Short‐term safety of an anti‐severe acute respiratory syndrome coronavirus 2 messenger RNA vaccine for patients with advanced lung cancer treated with anticancer drugs: A multicenter, prospective, observational study

Abstract Background: Of patients receiving moderate emetic risk chemotherapy (MEC), 30%–90% experience chemotherapy-induced nausea and vomiting (CINV); however, the optimal antiemetic treatment remains controversial. Methods: In this multicenter, prospective, observational study of adults treated with MEC while receiving chemotherapy for various cancer types in Japan, the enrolled patients kept diaries documenting CINV. All participants received a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone. Results: Of the 400 patients enrolled from May 2013 to January 2015, 386 were eligible for evaluation. The median age was 64 (range, 26–84). The overall complete response (CR; no emetic events and no antiemetic measures) rate was 64%. The proportion of patients showing CR was low in the carboplatin (CBDCA)- and oxaliplatin-based chemotherapy groups, especially among women. We showed that the CR rates in men were high in the CBDCA (AUC5) + etoposide (ETP) (80%), capecitabine plus oxaliplatin (CAPOX) (78%), and CBDCA+ paclitaxel (PTX) groups for lung cancer (73%). Total control (TC; no emetic events, no antiemetic measures, and no nausea) and complete control (CC; no emetic events, no antiemetic measures, and less than mild nausea) were achieved in 51% and 61% of patients, respectively. Logistic regression analysis revealed history of motion sickness, history of pregnancy-associated vomiting and CBDCA-based chemotherapy as risk factors for CR and history of motion sickness and history of pregnancy-associated vomiting as risk factors for TC. Additional, Ages ≥65 years is an independent predictive factor for achieving TC. Conclusion: Our data showed that two antiemetics were insufficient to control CINV in patients receiving CBDCA- or oxaliplatin-based chemotherapy. However, two antiemetics may be sufficiently effective for elderly male patients receiving CBDCA (AUC5)+ETP, CBDCA+PTX for lung cancer, or CAPOX. Additionally, we consider that three antiemetics are necessary for women with colorectal cancer receiving CAPOX. Risk factor analysis related to CR showed that CINV prophylaxis in patients treated with CBDCA-based chemotherapy was generally supportive of the guideline-recommended three antiemetics. However, the control of nausea in patients receiving non-CBDCA-based chemotherapy is a key point to note. The further individualization of antiemetic regimens for patients receiving MEC based on both types of chemotherapy regimens and sex is needed.

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Latent TB infection in newly diagnosed lung cancer patients – A multicenter prospective observational study

Lung Cancer ◽

10.1016/j.lungcan.2014.07.001 ◽

2014 ◽

Vol 85 (3) ◽

pp. 472-478 ◽

Cited By ~ 13

Author(s):

Wen-Chien Fan ◽

Wen-Ying Ting ◽

Ming-Che Lee ◽

Shiang-Fen Huang ◽

Chao-Hua Chiu ◽

...

Keyword(s):

Lung Cancer ◽

Observational Study ◽

Cancer Patients ◽

Prospective Observational Study ◽

Newly Diagnosed ◽

Lung Cancer Patients ◽

Latent Tb ◽

Multicenter Prospective Observational Study ◽

Latent Tb Infection

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Incidence of venous thromboembolism in advanced lung cancer and efficacy and safety of direct oral anticoagulant: A multicenter, prospective, observational study (Rising-VTE/NEJ037 Study).

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.12021 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. 12021-12021

Author(s):

Yukari Tsubata ◽

Takamasa Hotta ◽

Kosuke Hamai ◽

Naoki Furuya ◽

Toshihide Yokoyama ◽

...

