The predictability of the metabolic syndrome by adipokines

2020 ◽  
Vol 50 (6) ◽  
pp. 1255-1266
Author(s):  
Fereshteh Aliasghari ◽  
Soghra Aliasgharzadeh ◽  
Amir Hossein Faghfouri ◽  
Reza Mahdavi ◽  
Neda Lotfi Yagin
Keyword(s):  
Metabolic Syndrome ◽  
Serum Insulin ◽  
Area Under The Curve ◽  
Density Lipoprotein ◽  
Retinol Binding Protein ◽  
Operating Characteristics ◽  
Optimal Cutoff ◽  
Content Type ◽  
The Metabolic Syndrome ◽  
Cutoff Points

Purpose Obesity can cause impairment in adipose tissue-derived hormones levels, which, in turn, might lead to metabolic syndrome occurrence. This study aims to assess the relationship between the levels of adiponectin, resistin, retinol-binding protein 4 (RBP4) and insulin with metabolic syndrome (MetS) indices. Also, optimal cutoff points of the adipokines and insulin for MetS prediction were determined. Design/methodology/approach In this study, 180 women (90 women with MetS and 90 women without MetS) were studied. The National Cholesterol Education Program Adult Treatment Panel III criteria were used for MetS diagnosis. Anthropometric and biochemical indices were measured. Data were analyzed using SPSS software version 21. Findings Serum adiponectin correlated negatively with age, BMI, waist circumference (WC), triglyceride (TG), total cholesterol, SBP, DBP, FBS and positively correlated with high-density lipoprotein-cholesterol. Both resistin and RBP4 levels correlated positively with BMI, WC, TG, SBP, DBP and FBS. Also, serum insulin correlated positively with BMI, WC, SBP and DBP. All the studied adipokines and insulin showed significant areas under the receiver operating characteristics curve. The largest area under the curve was observed for adiponectin (0.93, 95 per cent CI = 0.89-0.97, p < 0.001) with the optimal cut-off point of 11.94 µg/L. Also, the upper level of adiponectin was associated with 70 per cent lower prevalence odds of metabolic syndrome after adjusting for confounders. Originality/value The authors determined the optimal cutoff points of the adipokines and insulin for MetS prediction and calculated the diagnostic odds ratio for various cutoff values. Adiponectin could be used as a biomarker in MetS regarding its largest AUC.

scholarly journals Investigating The Definitions of Metabolic Syndrome Among High School Students in Taipei and The Optimal Cutoff Points of Relevant Risk Factors

2020 ◽  
Author(s):  
Shao Chia Chiu Lin ◽  
Mei-Ju Chen
Keyword(s):  
Risk Factors ◽  
High School ◽  
Metabolic Syndrome ◽  
High School Students ◽  
International Diabetes Federation ◽  
Density Lipoprotein ◽  
Discriminatory Power ◽  
School Students ◽  
Optimal Cutoff ◽  
Cutoff Points

Abstract Background: The effects of different definitions for metabolic syndrome (MetS) on its prevalence were examined, and the differences in the discriminatory power, as well as the optimal cutoff points of relevant risk factors, were analyzed in this study. Methods: 45,756 health checkup data sets from 2011 to 2014 of high school students aged between 15 to 17 years were sourced in Taipei city. The database included the students’ gender, age, height, weight, waist circumference (WC), systolic and diastolic blood pressure, as well as biochemical markers such as triglycerides (TG), high-density lipoprotein cholesterol, and fasting glucose (FG) levels. The ROC curve statistical approach was used to analyze the discriminatory power and optimal cutoff points of the relevant MetS risk factors. Results: The prevalence of MetS among adolescents in Taipei was 2.3% and 1.2%, according to the criteria of the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and the International Diabetes Federation (IDF) respectively. The prevalence increased to 4.3% when this study’s criteria were used. Among the components of MetS analyzed, WC and TG had stronger discriminatory powers, while FG had the weakest. The optimal cutoff point for WC was approximately the 90 th percentile, while that for the TG was similar to the criteria of the modified NCEP ATP III. About 44.6% of adolescents had at least one MetS component. Body mass index also had good discriminatory power. Conclusions: The prevalence of MetS differs depending on the diagnostic criteria used. Redefining the cutoff points for the components of MetS in adolescents in different regions, as well as further screening and intervention, are crucial to prevent cardiovascular disease and type 2 diabetes mellitus in the future.

