IL-4 Induces Chemotaxis of Blood Eosinophils from Atopic Dermatitis Patients, but Not from Normal Individuals

1994 ◽  
Vol 102 (6) ◽  
pp. 843-846 ◽  
Author(s):  
Gerald R Dubois ◽  
Carla A F M Bruijnzeel-Koomen ◽  
Piet L B Bruijnzeel
Keyword(s):  
Atopic Dermatitis ◽  
Normal Individuals ◽  
Blood Eosinophils

scholarly journals Transcriptomic analysis of atopic dermatitis in African Americans is characterized by Th2/Th17-centered cutaneous immune activation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shannon Wongvibulsin ◽  
Nishadh Sutaria ◽  
Suraj Kannan ◽  
Martin Prince Alphonse ◽  
Micah Belzberg ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
African Americans ◽  
Immune Activation ◽  
Population Level ◽  
Research Network ◽  
Variation Analysis ◽  
Immune Signature ◽  
Key Drivers ◽  
Blood Eosinophils ◽  
Level Analysis

AbstractAtopic dermatitis (AD) often presents more severely in African Americans (AAs) and with greater involvement of extensor areas. To investigate immune signatures of AD in AAs with moderate to severe pruritus, lesional and non-lesional punch biopsies were taken from AA patients along with age-, race-, and sex-matched controls. Histology of lesional skin showed psoriasiform dermatitis and spongiotic dermatitis, suggesting both Th2 and Th17 activity. Gene Set Variation Analysis showed upregulation of Th2 and Th17 pathways in both lesional versus non-lesional and lesional versus control (p < 0.01), while Th1 and Th22 upregulation were observed in lesional versus control (p < 0.05). Evidence for a broad immune signature also was supported by upregulated Th1 and Th22 pathways, and clinically may represent greater severity of AD in AA. Furthermore, population-level analysis of data from TriNetX, a global federated health research network, revealed that AA AD patients had higher values for CRP, ferritin, and blood eosinophils compared to age-, sex-, and race-matched controls as well as white AD patients, suggesting broad systemic inflammation. Therefore, AA AD patients may feature broader immune activation than previously thought and may derive benefit from systemic immunomodulating therapies that modulate key drivers of multiple immune pathways.

Expression of a Human SOCS Protein, HSOCP-1, in Peripheral Blood Eosinophils from Patients with Atopic Dermatitis

2004 ◽  
Vol 134 (1) ◽  
pp. 2-6 ◽  
Author(s):  
Kaoru Ogawa ◽  
Mikito Itoh ◽  
Masami Miyagawa ◽  
Takeshi Nagasu ◽  
Yuji Sugita ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Peripheral Blood ◽  
Blood Eosinophils ◽  
Socs Protein

scholarly journals Topical Application of Herbal Mixture Extract Inhibits Ovalbumin- or 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Soon Re Kim ◽  
Han-Seok Choi ◽  
Hye Sook Seo ◽  
Youn Kyung Choi ◽  
Yong Cheol Shin ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Topical Application ◽  
Immunoglobulin E ◽  
Elevated Serum ◽  
Ethanol Extract ◽  
Inflammatory Cells ◽  
Skin Lesions ◽  
Serum Ige ◽  
Beneficial Effects ◽  
Blood Eosinophils

KM110329 is four traditional herbal medicine mixtures with anti-inflammatory properties. Atopic dermatitis (AD) is an inflammatory skin disease associated with enhanced T-helper2 (Th2) lymphocyte response to allergens that results in elevated serum eosinophil and Immunoglobulin E (IgE) levels and leukocyte infiltration in atopic skin sites. In this study, we investigated the effect of topical application of KM110329 ethanol extract on the ovalbumin (OVA) or 2,4-dinitrochlorobenzene- (DNCB-) induced AD mouse models. For that purpose, we observed the effects of KM110329 on blood eosinophils, skin mast cells, production of serum IgE, and expression of cytokine mRNA in the atopic dermatitis skin lesions of OVA allergen- or DNCB-treated BALB/c mice. KM110329 significantly reduced blood eosinophils cell numbers in OVA or DNCB-treated BALB/c mice. Histological analyses demonstrated decreased mast cell count as well as dermal infiltration by inflammatory cells. In the skin lesions, mRNA expression of interleukine (IL)-4, IL-13, and IL-17 was inhibited by KM110329. KM110329 also suppressed the production of serum IgE level in both the OVA- and DNCB-induced atopic dermatitis model. Taken together, our results showed that topical application of KM110329 extracts exerts beneficial effects in AD symptoms, suggesting that KM110329 might be a useful candidate for the treatment of AD.

Comparative proteomic analysis of peripheral blood eosinophils from healthy donors and atopic dermatitis patients with eosinophilia

PROTEOMICS ◽  
2005 ◽  
Vol 5 (7) ◽  
pp. 1987-1995 ◽  
Author(s):  
Sun Woo Yoon ◽  
Tae Yoon Kim ◽  
Moon Hee Sung ◽  
Chul Joong Kim ◽  
Haryoung Poo
Keyword(s):  
Atopic Dermatitis ◽  
Peripheral Blood ◽  
Proteomic Analysis ◽  
Comparative Proteomic Analysis ◽  
Healthy Donors ◽  
Blood Eosinophils

scholarly journals Secretory Leukocyte Protease Inhibitor Is Present in Circulating and Tissue-Recruited Human Eosinophils and Regulates Their Migratory Function

2022 ◽  
Vol 12 ◽  
Author(s):  
Oktawia Osiecka ◽  
Joanna Skrzeczynska-Moncznik ◽  
Agnieszka Morytko ◽  
Angelika Mazur ◽  
Pawel Majewski ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Granulomatosis With Polyangiitis ◽  
Allergic Diseases ◽  
Secretory Leukocyte Protease Inhibitor ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Normal Individuals ◽  
Crystalline Core ◽  
Diseased Skin ◽  
Blood Eosinophils ◽  
Eosinophilic Granulomatosis

Eosinophils and secretory leukocyte protease inhibitor (SLPI) are both associated with Th2 immune responses and allergic diseases, but whether the fact that they are both implicated in these conditions is pathophysiologically related remains unknown. Here we demonstrate that human eosinophils derived from normal individuals are one of the major sources of SLPI among circulating leukocytes. SLPI was found to be stored in the crystalline core of eosinophil granules, and its dislocation/rearrangement in the crystalline core likely resulted in changes in immunostaining for SLPI in these cells. High levels of SLPI were also detected in blood eosinophils from patients with allergy-associated diseases marked by eosinophilia. These include individuals with eosinophilic granulomatosis with polyangiitis (EGPA) and atopic dermatitis (AD), who were also found to have elevated SLPI levels in their plasma. In addition to the circulating eosinophils, diseased skin of AD patients also contained SLPI-positive eosinophils. Exogenous, recombinant SLPI increased numbers of migratory eosinophils and supported their chemotactic response to CCL11, one of the key chemokines that regulate eosinophil migratory cues. Together, these findings suggest a role for SLPI in controlling Th2 pathophysiologic processes via its impact on and/or from eosinophils.

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