scholarly journals A data-driven method for quantifying the impact of a genetic circuit on its host

2019 ◽  
Author(s):  
Aqib Hasnain ◽  
Diveena Becker ◽  
Atsede Siba ◽  
Narendra Maheshri ◽  
Ben Gordon ◽  
...  
Keyword(s):  
Data Driven ◽  
Genetic Circuit ◽  
The Impact

scholarly journals Quantifying the Impact of a Tsunami on Data-Driven Earthquake Relief Zone Planning in Los Angeles County via Multivariate Spatial Optimization

Geosciences ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 99 ◽  
Author(s):  
Yueqi Gu ◽  
Orhun Aydin ◽  
Jacqueline Sosa
Keyword(s):  
Los Angeles ◽  
A Priori ◽  
Safety Data ◽  
Spatial Optimization ◽  
Optimal Number ◽  
Multidisciplinary Optimization ◽  
Data Driven ◽  
Fault System ◽  
Design Data ◽  
The Impact

Post-earthquake relief zone planning is a multidisciplinary optimization problem, which required delineating zones that seek to minimize the loss of life and property. In this study, we offer an end-to-end workflow to define relief zone suitability and equitable relief service zones for Los Angeles (LA) County. In particular, we address the impact of a tsunami in the study due to LA’s high spatial complexities in terms of clustering of population along the coastline, and a complicated inland fault system. We design data-driven earthquake relief zones with a wide variety of inputs, including geological features, population, and public safety. Data-driven zones were generated by solving the p-median problem with the Teitz–Bart algorithm without any a priori knowledge of optimal relief zones. We define the metrics to determine the optimal number of relief zones as a part of the proposed workflow. Finally, we measure the impacts of a tsunami in LA County by comparing data-driven relief zone maps for a case with a tsunami and a case without a tsunami. Our results show that the impact of the tsunami on the relief zones can extend up to 160 km inland from the study area.

scholarly journals The INSESS-COVID19 Project. Evaluating the Impact of the COVID19 in Social Vulnerability While Preserving Privacy of Participants from Minority Subpopulations

2021 ◽  
Vol 11 (7) ◽  
pp. 3110
Author(s):  
Karina Gibert ◽  
Xavier Angerri
Keyword(s):  
Social Vulnerability ◽  
Data Science ◽  
Policy Design ◽  
Data Driven ◽  
Informed Decision Making ◽  
Technological Infrastructure ◽  
Moderate Number ◽  
Reliable Diagnosis ◽  
Multivariate Relationships ◽  
The Impact

In this paper, the results of the project INSESS-COVID19 are presented, as part of a special call owing to help in the COVID19 crisis in Catalonia. The technological infrastructure and methodology developed in this project allows the quick screening of a territory for a quick a reliable diagnosis in front of an unexpected situation by providing relevant decisional information to support informed decision-making and strategy and policy design. One of the challenges of the project was to extract valuable information from direct participatory processes where specific target profiles of citizens are consulted and to distribute the participation along the whole territory. Having a lot of variables with a moderate number of citizens involved (in this case about 1000) implies the risk of violating statistical secrecy when multivariate relationships are analyzed, thus putting in risk the anonymity of the participants as well as their safety when vulnerable populations are involved, as is the case of INSESS-COVID19. In this paper, the entire data-driven methodology developed in the project is presented and the dealing of the small subgroups of population for statistical secrecy preserving described. The methodology is reusable with any other underlying questionnaire as the data science and reporting parts are totally automatized.

AI Assisted High Fidelity Multi-Physics Digital Twin of Industrial Gas Turbines

2021 ◽  
Author(s):  
Senthil Krishnababu ◽  
Omar Valero ◽  
Roger Wells
Keyword(s):  
Gas Turbine ◽  
Data Storage ◽  
Gas Turbines ◽  
Building Blocks ◽  
Data Driven ◽  
High Fidelity ◽  
Test Field ◽  
Operating Characteristics ◽  
Digital Twin ◽  
The Impact

