difference between the SA and SR secretome being the number of isoforms of each protein. Proteomics data are available via ProteomeXchange with identifier PXD014833. Conclusion : Despite common behaviour, seasonal breeding, and genetic resources, the two species seem to adapt their sensory equipment in SA by different modalities: the variation of olfactory secretome in ewe could correspond to a specialization to detect male odours only in SA, whereas in goat the stability of the olfactory secretome could indicate a constant capacity of odours detection suggesting that the hallmark of SA in goat might be the emission of specific odours by the sexually active male. In both species, the olfactory secretome is a phenotype reflecting the physiological status of females, and could be used by breeders to monitor their receptivity to the male effect.

scholarly journals The olfactory secretome varies according to season in female sheep and goat

2019 ◽  
Author(s):  
Paul CANN ◽  
Malika CHABI ◽  
Aliénor DELSART ◽  
Chrystelle LE DANVIC ◽  
Jean-Michel SALIOU ◽  
...  
Keyword(s):  
Sexual Activity ◽  
Hormonal Control ◽  
Physiological Status ◽  
Sexually Active ◽  
Hormonal Changes ◽  
Seasonal Breeding ◽  
Proteomics Data ◽  
Specific Expression ◽  
Two Dimensional Gel Electrophoresis ◽  
Post Translational Modifications

Abstract Abstract: Background : Small ungulates (sheep and goat) display a seasonal breeding, characterised by two successive periods, sexual activity (SA) and sexual rest (SR). Odours emitted by a sexually active male can reactivate the ovulation of anoestrus females. The plasticity of the olfactory system under these hormonal changes has never been explored at the peripheral level of odours reception. As it was shown in pig that the olfactory secretome (proteins secreted in the nasal mucus) could be modified under hormonal control, we monitored its composition in females of both species through several reproductive seasons, thanks to a non-invasive sampling of olfactory mucus. For this purpose, two-dimensional gel electrophoresis (2D-E), western-blot with specific antibodies, MALDI-TOF and high-resolution (nano-LC-MS/MS) mass spectrometry, RACE-PCR and molecular modelling were used. Results : In both species the olfactory secretome is composed of isoforms of OBP-like proteins, generated by post-translational modifications, as phosphorylation, N-glycosylation and O -GlcNAcylation. Important changes were observed in the olfactory secretome between the sexual rest and the sexual activity periods, characterised in ewe by the specific expression of SAL-like proteins and the emergence of OBPs O- GlcNAcylation. In goat, the differences between SA and SR did not come from new proteins expression, but from different post-translational modifications, the main difference between the SA and SR secretome being the number of isoforms of each protein. Proteomics data are available via ProteomeXchange with identifier PXD014833. Conclusion : Despite common behaviour, seasonal breeding, and genetic resources, the two species seem to adapt their sensory equipment in SA by different modalities: the variation of olfactory secretome in ewe could correspond to a specialization to detect male odours only in SA, whereas in goat the stability of the olfactory secretome could indicate a constant capacity of odours detection suggesting that the hallmark of SA in goat might be the emission of specific odours by the sexually active male. In both species, the olfactory secretome is a phenotype reflecting the physiological status of females, and could be used by breeders to monitor their receptivity to the male effect.

scholarly journals The olfactory secretome varies according to season in female sheep and goat

BMC Genomics ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Paul Cann ◽  
Malika Chabi ◽  
Aliénor Delsart ◽  
Chrystelle Le Danvic ◽  
Jean-Michel Saliou ◽  
...  
Keyword(s):  
Sexual Activity ◽  
Hormonal Control ◽  
Physiological Status ◽  
Sexually Active ◽  
Hormonal Changes ◽  
Seasonal Breeding ◽  
Proteomics Data ◽  
Ovulatory Cycle ◽  
Specific Expression ◽  
Post Translational Modifications

