The effect of wavy surface on boundary layer instabilities of an airfoil

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Zbigniew Rarata
Keyword(s):  
Stability Analysis ◽  
Feedback Loop ◽  
Flow Fields ◽  
Wavy Surface ◽  
Content Type ◽  
Spatial Stability ◽  
Stability Analyses ◽  
Acoustic Feedback ◽  
Wide Range ◽  
Naca 0012

Purpose The purpose of this paper is to investigate airfoil’s tonal noise reduction mechanism when deploying surface irregularities, such as surface waviness by means of spatial stability analyses. Design/methodology/approach Flow field calculations over smooth and wavy-surface NACA 0012 airfoils at 2° angle of attack and at Reynolds number of 200,000 are performed using the large eddy simulation (LES) approach. Three geometrical configurations are considered: a smooth NACA 0012 airfoil, wavy surface on the suction side (SS) and wavy surface on the pressure side (PS). The spatial stability analyses using the LES-generated flow fields are conducted and validated against the Orr-Sommerfeld stability analysis for the smooth airfoil configuration. Findings The spatial stability analyses show that inclusion of the wavy-type modification on the SS of the airfoil does not lead to altering of the acoustic feedback loop mechanism, with respect to the mechanism observed for the smooth airfoil configuration. In contrast, applying the surface modifications to the airfoil PS leads to a significant reduction of the amplification range of disturbances in the vicinity of the trailing edge for the frequency of the acoustic feedback loop mechanism. Practical implications The spatial analyses using, for example, LES-generated flow fields can be widely used to determine acoustic sources and associated distributions of amplifications for a wide range of applications in the aeroacoustics. Originality/value The spatial stability analysis approach based on flow fields computed a priori using the LES method has been introduced, validated and used to determine behaviour of the acoustic feedback loop when accurate reconstruction of geometry effects is required.

scholarly journals Stability analysis of a signaling circuit with dual species of GTPase switches

2020 ◽  
Author(s):  
Lucas Martins Stolerman ◽  
Pradipta Ghosh ◽  
Padmini Rangamani
Keyword(s):  
Stability Analysis ◽  
Feedback Loop ◽  
Network Motif ◽  
Bound State ◽  
Steady States ◽  
Eukaryotic Cells ◽  
Nucleotide Exchange ◽  
Organelle Biogenesis ◽  
Stable States ◽  
Wide Range

GTPases are molecular switches that regulate a wide range of cellular processes, such as organelle biogenesis, position, shape, and function, vesicular transport between organelles, and signal transduction. These hydrolase enzymes operate by toggling between an active "ON") guanosine triphosphate (GTP)-bound state and an inactive ("OFF") guanosine diphosphate (GDP)-bound state; such a toggle is regulated by GEFs (guanine nucleotide exchange factors) and GAPs (GTPase activating proteins). Here we propose a model for a network motif between monomeric (m) and trimeric (t) GTPases assembled exclusively in eukaryotic cells of multicellular organisms. We develop a system of ordinary differential equations in which these two classes of GTPases are interlinked conditional to their ON/OFF states within a motif through coupling and feedback loops. We provide explicit formulae for the steady states of the system and perform classical local stability analysis to systematically investigate the role of the different connections between the GTPase switches. Interestingly, a coupling of the active mGTPase to the GEF of the tGTPase was sufficient to provide two locally stable states: one where both active/inactive forms of the mGTPase can be interpreted as having low concentrations and the other where both m- and tGTPase have high concentrations. Moreover, when a feedback loop from the GEF of the tGTPase to the GAP of the mGTPase was added to the coupled system, two other locally stable states emerged, both having the tGTPase inactivated and being interpreted as having low active tGTPase concentrations. Finally, the addition of a second feedback loop, from the active tGTPase to the GAP of the mGTPase, gives rise to a family of steady states that can be parametrized by a range of inactive tGTPase concentrations. Our findings reveal that the coupling of these two different GTPase motifs can dramatically change their steady state behaviors and shed light on how such coupling may impact signaling mechanisms in eukaryotic cells.

