Adding the missing time-dependent layout dependency into device-circuit-layout co-optimization - New findings on the layout dependent aging effects

2015 ◽  
Author(s):  
Pengpeng Ren ◽  
Xiaoqing Xu ◽  
Peng Hao ◽  
Junyao Wang ◽  
Runsheng Wang ◽  
...  
Keyword(s):  
Time Dependent ◽  
Aging Effects ◽  
Circuit Layout ◽  
New Findings

Creep and Plastic Strains of 304 Stainless Steel at 593°C Under Step Stress Changes, Considering Aging

1982 ◽  
Vol 49 (2) ◽  
pp. 297-304 ◽  
Author(s):  
U. W. Cho ◽  
W. N. Findley
Keyword(s):  
Stainless Steel ◽  
Constitutive Equations ◽  
Time Dependent ◽  
304 Stainless Steel ◽  
Flow Rule ◽  
Strain Component ◽  
Plastic Strains ◽  
Aging Effects ◽  
Stress Changes ◽  
Step Down

Nonlinear constitutive equations for varying stress histories are developed and used to predict the creep behavior of 304 stainless steel at 593°C (1100°F) under variable tension or torsion stresses including reloading, complete unloading, step-up, and step-down stress changes. The strain in the constitutive equations (a viscous-viscoelastic model) consists of: linear elastic, time-independent plastic, time-dependent-recoverable viscoelastic, and time-dependent-nonrecoverable viscous components. For variable stressing, the modified superposition principle, derived from the multiple integral representation, and the strain hardening theory were used to represent the recoverable and nonrecoverable components, respectively, of the time-dependent strain. Time-independent plastic strains were described by a flow rule of similar form to that for nonrecoverable, time-dependent strains. The material constants of the theory were determined from constant stress creep and creep recovery data. Considerable aging effects were found and the effects on the strain components were incorporated in each strain predicted by the theory. Some modifications of the theory for the viscoelastic strain component under step-down stress changes were made to improve the predictions. The final predictions combining the foregoing features made satisfactory agreements with the experimental creep data under step stress changes.

scholarly journals Time-dependent Canonical Correlation Analysis for Multilevel Time Series

2019 ◽  
Author(s):  
Xuefei Cao ◽  
Jun Ke ◽  
Björn Sandstede ◽  
Xi Luo
Keyword(s):  
Time Series ◽  
Correlation Analysis ◽  
Canonical Correlation Analysis ◽  
Canonical Correlation ◽  
Time Series Data ◽  
Temporal Dynamics ◽  
Temporal Variations ◽  
Time Dependent ◽  
Series Data ◽  
Aging Effects

AbstractCanonical Correlation Analysis is a technique in multivariate data analysis for finding linear projections that maximize the correlation between two groups of variables. The correlations are typically defined without accounting for the serial correlations between observations, a typical setting for time series data. To understand the coupling dynamics and temporal variations between the two time-varying sources, we introduce the time-dependent canonical correlation analysis (TDCCA), a method for inferring time-dependent canonical vectors from multilevel time series data. A convex formulation of the problem is proposed, which leverages the singular value decomposition (SVD) characterization of all solutions of the CCA problem. We use simulated datasets to validate the proposed algorithm. Moreover, we propose a novel measure, canonical correlation variation as another way to assess the dynamic pattern of brain connections and we apply it to a real resting state fMRI dataset to study the aging effects on brain connectivity. Additionally, we explore our proposed method in a task-related fMRI to detect the temporal dynamics due to different motor tasks. We show that, compared to extant methods, the TDCCA-based approach not only detect temporal changes but also improves feature extraction. Together, this paper contributes broadly to new computational methodologies in understanding multilevel time series.

48 Hour Multiaxial Creep and Creep Recovery of 2618 Aluminum Alloy at 200°C

1984 ◽  
Vol 51 (1) ◽  
pp. 125-132 ◽  
Author(s):  
J.-L. Ding ◽  
W. N. Findley
Keyword(s):  
Homogeneous Function ◽  
Maximum Shear Stress ◽  
Full Range ◽  
Viscoelastic Model ◽  
Multiple Integral ◽  
Constant Stress ◽  
Time Dependent ◽  
Creep Recovery ◽  
Aging Effects ◽  
Data Set

Data are reported from 48 hour constant multiaxial stress creep followed by 48 hour creep recovery with the magnitudes of the effective stress ranging from 34.5 MPa (5.00 ksi) to 175.5 MPa (25.46 ksi). They differed from a previous data set in the much longer constant-stress durations and the inclusion of data from low stress creep, compression creep, and short term aging tests. Data were represented by a viscous-viscoelastic model in which the time-dependent strain was resolved into recoverable and nonrecoverable components. Previous stress-strain relations for constant stress creep and recovery were modified to include the current experimental observations of the nonexistence of creep limits, negligible aging effects, and symmetry in tension and compression. The time dependence was represented by a power of time with different exponents for the recoverable and nonrecoverable components. A homogeneous function of maximum shear stress was developed to represent the full range of stress dependence of the nonrecoverable time-dependent components; the third-order multiple integral representation was used for the recoverable component.