Abstract Background Small ungulates (sheep and goat) display a seasonal breeding, characterised by two successive periods, sexual activity (SA) and sexual rest (SR). Odours emitted by a sexually active male can reactivate the ovulatory cycle of anoestrus females. The plasticity of the olfactory system under these hormonal changes has never been explored at the peripheral level of odours reception. As it was shown in pig that the olfactory secretome (proteins secreted in the nasal mucus) could be modified under hormonal control, we monitored its composition in females of both species through several reproductive seasons, thanks to a non-invasive sampling of olfactory mucus. For this purpose, two-dimensional gel electrophoresis (2D-E), western-blot with specific antibodies, MALDI-TOF and high-resolution (nano-LC-MS/MS) mass spectrometry, RACE-PCR and molecular modelling were used. Results In both species the olfactory secretome is composed of isoforms of OBP-like proteins, generated by post-translational modifications, as phosphorylation, N-glycosylation and O-GlcNAcylation. Important changes were observed in the olfactory secretome between the sexual rest and the sexual activity periods, characterised in ewe by the specific expression of SAL-like proteins and the emergence of OBPs O-GlcNAcylation. In goat, the differences between SA and SR did not come from new proteins expression, but from different post-translational modifications, the main difference between the SA and SR secretome being the number of isoforms of each protein. Proteomics data are available via ProteomeXchange with identifier PXD014833. Conclusion Despite common behaviour, seasonal breeding, and genetic resources, the two species seem to adapt their olfactory equipment in SA by different modalities: the variation of olfactory secretome in ewe could correspond to a specialization to detect male odours only in SA, whereas in goat the stability of the olfactory secretome could indicate a constant capacity of odours detection suggesting that the hallmark of SA in goat might be the emission of specific odours by the sexually active male. In both species, the olfactory secretome is a phenotype reflecting the physiological status of females, and could be used by breeders to monitor their receptivity to the male effect.

scholarly journals The olfactory secretome varies according to season in female sheep and goat

2019 ◽  
Author(s):  
Paul CANN ◽  
Malika CHABI ◽  
Aliénor DELSART ◽  
Chrystelle LE DANVIC ◽  
Jean-Michel SALIOU ◽  
...  
Keyword(s):  
Sexual Activity ◽  
Hormonal Control ◽  
Physiological Status ◽  
Sexually Active ◽  
Hormonal Changes ◽  
Seasonal Breeding ◽  
Proteomics Data ◽  
Specific Expression ◽  
Two Dimensional Gel Electrophoresis ◽  
Post Translational Modifications

Abstract Abstract: Background : Small ungulates (sheep and goat) display a seasonal breeding, characterised by two successive periods, sexual activity (SA) and sexual rest (SR). Odours emitted by a sexually active male can reactivate the ovulation of anoestrus females. The plasticity of the olfactory system under these hormonal changes has never been explored at the peripheral level of odours reception. As it was shown in pig that the olfactory secretome (proteins secreted in the nasal mucus) could be modified under hormonal control, we monitored its composition in females of both species through several reproductive seasons, thanks to a non-invasive sampling of olfactory mucus. For this purpose, two-dimensional gel electrophoresis (2D-E), western-blot with specific antibodies, MALDI-TOF and high-resolution (nano-LC-MS/MS) mass spectrometry, RACE-PCR and molecular modelling were used. Results : In both species the olfactory secretome is composed of isoforms of OBP-like proteins, generated by post-translational modifications, as phosphorylation, N-glycosylation and O -GlcNAcylation. Important changes were observed in the olfactory secretome between the sexual rest and the sexual activity periods, characterised in ewe by the specific expression of SAL-like proteins and the emergence of OBPs O- GlcNAcylation. In goat, the differences between SA and SR did not come from new proteins expression, but from different post-translational modifications, the main difference between the SA and SR secretome being the number of isoforms of each protein. Proteomics data are available via ProteomeXchange with identifier PXD014833. Conclusion : Despite common behaviour, seasonal breeding, and genetic resources, the two species seem to adapt their sensory equipment in SA by different modalities: the variation of olfactory secretome in ewe could correspond to a specialization to detect male odours only in SA, whereas in goat the stability of the olfactory secretome could indicate a constant capacity of odours detection suggesting that the hallmark of SA in goat might be the emission of specific odours by the sexually active male. In both species, the olfactory secretome is a phenotype reflecting the physiological status of females, and could be used by breeders to monitor their receptivity to the male effect.

scholarly journals The olfactory secretome varies according to season in female sheep and goat

2019 ◽  
Author(s):  
Paul CANN ◽  
Malika CHABI ◽  
Aliénor DELSART ◽  
Chrystelle LE DANVIC ◽  
Jean-Michel SALIOU ◽  
...  
Keyword(s):  
Sexual Activity ◽  
Hormonal Control ◽  
Physiological Status ◽  
Sexually Active ◽  
Hormonal Changes ◽  
Seasonal Breeding ◽  
Proteomics Data ◽  
Specific Expression ◽  
Two Dimensional Gel Electrophoresis ◽  
Post Translational Modifications