Keyword(s):

Lung Cancer ◽

Venous Thromboembolism ◽

Treatment Group ◽

Observational Study ◽

Cancer Diagnosis ◽

Prospective Observational Study ◽

Small Cell ◽

Small Cell Lung ◽

Lung Cancer Diagnosis ◽

Multicenter Prospective Observational Study

12021 Background: Venous thromboembolism (VTE) is a well-known kind of cancer-associated thrombosis and a common complication of malignancy. However, little is known about the incidence of VTE and the effectiveness of direct oral anticoagulants (DOACs) associated with lung cancer chemotherapy. Methods: The Rising-VTE/NEJ037 study was a multicenter, prospective, observational study with 40 participating Japanese institutions. A total of 1,021 patients diagnosed with lung cancer that was unsuitable for radical resection or radiation were enrolled and followed up for two years. The diagnosis of VTE was confirmed through a central review by two radiologists. Patients with VTE at the time of lung cancer diagnosis started treatment with edoxaban. The primary endpoint of this trial was the rate of newly diagnosed VTE after enrollment or the recurrence rate 6 months after the start of treatment with edoxaban. Results: Of the 1,021 enrolled patients, data were available for 1,008 patients. The median age was 70 years (range: 30-94 years), and 70.8% were males. Eighty-six percent of patients had non-small cell lung cancer, and 13.6% had small cell lung cancer. Histological types included adenocarcinoma (N = 641, 63.6%), squamous cell carcinoma (N = 187, 18.6%), and others (N = 42, 4.2%). Sixty-two patients (6.2%) had VTE at the time of lung cancer diagnosis, and 42 patients (4.2%) developed VTE during two years follow-up, making a total of 104 patients (10.3%). No cases of VTE recurrence were found 6 months after the start of treatment with edoxaban. Major and minor bleeding occurred in 95 patients (9.4%) and increased to 23% in the edoxaban treatment group. The two-year survival probability was 0.43 in the non-VTE group and 0.48 in the VTE with edoxaban treatment group, showing no difference. Conclusions: This study shows a high cumulative incidence of VTE, suggesting that attention should be paid to VTE during treatment for lung cancer. Treatment with edoxaban was highly effective in preventing recurrence of VTE, and there was no difference in survival with or without VTE, but treatment should be considered more carefully because of the high bleeding rate associated with DOAC. Clinical trial information: jRCTs061180025.

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170P Predictors for cancer-related fatigue among patients with advanced lung cancer attending palliative care department: A prospective observational study

Journal of Thoracic Oncology ◽

10.1016/s1556-0864(21)02012-8 ◽

2021 ◽

Vol 16 (4) ◽

pp. S791

Author(s):

C.R. Patil ◽

S. Atreya

Keyword(s):

Lung Cancer ◽

Palliative Care ◽

Observational Study ◽

Prospective Observational Study ◽

Advanced Lung Cancer ◽

Care Department ◽

Cancer Related Fatigue

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5-Hydroxytryptamine-3 receptor antagonist and dexamethasone as prophylaxis for chemotherapy-induced nausea and vomiting during moderately emetic chemotherapy for solid tumors: a multicenter, prospective, observational study

BMC Pharmacology and Toxicology ◽

10.1186/s40360-020-00445-y ◽

2020 ◽

Vol 21 (1) ◽

Cited By ~ 1

Author(s):

Reiko Matsui ◽

Kenichi Suzuki ◽

Tomomi Takiguchi ◽

Makoto Nishio ◽

Takeshi Koike ◽

...

