Febuxostat inhibited axillary osmidrosis risk factor ATP‐binding cassette transporter C11 in vitro

2020 ◽  
Vol 47 (10) ◽  
pp. 1198-1199
Author(s):  
Yu Toyoda ◽  
Tappei Takada ◽  
Hiroshi Suzuki
Keyword(s):  
Risk Factor ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Axillary Osmidrosis ◽  
Atp Binding Cassette

scholarly journals Dichlorodiphenyltrichloroethane Impairs Amyloid Beta Clearance by Decreasing Liver X Receptor α Expression

2021 ◽  
Vol 13 ◽  
Author(s):  
Dongmei Wu ◽  
Yang Hu ◽  
Min Song ◽  
Gongbo Li
Keyword(s):  
Amyloid Beta ◽  
Critical Role ◽  
Liver X Receptor ◽  
Dynamics Simulation ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Liver X Receptor Α ◽  
Aβ Clearance ◽  
Atp Binding Cassette

Abnormal amyloid beta (Aβ) clearance is a distinctive pathological mechanism for Alzheimer’s disease (AD). ATP-binding cassette transporter A1 (ABCA1), which mediates the lipidation of apolipoprotein E, plays a critical role in Aβ clearance. As an environmental factor for AD, dichlorodiphenyltrichloroethane (DDT) can decrease ATP-binding cassette transporter A1 (ABCA1) expression and disrupt Aβ clearance. Liver X receptor α (LXRα) is an autoregulatory transcription factor for ABCA1 and a target of some environmental pollutants, such as organophosphate pesticides. In this study, we aimed to investigate whether DDT could affect Aβ clearance by targeting LXRα. The DDT-pretreated H4 human neuroglioma cells and immortalized astrocytes were incubated with exogenous Aβ to evaluate Aβ consumption. Meanwhile, cytotoxicity and LXRα expression were determined in the DDT-treated cells. Subsequently, the antagonism of DDT on LXRα agonist T0901317 was determined in vitro. The interaction between DDT and LXRα was predicted by molecular docking and molecular dynamics simulation technology. We observed that DDT could inhibit Aβ clearance and decrease the levels of LXRα mRNA and LXRα protein. Moreover, DDT is supposed to strongly bind to LXRα and exert antagonistic effects on LXRα. In conclusion, this study firstly presented that DDT could inhibit LXRα expression, which would contribute to Aβ clearance decline in vitro. It provides an experimental basis to search for potential therapeutic targets of AD.

scholarly journals NtcA-Dependent Expression of the devBCAOperon, Encoding a Heterocyst-Specific ATP-Binding Cassette Transporter in Anabaena spp

2001 ◽  
Vol 183 (12) ◽  
pp. 3795-3799 ◽  
Author(s):  
Gabriele Fiedler ◽  
Alicia M. Muro-Pastor ◽  
Enrique Flores ◽  
Iris Maldener
Keyword(s):  
Nitrogen Deficiency ◽  
Transcriptional Regulator ◽  
Atp Binding ◽  
Translation Start Site ◽  
Atp Binding Cassette Transporter ◽  
Translation Start ◽  
Transcriptional Start Point ◽  
Pcc 7120 ◽  
Atp Binding Cassette

ABSTRACT The devBCA operon, encoding subunits of an ATP-binding cassette exporter, is essential for differentiation of N2-fixing heterocysts in Anabaena spp. Nitrogen deficiency-dependent transcription of the operon and the use of its transcriptional start point, located 762 (Anabaena variabilis strain ATCC 29413-FD) or 704 (Anabaena sp. strain PCC 7120) bp upstream of the translation start site, were found to require the global nitrogen transcriptional regulator NtcA. Furthermore, NtcA was shown to bind in vitro to the promoter ofdevBCA.

