scholarly journals Robotic microscopy for everyone: the OpenFlexure Microscope

2019 ◽  
Author(s):  
Joel T. Collins ◽  
Joe Knapper ◽  
Julian Stirling ◽  
Joram Mduda ◽  
Catherine Mkindi ◽  
...  
Keyword(s):  
Open Source ◽  
High Performance ◽  
Clinical Applications ◽  
Maintenance Cost ◽  
Contrast Imaging ◽  
Scientific Analysis ◽  
The World ◽  
Local Manufacturing ◽  
3D Printed ◽  
Low Volume

AbstractOptical microscopes are an essential tool for both the detection of disease in clinics, and for scientific analysis. However, in much of the world access to high-performance microscopy is limited by both the upfront cost and maintenance cost of the equipment. Here we present an open-source, 3D-printed, and fully-automated laboratory microscope, with motorised sample positioning and focus control. The microscope is highly customisable, with a number of options readily available including trans- and epi-illumination, polarisation contrast imaging, and epi-florescence imaging. The OpenFlexure Microscope has been designed to enable low-volume manufacturing and maintenance by local personnel, vastly increasing accessibility. We have produced over 100 microscopes in Tanzania and Kenya for educational, scientific, and clinical applications, demonstrating that local manufacturing can be a viable alternative to international supply chains that can often be costly, slow, and unreliable.

scholarly journals Collaborative Development within Open Source Communities

2011 ◽  
pp. 1265-1271
Author(s):  
Javier Soriano ◽  
Sonia Frutos ◽  
Jiménez. Miguel
Keyword(s):  
Open Source ◽  
High Performance ◽  
Ad Hoc ◽  
Community Building ◽  
The Internet ◽  
Collaborative Development ◽  
The World ◽  
Open Source Communities

Open source communities are one of the most successful-- and least appreciated--examples of high-performance collaboration and community building on the Internet today. Open source communities began as loosely organized, ad-hoc communities of contributors from all over the world who shared an interest in meeting a common need. However, the organization of these communities has proven to be very flexible and capable of carrying out all kind of developments, ranging from minor projects to huge programs such as Apache (Höhn, & Herr, 2004; Mockus, Fielding, & Herbsleb, 2005).

scholarly journals A universal, open-source, high-performance tool for automated sleep staging

2021 ◽  
Author(s):  
Raphael Vallat ◽  
Matthew P Walker
Keyword(s):  
Open Source ◽  
Scoring System ◽  
High Performance ◽  
Small Samples ◽  
Sleep Staging ◽  
Sleep Scoring ◽  
Industry Standard ◽  
Staging Accuracy ◽  
The World ◽  
Novel Algorithm

The creation of a completely automated sleep-scoring system that is highly accurate, flexible, well validated, free and simple to use by anyone has yet to be accomplished. In part, this is due to the difficulty of use of existing algorithms, algorithms having been trained on too small samples, and paywall demotivation. Here we describe a novel algorithm trained and validated on +27,000 hours of polysomnographic sleep recordings across heterogeneous populations around the world. This tool offers high sleep-staging accuracy matching or exceeding human accuracy and interscorer agreement no matter the population kind. The software is easy to use, computationally low-demanding, open source, and free. Such software has the potential to facilitate broad adoption of automated sleep staging with the hope of becoming an industry standard.

scholarly journals An open-source, high-performance tool for automated sleep staging

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Raphael Vallat ◽  
Matthew P Walker
Keyword(s):  
Open Source ◽  
High Performance ◽  
Sleep Staging ◽  
Sleep Research ◽  
Industry Standard ◽  
Visual Scoring ◽  
Staging Accuracy ◽  
The World ◽  
Scoring Accuracy ◽  
Medical Analysis

The clinical and societal measurement of human sleep has increased exponentially in recent years. However, unlike other fields of medical analysis that have become highly automated, basic and clinical sleep research still relies on human visual scoring. Such human-based evaluations are time-consuming, tedious, and can be prone to subjective bias. Here, we describe a novel algorithm trained and validated on +30,000 hr of polysomnographic sleep recordings across heterogeneous populations around the world. This tool offers high sleep-staging accuracy that matches human scoring accuracy and interscorer agreement no matter the population kind. The software is designed to be especially easy to use, computationally low-demanding, open source, and free. Our hope is that this software facilitates the broad adoption of an industry-standard automated sleep staging software package.

scholarly journals A low-cost and high-precision scanning electrochemical microscope built with open source tools

2019 ◽  
Author(s):  
Alperen Guver ◽  
Nafetalai Fifita ◽  
Peker Milas ◽  
Michael Straker ◽  
Michael Guy ◽  
...  
Keyword(s):  
Open Source ◽  
High Precision ◽  
High Performance ◽  
Low Cost ◽  
Measurement Capability ◽  
Scanning Electrochemical Microscope ◽  
Inverted Microscope ◽  
Stepper Motors ◽  
3D Printed ◽  
Software And Hardware

