scholarly journals Tumoral presence of human cytomegalovirus is associated with shorter disease-free survival in elderly patients with colorectal cancer and higher levels of intratumoral interleukin-17

2014 ◽  
Vol 20 (7) ◽  
pp. 664-671 ◽  
Author(s):  
H.-P. Chen ◽  
J.-K. Jiang ◽  
P.-Y. Lai ◽  
C.-Y. Chen ◽  
T.-Y. Chou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Elderly Patients ◽  
Human Cytomegalovirus ◽  
Disease Free Survival ◽  
Interleukin 17 ◽  
Free Survival ◽  
Disease Free

scholarly journals Laparoscopic vs open colorectal cancer surgery in elderly patients: short- and long-term outcomes and predictors for overall and disease-free survival

BMC Surgery ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Sicheng Zhou ◽  
Xuewei Wang ◽  
Chuanduo Zhao ◽  
Qian Liu ◽  
Haitao Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Elderly Patients ◽  
Open Surgery ◽  
Perineural Invasion ◽  
Disease Free Survival ◽  
Short Term ◽  
Free Survival ◽  
Disease Free ◽  
Surgery In Elderly

Abstract Background Colorectal cancer is common in elderly patients. Laparoscopy is widely used to approach this kind of disease. This study was to examine short-term outcomes and long-term survival for laparoscopic and open surgery in elderly patients with colorectal cancer. Methods From January 2007 to December 2018, patients with colorectal cancer older than 80 operated at China National Cancer Center were included in the study. Propensity score matching (PSM) was used to minimize the adverse effects. The clinical data between open and laparoscopic surgery was compared, and the effect of factors on overall survival (OS) and disease-free survival (DFS) was analyzed by Cox proportional hazard model. Results Ninety-three pairs were selected after PSM. Patients in laparoscopic group had less intraoperative blood loss, postoperative complications, time to first flatus, time to oral feeding, postoperative hospital stay, and higher retrieved lymph node (P < 0.05). The OS and DFS rates were similar (P > 0.05), besides the CEA level, III/IV stage, and perineural invasion were independent predictors of survival (P < 0.05). Conclusion In elderly patients with colorectal cancer, laparoscopic surgery had better short-term outcomes than open surgery. CEA level, III/IV stage, and perineural invasion were reliable predictors for OS and DFS.

534 Better immune profiles on elderly colorectal cancer patients correlated with 1 year diseases free survival (DFS)

2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A570-A570
Author(s):  
Budhi Ida Bagus ◽  
Metria Ida Bagus ◽  
Mastini Ida Ayu Kade
Keyword(s):  
Colorectal Cancer ◽  
Adjuvant Chemotherapy ◽  
Elderly Patients ◽  
Cancer Patients ◽  
Disease Free Survival ◽  
X Rays ◽  
Free Survival ◽  
Colorectal Cancer Patients ◽  
Ig G ◽  
Disease Free

BackgroundColorectal cancer is the most common gastrointestinal tract cancer, there are many factors which plays an important role on short and long term outcome prior to surgery and adjuvant therapy. For many decades, oncological factor has been state as the main of favorable outcome which could be evaluated by diseases free survival (DFS). Current study already evaluated the immune factor which has an important role on the progression on this colorectal cancer patients.MethodsWe evaluated the colorectal cancer patients whose has been diagnosed as adenocarsinoma colon and rectal from operative speciments. The blood level of CRP, IL-6, IFN?, CB-8, IG G and IG M will be examined initially before the operative procedure done. All patients were stage III colorectal adeno carcinoma and adjuvant chemotherapy has been administered for six months period. The patients whose could not completed the adjuvant chemotherapy will be excluded from the study. The outcome of this study will be evaluated the 1 year disease free survival based on the abdominal CT Scan and chest x-rays.ResultsThere were 2 groups on this study, adults (< 60 years old) and elderly (>60 years old). 62 patients were included, 30 adults patients and 32 elderly patients has been evaluated for the immune profiles. We found the signifance difference were on the level of CRP, IL-6,IFN?, CB-8, IG G and IG M (p < 0.05). All patients had R0 resection and completed the adjuvant chemotherapy. 5 patients in the adult colorectal cancer group has locoregional and distant metastases in the lung and liver after 1 year evaluation. On the contraty, we could achieved 1 year diseases free survival in the elderly patients (p < 0.05) respectively.ConclusionsElderly colorectal cancer patients has better immune profiles and has better 1 year disease free survival.Ethics ApprovalThe study has approved by Ethical Committe of Health Study Faculty of Medicine Sebelas Maret University, Indonesia. Approval number: 21457/BD/2020ConsentAll of the patients already have a consent for this study

scholarly journals TRIM25 regulates oxaliplatin resistance in colorectal cancer by promoting EZH2 stability

2021 ◽  
Vol 12 (5) ◽  
Author(s):  
Sha Zhou ◽  
Jianhong Peng ◽  
Liuniu Xiao ◽  
Caixia Zhou ◽  
Yujing Fang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Disease Free Survival ◽  
Free Survival ◽  
Epigenetic Regulator ◽  
Crc Management ◽  
Disease Free ◽  
Resistance To Chemotherapy

AbstractResistance to chemotherapy remains the major cause of treatment failure in patients with colorectal cancer (CRC). Here, we identified TRIM25 as an epigenetic regulator of oxaliplatin (OXA) resistance in CRC. The level of TRIM25 in OXA-resistant patients who experienced recurrence during the follow-up period was significantly higher than in those who had no recurrence. Patients with high expression of TRIM25 had a significantly higher recurrence rate and worse disease-free survival than those with low TRIM25 expression. Downregulation of TRIM25 dramatically inhibited, while overexpression of TRIM25 increased, CRC cell survival after OXA treatment. In addition, TRIM25 promoted the stem cell properties of CRC cells both in vitro and in vivo. Importantly, we demonstrated that TRIM25 inhibited the binding of E3 ubiquitin ligase TRAF6 to EZH2, thus stabilizing and upregulating EZH2, and promoting OXA resistance. Our study contributes to a better understanding of OXA resistance and indicates that inhibitors against TRIM25 might be an excellent strategy for CRC management in clinical practice.