Abstract Data driven technologies are revolutionising the engineering sector by providing new ways of performing day to day tasks through the life cycle of a product as it progresses through manufacture, to build, qualification test, field operation and maintenance. Significant increase in data transfer speeds combined with cost effective data storage, and ever-increasing computational power provide the building blocks that enable companies to adopt data driven technologies such as data analytics, IOT and machine learning. Improved business operational efficiency and more responsive customer support provide the incentives for business investment. Digital twins, that leverages these technologies in their various forms to converge physics and data driven models, are therefore being widely adopted. A high-fidelity multi-physics digital twin, HFDT, that digitally replicates a gas turbine as it is built based on part and build data using advanced component and assembly models is introduced. The HFDT, among other benefits enables data driven assessments to be carried out during manufacture and assembly for each turbine allowing these processes to be optimised and the impact of variability or process change to be readily evaluated. On delivery of the turbine and its associated HFDT to the service support team the HFDT supports the evaluation of in-service performance deteriorations, the impact of field interventions and repair and the changes in operating characteristics resulting from overhaul and turbine upgrade. Thus, creating a cradle to grave physics and data driven twin of the gas turbine asset. In this paper, one branch of HFDT using a power turbine module is firstly presented. This involves simultaneous modelling of gas path and solid using high fidelity CFD and FEA which converts the cold geometry to hot running conditions to assess the impact of various manufacturing and build variabilities. It is shown this process can be executed within reasonable time frames enabling creation of HFDT for each turbine during manufacture and assembly and for this to be transferred to the service team for deployment during field operations. Following this, it is shown how data driven technologies are used in conjunction with the HFDT to improve predictions of engine performance from early build information. The example shown, shows how a higher degree of confidence is achieved through the development of an artificial neural network of the compressor tip gap feature and its effect on overall compressor efficiency.

scholarly journals Data-Driven Localization Mappings in Filtering the Monsoon–Hadley Multicloud Convective Flows

2018 ◽  
Vol 146 (4) ◽  
pp. 1197-1218
Author(s):  
Michèle De La Chevrotière ◽  
John Harlim
Keyword(s):  
Learning Algorithm ◽  
Data Driven ◽  
Radiative Transfer Model ◽  
Transfer Model ◽  
Model Errors ◽  
Accurate Analysis ◽  
Perfect Model ◽  
Nonlinear Stochastic Model ◽  
Correlation Statistics ◽  
The Impact

This paper demonstrates the efficacy of data-driven localization mappings for assimilating satellite-like observations in a dynamical system of intermediate complexity. In particular, a sparse network of synthetic brightness temperature measurements is simulated using an idealized radiative transfer model and assimilated to the monsoon–Hadley multicloud model, a nonlinear stochastic model containing several thousands of model coordinates. A serial ensemble Kalman filter is implemented in which the empirical correlation statistics are improved using localization maps obtained from a supervised learning algorithm. The impact of the localization mappings is assessed in perfect-model observing system simulation experiments (OSSEs) as well as in the presence of model errors resulting from the misspecification of key convective closure parameters. In perfect-model OSSEs, the localization mappings that use adjacent correlations to improve the correlation estimated from small ensemble sizes produce robust accurate analysis estimates. In the presence of model error, the filter skills of the localization maps trained on perfect- and imperfect-model data are comparable.

scholarly journals The Impact of Criteria-based and Data-driven Sampling Approaches on the Heterogeneity and Interpretability of Posttraumatic Stress Symptom Networks

2020 ◽  
Author(s):  
Santiago Papini ◽  
Mikael Rubin ◽  
Michael J Telch ◽  
Jasper A. J. Smits
Keyword(s):  
Data Driven ◽  
Network Heterogeneity ◽  
Psychopathological Symptom ◽  
Highly Correlated ◽  
And Cluster Analysis ◽  
Sensitivity Specificity ◽  
Future Work ◽  
The Impact ◽  
Sample Heterogeneity ◽  
Source Of Error