Abstract 3733: Postprandial Free Fatty Acid Metabolism During Fenofibrate Treatment Predicts Postprandial Lipid And Lipoprotein Changes

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Robert S Rosenson
Keyword(s):  
Metabolic Syndrome ◽  
Test Meal ◽  
Low Density Lipoprotein ◽  
Area Under The Curve ◽  
Density Lipoprotein ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
The Metabolic Syndrome ◽  
Ldl Particles ◽  
Postprandial Triglycerides

Objective: To determine the effects of fenofibrate (160 mg/d) on fasting and postprandial non-esterified fatty acids (NEFA) and lipoproteins in subjects with hypertriglyceridemia and the metabolic syndrome. Methods: Fifty-nine subjects with fasting hypertriglyceridemia (≥1.7 mmol/L and <6.9 mmol/L) and two or more of the Adult Treatment Panel III criteria of the metabolic syndrome were randomized to fenofibrate (160 mg/d) or placebo in a double-blind controlled clinical trial. A standardized fat load (50 g/m 2 ) was given after a 12 h fast. Blood specimens were obtained at fasting and 3.5 h and 8 h after the test meal. Results: After the test meal, postprandial (area under the curve) NEFA increased (mean ± SEM) by 11.2 ± 5.1% in the placebo group; in contrast NEFA decreased by 18.6 ± 3.8% in the fenofibrate group ( P =0.0001). No differences in fasting NEFA were observed between groups ( P =0.16). Fenofibrate reduced postprandial triglycerides (−45.4%, P <0.0001) and significantly decreased postprandial large (−40.8%, P <0.0001) and medium (−49.5%, p<0.0001) very low-density lipoprotein (VLDL) particles, as well as small LDL (−40.3%, P <0.0001) and total LDL particles (−19.0%, P <0.005). Reduction in NEFA (AUC) correlated with reductions in postprandial triglycerides (r=0.73, P <0.0001), non-HDL-C (r=0.67, P <0.0001) and with increases in HDL-C (r=0.38, P <0.01). The reduction in NEFA was more strongly correlated with decreased large VLDL (r=0.72, P <0.0001) than medium VLDL (r=0.34, P <0.02) or small VLDL particles (r=0.22, P <0.13). Postprandial reductions in NEFA were also correlated with lowering of small LDL (r=0.53, P <0.0001) and total LDL particles (r=0.60, P <0.0001). Conclusions: Treatment with fenofibrate significantly decreases postprandial NEFA and the reductions in NEFA are highly correlated with reductions in triglycerides, non-HDL-C and an increase in HDL-C. Postprandial NEFA are an important predictor of postprandial lipoprotein changes in subjects with hypertriglyceridemia.

scholarly journals Metabolic syndrome in haemodialysis patients: Prevalence, determinants and association to cardiovascular outcomes

2020 ◽  
Author(s):  
Arnaud Delautre ◽  
François Chantrel ◽  
Yves Dimitrov ◽  
Alexandre Klein ◽  
Olivier Imhoff ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Visceral Obesity ◽  
Density Lipoprotein ◽  
Roc Curves ◽  
Major Adverse Cardiovascular Events ◽  
Operating Characteristics ◽  
Clinical Predictors ◽  
Cross Sectional ◽  
The Metabolic Syndrome