Numerical solutions for unsteady boundary layer flow of a dusty fluid past a permeable stretching/shrinking surface with particulate viscous effect

2018 ◽  
Vol 28 (6) ◽  
pp. 1374-1391 ◽  
Author(s):  
Rohana Abdul Hamid ◽  
Roslinda Nazar ◽  
Ioan Pop
Keyword(s):  
Stability Analysis ◽  
Differential Equations ◽  
Unsteady Flow ◽  
Fluid Particle ◽  
Dust Particles ◽  
Physical Parameters ◽  
Suction Parameter ◽  
Content Type ◽  
Dusty Fluid ◽  
Wide Range

Purpose This present aims to present the numerical study of the unsteady stretching/shrinking flow of a fluid-particle suspension in the presence of the constant suction and dust particle slip on the surface. Design/methodology/approach The governing partial differential equations for the two phases flows of the fluid and the dust particles are reduced to the pertinent ordinary differential equations using a similarity transformation. The numerical results are obtained using the bvp4c function in the Matlab software. Findings The results revealed that in the decelerating shrinking flow, the wall skin friction is higher in the dusty fluid when compared to the clean fluid. In addition, the effect of the fluid-particle interaction parameter to the fluid-phase can be seen more clearly in the shrinking flow. Other non-dimensional physical parameters such as the unsteadiness parameter, the mass suction parameter, the viscosity ratio parameter, the particle slip parameter and the particle loading parameter are also considered and presented in figures. Further, the second solution is discovered in this problem and the solution expanded with higher unsteadiness and suction values. Hence, the stability analysis is performed, and it is confirmed that the second solution is unstable. Practical implications In practice, the flow conditions are commonly varying with time; thus, the study of the unsteady flow is very crucial and useful. The problem of unsteady flow of a dusty fluid has a wide range of possible applications such as in the centrifugal separation of particles, sedimentation and underground disposable of radioactive waste materials. Originality/value Even though the problem of dusty fluid has been broadly investigated, limited discoveries can be found over an unsteady shrinking flow. Indeed, this paper managed to obtain the second (dual) solutions, and stability analysis is performed. Furthermore, the authors also considered the artificial particle-phase viscosity, which is an important term to study the particle-particle and particle-wall interactions. With the addition of this term, the effects of the particle slip and suction parameters can be investigated. Very few studies in the dusty fluid embedded this parameter in their problems.

scholarly journals Transfer of Plasmid DNA to Clinical Coagulase-Negative Staphylococcal Pathogens by Using a Unique Bacteriophage

2015 ◽  
Vol 81 (7) ◽  
pp. 2481-2488 ◽  
Author(s):  
Volker Winstel ◽  
Petra Kühner ◽  
Bernhard Krismer ◽  
Andreas Peschel ◽  
Holger Rohde
Keyword(s):  
Plasmid Dna ◽  
Genetic Manipulation ◽  
Current Knowledge ◽  
Virulence Determinants ◽  
Coagulase Negative Staphylococci ◽  
Reliable Technique ◽  
Content Type ◽  
Research Activities ◽  
Wide Range ◽  
Genetic Barriers

ABSTRACTGenetic manipulation of emerging bacterial pathogens, such as coagulase-negative staphylococci (CoNS), is a major hurdle in clinical and basic microbiological research. Strong genetic barriers, such as restriction modification systems or clustered regularly interspaced short palindromic repeats (CRISPR), usually interfere with available techniques for DNA transformation and therefore complicate manipulation of CoNS or render it impossible. Thus, current knowledge of pathogenicity and virulence determinants of CoNS is very limited. Here, a rapid, efficient, and highly reliable technique is presented to transfer plasmid DNA essential for genetic engineering to important CoNS pathogens from a uniqueStaphylococcus aureusstrain via a specificS. aureusbacteriophage, Φ187. Even strains refractory to electroporation can be transduced by this technique once donor and recipient strains share similar Φ187 receptor properties. As a proof of principle, this technique was used to delete the alternative transcription factor sigma B (SigB) via allelic replacement in nasal and clinicalStaphylococcus epidermidisisolates at high efficiencies. The described approach will allow the genetic manipulation of a wide range of CoNS pathogens and might inspire research activities to manipulate other important pathogens in a similar fashion.

