Age‐specific reference ranges of serum anti‐müllerian hormone in healthy women and its application in diagnosis of polycystic ovary syndrome: a population study

2020 ◽  
Vol 127 (6) ◽  
pp. 720-728 ◽  
Author(s):  
HWR Li ◽  
Y‐L He ◽  
R Li ◽  
CYG Wong ◽  
B Sy ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Population Study ◽  
Polycystic Ovary ◽  
Specific Reference ◽  
Reference Ranges ◽  
Ovary Syndrome ◽  
Healthy Women

Age-specific reference values improve the diagnostic performance of AMH in polycystic ovary syndrome

2020 ◽  
Vol 58 (8) ◽  
pp. 1291-1301 ◽  
Author(s):  
Osman Evliyaoglu ◽  
Mathias Imöhl ◽  
Ralf Weiskirchen ◽  
Josef van Helden
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Diagnostic Performance ◽  
Polycystic Ovary ◽  
Reproductive Hormones ◽  
Youden Index ◽  
Specific Reference ◽  
Reference Ranges ◽  
Ovary Syndrome ◽  
Significant Difference ◽  
Age Dependent

AbstractBackgroundThe increased secretion of anti-Müllerian hormone (AMH) by the growing follicles has been supposed as a determinative feature of polycystic ovary syndrome (PCOS). The diagnostic performance of AMH in PCOS is superior compared to the free androgen index (FAI) and luteinizing hormone (LH)/follicle-stimulating hormone (FSH) quotient. We established age-dependent reference ranges to further improve the diagnostic performance of AMH.MethodsIn a cross-sectional study, in samples of 4712 reproductive age patients, ranging from 14 to 50 years, BMI, AMH and other reproductive hormones were determined by immunoassay or tandem mass spectrometry (LC-MS/MS) to calculate age-specific reference ranges and the diagnostic performance.ResultsAge-specific diagnostic performances for Elecsys® AMH, FAI and LH/FSH ratio were established in the reference group. No significant difference in BMI was found between the groups. AMH values were significantly negatively correlated with age (r = −0.628, p < 0.001) in patients with normal ovarian function, but there was no correlation between age and AMH levels in PCOS patients (r = − 0.041, p < 0.174). In all the study groups, AMH showed a weak correlation between FAI and LH/FSH ratio (r = 0.302, p < 0.001 and r = 0.434, p < 0.001, respectively). The sensitivity/specificity for AMH, FAI and LH/FSH ratio were 89/96%, 71/69% and 75/72%, respectively, according to the Youden index.ConclusionsWe determined the age-dependent reference ranges for serum AMH levels in a large population-based study and calculated the age-specific diagnostic performance of FAI and LH/FSH ratio, which allows physicians to evaluate patients with PCOS who have normal AMH levels. AMH is suggested as the strongest diagnostic marker in patients with PCOS compared to FAI and LH/FSH ratio.

scholarly journals Serum Melatonin in Women with Polycystic Ovary Syndrome

Folia Medica ◽  
2013 ◽  
Vol 55 (2) ◽  
pp. 10-15 ◽  
Author(s):  
Dora D. Terzieva ◽  
Maria M. Orbetzova ◽  
Mitko D. Mitkov ◽  
Nonka G. Mateva
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Levels ◽  
Dehydroepiandrosterone Sulfate ◽  
Immunoreactive Insulin ◽  
Total Testosterone ◽  
Melatonin Level ◽  
Night Time ◽  
Ovary Syndrome ◽  
Healthy Women

