Simulation Analysis of Lateral Propagation Mechanism of EGF Signaling on Cell Surface

2009 ◽  
Author(s):  
Takashi Naka
Keyword(s):  
Cell Surface ◽  
Simulation Analysis ◽  
Propagation Mechanism ◽  
Egf Signaling ◽  
Lateral Propagation

scholarly journals Lateral Propagation of EGF Signaling after Local Stimulation Is Dependent on Receptor Density

2002 ◽  
Vol 3 (2) ◽  
pp. 245-257 ◽  
Author(s):  
Asako Sawano ◽  
Shuichi Takayama ◽  
Michiyuki Matsuda ◽  
Atsushi Miyawaki
Keyword(s):  
Receptor Density ◽  
Egf Signaling ◽  
Local Stimulation ◽  
Lateral Propagation

Effects of unstirred Disse fluid, nonequilibrium binding, and surface-mediated dissociation on hepatic removal of albumin-bound organic anions

1985 ◽  
Vol 248 (6) ◽  
pp. G709-G717
Author(s):  
E. L. Forker ◽  
B. A. Luxon
Keyword(s):  
Cell Surface ◽  
Simulation Analysis ◽  
Present Report ◽  
Intrinsic Clearance ◽  
Organic Anions ◽  
Distributed Model ◽  
Extended Model ◽  
Hepatic Extraction ◽  
Unknown Parameter Vector ◽  
Rate Limiting

Proceeding from the observation that organic anions bound to albumin have hepatic extraction fractions that are unexpectedly high, we have studied a distributed model that accounts for this phenomenon by invoking sites on the cell surface that catalyze the dissociation of albumin-anion complexes. The present report extends this model to include nonequilibrium binding and rate-limiting diffusion of bound anion to the cell surface. Simulation analysis of the extended model provides an unambiguous basis for interpreting the apparent intrinsic clearance of free anion. The model is fully consistent with the transport data that we obtained with rose bengal [Am. J. Physiol. 248 (Gastrointest. Liver Physiol. 11): G702-G708, 1985] but is suited to estimating only selected components of the unknown parameter vector. Uncertainties inherent in an alternate approach are discussed and illustrated.

Internet public opinion dissemination mechanism of COVID-19: evidence from the Shuanghuanglian event

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Xing Zhang ◽  
Yan Zhou ◽  
Fuli Zhou ◽  
Saurabh Pratap
Keyword(s):  
Public Health ◽  
Public Opinion ◽  
Simulation Analysis ◽  
Decisive Role ◽  
The Internet ◽  
Propagation Mechanism ◽  
Evolution System ◽  
Content Type ◽  
Public Health Emergencies ◽  
The Government

PurposeThe sudden outbreak of COVID-19 has become a major public health emergency of global concern. Studying the Internet public opinion dissemination mechanism of public health emergencies is of great significance for creating a legalized network environment, and it is also helpful for managers to make scientific decisions when encountering Internet public opinion crisis.Design/methodology/approachBased on the analysis of the process of spreading the Internet public opinion in major epidemics, a dynamic model of the Internet public opinion spread system was constructed to study the interactive relationship among the public opinion events, network media, netizens and government and the spread of epidemic public opinion. The Shuanghuanglian event in COVID-19 in China was taken as a typical example to make simulation analysis.FindingsResearch results show three points: (1) the government credibility plays a decisive role in the spread of Internet public opinion; (2) it is the best time to intervene when Internet public opinion occurred at first time; (3) the management and control of social media are the key to public opinion governance. Besides, specific countermeasures are proposed to assist control of Internet public opinion dissemination.Originality/valueThe epidemic Internet public opinion risk evolution system is a complex nonlinear social system. The system dynamics model is used to carry out research to facilitate the analysis of the Internet public opinion propagation mechanism and explore the interrelationship of various factors.

scholarly journals 1H1710 Lateral Propagation of EGF SIgnaling after Local Stimulation Is Dependent on Receptor Density

2002 ◽  
Vol 42 (supplement2) ◽  
pp. S46
Author(s):  
A. Sawano-Sakaue ◽  
Shuichi Takayama ◽  
M. Matsuda ◽  
A. Miyawaki
Keyword(s):  
Receptor Density ◽  
Egf Signaling ◽  
Local Stimulation ◽  
Lateral Propagation