Abstract Background: Small ungulates (sheep and goat) display a seasonal breeding, characterised by two successive periods, sexual activity (SA) and sexual rest (SR). Odours emitted by a sexually active male can reactivate the ovulation of anoestrus females. The plasticity of the olfactory system under these hormonal changes has never been explored at the peripheral level of odours reception. As it was shown in pig that the olfactory secretome (proteins secreted in the nasal mucus) could be modified under hormonal control, we monitored its composition in females of both species through several reproductive seasons, thanks to a non-invasive sampling of olfactory mucus. For this purpose, two-dimensional gel electrophoresis (2D-E), western-blot with specific antibodies, MALDI-TOF and high-resolution (nano-LC-MS/MS) mass spectrometry, RACE-PCR and molecular modelling were used. Results: In both species the olfactory secretome is composed of isoforms of OBP-like proteins, generated by post-translational modifications, as phosphorylation, N-glycosylation and O-GlcNAcylation. Important changes were observed in the olfactory secretome between the sexual rest and the sexual activity periods, characterised in ewe by the specific expression of SAL-like proteins and the emergence of OBPs O-GlcNAcylation. In goat, the differences between SA and SR did not come from new proteins expression, but from different post-translational modifications, the main difference between the SA and SR secretome being the number of isoforms of each protein. Proteomics data are available via ProteomeXchange with identifier PXD014833. Conclusion: Despite common behaviour, seasonal breeding, and genetic resources, the two species seem to adapt their sensory equipment in SA by different modalities: the variation of olfactory secretome in ewe could correspond to a specialization to detect male odours only in SA, whereas in goat the stability of the olfactory secretome could indicate a constant capacity of odours detection suggesting that the hallmark of SA in goat might be the emission of specific odours by the sexually active male. In both species, the olfactory secretome is a phenotype reflecting the physiological status of females, and could be used by breeders to monitor their receptivity to the male effect.

Model IMB(Information, Motivation, Behavioral Skills) Sebagai Prevensi Primer Seks Pranikah Remaja

2019 ◽  
Vol 4 (3) ◽  
pp. 622
Author(s):  
Hendri Fitrian ◽  
Linda Suwarni ◽  
Andri Dwi Hernawan
Keyword(s):  
Sexual Behavior ◽  
Statistical Analysis ◽  
Primary Prevention ◽  
Peer Influence ◽  
Sampling Technique ◽  
Premarital Sex ◽  
Sex Behavior ◽  
Imb Model ◽  
Premarital Sexual ◽  
And Behavior

<p>Perilaku seksual remaja di Indonesia saat ini sudah sangat mengkhawatirkan, termasuk di Kalimantan Barat, khususnya Kota Pontianak. Faktor yang melatar belakangi perilaku seks pranikah remaja, baik faktor internal maupun eksternal. Beberapa penelitian menunjukkan bahwa determinan perilaku seks pranikah, antara lain pengetahuan, efikasi diri, pengaruh teman sebaya, peran orangtua. Salah satu model yang dapat diterapkan sebagai prevensi primer seks pranikah remaja adalah <em>information, motivation, and behavior skill </em>(IMB). Tujuan penelitian ini adalah untuk mengaplikasikan model IMB sebagai prevensi primer perilaku seks pranikah remaja, melalui peningkatan informasi, motivasi, dan skill dalam menolak ajakan seks pranikah. Penelitian ini menggunakan pendekatan kuantitatif dengan metode eksperimen semu (Quasi Eksperimen) jenis one group pretest-posttest design. Jumlah sampel yaitu 31 reponden. Teknik pengambilan sampel adalah <em>Total Sampling</em>. Data diperoleh dengan menggunakan kuesioner dan dianalisis dengan uji wilxocon. Hasil penelitian menunjukkan bahwa ada peningkatan informasi, motivasi dan keterampilan seta niat terhadap hasil analisis statistik terhadap informasi, motivasi dan keterampilan yang diperoleh nilai 0,000 &lt;0,05. Sedangkan untuk hasil analisis statistic niat diperoleh nilai p = 0,006 &lt;0,05. Terdapat hubungan yang bermakna antara informasi, motivasi, keterampilan serta niat siswa dengan menerapkan model IMB di MTS Aswaja Pontianak Barat. Dengan demikian model IMB efektif sebagai pencegahan primer untuk mencegah perilaku seks pranikah pada remaja.</p><p> </p><p><em>Teenage sexual behavior in Indonesia is currently very worrying, including in West Kalimantan, especially Pontianak City. Factors underlying the premarital sexual behavior of adolescents, both internal and external factors. Some studies show that the determinants of premarital sex behavior include knowledge, self-efficacy, peer influence, parental role. One model that can be applied as the primary prevention of premarital sex for adolescents is information, motivation, and behavior skills (IMB). The purpose of this study was to apply the IMB model as a primary prevention of adolescent premarital sexual behavior, through increasing information, motivation and skills in rejecting premarital sex requests. This study uses a quantitative approach with quasi-experimental methods of one group pretest-posttest design. The number of samples is 31 respondents. The sampling technique is total sampling. Data were obtained using a questionnaire and analyzed by the Wilxocon test. The results of the study for 3 interventions with 60 minutes showed that there was an increase in information, motivation and skills and intentions. the results of statistical analysis of information, motivation and skills obtained value of 0,000 &lt;0.05. As for the results of statistical analysis of intentions the value of p = 0.006 &lt;0.05 is obtained. There is a meaningful relationship between information, motivation, skills and student intentions by applying the IMB model in MTS Aswaja, West Pontianak. Thus the IMB model is effective as a primary prevention to prevent premarital sexual behavior in adolescents</em></p>