scholarly journals Use of Proteins Identified through a Functional Genomic Screen To Develop a Protein Subunit Vaccine That Provides Significant Protection against Virulent Streptococcus suis in Pigs

2017 ◽  
Vol 86 (3) ◽  
Author(s):  
Susan L. Brockmeier ◽  
Crystal L. Loving ◽  
Tracy L. Nicholson ◽  
Jinhong Wang ◽  
Sarah E. Peters ◽  
...  
Keyword(s):  
Immune Response ◽  
Vaccine Trial ◽  
Streptococcus Suis ◽  
Protein Subunit ◽  
Content Type ◽  
Degree Of Protection ◽  
Wide Range ◽  
Associated Proteins ◽  
Clinical Protection ◽  
Cellular Immune

ABSTRACT Streptococcus suis is a bacterium that is commonly carried in the respiratory tract and that is also one of the most important invasive pathogens of swine, commonly causing meningitis, arthritis, and septicemia. Due to the existence of many serotypes and a wide range of immune evasion capabilities, efficacious vaccines are not readily available. The selection of S. suis protein candidates for inclusion in a vaccine was accomplished by identifying fitness genes through a functional genomics screen and selecting conserved predicted surface-associated proteins. Five candidate proteins were selected for evaluation in a vaccine trial and administered both intranasally and intramuscularly with one of two different adjuvant formulations. Clinical protection was evaluated by subsequent intranasal challenge with virulent S. suis . While subunit vaccination with the S. suis proteins induced IgG antibodies to each individual protein and a cellular immune response to the pool of proteins and provided substantial protection from challenge with virulent S. suis , the immune response elicited and the degree of protection were dependent on the parenteral adjuvant given. Subunit vaccination induced IgG reactive against different S. suis serotypes, indicating a potential for cross protection.

The role of organizational culture in the knowledge management process

2015 ◽  
Vol 19 (3) ◽  
pp. 433-455 ◽  
Author(s):  
Christina Ling-hsing Chang ◽  
Tung-Ching Lin
Keyword(s):  
Organizational Culture ◽  
Knowledge Management ◽  
Customer Service ◽  
Survey Methodology ◽  
Cultural Dimensions ◽  
Content Type ◽  
Knowledge Resources ◽  
Positive Effects ◽  
Wide Range ◽  
The Individual

Purpose – The purpose of the study is to focus on the enhancement of knowledge management (KM) performance and the relationship between organizational culture and KM process intention of individuals because of the diversity of organizational cultures (which include results-oriented, tightly controlled, job-oriented, closed system and professional-oriented cultures). Knowledge is a primary resource in organizations. If firms are able to effectively manage their knowledge resources, then a wide range of benefits can be reaped such as improved corporate efficiency, effectiveness, innovation and customer service. Design/methodology/approach – The survey methodology, which has the ability to enhance generalization of results (Dooley, 2001), was used to collect the data utilized in the testing of the research hypotheses. Findings – Results- and job-oriented cultures have positive effects on employee intention in the KM process (creation, storage, transfer and application), whereas a tightly controlled culture has negative effects. Research limitations/implications – However, it would have been better to use a longitudinal study to collect useful long-term data to understand how the KM process would be influenced when organizational culture dimensions are changed through/by management. This is the first limitation of this study. According to Mason and Pauleen (2003), KM culture is a powerful predictor of individual knowledge-sharing behavior, which is not included in this study. Thus, this is the second limitation of this paper. Moreover, national culture could be an important issue in the KM process (Jacks et al., 2012), which is the third limitation of this paper for not comprising it. Practical implications – In researchers’ point of view, results- and job-oriented cultures have positive effects, whereas a tightly controlled culture has a negative effect on the KM process intention of the individual. These findings provide evidences that challenge the perspective of Kayworth and Leidner (2003) on this issue. As for practitioners, management has a direction to modify their organizational culture to improve the performance of KM process. Social implications – Both behavioral and value perspectives of the organizational cultural dimensions (results-oriented, tightly control, job-oriented, sociability, solidarity, need for achievement and democracy) should be examined to ascertain their effects firstly on KM culture and then on the KM process intention of the individual. It is hoped that the current study will spawn future investigations that lead to the development of an integrated model which includes organizational culture, KM culture and the KM process intention of the individual. Originality/value – The results-oriented, loosely controlled and job-oriented cultures will improve the effectiveness of the KM process and will also increase employees’ satisfaction and willingness to stay with the organization.