ABSTRACT There has been a surge of interest in recent years in studying the changes of serum melatonin concentrations in disorders that are associated with insulin resistance such as diabetes mellitus type 2 and polycystic ovary syndrome (PCOS). AIM: The present study was designed to investigate the day-time and night-time levels of serum melatonin and the cortisol rhythm in women with PCOS and compare them with those of healthy women. PATIENTS AND METHODS: This is a case-control study which included 30 women with PCOS and 25 healthy women. All hormonal measurements in both the study group and controls were carried out between days 3 and 5 counted from the beginning of the last regular menstrual cycle; they included serum levels of melatonin and cortisol at 03:00 a.m and 08:00 a.m, total testosterone (T), dehydroepiandrosterone sulfate (DHEA-S), luteinizing hormone (LH), follicle stimulating hormone (FSH), and immunoreactive insulin at 08:00 a.m. RESULTS: Women with PCOS were found to have a significantly higher melatonin level at 08:00 a.m. and smaller mean night-day difference in the concentrations of melatonin in comparison with those of healthy women (natural log (Ln) night-day difference 0.60 ± 0.10 pg/ml versus 1.15 ± 0.14, p < 0.002). Melatonin to cortisol ratios at 03:00 a.m. and 08:00 a.m. showed no statistically significant differences between the two groups (Ln melatonin/ cortisol 03:00 a.m., 1.01 ± 0.06 versus 1.05 ± 0.05; Ln melatonin/cortisol at 08:00 a.m., 0.62 ± 0.01 versus 0.56 ± 0.03, p > 0.05). CONCLUSION: The results we obtained about the changes of melatonin in women with PCOS could help in elucidating the complex pathophysiological pattern of this disease.

Activation profiles of monocyte-macrophages and HDL function in healthy women in relation to menstrual cycle and in polycystic ovary syndrome patients

Endocrine ◽  
2019 ◽  
Vol 66 (2) ◽  
pp. 360-369 ◽  
Author(s):  
Serena Tedesco ◽  
Maria Pia Adorni ◽  
Nicoletta Ronda ◽  
Roberta Cappellari ◽  
Roberto Mioni ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Healthy Women ◽  
Hdl Function

scholarly journals Retinal Nerve Fiber Layer Thickness in Women with Polycystic Ovary Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Mehmet Demir ◽  
Dilek Guven ◽  
Arzu Koc ◽  
Savas Ozdemir ◽  
Efe Can
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Polycystic Ovary ◽  
Refractive Errors ◽  
Fiber Layer ◽  
Ovary Syndrome ◽  
Nerve Fiber Layer ◽  
Healthy Women ◽  
Retinal Nerve Fiber

Aim. To compare the retinal nerve fiber layer (RNFL) thickness between women with polycystic ovary syndrome (PCOS) and healthy women.Materials and Methods. The study included 88 eyes of 44 women (group 1) with PCOS and 84 eyes of 42 healthy women (group 2). In all subjects, the RNFL and ganglion cell complex (GCC) thicknesses were measured by optical coherence tomography (OCT). In addition, visual acuity (VA), intraocular pressure (IOP), refractive errors, central macular thickness (CMT), central corneal thickness (CCT), and excavation of optic disc were evaluated in all subjects.Results. Mean values of GCC, IOP, VA, CMT, CCT, and refractive errors were similar between the 2 groups. The average RNFL, superior average RNFL, and inferior average RNFL thicknesses were higher in subjects with PCOS than in healthy subjects (P=0.003,P=0.012, andP=0.009), respectively.Conclusion. The average RNFL, superior average RNFL, and inferior average RNFL thicknesses in women with PCOS were significantly higher than in healthy women.

Short-term effect of orlistat on dietary glycotoxins in healthy women and women with polycystic ovary syndrome

Metabolism ◽  
2006 ◽  
Vol 55 (4) ◽  
pp. 494-500 ◽  
Author(s):  
Evanthia Diamanti-Kandarakis ◽  
Christina Piperi ◽  
Krystallenia Alexandraki ◽  
Nikolaos Katsilambros ◽  
Eirini Kouroupi ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Term Effect ◽  
Short Term ◽  
Ovary Syndrome ◽  
Short Term Effect ◽  
Healthy Women

scholarly journals Does Polycystic Ovary Syndrome Itself Have Additional Effect on Apelin Levels?

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Dilek Benk Silfeler ◽  
Cumali Gokce ◽  
Raziye Keskin Kurt ◽  
Nigar Yilmaz Atilgan ◽  
Oktay Hasan Ozturk ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Study Design ◽  
Healthy Subjects ◽  
Polycystic Ovary ◽  
Serum Levels ◽  
Ovary Syndrome ◽  
Control Subjects ◽  
Healthy Women ◽  
Regular Menses

Objective. The present study was designed to compare serum levels of apelin between lean PCOS women and healthy women with regular menses.Study Design. A total of 30 lean patients with PCOS and 30 healthy subjects were included in this study. Serum apelin levels were compared between groups.Results. Serum apelin levels in lean PCOS patients were not significantly different from the control subjects.Conclusion. Our findings indicate that PCOS itself does not seem to change apelin levels. Further investigation on a large number of subjects will need to be conducted to prove the consistent or variable association in PCOS.