Abstract Background In the general population, the metabolic syndrome (MetS) has been identified as predictive of major adverse cardiovascular events (MACE). Waist circumference (WC), a component of the MetS criteria, is linked to visceral obesity, which in turn is correlated with MACE. However, in haemodialysis (HD) patients, the association between MetS, WC and MACE is unclear.Methods In a cross-sectional study of 1000 HD patients, we evaluated the prevalence and characterised the clinical predictors of MetS. The relationship between MetS and its components, alone or in combination, and MACE, as defined by comorbidity among coronary diseases, peripheral arteriopathy, stroke or cardiac failure, was further studied using receiver operating characteristics (ROC) curves and logistic regression.Results A total of 753 patients were included between October 2011 and April 2013. The prevalence of MetS was 68.5%. Waist circumference (> 88 cm in women, 102 cm in men) was the best predictor of MetS (sensitivity 80.2; specificity 82.3; AUC 0.80; p < 0.05). In multivariate analysis, MetS was associated with MACE (OR: 1.85; 95CI 1.24-2.75; p < 0.01), but not WC alone. There was a stronger association between the combination of abdominal obesity, hypertriglyceridaemia and low high-density lipoprotein cholesterol with MACE after exclusion of impaired fasting glucose and hypertension.ConclusionsMetS is frequent and associated with MACE in HD patients in our region and probably in other European dialysis populations. In HD patients, a new simplified definition could be proposed, in keeping with the concept of hypertriglyceridaemic waist.

Effects of cranberry consumption on features of the metabolic syndrome: a systematic review and meta-analysis of randomized control trials

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Razie Hormoznejad ◽  
Anahita Mansoori ◽  
Seyed Ahmad Hosseini ◽  
Marzie Zilaee ◽  
Maryam Asadi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Metabolic Syndrome ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Cochrane Library ◽  
Content Type ◽  
Beneficial Effects ◽  
The Metabolic Syndrome

Purpose The purpose of this paper with meta-analysis is to clarify the effects of cranberry consumption on features of the metabolic syndrome of interest of all relevant randomized controlled trials (RCTs). Design/methodology/approach A systematic literature search was conducted on ISI web of science, PubMed, Embase, the Cochrane library and Google Scholar databases, to include trials published up to March 2019. Weighted mean differences (WMD) were calculated from a random or fixed-effects models. Between‐study heterogeneity was assessed by Cochrane’s test and I2 index. Findings Ten RCTs were included in this review which involving a total of 371 subjects. Our meta-analysis showed that cranberry consumption had beneficial effects on waist circumference (WMD −0.49, 95% CI −0.96 to −0.036; p = 0.034). No significant effect of cranberry consumption on fasting blood glucose, high-density lipoprotein cholesterol, triglycerides and blood pressure was found in this meta-analysis. Originality/value To the best of the authors’ knowledge, this is the first systematic review with meta-analysis of RCTs that investigate the effect of cranberry consumption on features of the metabolic syndrome.

scholarly journals The Prevalence and Predictors of Hypertension and the Metabolic Syndrome in Police Personnel

2021 ◽  
Vol 18 (13) ◽  
pp. 6728
Author(s):  
James D. Yates ◽  
Jeffrey W. F. Aldous ◽  
Daniel P. Bailey ◽  
Angel M. Chater ◽  
Andrew C. S. Mitchell ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Density Lipoprotein ◽  
Cross Sectional ◽  
Job Type ◽  
The Metabolic Syndrome ◽  
High Prevalence ◽  
Police Personnel ◽  
Behavioural Factors ◽  
Cardiometabolic Risk Markers ◽  
Police Forces

Hypertension and metabolic syndrome (METSYN) are reportedly high in police forces. This may contribute to health deterioration and absenteeism in police personnel. Police forces comprise of staff in ‘operational’ and ‘non-operational’ job types but it is not known if job type is associated to hypertension and METSYN prevalence. This study aimed to explore the prevalence of hypertension and METSYN, the factors associated with the risk of hypertension and METSYN, and compare physiological, psychological, and behavioural factors between operational and non-operational police personnel. Cross-sectional data was collected from 77 operational and 60 non-operational police workers. Hypertension and METSYN were prevalent in 60.5% and 20% of operational and 60.0% and 13.6% of non-operational police personnel, respectively (p > 0.05). Operational job type, moderate organisational stress (compared with low stress) and lower high-density lipoprotein cholesterol were associated with lower odds of hypertension, whereas increasing body mass index was associated with increased odds of hypertension (p < 0.05). None of the independent variables were significantly associated with the odds of METSYN. Operational police had several increased cardiometabolic risk markers compared with non-operational police. Given the high prevalence of hypertension and METSYN in operational and non-operational personnel, occupational health interventions are needed for the police and could be informed by the findings of this study.

