Penile intraepithelial neoplasia, penile cancer precursors and human papillomavirus prevalence in symptomatic preputium: a cross-sectional study of 351 circumcised men in Sweden

Previous research has produced conflicting results regarding the association of bacterial vaginosis (BV) and cervical intraepithelial neoplasia (CIN). These studies have been weakened in their conclusions mainly by failure to adequately control for the presence of sexually transmitted infections (STIs). One proposed mechanism suggesting that carcinogenic nitrosamines acting either independently or via human papilloma virus (HPV) has not been fully tested previously. We undertook a prospective, case-controlled, cross-sectional study where the presence of STIs, in particular human papillomavirus (HPV) which is known to be associated with the development of CIN, was controlled for. Women with BV were not found to have CIN more frequently than women with normal vaginal flora and the quantities of nitrosamines produced by women with BV did not differ significantly from women without BV. We thus found that BV is not associated with CIN.

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The Association of Dietary Patterns with High-Risk Human Papillomavirus Infection and Cervical Cancer: A Cross-Sectional Study in Italy

10.20944/preprints201803.0109.v1 ◽

2018 ◽

Author(s):

Martina Barchitta ◽

Andrea Maugeri ◽

Annalisa Quattrocchi ◽

Ottavia Agrifoglio ◽

Aurora Scalisi ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

High Risk ◽

Mediterranean Diet ◽

Dietary Patterns ◽

Intraepithelial Neoplasia ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Logistic Regression Models

Specific foods and nutrients help prevent the progression from persistent high-risk human papillomavirus (hrHPV) infection to cervical cancer (CC). We aimed to focus on dietary patterns which may be associated with hrHPV status and risk of high-grade cervical intraepithelial neoplasia (CIN2+). Overall, 539 eligible women, including 127 CIN2+, were enrolled in a cross-sectional study, and tested for hrHPV infection. Food intakes were estimated using a food frequency questionnaire. Logistic regression models were applied. Using the Mediterranean Diet Score, we demonstrated that, among 252 women with normal cervical epithelium, medium adherence to Mediterranean diet decreased odds of hrHPV infection when compared to low adherence (adjOR=0.40, 95%CI=0.22-0.73). Using principle component analysis, we also identified two dietary patterns which explained 14.31% of variance. Women in the 3rd and 4th quartiles of the “western pattern” had higher odds of hrHPV infection when compared with 1st quartile (adjOR=1.77, 95%CI=1.04-3.54 and adjOR=1.97, 95%CI=1.14-4.18, respectively). Adjusting for hrHPV status and age, women in the 3rd quartile of the “prudent pattern” had lower odds of CIN2+ when compared with 1st quartile (OR=0.50, 95%CI=0.26-0.98). Our study is the first to demonstrate the association of dietary patterns with hrHPV infection and CC, discouraging unhealthy habits in favour of Mediterranean-like diet.

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A cross-sectional study exploring triage of human papillomavirus (HPV)-positive women by visual assessment, manual and computer-interpreted cytology, and HPV-16/18–45 genotyping in Cameroon

International Journal of Gynecological Cancer ◽

10.1136/ijgc-2020-002302 ◽

2021 ◽

pp. ijgc-2020-002302

Author(s):

Pierre Vassilakos ◽

Ania Wisniak ◽

Rosa Catarino ◽

Eveline Tincho Foguem ◽

Christine Balli ◽

...

Keyword(s):

Human Papillomavirus ◽

Intraepithelial Neoplasia ◽

Visual Assessment ◽

Cross Sectional Study ◽

Sectional Study ◽

Treatment Rate ◽

Cervical Intraepithelial Neoplasia Grade ◽

Cross Sectional ◽

Hpv 16 ◽

Referral Rates

BackgroundHigh-risk human papillomavirus (HPV)-positive women require triage to identify those at higher risk of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). We aimed to compare visual assessment of the cervix, manual cytology and automated cytology as triage tests to screen HPV-positive women, and to assess over-treatment rates after visual assessment and over-referral rates to colposcopy after cytology.MethodsThe present cross-sectional study is nested in a large prospective screening trial in Cameroon. Evaluations of the tests have been conducted individually and in combination with HPV-16/HPV-18/45 genotyping. For the evaluation of over-treatment and colposcopic over-referral, we simulated two screening scenarios: (1) one-visit scenario (test-triage-and-treatment); and (2) two-visit scenario (test-triage-and-colposcopy).Results1582 women with a median age of 40 years (IQR 35–45) performed self-sampling for HPV testing, of which 294 (18.6%) were HPV-positive, and 12.2% had CIN2+. Sensitivities for CIN2+ detection were 77.1% for visual assessment, 80.0% for manual cytology, and 84.8% for automated cytology. Sensitivity of combined tests was higher compared with single tests. The highest sensitivity was obtained by the combination of genotyping and automated cytology (91.2%). In the one-visit scenario, the over-treatment rate was 83.9% in referred women, with a ratio of 6.2 treated women per CIN2+. In the two-visit scenario, the lowest over-referral rate would have been under manual cytology (45.0%), with a ratio of 1.8 referred women per CIN2+. Single and combined triage strategies by automated cytology gave rise to over-referral rates of 69.2% and 76.7%, respectively, and a ratio of 3.2 and 4.3 referred women per CIN2+, respectively.DiscussionTriage of HPV-positive women using a combination of genotyping and automated cytology for CIN2+ detection may provide public benefits in low- and middle-income countries.