Background. The application of psychopathological symptom networks requires reconciliation of the observed cross-sample heterogeneity. We leveraged the largest sample to be used in a PTSD network analysis (N = 28,594) to examine the impact of criteria-based and data-driven sampling approaches on the heterogeneity and interpretability of networks.Methods. Severity and diagnostic criteria identified four overlapping subsamples and cluster analysis identified three distinct data-derived profiles. Networks estimated on each subsample were compared to a respective benchmark network at the symptom-relation level by calculating sensitivity, specificity, correlation, and density of the edges. Negative edges were assessed for Berkson’s bias, a source of error that can be induced by threshold samples on severity.Results. Criteria-based networks showed reduced sensitivity, specificity, and density but edges remained highly correlated and a meaningfully higher proportion of negative edges was not observed relative to the benchmark network of all cases. Among the data-derived profile networks, the Low Severity network had the highest proportion of negative edges not present in the benchmark network of symptomatic cases. The High Severity profile also showed a higher proportion of negative edges, whereas the Medium Severity profile did not. Conclusion. Although networks showed differences, Berkson’s bias did not appear to be a meaningful source of systematic error. These results can guide expectations about the generalizability of symptom networks across samples that vary in their ranges of severity. Future work should continue to explore whether network heterogeneity is reflective of meaningful and interpretable differences in the symptom relations from which they are composed.

La orientación al dato, nuevos desafíos

Tábula ◽  
2021 ◽  
Author(s):  
Miguel Ángel Amutio Gómez
Keyword(s):  
European Union ◽  
Digital Transformation ◽  
Data Driven ◽  
The European Union ◽  
Data Preservation ◽  
The Future ◽  
Data Driven Approach ◽  
New Challenges ◽  
The Impact

La orientación al dato en el contexto de la transformación digital lleva aparejada la aparición de nuevas regulaciones, dinámicas de gobernanza y roles, y servicios, junto con las correspondientes prácticas, instrumentos y estándares. A la vez se suscitan retos en relación con la ciberseguridad y la preservación de los datos. En este artículo se exponen la transformación digital y la orientación al dato, la proyección de lo anterior en la administración digital, el contexto de la Unión Europea, trayectoria y su orientación, aspectos de la interoperabilidad, ciberseguridad y preservación de los datos, cuestiones de gobernanza y roles en la orientación al dato y, finalmente, unas conclusiones. The data-driven approach in the context of digital transformation entails the appearance of new regulations, governance dynamics and roles, and services, together with the corresponding practices, instruments and standards. At the same time new challenges appear in relation to cybersecurity and data preservation. This article presents the digital transformation and data-driven approach, the impact in digital administration, the context of the European Union, trajectory and orientation towards the future, along with aspects of interoperability, cybersecurity and data preservation, as well as issues of governance and roles in data orientation and finally some conclusions.

scholarly journals Data-driven multiscale modeling reveals the role of metabolic coupling for the spatio-temporal growth dynamics of yeast colonies

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Jukka Intosalmi ◽  
Adrian C. Scott ◽  
Michelle Hays ◽  
Nicholas Flann ◽  
Olli Yli-Harja ◽  
...  
Keyword(s):  
Experimental Data ◽  
Time Course ◽  
Growth Dynamics ◽  
Colony Growth ◽  
Data Driven ◽  
Coarse Grained ◽  
Colony Development ◽  
Intercellular Signaling ◽  
Metabolic Coupling ◽  
The Impact

Abstract Background Multicellular entities like mammalian tissues or microbial biofilms typically exhibit complex spatial arrangements that are adapted to their specific functions or environments. These structures result from intercellular signaling as well as from the interaction with the environment that allow cells of the same genotype to differentiate into well-organized communities of diversified cells. Despite its importance, our understanding how this cell–cell and metabolic coupling lead to functionally optimized structures is still limited. Results Here, we present a data-driven spatial framework to computationally investigate the development of yeast colonies as such a multicellular structure in dependence on metabolic capacity. For this purpose, we first developed and parameterized a dynamic cell state and growth model for yeast based on on experimental data from homogeneous liquid media conditions. The inferred model is subsequently used in a spatially coarse-grained model for colony development to investigate the effect of metabolic coupling by calibrating spatial parameters from experimental time-course data of colony growth using state-of-the-art statistical techniques for model uncertainty and parameter estimations. The model is finally validated by independent experimental data of an alternative yeast strain with distinct metabolic characteristics and illustrates the impact of metabolic coupling for structure formation. Conclusions We introduce a novel model for yeast colony formation, present a statistical methodology for model calibration in a data-driven manner, and demonstrate how the established model can be used to generate predictions across scales by validation against independent measurements of genetically distinct yeast strains.

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