scholarly journals Assessment of serum adiponectin levels in women with polycystic ovary syndrome

2021 ◽  
Vol 7 (2) ◽  
pp. 21-27
Author(s):  
Dr. Mukund B. Patel ◽  
◽  
Dr. Ramesh C. Patel ◽  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Tertiary Care ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Study Groups ◽  
Reproductive Age ◽  
Serum Adiponectin ◽  
Ovary Syndrome ◽  
Healthy Women

Background and Aim: Serum adiponectin levels were found to be altered in women with polycysticovary syndrome (PCOS) due to the increased adiposity commonly observed in them. Accordingly,earlier studies have reported decreased adiponectin levels in PCOS women. the present study wasconducted to measure serum adiponectin levels in women with PCOS and to evaluate its associationwith the biochemical parameters studied.Material and Methods: The present study included 50women of reproductive age attending the department of Gynecology, tertiary care institute of Indiaand diagnosed with polycystic ovary syndrome based on Rotterdam criteria. Fifty age-matchedhealthy women were recruited as controls. t. Adiponectin levels were measured along withmeasurement of fasting blood glucose, lipid profile using commercial kits and insulin resistance(HOMA-IR) was calculated. Results: Both the study groups were matched concerning age, however,PCOS women were obese when compared to healthy women (p<0.001). Serum total cholesterol andtriglyceride levels were significantly higher (p≤0.05) and serum adiponectin concentration wassignificantly lower in PCOS women when compared to controls (p≤0.05). HDL cholesterol, fastinginsulin and HOMA-IR were similar between cases and controls. Adiponectin did not show significantassociation with any of the parameters studied (Table 2). Conclusion: Serum adiponectin levels aresignificantly lower in women with polycystic ovary syndrome compared to healthy women. Thehyperandrogenemia which is one of the characteristic features of PCOS leads to a state of adipositywhich can further cause a decrease in adiponectin levels.

scholarly journals Evaluation the levels of some hormones in women with polycystic ovary syndrome

2019 ◽  
Vol 24 (5) ◽  
pp. 25
Author(s):  
Namareq Ata allah Mohemeed1 ◽  
Firas Shawki Abdul-razzak2
Keyword(s):  
Menstrual Cycle ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Follicle Stimulating Hormone ◽  
Control Group ◽  
Age Group ◽  
Ovary Syndrome ◽  
Blood Samples ◽  
Healthy Women ◽  
Stimulating Hormone

This study was conducted on 40 Samples of Patients with polycystic ovary syndrome (PCOS) after their diagnosis, The study aimed to identify the most important  hormonal disorders associated  with  this syndrome . The study begins from Octobar 2017 to March 2018 , the age from(19-45) years .Blood samples were taken during the (2-4( days of menstrual cycle and the selected samples were compared with 20 healthy women as control group ,and the following hormones were evaluated Luteninzing hormone (LH), Follicle Stimulating Hormone (FSH), Prolactin (PRL),Testosterone (Testo) and Oxytocin (OX) ,the study showed a high significant in the concentrations of OX ,Testo and LH (P≤0.01) , a high significant in the PRL concentration (P≤0.05) and a high significant in the FSH concentration (P≤0.05(,the results were distributed to three groups according to BMI ,age and treatment, in term BMI it was divided into three groups, BMI(18.5-24.9)(25.0-29.9) (≥30)kg/m2 the results showed a high significant (P≤0.05)  in the LH and OX concentration in  group BMI (18.5-24.9)kg/m2 and in both PRL and Testo in group BMI(≥30)kg/m2. in term age, it was divided into three groups (19-26) (27-35) (36-45)years, the results showed a high significant (P≤0.05) in LH  and Testo concentration at age group (36-45)years ,compared to other groups, and a high significant (P≤0.05) in both PRL and OX, between three group of age , treatment it was divided  into three groups of metformin, progesterone contraceptive used and non-used of the treatment .the results showed a high significant (P≤0.05) in LH, PRL, OX and Testo concentrations, and a high significant (P≤0.05) of FSH in women treated compared with non-used  .   http://dx.doi.org/10.25130/tjps.24.2019.085

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