From digital citizen to digital professional

Kybernetes ◽  
2019 ◽  
Vol 48 (7) ◽  
pp. 1463-1477
Author(s):  
Olga Marino ◽  
Jaime Andres Gutierrez ◽  
Sandra Aguirre
Keyword(s):  
Information And Communication Technologies ◽  
Communication Technologies ◽  
Cutting Edge ◽  
Case Study Methodology ◽  
Content Type ◽  
Innovative Strategy ◽  
Global Issues ◽  
Wide Range ◽  
Information And Communication ◽  
Teaching Learning

Purpose This paper aims to propose and evaluate a pedagogically sound and innovative strategy to teach a higher education course that prepares future professionals to intelligently use information and communication technologies (ICTs) in their personal and professional lives. Design/methodology/approach The conceptual framework used for the design of the course was the socio-constructivism and activity theories. The implementation of the course was evaluated using the intrinsic case study methodology by including several instruments. Findings The pedagogical strategy proposed proved to be sound, as the evaluation showed that students were able to describe, use and propose innovative uses of a wide range of cutting-edge technologies in their both everyday lives and professional settings; they also had the skills to analyse the opportunities and challenges that these presented. Moreover, students liked this innovative way of learning and ended with a positive attitude towards ICT. Originality/value Although several courses prepare students to be digital citizens or use ICT to enhance the teaching-learning process, millennials are ill prepared to use cutting-edge technologies in an innovative, responsible and critical way in their future professions. The course that was designed is original in that it goes beyond preparing digital citizens to prepare professionals in any domain to use ICT in an informed and responsible way. Moreover, it is a documented, successful example of an undergraduate universal course in a highly important current society dimension. The authors believe that its pedagogical proposal could be transferred to courses dealing with other global issues such as the environment, economy and peace.

Incompressible smoothed particle hydrodynamics for MHD double-diffusive natural convection of a nanofluid in a cavity containing an oscillating pipe

2019 ◽  
Vol 30 (2) ◽  
pp. 882-917 ◽  
Author(s):  
Abdelraheem M. Aly
Keyword(s):  
Natural Convection ◽  
Smoothed Particle Hydrodynamics ◽  
Cavity Wall ◽  
Lagrangian Description ◽  
Content Type ◽  
Wide Range ◽  
Particle Hydrodynamics ◽  
Smoothed Particle ◽  
Incompressible Smoothed Particle Hydrodynamics ◽  
Double Diffusive

Purpose This paper aims to adopt incompressible smoothed particle hydrodynamics (ISPH) method to simulate MHD double-diffusive natural convection in a cavity containing an oscillating pipe and filled with nanofluid. Design/methodology/approach The Lagrangian description of the governing partial differential equations are solved numerically using improved ISPH method. The inner oscillating pipe is divided into two different pipes as an open and a closed pipe. The sidewalls of the cavity are cooled with a lower concentration C_c and the horizontal walls are adiabatic. The inner pipe is heated with higher concentration C_h. The analysis has been conducted for the two different cases of inner oscillating pipes under the effects of wide range of governing parameters. Findings It is found that a suitable oscillating pipe makes a well convective transport inside a cavity. Presence of the oscillating pipe has effects on the heat and mass transfer and fluid intensity inside a cavity. Hartman parameter suppresses the velocity and weakens the maximum values of the stream function. An increase on Hartman, Lewis and solid volume fraction parameters leads to an increase on average Nusselt number on an oscillating pipe and left cavity wall. Average Sherwood number on an oscillating pipe and left cavity wall decreases as Hartman parameter increases. Originality/value The main objective of this work is to study the MHD double-diffusive natural convection of a nanofluid in a square cavity containing an oscillating pipe using improved ISPH method.

