Systematic review: gastric microbiota in health and disease

2020 ◽  
Vol 51 (6) ◽  
pp. 582-602 ◽  
Author(s):  
Mirjana Rajilic-Stojanovic ◽  
Ceu Figueiredo ◽  
Annemieke Smet ◽  
Richard Hansen ◽  
Juozas Kupcinskas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Health And Disease ◽  
Gastric Microbiota

scholarly journals The Lipocalin Apolipoprotein D Functional Portrait: A Systematic Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Diego Sanchez ◽  
Maria D. Ganfornina
Keyword(s):  
Systematic Review ◽  
Physiological Function ◽  
Physiological Role ◽  
Future Research ◽  
Lipid Management ◽  
Health And Disease ◽  
Apolipoprotein D ◽  
Extracellular Structures ◽  
Cellular Compartments

Apolipoprotein D is a chordate gene early originated in the Lipocalin protein family. Among other features, regulation of its expression in a wide variety of disease conditions in humans, as apparently unrelated as neurodegeneration or breast cancer, have called for attention on this gene. Also, its presence in different tissues, from blood to brain, and different subcellular locations, from HDL lipoparticles to the interior of lysosomes or the surface of extracellular vesicles, poses an interesting challenge in deciphering its physiological function: Is ApoD a moonlighting protein, serving different roles in different cellular compartments, tissues, or organisms? Or does it have a unique biochemical mechanism of action that accounts for such apparently diverse roles in different physiological situations? To answer these questions, we have performed a systematic review of all primary publications where ApoD properties have been investigated in chordates. We conclude that ApoD ligand binding in the Lipocalin pocket, combined with an antioxidant activity performed at the rim of the pocket are properties sufficient to explain ApoD association with different lipid-based structures, where its physiological function is better described as lipid-management than by long-range lipid-transport. Controlling the redox state of these lipid structures in particular subcellular locations or extracellular structures, ApoD is able to modulate an enormous array of apparently diverse processes in the organism, both in health and disease. The new picture emerging from these data should help to put the physiological role of ApoD in new contexts and to inspire well-focused future research.

Deoxygenation of inspiratory muscles during cycling, hyperpnoea and loaded breathing in health and disease: a systematic review

2017 ◽  
Vol 38 (4) ◽  
pp. 554-565 ◽  
Author(s):  
Takako Tanaka ◽  
Nada Basoudan ◽  
Luana T. Melo ◽  
Lisa Wickerson ◽  
Laurent J. Brochard ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inspiratory Muscles ◽  
Loaded Breathing ◽  
Health And Disease

Syndecan in health and disease – A systematic review

2016 ◽  
Vol 4 (4) ◽  
pp. 184-189
Author(s):  
Tanoj Kumar ◽  
Veena Bhojaraj Pujari ◽  
Manish Kumar ◽  
Smitha C N ◽  
Virsen Jaysingrao Patil ◽  
...  
Keyword(s):  
Systematic Review ◽  
Health And Disease

scholarly journals Gut Microbiota, Probiotics and Psychological States and Behaviors after Bariatric Surgery—A Systematic Review of Their Interrelation

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2396
Author(s):  
Jessica Cook ◽  
Christine Lehne ◽  
Alisa Weiland ◽  
Rami Archid ◽  
Yvonne Ritze ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bariatric Surgery ◽  
Treatment Success ◽  
Alpha Diversity ◽  
Psychological States ◽  
Behavioral Parameters ◽  
Probiotic Strains ◽  
Health And Disease ◽  
And Behavior ◽  
The Impact

The gastrointestinal (GI) microbiota plays an important role in health and disease, including brain function and behavior. Bariatric surgery (BS) has been reported to result in various changes in the GI microbiota, therefore demanding the investigation of the impact of GI microbiota on treatment success. The goal of this systematic review was to assess the effects of BS on the microbiota composition in humans and other vertebrates, whether probiotics influence postoperative health, and whether microbiota and psychological and behavioral factors interact. A search was conducted using PubMed and Web of Science to find relevant studies with respect to the GI microbiota and probiotics after BS, and later screened for psychological and behavioral parameters. Studies were classified into groups and subgroups to provide a clear overview of the outcomes. Microbiota changes were further assessed for whether they were specific to BS in humans through the comparison to sham operated controls in other vertebrate studies. Changes in alpha diversity appear not to be specific, whereas dissimilarity in overall microbial community structure, and increases in the abundance of the phylum Proteobacteria and Akkermansia spp. within the phylum Verrucomicrobia after surgery were observed in both human and other vertebrates studies and may be specific to BS in humans. Human probiotic studies differed regarding probiotic strains and dosages, however it appeared that probiotic interventions were not superior to a placebo for quality of life scores or weight loss after BS. The relationship between GI microbiota and psychological diseases in this context is unclear due to insufficient available data.

scholarly journals Gastric Microbiota: Tracing the Culprit

2017 ◽  
Vol 90 (4) ◽  
pp. 369-376 ◽  
Author(s):  
Cristian Vasile Petra ◽  
Aronel Rus ◽  
Dan Lucian Dumitrașcu
Keyword(s):  
Current Knowledge ◽  
Scientific Evidence ◽  
Diagnostic Methods ◽  
Culture Independent ◽  
Long Time ◽  
Health And Disease ◽  
H Pylori ◽  
Insight Into ◽  
Gastric Microbiota ◽  
Entire Gastrointestinal Tract

The gastric environment has been long time considered bacteria-free, but the discovery of Helicobacter pylori (H. pylori) in 1982 superseded this conception. Over the last decades new diagnostic methods have been developed, starting with culture-dependent and advancing to culture-independent ones. These modern techniques provide new insight into the composition and influence of this ecosystem on the entire gastrointestinal tract. H. pylori is no longer considered the only microorganism in the stomach, other non-H. pylori microbial species may populate the same environment and exercise their role. Current knowledge suggests possible links of these bacteria with gastroduodenal diseases, such as peptic ulcer and gastric cancer but most of them need further scientific evidence. This review summarizes current information on these complex interrelations between gastric microbial communities and host in health and disease.