Study of ATP-binding Cassette Transporter A1 (ABCA1)-mediated Cellular Cholesterol Efflux in Diabetic Golden Hamsters

2007 ◽  
Vol 35 (4) ◽  
pp. 508-516 ◽  
Author(s):  
Y Zhu ◽  
H-J Wang ◽  
L-F Chen ◽  
Q Fang ◽  
X-W Yan
Keyword(s):  
Cholesterol Efflux ◽  
Adenosine Monophosphate ◽  
Peritoneal Macrophages ◽  
Atp Binding ◽  
Cellular Cholesterol ◽  
Golden Hamsters ◽  
Atp Binding Cassette Transporter ◽  
Cellular Cholesterol Efflux ◽  
Atp Binding Cassette

The effects of cyclic adenosine monophosphate (cAMP) and atorvastatin on macrophage adenosine triphosphate (ATP)-binding cassette transporter A1 (ABCA1)-mediated cholesterol efflux were investigated in a diabetic animal model. Golden hamsters were fed a high-fat diet which resulted in insulin resistance. Diabetes was induced by a single intraperitoneal injection of streptozotocin (30 mg/kg). Normal golden hamsters were used as controls. Peritoneal macrophages were incubated with apolipoprotein A-1 (apoA-1), 8-bromoadenosine-3′,5′-cyclic monophosphate (8-br-cAMP), and atorvastatin in vitro Intracellular cholesterol accumulation was greater in the diabetic animals than in the insulin-resistant animals. Expression of ABCA1 mRNA in macrophages from diabetic animals was upregulated by 8-br-cAMP and atorvastatin. ApoA-1 caused a time-dependent cellular cholesterol efflux. Both atorvastatin and 8-br-cAMP significantly facilitated ABCA1-mediated cellular cholesterol efflux, with the maximal cholesterol efflux rate observed in the macrophages from diabetic animals. Accumulation of cholesterol in the macrophages of diabetic animals can be significantly alleviated by atorvastatin or 8-br-cAMP through improving ABCA1-mediated cellular cholesterol efflux.

Osimertinib (AZD9291) Attenuates the Function of Multidrug Resistance-Linked ATP-Binding Cassette Transporter ABCB1 in Vitro

2016 ◽  
Vol 13 (6) ◽  
pp. 2117-2125 ◽  
Author(s):  
Sung-Han Hsiao ◽  
Yu-Jen Lu ◽  
Yan-Qing Li ◽  
Yang-Hui Huang ◽  
Chia-Hung Hsieh ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

scholarly journals ATP-binding cassette transporter Abcg2 lineage contributes to the cardiac vasculature after oxidative stress

2014 ◽  
Vol 306 (12) ◽  
pp. H1610-H1618 ◽  
Author(s):  
Travis J. Maher ◽  
Yi Ren ◽  
Qinglu Li ◽  
Elizabeth Braunlin ◽  
Mary G. Garry ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Immunohistochemical Analysis ◽  
Atp Binding ◽  
Coronary Artery Ligation ◽  
Artery Ligation ◽  
Systemic Oxidative Stress ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

Due to their specialized location, stem and progenitor cells are often exposed to oxidative stress. Although ATP-binding cassette transporter subfamily G member 2 (Abcg2)-expressing cells have been implicated in cardiac protective mechanisms involving oxidative stress, there remains a lack of understanding regarding the behavior of cardiac Abcg2-expressing cells when exposed to ROS. The aim of the present study was to characterize the response of the cardiac Abcg2 lineage to oxidative stress. In vitro analysis demonstrated that the antioxidant program regulated by Abcg2 is dependent on a functional transporter. Delivery of paraquat dichloride (PQ), a systemic oxidative stress-inducing agent, to mice confirmed that Abcg2 provides a survival benefit. When exposed to PQ, reporter mice showed an increase in the Abcg2 lineage. Transcriptional and immunohistochemical analysis of Abcg2 lineage-positive cells revealed an enhanced vascular commitment after stress. Finally, preconditioning with PQ demonstrated a reduction in scar size and an increase in angiogenesis after permanent left coronary artery ligation. In conclusion, the data suggest that Abcg2 plays a cytoprotective role in response to in vivo oxidative stress. The contribution of the Abcg2 lineage to the vasculature in the heart is increased after PQ delivery.

Sign in / Sign up

Export Citation Format

Share Document