Keyword(s):

Risk Factors ◽

Lung Cancer ◽

Observational Study ◽

Receptor Antagonist ◽

Motion Sickness ◽

Prospective Observational Study ◽

Nausea And Vomiting ◽

Complete Control ◽

History Of ◽

Multicenter Prospective Observational Study

Abstract Background Of patients receiving moderate emetic risk chemotherapy (MEC), 30–90% experience chemotherapy-induced nausea and vomiting (CINV); however, the optimal antiemetic treatment remains controversial. Methods In this multicenter, prospective, observational study of adults treated with MEC while receiving chemotherapy for various cancer types in Japan, the enrolled patients kept diaries documenting CINV. All participants received a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone. Results Of the 400 patients enrolled from May 2013 to January 2015, 386 were eligible for evaluation. The median age was 64 (range, 26–84). The overall complete response (CR; no emetic events and no antiemetic measures) rate was 64%. The proportion of patients showing CR was low in the carboplatin (CBDCA)- and oxaliplatin-based chemotherapy groups, especially among women. We showed that the CR rates in men were high in the CBDCA (AUC5) + etoposide (ETP) (80%), capecitabine plus oxaliplatin (CAPOX) (78%), and CBDCA+ paclitaxel (PTX) groups for lung cancer (73%). Total control (TC; no emetic events, no antiemetic measures, and no nausea) and complete control (CC; no emetic events, no antiemetic measures, and less than mild nausea) were achieved in 51 and 61% of patients, respectively. Logistic regression analysis revealed history of motion sickness, history of pregnancy-associated vomiting and CBDCA-based chemotherapy as risk factors for CR and history of motion sickness and history of pregnancy-associated vomiting as risk factors for TC. Additional, Ages ≥65 years is an independent predictive factor for achieving TC. Conclusions Our data showed that two antiemetics were insufficient to control CINV in patients receiving CBDCA- or oxaliplatin-based chemotherapy. However, two antiemetics may be sufficiently effective for elderly male patients receiving CBDCA (AUC5) + ETP, CBDCA+PTX for lung cancer, or CAPOX. Additionally, we consider that three antiemetics are necessary for women with colorectal cancer receiving CAPOX. Risk factor analysis related to CR showed that CINV prophylaxis in patients treated with CBDCA-based chemotherapy was generally supportive of the guideline-recommended three antiemetics. However, the control of nausea in patients receiving non-CBDCA-based chemotherapy is a key point to note. The further individualization of antiemetic regimens for patients receiving MEC based on both types of chemotherapy regimens and sex is needed.

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5-Hydroxytryptamine-3 Receptor Antagonist and Dexamethasone as Prophylaxis for Chemotherapy Induced Nausea and Vomiting during Moderately Emetic Chemotherapy for Solid Tumors: A Multicenter, Prospective, Observational Study

10.21203/rs.3.rs-16203/v3 ◽

2020 ◽

Author(s):

Reiko Matsui ◽

Kenichi Suzuki ◽

Tomomi Takiguchi ◽

Makoto Nishio ◽

Takeshi Koike ◽

...

Keyword(s):

