Preliminary study of coating 3D Printed Polymeric Gyroid structures using ‘Dragon’s blood’ extract as a potential delivery system

Utilization of brown algae especially in Madura, where it’s close to Surabaya, only limited for food. This become a reference for developing and increasing the potential of this algae by extracting one of the ingredients, namely alginate. This paper deals with the characterization of sodium alginate extracted from sargassum sp. using modified-purified calcium routes. The extracted sodium alginate will be further used as composite hydrogel materials and compared with commercial sodium alginate. Hereafter, the synthesized composite is expected to be bio-ink for 3d printer. Chemical composition analysis were analyzed using X-Ray Fluorosense (XRF) followed by Fourier-transform infrared spectroscopy (FTIR) analysis to identify the functional group of composite and X-Ray Diffraction (XRD). Furthermore, viscosity bath is performed to compare the viscosity of extracted and commercial one. The result shows that modified-purified calcium routes in the extraction process of sodium alginate is desirable for improving their properties. Interestingly enough, with the goal of using it as bio-ink in 3d printed fabrication, the synthesized composite shows viscosity, 300 cSt, which meets the criteria for bio-ink in 3d printer.

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3D Printed Composite Scaffolds Incorporating Ruthenium Complex–Loaded Liposomes as a Delivery System to Prevent the Proliferation of MG‐63 Cells

Macromolecular Materials and Engineering ◽

10.1002/mame.201900295 ◽

2019 ◽

Vol 304 (11) ◽

pp. 1900295 ◽

Cited By ~ 2

Author(s):

Lijuan Ye ◽

Jingguang Wang ◽

Cancheng Liao ◽

Shuqi Li ◽

Yuqi Fang ◽

...

Keyword(s):

Delivery System ◽

Ruthenium Complex ◽

Composite Scaffolds ◽

3D Printed

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Preliminary study of the dosimetric characteristics of 3D-printed materials with megavoltage photons

Journal of the Korean Physical Society ◽

10.3938/jkps.67.189 ◽

2015 ◽

Vol 67 (1) ◽

pp. 189-194 ◽

Cited By ~ 4

Author(s):

Seonghoon Jeong ◽

Myonggeun Yoon ◽

Weon Kuu Chung ◽

Dong Wook Kim

Keyword(s):

3D Printed ◽

Preliminary Study ◽

Printed Materials

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Dragon's Blood extract has antithrombotic properties, affecting platelet aggregation functions and anticoagulation activities

Journal of Ethnopharmacology ◽

10.1016/j.jep.2011.03.063 ◽

2011 ◽

Vol 135 (2) ◽

pp. 510-514 ◽

Cited By ~ 50

Author(s):

Nian Xin ◽

Yu-Juan Li ◽

Yan Li ◽

Rong-Ji Dai ◽

Wei-Wei Meng ◽

...

Keyword(s):

Platelet Aggregation ◽

Dragon’S Blood ◽

Aggregation Functions ◽

Blood Extract

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Levodopa-Loaded 3D-Printed Poly (lactic) Acid/Chitosan Neural Tissue Scaffold as a Promising Drug Delivery System for the Treatment of Parkinson’s Disease

Applied Sciences ◽

10.3390/app112210727 ◽

2021 ◽

Vol 11 (22) ◽

pp. 10727

Author(s):

Ezgi Saylam ◽

Yigit Akkaya ◽

Elif Ilhan ◽

Sumeyye Cesur ◽

Ece Guler ◽

...

Keyword(s):

Parkinson’S Disease ◽

Drug Delivery ◽

Tissue Engineering ◽

Parkinson's Disease ◽

Drug Delivery System ◽

Delivery System ◽

Neural Tissue ◽

Fickian Diffusion ◽

Pore Sizes ◽

3D Printed

Parkinson’s disease, the second most common neurodegenerative disease in the world, develops due to decreased dopamine levels in the basal ganglia. Levodopa, a dopamine precursor used in the treatment of Parkinson’s disease, can be used as a drug delivery system. This study presents an approach to the use of 3D-printed levodopa-loaded neural tissue scaffolds produced with polylactic acid (PLA) and chitosan (CS) for the treatment of Parkinson’s disease. Surface morphology and pore sizes were examined by scanning electron microscopy (SEM). Average pore sizes of 100–200 µm were found to be ideal for tissue engineering scaffolds, allowing cell penetration but not drastically altering the mechanical properties. It was observed that the swelling and weight loss behaviors of the scaffolds increased after the addition of CS to the PLA. Levodopa was released from the 3D-printed scaffolds in a controlled manner for 14 days, according to a Fickian diffusion mechanism. Mesenchymal stem cells (hAD-MSCs) derived from human adipose tissue were used in MTT analysis, fluorescence microscopy and SEM studies and confirmed adequate biocompatibility. Overall, the obtained results show that PLA/CS 3D-printed scaffolds have an alternative use for the levodopa delivery system for Parkinson’s disease in neural tissue engineering applications.