The role of hormones

2018 ◽  
Author(s):  
H. Frederik Nijhout ◽  
Emily Laub
Keyword(s):  
Phenotypic Plasticity ◽  
Social Behavior ◽  
Parental Care ◽  
Juvenile Hormone ◽  
Reproductive Behavior ◽  
Hormonal Control ◽  
Plastic Trait

Many behaviors of insects are stimulated, modified, or modulated by hormones. The principal hormones involved are the same as the ones that control moulting, metamorphosis, and other aspects of development, principally ecdysone and juvenile hormone. In addition, a small handful of neurosecretory hormones are involved in the control of specific behaviors. Because behavior is a plastic trait, this chapter begins by outlining the biology and hormonal control of phenotypic plasticity in insects, and how the hormonal control of behavior fits in with other aspects of the control of phenotypic plasticity. The rest of the chapter is organized around the diversity of behaviors that are known to be controlled by or affected by hormones. These include eclosion and moulting behavior, the synthesis and release of pheromones, migration, parental care, dominance, reproductive behavior, and social behavior.

scholarly journals Sexual Health in Spanish People with Intellectual Disability: the Impact of the Lockdown due to COVID-19

2021 ◽  
Author(s):  
M. Dolores Gil-Llario ◽  
Irene Díaz-Rodríguez ◽  
Vicente Morell-Mengual ◽  
Beatriz Gil-Juliá ◽  
Rafael Ballester-Arnal
Keyword(s):  
Sexual Abuse ◽  
Sexual Behavior ◽  
Sexual Health ◽  
Intellectual Disabilities ◽  
Sexual Activity ◽  
Policy Implications ◽  
The People ◽  
People With Intellectual Disabilities ◽  
Technological Improvements ◽  
The Impact

Abstract Introduction The lockdown due to COVID-19 affected the sexual health of the people with intellectual disabilities by differentially modifying the frequency and characteristics of people’s sexual activity depending on whether or not they lived with a partner during this period. The aim of this study was to analyze the extent to which the sexual behavior of people with intellectual disabilities (with and without a partner) was affected during the lockdown. Methods The sample consisted of 73 people with intellectual disabilities between 21 and 63 years old (M = 39.63; SD = 10.11). The variables analyzed were the physical, social, and technological environment during the lockdown, sexual appetite, sexual behavior, online sexual activity, and sexual abuse. The data were collected between the months of May and June of 2020. Results The lockdown increased the sexual appetite of a third of the sample (38%), especially the youngest participants. Sexual activity focused on autoeroticism and online behavior, particularly sending nude images of oneself (88%) and viewing pornography (83.6%). Rates of sexual abuse during this period were relatively high (6.8%). Conclusions The sexual activity of people with ID was important during the lockdown, and they had to adapt to the circumstances of isolation in a similar way to the general population. Technological improvements in terms of devices and connection quality at home allowed their sexual behavior to be reoriented, opening the door to new risks for the sexual health of people with ID. Policy Implications Cybersex and the increase in sexual abuse due to confinement are aspects that should be included in programs to improve the sexual health of this group.

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