scholarly journals Glucose Transporter 8 (GLUT8) Regulates Enterocyte Fructose Transport and Global Mammalian Fructose Utilization

Endocrinology ◽  
2012 ◽  
Vol 153 (9) ◽  
pp. 4181-4191 ◽  
Author(s):  
Brian J. DeBosch ◽  
Maggie Chi ◽  
Kelle H. Moley
Keyword(s):  
Glucose Transporter ◽  
Serum Insulin ◽  
Density Lipoprotein ◽  
Wild Type ◽  
In Vivo Models ◽  
The Metabolic Syndrome ◽  
High Fructose

Enterocyte fructose absorption is a tightly regulated process that precedes the deleterious effects of excess dietary fructose in mammals. Glucose transporter (GLUT)8 is a glucose/fructose transporter previously shown to be expressed in murine intestine. The in vivo function of GLUT8, however, remains unclear. Here, we demonstrate enhanced fructose-induced fructose transport in both in vitro and in vivo models of enterocyte GLUT8 deficiency. Fructose exposure stimulated [14C]-fructose uptake and decreased GLUT8 protein abundance in Caco2 colonocytes, whereas direct short hairpin RNA-mediated GLUT8 knockdown also stimulated fructose uptake. To assess GLUT8 function in vivo, we generated GLUT8-deficient (GLUT8KO) mice. GLUT8KO mice exhibited significantly greater jejunal fructose uptake at baseline and after high-fructose diet (HFrD) feeding vs. wild-type mice. Strikingly, long-term HFrD feeding in GLUT8KO mice exacerbated fructose-induced increases in blood pressure, serum insulin, low-density lipoprotein and total cholesterol vs. wild-type controls. Enhanced fructose uptake paralleled with increased abundance of the fructose and glucose transporter, GLUT12, in HFrD-fed GLUT8KO mouse enterocytes and in Caco2 cultures exposed to high-fructose medium. We conclude that GLUT8 regulates enterocyte fructose transport by regulating GLUT12, and that disrupted GLUT8 function has deleterious long-term metabolic sequelae. GLUT8 may thus represent a modifiable target in the prevention and treatment of malnutrition or the metabolic syndrome.

scholarly journals Cortisol, DHEAS, their ratio and the metabolic syndrome: evidence from the Vietnam Experience Study

2010 ◽  
Vol 162 (5) ◽  
pp. 919-923 ◽  
Author(s):  
Anna C Phillips ◽  
Douglas Carroll ◽  
Catharine R Gale ◽  
Janet M Lord ◽  
Wiebke Arlt ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Military Service ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Cross Sectional ◽  
Us Army ◽  
Telephone Interviews ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Vietnam Era

ObjectivesThe aim of these analyses was to examine the association of cortisol, DHEAS and the cortisol:DHEAS ratio with the metabolic syndrome (MetS) and its components.DesignThe analyses were cross-sectional.MethodsParticipants were 4255 Vietnam era US army veterans. From military service files, telephone interviews and a medical examination, occupational, socio-demographic and health data were collected. MetS was ascertained from data on body mass index; fasting blood glucose or a diagnosis of diabetes; blood pressure or a diagnosis of hypertension; high-density lipoprotein cholesterol; and triglyceride levels. Contemporary morning fasted cortisol and DHEAS concentrations were determined. The outcomes were MetS and its components. Analysis was by logistic regression, first adjusting for age and then additionally for an array of candidate confounders.ResultsCortisol, although not in the fully adjusted analysis, and DHEAS were both related to MetS. Whereas high cortisol concentrations were associated with an increased risk of MetS, high DHEAS concentrations appeared protective. By far, the strongest associations with MetS were observed for the cortisol:DHEAS ratio; the higher the ratio, the greater the risk of having MetS. The ratio was also significantly related to four of the five MetS components.ConclusionsThe cortisol:DHEAS ratio is positively associated with MetS. Prospective analyses are needed to help untangle direction of causality, but this study suggests that the cortisol:DHEAS ratio is worthy of further study in this and other health contexts.

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