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3D printed biodegradable implants as an individualized drug delivery system for local chemotherapy of osteosarcoma

Materials & Design ◽

10.1016/j.matdes.2019.108336 ◽

2020 ◽

Vol 186 ◽

pp. 108336 ◽

Cited By ~ 15

Author(s):

Yonghui Wang ◽

Liang Sun ◽

Zhigang Mei ◽

Fazhou Zhang ◽

Meifang He ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Biodegradable Implants ◽

Local Chemotherapy ◽

3D Printed

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Novel 3D printed device with integrated macroscale magnetic field triggerable anti-cancer drug delivery system

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2020.111068 ◽

2020 ◽

Vol 192 ◽

pp. 111068 ◽

Cited By ~ 2

Author(s):

Kejing Shi ◽

Rodrigo Aviles-Espinosa ◽

Elizabeth Rendon-Morales ◽

Lisa Woodbine ◽

Mohammed Maniruzzaman ◽

...

Keyword(s):

Magnetic Field ◽

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Cancer Drug ◽

Anti Cancer ◽

3D Printed ◽

Cancer Drug Delivery

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Pharmaceutical Product Development Exploiting 3D Printing Technology: Conventional to Novel Drug Delivery System

Current Pharmaceutical Design ◽

10.2174/1381612825666190206195808 ◽

2019 ◽

Vol 24 (42) ◽

pp. 5029-5038 ◽

Cited By ~ 5

Author(s):

Md. Shoaib Alam ◽

Ayesha Akhtar ◽

Iftikhar Ahsan ◽

Sheikh Shafiq-un-Nabi

Keyword(s):

Drug Delivery ◽

3D Printing ◽

Personalized Medicine ◽

Drug Delivery System ◽

Delivery System ◽

Printing Technology ◽

3D Printing Technology ◽

3D Printed ◽

Novel Drug Delivery System ◽

Novel Drug

Background: 3D printed pharmaceutical products are revolutionizing the pharmaceutical industry as a prospective mean to achieve a personalized method of treatments acquired to the specially designed need of each patient. It will depend upon age, weight, concomitants, pharmacogenetics and pharmacokinetic profile of the patient and thus transforming the current pharmaceutical market as a potential alternative to conventional medicine. 3D printing technology is getting more consideration in new medicine formulation development as a modern and better alternative to control many challenges associated with conventional medicinal products. There are many advantages of 3D printed medicines which create tremendous opportunities for improving the acceptance, accuracy and effectiveness of these medicines. In 2015, United State Food and Drug Administration has approved the first 3D printed tablet (Spritam®) and had shown the emerging importance of this technology. Methods: This review article summarizes as how in-depth knowledge of drugs and their manufacturing processes can assist to manage different strategies for various 3D printing methods. The principal goal of this review is to provide a brief introduction about the present techniques employed in tech -medicine evolution from conventional to a novel drug delivery system. Results: It is evidenced that through its unparalleled advantages of high-throughput, versatility, automation, precise spatial control and fabrication of hierarchical structures, the implementation of 3D printing for the expansion and delivery of controlled drugs acts as a pivotal role. Conclusion: 3D printing technology has an extraordinary ability to provide elasticity in the manufacturing and designing of composite products that can be utilized in programmable and personalized medicine. Personalized medicine helps in improving drug safety and minimizes side effects such as toxicity to individual human being which is associated with unsuitable drug dose.

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A Preliminary Study on 3D Printed Smart Insoles With Stretchable Piezoresistive Sensors for Plantar Pressure Monitoring

Volume 2: Advanced Manufacturing ◽

10.1115/imece2017-71817 ◽

2017 ◽

Cited By ~ 1

Author(s):

Md Omar Faruk Emon ◽

Jae-Won Choi

Keyword(s):

Screen Printing ◽

Pressure Sensors ◽

Heel Strike ◽

Pressure Monitoring ◽

Piezoresistive Sensors ◽

Flexible Material ◽

Entire Structure ◽

Multi Walled Carbon Nanotube ◽

3D Printed ◽

Preliminary Study

In this report, we present a 3D printed insole which has multiple soft pressure sensors inserted in it to detect the force on the sole including heel, midfoot, and forefoot as well as timing and location of the strike while walking. The insole was 3D printed using a soft and flexible material having multiple open channels on it to attach sensors. Flexible and stretchable piezoresistive sensors were fabricated via screen printing and molding processes. The multi-layer sensor comprises an ionic liquid (IL) based piezoresistive layer sandwiched between two multi-walled carbon nanotube (MWCNT) based stretchable electrodes and finally, top and bottom insulation layers. The sensor was constructed using 3D printable photopolymer as 3D printing is our target manufacturing technique to build the entire structure including insole. The sensor embedded insole was evaluated for different foot landing conditions such as heel strike, midfoot strike, and forefoot strike. Experimental results showed that the developed insole could indicate the amount of force on insole when foot hits ground, with timing and location of the strike.

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