Helicobacter pylori and Other Gastric Microbiota in Gastroduodenal Pathologies

2016 ◽  
Vol 34 (3) ◽  
pp. 210-216 ◽  
Author(s):  
Christian Schulz ◽  
Kerstin Schütte ◽  
Peter Malfertheiner
Keyword(s):  
Helicobacter Pylori ◽  
Current Knowledge ◽  
Nucleotide Sequencing ◽  
Bacterial Survival ◽  
Gi Tract ◽  
Ulcer Disease ◽  
Health And Disease ◽  
Gastric Neoplasia ◽  
H Pylori ◽  
Gastric Microbiota

The discovery of Helicobacter pylori changed the traditional view of the stomach as a hostile organ to bacterial survival. H. pylori induces chronic gastritis, which has the potential to progress to severe complications such as peptic ulcer disease and gastric neoplasia. The development of modern nucleotide sequencing techniques and new biocomputational tools allow the possibility of studying the diversity and complexity of the microbiome in the whole gastrointestinal (GI) tract and overcome the limitations of culturing techniques. However, the differentiation of alive resident and transient microbes in the upper GI tract and their role in the pathogenesis of gastroduodenal diseases requires an analysis beyond the detection of bacterial genomic material alone. Metabolomic and transcriptomic analyses of the bacteria may add important insights into their interaction with the host. Currently, the interaction of H. pylori with other microbes in the stomach and duodenum and their role for health and disease is poorly understood. This review provides a concise overview on the current knowledge of H. pylori and other gastric microbiota in the relationship with gastroduodenal pathologies.

Pancreas volume in health and disease: a systematic review and meta-analysis

2018 ◽  
Vol 12 (8) ◽  
pp. 757-766 ◽  
Author(s):  
Steve V. DeSouza ◽  
Ruma G. Singh ◽  
Harry D. Yoon ◽  
Rinki Murphy ◽  
Lindsay D. Plank ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Health And Disease ◽  
Pancreas Volume

scholarly journals Current Explorations of Nutrition and the Gut Microbiome: A Systematic Review (P20-032-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Leigh Frame ◽  
Elise Costa ◽  
Scott Jackson
Keyword(s):  
Systematic Review ◽  
Gut Microbiome ◽  
Food Additives ◽  
Short Chain Fatty Acids ◽  
Healthy Adults ◽  
Future Research ◽  
Intestinal Transit Time ◽  
Food Components ◽  
Health And Disease

Abstract Objectives The ability to measure and describe the microbiome has led to a surge in information about the gut microbiome and its role in health and disease. The relationship between nutrition and the gut microbiome is central, as the diet is a source of microbiota, a source of fuel for the microbiota, and an indicator of the composition of the gut microbiome. We aim to assess the current understanding of the interactions between nutrition and the gut microbiome in healthy adults. A solid understanding of the interactions between nutrition and a healthy gut microbiome will form the foundation for understanding the role in disease prevention and treatment. Methods PubMed and Google Scholar searches for review articles relating to nutrition and the gut microbiome in healthy adults led to the inclusion of 38 articles in this systematic review. Results Much of the research has focused on carbohydrates in the form of dietary fiber, which are fuel for the gut microbiota. The beneficial effects of fiber have centered on Short Chain Fatty Acids (SCFAs) that are required by colonocytes (barrier function), improve absorption (minerals, water), and reduce intestinal transit time (colon cancer). Contrastingly, a low fiber, high protein diet promotes microbial protein metabolism, leading to potentially dangerous by-products that can stagnate in the gut. The bidirectional relationship between micronutrition and the gut microbiome is emerging. The microbiota utilize and produce micronutrients, leading to confounding relationships between nutritional status and biologic micronutrient concentrations, chiefly the B and K vitamins. While promising, the study of non-nutritive food components (polyphenols) and the gut microbiome is in its infancy. The role of other food components (food additives, contaminants) warrant exploration and are a significant research gap to-date. Conclusions Diet and nutrition have profound effects on the gut microbiome composition. This, in turn, affects a wide array of metabolic, hormonal, and neurological processes that influence our health and disease. Currently, there is no consensus in the scientific community on what defines a “healthy” gut microbiome. Future research must consider individual responses to diet and the role of diet in the response of the gut microbiome to interventions. Funding Sources N/A. Supporting Tables, Images and/or Graphs

scholarly journals Systematic review: ileoanal pouch microbiota in health and disease

2017 ◽  
Vol 47 (4) ◽  
pp. 466-477 ◽  
Author(s):  
J. P. Segal ◽  
S. Oke ◽  
G. L. Hold ◽  
S. K. Clark ◽  
O. D. Faiz ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ileoanal Pouch ◽  
Health And Disease
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