Radiofrequency Ablation of Hepatic Metastases from Colorectal Cancer: Are Newer Generation Probes Better?

2006 ◽  
Vol 72 (10) ◽  
pp. 875-879 ◽  
Author(s):  
Aziz Ahmad ◽  
Steven L. Chen ◽  
Maihgan A. Kavanagh ◽  
David P. Allegra ◽  
Anton J. Bilchik
Keyword(s):  
Colorectal Cancer ◽  
Radiofrequency Ablation ◽  
First Generation ◽  
Hepatic Metastases ◽  
Disease Free Survival ◽  
Cancer Center ◽  
Free Survival ◽  
Alive With Disease ◽  
Disease Free

Second-generation radiofrequency ablation (RFA) probes and their successors have more power, shorter ablation times, and an increased area of ablation compared with the first-generation probes used before 2000. We examined whether the use of the newer probes has improved the clinical outcome of RFA for hepatic metastases of colorectal cancer at our tertiary cancer center. Of 160 patients who underwent RFA between 1997 and 2003, 52 had metastases confined to the liver: 21 patients underwent 46 ablations with the first-generation probes and 31 patients underwent 58 ablations with the newer probes. The two groups had similar demographic characteristics. At a median follow-up of 26.2 months, patients treated with the newer probes had a longer median disease-free survival (16 months vs 8 months, P < 0.01) and a lower rate of margin recurrence (5.2% vs 17.4%); eight patients had no evidence of disease and one patient was alive with disease. By contrast, of the 46 patients treated with the first-generation probes, 2 patients had no evidence of disease and 1 patient was alive with disease. Newer-generation probes are associated with lower rates of margin recurrence and higher rates of disease-free survival after RFA of hepatic metastases from colorectal cancer.

DPYD c.1905 + 1G>A Promotes Fluoropyrimidine-Induced Anemia, a Prognostic Factor in Disease-Free Survival, in Colorectal Cancer

2021 ◽  
Vol 25 (4) ◽  
pp. 276-283
Author(s):  
Adem Deligonul ◽  
Secil Aksoy ◽  
Gulcin Tezcan ◽  
Berrin Tunca ◽  
Ozkan Kanat ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factor ◽  
Disease Free Survival ◽  
Free Survival ◽  
Disease Free

scholarly journals Combination of CDX2 expression and T stage improves prognostic prediction of colorectal cancer

2019 ◽  
Vol 47 (5) ◽  
pp. 1829-1842 ◽  
Author(s):  
Weimin Xu ◽  
Yilian Zhu ◽  
Wei Shen ◽  
Wenjun Ding ◽  
Tingyu Wu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Disease Free Survival ◽  
Hazard Ratio ◽  
Free Survival ◽  
T Stage ◽  
Cdx2 Expression ◽  
Prognostic Prediction ◽  
Disease Free

Objective Prognostic prediction of colorectal cancer (CRC) remains challenging because of its heterogeneity. Aberrant expression of caudal-type homeobox transcription factor 2 (CDX2) is strongly correlated with the prognosis of CRC. Methods Tissue samples of patients with CRC who underwent surgery in Xinhua Hospital (Shanghai, China) from January 2010 to January 2013 were collected. CDX2 expression was semiquantitatively evaluated via immunohistochemistry. Results In total, 138 patients were enrolled in this study from a prospectively maintained institutional cancer database. The median follow-up duration was 57.5 months (interquartile range, 17.0–71.0 months). In the Cox proportional hazards model, low CDX2 expression combined with stage T4 CRC was significantly the worst prognostic factor for disease-free survival (hazard ratio = 7.020, 95% confidence interval = 3.922–12.564) and overall survival (hazard ratio = 5.176, 95% CI = 3.237–10.091). In the Kaplan–Meier survival analysis, patients with low CDX2 expression and stage T4 CRC showed significantly worse disease-free survival and overall survival than those with low CDX2 expression alone. Conclusion CDX2 expression combined with the T stage was more accurate for predicting the prognosis of CRC. Determining the prognosis of CRC using more than one variable is valuable in developing appropriate treatment and follow-up strategies.

DNA copy number alterations, gene expression changes and disease-free survival in patients with colorectal cancer: a 10 year follow-up

2016 ◽  
Vol 39 (6) ◽  
pp. 545-558 ◽  
Author(s):  
Elisabetta Bigagli ◽  
Carlotta De Filippo ◽  
Cinzia Castagnini ◽  
Simona Toti ◽  
Francesco Acquadro ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Copy Number ◽  
Disease Free Survival ◽  
Copy Number Alterations ◽  
Dna Copy Number ◽  
Free Survival ◽  
Dna Copy Number Alterations ◽  
Disease Free
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