scholarly journals Evaluation of skin phototoxicity of transdermally administered pharmaceuticals in Sprague-Dawley rats

2020 ◽  
Vol 36 (1) ◽  
Author(s):  
Nam Hee Youn ◽  
Eun Ji Kim ◽  
Jung-Sun Yi ◽  
Joo Hwan Kim ◽  
Ye-Jin Cho ◽  
...  
Keyword(s):  
Skin Irritation ◽  
Test Method ◽  
Time Dependent ◽  
Pharmaceutical Drugs ◽  
Sprague Dawley ◽  
Sd Rats ◽  
Sprague Dawley Rats ◽  
New Findings

AbstractSome drugs cause phototoxicity in humans when exposed to light, thus there is a need for an in vivo phototoxicity test to evaluate them. However, an in vivo phototoxicity test method to evaluate this has not been established. This study aimed to establish an in vivo phototoxicity test method for transdermally administered drugs. For this, we evaluated the phototoxicity using Sprague-Dawley (SD) rats for transdermal administered drugs and we studied the appropriate UVA dose using 8-methoxypsalen, which is a well-known phototoxic drug. We found that a UVA dose of 15 J/cm2 was dose and time dependent response compared to other UVA doses. We performed the Minimum Erythema Dose (MED) test because UVB can cause skin irritation by itself and selected 0.01 J/cm2 as an appropriate dose of UVB. Using the selected UVA and UVB doses, we performed a phototoxicity study of 6 pharmaceutical drugs, which included phototoxic and non-phototoxic drugs. As a result of the phototoxicity test, 100% accuracy was obtained when compared with previous studies. In addition, we performed histopathology to confirm the new findings. We found that histopathology can be used as an additional indicator of phototoxicity test for transdermally administered drugs.

A new cumulative damage model for time-dependent reliability analysis of deteriorating structures

2019 ◽  
Vol 234 (2) ◽  
pp. 290-302
Author(s):  
Junxiang Li ◽  
Jianqiao Chen ◽  
Zhiqiang Chen
Keyword(s):  
Reliability Analysis ◽  
Damage Model ◽  
Aging Effect ◽  
Cumulative Damage ◽  
Time Dependent ◽  
Sustained Load ◽  
Aging Effects ◽  
Sustained Loads ◽  
Cumulative Damage Model ◽  
Transient Loads

Performance and reliability of structures will deteriorate with the effects of loads, environment, and interior factors of materials. In this article, a novel cumulative damage model is developed for time-dependent reliability analysis of deteriorating structures. The deterioration is a combination of three stochastic processes: the gradual deterioration posed by aging effects, the sudden deterioration caused by transient loads, and the additional deterioration introduced by sustained loads. The aging effect is modeled as a gamma process, while the transient load is described by a Poisson process. The sustained load is modeled by a stationary binomial process and a Poisson square wave process, respectively. The load threshold for three different scenarios are all considered and applied to not only the transient loads but also the sustained loads. The time-dependent reliability of deteriorating structures is then evaluated based on this model via semi-analytical methods or numerical simulation methods. Three numerical examples and an example involving a natural gas pipeline are used to validate the effectiveness of the proposed model for computing the time-dependent reliability.

Further studies on the ultrastructure of the cochlea

1990 ◽  
Vol 48 (3) ◽  
pp. 440-441
Author(s):  
Zhixian Wang ◽  
Pinjin Zhu ◽  
Jianhe Sun ◽  
Xuezheng Song
Keyword(s):  
Hair Cells ◽  
Military Medicine ◽  
Outer Hair Cells ◽  
Apical Surface ◽  
Epithelial Surface ◽  
Hearing Research ◽  
New Findings ◽  
Fine Structures ◽  
Temporal Bones ◽  
Accurate Observation

Hearing research is important not only for clinical, professional and military medicine, but also for toxicology, gerontology and genetics. Ultrastructure of the cochlea attracts much attention of electron microscopists, (1―3) but the research lags far behind that of the other parts of the organnism. On the basis of careful microdissection, technical improvment and accurate observation, we have got some new findings which have not been reported in the literature.We collected four cochleas from human corpses. Temporal bones dissected 1 h after death and cochleas perfused with fixatives 4 h after death were good enough in terms of preservation of fine structures. SEM:The apical surface of OHCs (Outer hair cells) and DTs (Deiters cells) is narrower than that of IPs (Inner pillar cells). The mosaic configuration of the reticular membrane is not typical. The stereocilia of IHCs (Inner hair cells) are not uniform and some kinocilia could be seen on the OHCs in adults. The epithelial surface of RM (Reissner’s membrane) is not smooth and no mesh could be seen on the mesothelial surface of RM. TEM.

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