Risk Factors ◽

Lung Cancer ◽

Observational Study ◽

Receptor Antagonist ◽

Motion Sickness ◽

Prospective Observational Study ◽

Nausea And Vomiting ◽

Complete Control ◽

History Of ◽

Multicenter Prospective Observational Study

Abstract Background: Of patients receiving moderate emetic risk chemotherapy (MEC), 30%–90% experience chemotherapy-induced nausea and vomiting (CINV); however, the optimal antiemetic treatment remains controversial.Methods: In this multicenter, prospective, observational study of adults treated with MEC while receiving chemotherapy for various cancer types in Japan, the enrolled patients kept diaries documenting CINV. All participants received a 5-hydroxytryptamine-3 receptor antagonist and dexamethasone.Results: Of the 400 patients enrolled from May 2013 to January 2015, 386 were eligible for evaluation. The median age was 64 (range, 26–84). The overall complete response (CR; no emetic events and no antiemetic measures) rate was 64%. The proportion of patients showing CR was low in the carboplatin (CBDCA)- and oxaliplatin-based chemotherapy groups, especially among women. We showed that the CR rates in men were high in the CBDCA (AUC5) + etoposide (ETP) (80%), capecitabine plus oxaliplatin (CAPOX) (78%), and CBDCA+ paclitaxel (PTX) groups for lung cancer (73%). Total control (TC; no emetic events, no antiemetic measures, and no nausea) and complete control (CC; no emetic events, no antiemetic measures, and less than mild nausea) were achieved in 51% and 61% of patients, respectively. Logistic regression analysis revealed history of motion sickness, history of pregnancy-associated vomiting and CBDCA-based chemotherapy as risk factors for CR and history of motion sickness and history of pregnancy-associated vomiting as risk factors for TC. Additional, Ages ≥65 years is an independent predictive factor for achieving TC.Conclusion: Our data showed that two antiemetics were insufficient to control CINV in patients receiving CBDCA- or oxaliplatin-based chemotherapy. However, two antiemetics may be sufficiently effective for elderly male patients receiving CBDCA (AUC5)+ETP, CBDCA+PTX for lung cancer, or CAPOX. Additionally, we consider that three antiemetics are necessary for women with colorectal cancer receiving CAPOX. Risk factor analysis related to CR showed that CINV prophylaxis in patients treated with CBDCA-based chemotherapy was generally supportive of the guideline-recommended three antiemetics. However, the control of nausea in patients receiving non-CBDCA-based chemotherapy is a key point to note. The further individualization of antiemetic regimens for patients receiving MEC based on both types of chemotherapy regimens and sex is needed.

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5-Hydroxytryptamine-3 Receptor Antagonist and Dexamethasone as Prophylaxis for Chemotherapy Induced Nausea and Vomiting during Moderately Emetic Chemotherapy for Solid Tumors: A Multicenter, Prospective, Observational Study

10.21203/rs.3.rs-16203/v1 ◽

2020 ◽

Author(s):

Reiko Matsui ◽

Kenichi Suzuki ◽

Tomomi Takiguchi ◽

Makoto Nishio ◽

Takeshi Koike ◽

...

Keyword(s):

Risk Factors ◽

Lung Cancer ◽

Observational Study ◽

Receptor Antagonist ◽

Prospective Observational Study ◽

Complete Response ◽

Nausea And Vomiting ◽

Complete Control ◽

History Of ◽

Multicenter Prospective Observational Study

Abstract Background Patients receiving moderate emetic risk chemotherapy (MEC) occurs chemotherapy-induced nausea and vomiting (CINV) in 30–90%, however the optimal antiemetic treatment remains controversial. Methods In this multicenter, prospective, observational study of adults treated with MEC for various cancer types in Japan, We enrolled patients kept diaries documenting CINV. All participants received a 5-HT3 receptor antagonist(5HT3RAs) and dexamethasone. We assessed various possible risk factors for complete response (CR; no emetic events and no antiemetic measures), total control (TC; no emetic events , no antiemetic measures and no nausea) and complete control (CC; no emetic events, no antiemetic measures and less than mild nausea) by univariate and multivariate analysis. Results Of the 400 patients enrolled from May 2013 to January 2015, 386 were eligible for evaluation. The overall CR rate was 64%, CBDCA-based chemotherapy and oxaliplatin-based chemotherapy were particularly low. However, we showed that the CR rates in men were high in CBDCA(AUC5)＋ETP (80%), CapeOX (78%) and CBDCA+PTX for lung cancer(73% ). Emesis occurred significantly more women (30%) than men (16%) of patients overall. TC and CC were achieved by 51% and 61% of patients. Logistic regression analysis revealed that age <65 years and history of motion sickness or pregnancy-associated vomiting were risk factors for nausea and being women for vomiting. Conclusions Our data support triplet regimen including NK1 receptor antagonist with woman receiving CBDCA-based chemotherapy or oxaliplatin-based chemotherapy. However, it became clear that two antiemetics for men received CBDCA(AUC5)＋ETP, CBDCA＋PTX for lung cancer and CAPOX may be sufficiently effective. Further individualization of antiemetic regimens for patients receiving MEC on the basis of both type of chemotherapy regimen and sex is needed.

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