A Polarization Isolation Method for High-Sensitivity, Low-Cost On-Chip Fluorescence Detection for Microfluidic Lab-on-a-Chip

Significant attention has been given on the development of droplets–based microfluidic system because of its potential and apparent advantages. Beside the advantages of reducing the sample volume, it’s also offer less time consuming for the analysis. Optical and fluorescence among the famous method that was used in detection of droplets but they are normally bulky, expensive and not easily accessed. This paper proposed a simple, low cost and high sensitivity for droplets sensing in microfluidic devices by using capacitive sensor. Coplanar electrodes are used to form a capacitance through the microfluidic channel. The design of eight pair of electrodes was used to detect the presence of a droplet. Changes in capacitance due to the presence of a droplet in the sensing area is detected and used to trigger the microscope to capture the image of detected droplets in microchannel. The measurement of droplets detected and counting are displayed through a LABVIEW interface in the real time.

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Regenerable Bead-Based Microfluidic Device with integrated THIN-Film Photodiodes for Real Time Monitoring of DNA Detection

Proceedings ◽

10.3390/proceedings2130953 ◽

2018 ◽

Vol 2 (13) ◽

pp. 953

Author(s):

Catarina R. F. Caneira ◽

Denis R. Santos ◽

Virginia Chu ◽

João P. Conde

Keyword(s):

Thin Film ◽

Real Time ◽

Microfluidic Device ◽

Low Cost ◽

High Sensitivity ◽

Significant Loss ◽

Real Time Monitoring ◽

Target Dna ◽

On Chip ◽

Biosensing System

Nanoporous microbead-based microfluidic systems for biosensing applications allow enhanced sensitivities, while being low cost and amenable for miniaturization. The regeneration of the microfluidic biosensing system results in a further decrease in costs while the integration of on-chip signal transduction enhances portability. Here, we present a regenerable bead-based microfluidic device, with integrated thin-film photodiodes, for real-time monitoring of molecular recognition between a target DNA and complementary DNA (cDNA). High-sensitivity assay cycles could be performed without significant loss of probe DNA density and activity, demonstrating the potential for reusability, portability and reproducibility of the system.

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High Sensitivity On-Chip Fluorescence Detection Based on Cross-Polarization and Thin-Film Organic Photodetectors

TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference ◽

10.1109/sensor.2007.4300586 ◽

2007 ◽

Author(s):

Andrea Pais ◽

Ansuman Banerjee ◽

Dilip K. Bandi ◽

David Klotzkin ◽

Ian Papautsky

Keyword(s):

Thin Film ◽

Fluorescence Detection ◽

High Sensitivity ◽

Cross Polarization ◽

On Chip ◽

Organic Photodetectors

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A low-cost 2D fluorescence detection system for μm sized beads on-chip

Lab on a Chip ◽

10.1039/c2lc21187d ◽

2012 ◽

Vol 12 (10) ◽

pp. 1780 ◽

Cited By ~ 7

Author(s):

Loes I. Segerink ◽

Maarten J. Koster ◽

Ad J. Sprenkels ◽

Albert van den Berg

Keyword(s):

Fluorescence Detection ◽

Detection System ◽

Low Cost ◽

On Chip ◽

Fluorescence Detection System

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SMILE Platform: An Innovative Microfluidic Approach for On-Chip Sample Manipulation and Analysis in Oral Cancer Diagnosis

Micromachines ◽

10.3390/mi12080885 ◽

2021 ◽

Vol 12 (8) ◽

pp. 885

Author(s):

Sofia Zoupanou ◽

Annalisa Volpe ◽

Elisabetta Primiceri ◽

Caterina Gaudiuso ◽

Antonio Ancona ◽

...

Keyword(s):

Oral Cancer ◽

Low Cost ◽

High Sensitivity ◽

Ease Of Use ◽

Early Screening ◽

Chip Sample ◽

Large Audience ◽

On Chip ◽

Sensitivity Specificity ◽

Large Diffusion

Oral cancer belongs to the group of head and neck cancers, and, despite its large diffusion, it suffers from low consideration in terms of prevention and early diagnosis. The main objective of the SMILE platform is the development of a low-cost device for oral cancer early screening with features of high sensitivity, specificity, and ease of use, with the aim of reaching a large audience of possible users and realizing real prevention of the disease. To achieve this goal, we realized two microfluidic devices exploiting low-cost materials and processes. They can be used in combination or alone to obtain on-chip sample preparation and/or detection of circulating tumor cells, selected as biomarkers of oral cancer. The realized devices are completely transparent with plug-and-play features, obtained thanks to a highly customized architecture which enables users to easily use them, with potential for a common use among physicians or dentists with minimal training.

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Terahertz Detectors Based on Silicon Technology Field Effect Transistors

MRS Proceedings ◽

10.1557/opl.2012.1187 ◽

2012 ◽

Vol 1437 ◽

Author(s):

Wojciech Knap ◽

Franz Schuster ◽

Dominique Coquillat ◽

Frédéric Teppe ◽

Benoît Giffard ◽

...

Keyword(s):

Field Effect ◽

Large Scale ◽

Field Effect Transistors ◽

Low Cost ◽

High Sensitivity ◽

Focal Plane Arrays ◽

Terahertz Detectors ◽

Silicon Technology ◽

Thz Detection ◽

On Chip

ABSTRACTThe concept of THz detection based on excitation of plasma waves in two-dimensional electron gas in Si FETs is one of the most attractive ones, as it makes possible the development of the large-scale integrated devices based on a conventional microelectronic technology including on-chip antennas and readout devices integration. In this work we report on investigations of Terahertz detectors based on low-cost silicon technology field effect transistors. We show that detectors, consisting of a coupling antenna and a n-MOS field effect transistor as rectifying element, are efficient for THz detection and imaging. We demonstrate that in the atmospheric window around 300 GHz, these detectors can achieve a record noise equivalent power below 10 pW/Hz0.5 and a responsivity above 90 kV/W once integrated with on-chip amplifier. We show also that they can be used in a very wide frequency range: from ∼0.2 THz up to 1.1 THz. THz detection by Si FETs pave the way towards high sensitivity silicon technology based focal plane arrays for THz imaging.

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