Numerical investigation of anguilliform locomotion by the SPH method

2019 ◽  
Vol 30 (1) ◽  
pp. 328-346 ◽  
Author(s):  
Amin Rahmat ◽  
Hossein Nasiri ◽  
Marjan Goodarzi ◽  
Ehsan Heidaryan
Keyword(s):  
Drag Coefficient ◽  
Numerical Investigation ◽  
Sph Method ◽  
Content Type ◽  
Aquatic Locomotion ◽  
Wide Range ◽  
Particle Hydrodynamics ◽  
Dummy Particles ◽  
Smoothed Particle ◽  
Sph Algorithm

Purpose This paper aims to introduce a numerical investigation of aquatic locomotion using the smoothed particle hydrodynamics (SPH) method. Design/methodology/approach To model this problem, a simple improved SPH algorithm is presented that can handle complex geometries using updatable dummy particles. The computational code is validated by solving the flow over a two-dimensional cylinder and comparing its drag coefficient for two different Reynolds numbers with those in the literature. Findings Additionally, the drag coefficient and vortices created behind the aquatic swimmer are quantitatively and qualitatively compared with available credential data. Afterward, the flow over an aquatic swimmer is simulated for a wide range of Reynolds and Strouhal numbers, as well as for the amplitude envelope. Moreover, comprehensive discussions on drag coefficient and vorticity patterns behind the aquatic are made. Originality/value It is found that by increasing both Reynolds and Strouhal numbers separately, the anguilliform motion approaches the self-propulsion condition; however, the vortices show different pattern with these increments.

Encouraging millennials to collaborate and learn on the job

2015 ◽  
Vol 14 (4) ◽  
pp. 118-123 ◽  
Author(s):  
Lauren Trees
Keyword(s):  
Knowledge Management ◽  
Best Practices ◽  
Social Networking ◽  
Age Groups ◽  
Lessons Learned ◽  
Retention Rates ◽  
Direct Access ◽  
Content Type ◽  
Business Outcomes ◽  
Wide Range

Purpose – The purpose of this paper is to present enterprise social networking and gamification as two potential tools to help organizations engage Millennial employees in collaboration and learning. Design/methodology/approach – The research provides general descriptions of enterprise social networking and gamification approaches, shares data on adoption of these approaches from APQC’s “2015 Knowledge Management Priorities Data Report” (based on a January 2015 survey of 524 knowledge management professionals) and includes four company examples adapted from APQC’s Connecting People to Content and Transferring and Applying Critical Knowledge best practices studies. The methodology for APQC’s best practices studies involves screening 50 or more organizations with potential best practices in a given research scope area and identifying five or six with proven best practices. APQC then conducts detailed site visits with the selected organizations and publishes case studies based on those site visits. Findings – Enterprise social networking platforms are in place at 50 per cent of organizations, with another 25 per cent planning to implement them by the end of 2015. By providing near-immediate access to information and answers, enterprise social networking helps Millennials learn the ropes at their new workplaces, gives them direct access to more knowledgeable colleagues who can assist and mentor them, and helps them improve their business outcomes by reusing knowledge and lessons learned across projects. Younger workers can also harness the power of social networking to create a sense of belonging and build their reputations in large, dispersed firms, where it is particularly difficult for them to gain visibility. A recent APQC survey indicates that 54 per cent of organizations either currently employ gamification to encourage collaboration or expect to implement it within the next three years. The rush to gamify the enterprise is, at least in part, a reflection of employers’ desire to satisfy Millennials and make them feel connected to a community of co-workers. Although games appeal to a wide range of age groups, Millennials grew up with digital interaction and tend to prefer environments that emphasize teamwork, social learning and frequent feedback – all of which can be delivered through gamification. Originality/value – The value of this paper is to introduce the value of and relationship between enterprise social networking and gamification platforms to human resource (HR) professionals looking to increase engagement and retention rates for Millennial employees.

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