scholarly journals Integrin Targeting and Toxicological Assessment of Peptide-Conjugated Liposome Delivery Systems to Activated Endothelial Cells

2017 ◽  
Vol 120 (4) ◽  
pp. 380-389 ◽  
Author(s):  
Ali Kermanizadeh ◽  
Klaus Villadsen ◽  
Ragnhild G. Østrem ◽  
Knud J. Jensen ◽  
Peter Møller ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Delivery Systems ◽  
Toxicological Assessment

Encapsulation of VEGF165into magnetic PLGA nanocapsules for potential local delivery and bioactivity in human brain endothelial cells

2015 ◽  
Vol 3 (12) ◽  
pp. 2538-2544 ◽  
Author(s):  
E. Carenza ◽  
O. Jordan ◽  
P. Martínez-San Segundo ◽  
R. Jiřík ◽  
Z. Starčuk jr ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Endothelial Cells ◽  
Human Brain ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Therapeutic Angiogenesis ◽  
Delivery Systems ◽  
Local Delivery ◽  
Brain Endothelial Cells ◽  
Angiogenic Proteins

New drug delivery systems based on biodegradable magnetic nanocapsules for targeted delivery of pro-angiogenic proteins, potentially useful in therapeutic angiogenesis, are reported.

Multitargeting Gene Delivery Systems for Enhancing the Transfection of Endothelial Cells

2016 ◽  
Vol 37 (23) ◽  
pp. 1926-1931 ◽  
Author(s):  
Jing Yang ◽  
Qian Li ◽  
Xiao Yang ◽  
Yakai Feng ◽  
Xiangkui Ren ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Gene Delivery ◽  
Delivery Systems

scholarly journals Delivery Systems of Retinoprotective Proteins in the Retina

2021 ◽  
Vol 22 (10) ◽  
pp. 5344
Author(s):  
Ivan T. Rebustini ◽  
Alexandra Bernardo-Colón ◽  
Alejandra Isasi Nalvarte ◽  
S. Patricia Becerra
Keyword(s):  
Endothelial Cells ◽  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Delivery Systems ◽  
Rpe Cells ◽  
Retinal Tissue ◽  
Tissue Integrity ◽  
Pigment Epithelium Derived Factor ◽  
Degenerative Disorders

Retinoprotective proteins play important roles for retinal tissue integrity. They can directly affect the function and the survival of photoreceptors, and/or indirectly target the retinal pigment epithelium (RPE) and endothelial cells that support these tissues. Retinoprotective proteins are used in basic, translational and in clinical studies to prevent and treat human retinal degenerative disorders. In this review, we provide an overview of proteins that protect the retina and focus on pigment epithelium-derived factor (PEDF), and its effects on photoreceptors, RPE cells, and endothelial cells. We also discuss delivery systems such as pharmacologic and genetic administration of proteins to achieve photoreceptor survival and retinal tissue integrity.

Endotoxin Alteration of the Mucopolysaccharide Blood Vessel Coating in Rats

1974 ◽  
Vol 32 ◽  
pp. 148-149
Author(s):  
D. E. Philpott ◽  
A. Takahashi
Keyword(s):  
Skeletal Muscle ◽  
Endothelial Cells ◽  
Salivary Gland ◽  
Carotid Artery ◽  
Basement Membrane ◽  
Coronary Vessels ◽  
Ruthenium Red ◽  
E Coli ◽  
Old Rats ◽  
The Brain

Two month, eight month and two year old rats were treated with 10 or 20 mg/kg of E. Coli endotoxin I. P. The eight month old rats proved most resistant to the endotoxin. During fixation the aorta, carotid artery, basil arartery of the brain, coronary vessels of the heart, inner surfaces of the heart chambers, heart and skeletal muscle, lung, liver, kidney, spleen, brain, retina, trachae, intestine, salivary gland, adrenal gland and gingiva were treated with ruthenium red or alcian blue to preserve the mucopolysaccharide (MPS) coating. Five, 8 and 24 hrs of endotoxin treatment produced increasingly marked capillary damage, disappearance of the MPS coating, edema, destruction of endothelial cells and damage to the basement membrane in the liver, kidney and lung.

Complex Vesicles, Microtubules, and Cytoplasmic Filaments in the Endothelial Cells of Normal Dog Aorta

1968 ◽  
Vol 26 ◽  
pp. 172-173
Author(s):  
C. N. Sun ◽  
J. J. Ghidoni
Keyword(s):  
Electron Microscopy ◽  
Endothelial Cells ◽  
Cross Sections ◽  
Functional Significance ◽  
Tubular Structures ◽  
Aldehyde Fixation ◽  
Cytoplasmic Filaments

Endothelial cells in longitudinal and cross sections of aortas from 3 randomly selected “normal” mongrel dogs were studied by electron microscopy. Segments of aorta were distended with cold cacodylate buffered 5% glutaraldehyde for 10 minutes prior to being cut into small, well oriented tissue blocks. After an additional 1-1/2 hour period in glutaraldehyde, the tissue blocks were well rinsed in buffer and post-fixed in OsO4. After dehydration they were embedded in a mixture of Maraglas, D.E.R. 732, and DDSA.Aldehyde fixation preserves the filamentous and tubular structures (300 Å and less) for adequate demonstration and study. The functional significance of filaments and microtubules has been recently discussed by Buckley and Porter; the precise roles of these cytoplasmic components remains problematic. Endothelial cells in canine aortas contained an abundance of both types of structures.

Ultrastructural Alterations in Sinusoidal Endothelial Fenestrae as a Result of Hypoxia

1976 ◽  
Vol 34 ◽  
pp. 168-169
Author(s):  
Waykin Nopanitaya ◽  
Raeford E. Brown ◽  
Joe W. Grisham ◽  
Johnny L. Carson
Keyword(s):  
Endothelial Cells ◽  
Experimental Model ◽  
Hepatic Lobule ◽  
Ultrastructural Alterations ◽  
Large Type ◽  
Sinusoidal Endothelial Fenestrae ◽  
General Size ◽  
Sem Studies

Mammalian endothelial cells lining hepatic sinusoids have been found to be widely fenestrated. Previous SEM studies (1,2) have noted two general size catagories of fenestrations; large fenestrae were distributed randomly while the small type occurred in groups. These investigations also reported that large fenestrae were more numerous and larger in the endothelial cells at the afferent ends of sinusoids or around the portal areas, whereas small fenestrae were more numerous around the centrilobular portion of the hepatic lobule. It has been further suggested that under some physiologic conditions small fenestrae could fuse and subsequently become the large type, but this is, as yet, unproven.We have used a reproducible experimental model of hypoxia to study the ultrastructural alterations in sinusoidal endothelial fenestrations in order to investigate the origin of occurrence of large fenestrae.

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