Influence of Calcium Ions on the Plant Cell Surface: Membrane Fusions and Conformational Changes

1974 ◽  
Vol 32 ◽  
pp. 154-155
Author(s):  
D. James Morré ◽  
Charles E. Bracker ◽  
William J. VanDerWoude
Keyword(s):  
Cell Wall ◽  
Cell Surface ◽  
Conformational Changes ◽  
Calcium Ions ◽  
Surface Membrane ◽  
Carboxyl Groups ◽  
Cross Linking ◽  
Ultrastructural Evidence ◽  
Glycine Max L ◽  
Wall Extensibility

Calcium ions in the concentration range 5-100 mM inhibit auxin-induced cell elongation and wall extensibility of plant stems. Inhibition of wall extensibility requires that the tissue be living; growth inhibition cannot be explained on the basis of cross-linking of carboxyl groups of cell wall uronides by calcium ions. In this study, ultrastructural evidence was sought for an interaction of calcium ions with some component other than the wall at the cell surface of soybean (Glycine max (L.) Merr.) hypocotyls.

Morphological Changes in the Rat Granulosa Cell Surface During Differentiation Induced by Estradiol and Gonadotropins

1977 ◽  
Vol 35 ◽  
pp. 484-485
Author(s):  
P. Bagavandoss ◽  
JoAnne S. Richards ◽  
A. Rees Midgley
Keyword(s):  
Cell Surface ◽  
Granulosa Cell ◽  
Morphological Changes ◽  
Follicular Development ◽  
Female Rats ◽  
Functional Changes ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

During follicular development in the mammalian ovary, several functional changes occur in the granulosa cells in response to steroid hormones and gonadotropins (1,2). In particular, marked changes in the content of membrane-associated receptors for the gonadotropins have been observed (1).We report here scanning electron microscope observations of morphological changes that occur on the granulosa cell surface in response to the administration of estradiol, human follicle stimulating hormone (hFSH), and human chorionic gonadotropin (hCG).Immature female rats that were hypophysectcmized on day 24 of age were treated in the following manner. Group 1: control groups were injected once a day with 0.1 ml phosphate buffered saline (PBS) for 3 days; group 2: estradiol (1.5 mg/0.2 ml propylene glycol) once a day for 3 days; group 3: estradiol for 3 days followed by 2 days of hFSH (1 μg/0.1 ml) twice daily, group 4: same as in group 3; group 5: same as in group 3 with a final injection of hCG (5 IU/0.1 ml) on the fifth day.

Surface Structure of Nucleated Animal Cells: Carbon Replicas

1967 ◽  
Vol 25 ◽  
pp. 120-121
Author(s):  
Robert M. Glaeser ◽  
Thea B. Scott
Keyword(s):  
Cell Surface ◽  
Surface Structure ◽  
Particle Diameter ◽  
Cellular Functions ◽  
Animal Cells ◽  
Replica Technique ◽  
Carbon Replica ◽  
Characteristic Particle ◽  
Cell Surface Structure ◽  
Carbon Replicas

The carbon-replica technique can be used to obtain information about cell-surface structure that cannot ordinarily be obtained by thin-section techniques. Mammalian erythrocytes have been studied by the replica technique and they appear to be characterized by a pebbly or “plaqued“ surface texture. The characteristic “particle” diameter is about 200 Å to 400 Å. We have now extended our observations on cell-surface structure to chicken and frog erythrocytes, which possess a broad range of cellular functions, and to normal rat lymphocytes and mouse ascites tumor cells, which are capable of cell division. In these experiments fresh cells were washed in Eagle's Minimum Essential Medium Salt Solution (for suspension cultures) and one volume of a 10% cell suspension was added to one volume of 2% OsO4 or 5% gluteraldehyde in 0.067 M phosphate buffer, pH 7.3. Carbon replicas were obtained by a technique similar to that employed by Glaeser et al. Figure 1 shows an electron micrograph of a carbon replica made from a chicken erythrocyte, and Figure 2 shows an enlarged portion of the same cell.

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