AbstractA low-cost Scanning Electrochemical Microscope (SECM) was built with a 0.6 pA current measurement capability potentiostat and submicron resolution motorized stage, using open source software and hardware tools. The high performance potentiostat with a Python graphical user interface was built based on an open source project. Arduino boards, stepper motors, a manual XY micromanipulator stage, 3D printed couplers and gears were used in building the motorized stage. An open source motor control software was used for moving the motorized stage with high precision. An inverted microscope was utilized for viewing a standard microelectrode while scanning. The setup was tested in the formation of a map of electrochemical signals from an array of pores on a parafilm membrane. As the setup will be used in future biosensing experiments, DNA hybridization detection experiments were also performed with the setup.

scholarly journals A Portable 3D-Printed Platform for Point-of-Care Diagnosis of Clostridium Difficile Infection and Malaria

2019 ◽  
Author(s):  
Soichiro Tsuda ◽  
Lewis A. Fraser ◽  
Salah Sharabi ◽  
Mohammed Hezwani ◽  
Andrew Kinghorn ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
3D Printing ◽  
Open Source ◽  
Clostridium Difficile Infection ◽  
Point Of Care ◽  
Low Cost ◽  
Clinical Applications ◽  
Printing Technology ◽  
3D Printing Technology ◽  
3D Printed

Here, we integrate 3D-printing technology with low-cost open source electronics to develop a portable diagnostic platform suitable for a wide variety of diagnostic and sensing assays. We demonstrate two different clinical applications in the diagnosis of <i>Clostridium difficile</i> infection and malaria.

scholarly journals A Portable 3D-Printed Platform for Point-of-Care Diagnosis of Clostridium Difficile Infection and Malaria

2019 ◽  
Author(s):  
Soichiro Tsuda ◽  
Lewis A. Fraser ◽  
Salah Sharabi ◽  
Mohammed Hezwani ◽  
Andrew Kinghorn ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
3D Printing ◽  
Open Source ◽  
Clostridium Difficile Infection ◽  
Point Of Care ◽  
Low Cost ◽  
Clinical Applications ◽  
Printing Technology ◽  
3D Printing Technology ◽  
3D Printed

Here, we integrate 3D-printing technology with low-cost open source electronics to develop a portable diagnostic platform suitable for a wide variety of diagnostic and sensing assays. We demonstrate two different clinical applications in the diagnosis of <i>Clostridium difficile</i> infection and malaria.

scholarly journals Collaborative Development within Open Source Communities

2011 ◽  
pp. 232-236
Author(s):  
Javier Soriano ◽  
Sonia Frutos ◽  
Jiménez. Miguel
Keyword(s):  
Open Source ◽  
High Performance ◽  
Ad Hoc ◽  
Community Building ◽  
The Internet ◽  
Collaborative Development ◽  
The World ◽  
Open Source Communities

Open source communities are one of the most successful-- and least appreciated--examples of high-performance collaboration and community building on the Internet today. Open source communities began as loosely organized, ad-hoc communities of contributors from all over the world who shared an interest in meeting a common need. However, the organization of these communities has proven to be very flexible and capable of carrying out all kind of developments, ranging from minor projects to huge programs such as Apache (Höhn, & Herr, 2004; Mockus, Fielding, & Herbsleb, 2005).

Sulphonamide: Distribution, Toxicology, Environmental Characteristics, and Analysis - A Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Kirubanandam Grace Pavithra ◽  
Vasudevan Jaikumar ◽  
Ponnusamy Senthil Kumar ◽  
PanneerSelvam SundarRajan
Keyword(s):  
Aqueous Solution ◽  
High Performance Liquid Chromatography ◽  
Capillary Electrophoresis ◽  
Liquid Chromatography ◽  
High Performance ◽  
Uv Spectroscopy ◽  
Relevant Information ◽  
Fluorometric Determination ◽  
Distinctive Features ◽  
The World

Background: Many antibiotics were widely used as medication based on their distinctive features. Among them, sulphonamides were commonly used, however their recalcitrant nature makes them difficult to dispose. Hence, their interaction with environment and analytic technique requires considerable attention globally. Objective: Therefore, this review aimed to provide detailed discussion about environmental as well as human health behaviour and analytic techniques corresponding to sulphonamides. Methods: Various results and discussion were extracted from technical journals and books published by different researchers from all over the world. The cited bibliographic references were intentionally investigated in order to extract relevant information related to proposed work. Results: In this review, the determination techniques such as UV-spectroscopy, Enthalpimetry, Immunosensor, Chromatography, Chemiluminescence, Photoinduced fluorometric determination, Capillary electrophoresis for sulphonamide determination were discussed in detail. Among them, High performance liquid chromatography (HPLC) and UV-spectroscopy was effective and extensively used for screening sulphonamide. Conclusion: Knowing the quantification and behaviour of sulphonamide in aqueous solution is mandatory to opt the suitable wastewater treatment required. Hence, choosing appropriate high precision and feasible screening techniques is necessary, which can be attained with this review.

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