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Knowledge and awareness of human papillomavirus (HPV) among young adults – a cross-sectional study

Obstetrica şi Ginecologia ◽

10.26416/obsgin.68.2.3858 ◽

2020 ◽

Vol 2 (68) ◽

pp. 94

Author(s):

Larisa Tomescu ◽

Denis Şerban ◽

Nicoleta Nicolae ◽

Florina Borozan ◽

Ioan Sas

Keyword(s):

Young Adults ◽

Human Papillomavirus ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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Faculty Opinions recommendation of Comparison of the vaginal microbiota diversity of women with and without human papillomavirus infection: a cross-sectional study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718101776.793483171 ◽

2013 ◽

Author(s):

Steven Witkin

Keyword(s):

Human Papillomavirus ◽

Cross Sectional Study ◽

Vaginal Microbiota ◽

Sectional Study ◽

Cross Sectional ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection ◽

Microbiota Diversity

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The association between human papillomavirus and cervical high‐grade cytology among HIV‐positive and HIV‐negative Tanzanian women: A cross‐sectional study

Acta Obstetricia Et Gynecologica Scandinavica ◽

10.1111/aogs.14102 ◽

2021 ◽

Author(s):

Patricia Swai ◽

Susanne K. Kjaer ◽

Bariki Mchome ◽

Rachel Manongi ◽

Sia E. Msuya ◽

...

Keyword(s):

Human Papillomavirus ◽

Cross Sectional Study ◽

Hiv Positive ◽

High Grade ◽

Sectional Study ◽

Cross Sectional ◽

Hiv Negative

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Nurses’ and midwives’ knowledge, attitudes, and acceptance regarding human papillomavirus vaccination in Ghana: a cross-sectional study

BMC Nursing ◽

10.1186/s12912-020-00530-x ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Nancy Innocentia Ebu ◽

Gifty Esinam Abotsi-Foli ◽

Doreen Faakonam Gakpo

Keyword(s):

Risk Factors ◽

Cervical Cancer ◽

Human Papillomavirus ◽

Hpv Vaccination ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Cancer Risk Factors ◽

Cervical Cancer Risk ◽

Nurses And Midwives

Abstract Background Nurses and midwives play important roles in educating the public on cervical cancer prevention strategies. Aim This study sought to assess nurses’ and midwives’ knowledge of, attitudes towards, and acceptance of human papillomavirus (HPV) vaccination in relation to their background characteristics. Methods A descriptive cross-sectional study using questionnaires was conducted with a convenience sample of 318 female nurses and midwives, ages 20 to 59, at the Korle-Bu Teaching Hospital in Ghana. The data were summarised using frequencies, percentages, chi-square tests, and Fisher’s exact tests. Results The results indicated that 41.5% (n = 132) of the participants had high levels of knowledge about cervical cancer risk factors, and 17.6% (n = 56) of the respondents had received at least one dose of the HPV vaccine. Reasons for receiving the HPV vaccination included advice from a colleague (12.9%, n = 41) and perceived threat of cervical cancer (11.7%, n = 37). Of the 262 respondents who had not been vaccinated, 24.45% (n = 78) strongly agreed and 28.0% (n = 89) agreed with the statement that there was limited information on HPV vaccination. Also, there were statistically significant associations between age (X2 = 23.746, p = 0.001), marital status (X2 = 14.758, p = 0.005), completed level of education (X2 = 21.692, p = 0.001), and duration of working at the hospital (X2 = 8.424, p = 0.038) and acceptance of HPV vaccination. Conclusions This study demonstrated gaps in knowledge about cervical cancer risk factors and attitudes towards HPV vaccination, indicating the need for targeted measures to improve knowledge and attitudes. Also, measures to increase acceptance of HPV vaccination among nurses and midwives should consider their sociodemographic characteristics.

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