The association between human papillomavirus and cervical high‐grade cytology among HIV‐positive and HIV‐negative Tanzanian women: A cross‐sectional study

Author(s):  
Patricia Swai ◽  
Susanne K. Kjaer ◽  
Bariki Mchome ◽  
Rachel Manongi ◽  
Sia E. Msuya ◽  
...  
2020 ◽  
Author(s):  
Tafadzwa G Dhokotera ◽  
Julia Bohlius ◽  
Matthias Egger ◽  
Adrian Spoerri ◽  
Jabulani Ncayiyana ◽  
...  

Objective: To determine the spectrum of cancers in AYAs living with HIV in South Africa compared to their HIV negative peers. Design: Cross sectional study with cancer data provided by the National Cancer Registry and HIV data from the National Health Laboratory Service. Setting and participants: The NHLS is the largest provider of pathology services in the South African public sector with an estimated coverage of 80%. The NCR is a division of the NHLS. We included AYAs (aged 10-24 years) diagnosed with cancer by public health sector laboratories between 2004 and 2014 (n=8 479). We included 3 672 in the complete case analysis. Primary and secondary outcomes: We used linked NCR and NHLS data to determine the spectrum of cancers by HIV status in AYAs. We also used multivariable logistic regression to describe the association of cancer in AYAs with HIV, adjusting for age, sex (as appropriate), ethnicity, and calendar period. Due to the large proportion of unknown HIV status we also imputed (post-hoc) the missing HIV status. Results: From 2004-2014, 8 479 AYAs were diagnosed with cancer, HIV status was known for only 45% (n=3812); of those whose status was known, about half were HIV positive (n=1853). AYAs living with HIV were more likely to have Kaposi's sarcoma (adjusted odds ratio (aOR) 218, 95% CI 89.9-530), cervical cancer (aOR 2.18, 95% CI 1.23-3.89), non-Hodgkin's lymphoma (aOR 2.12, 95% CI 1.69-2.66), and anogenital cancers other than cervix (aOR 2.73, 95% CI 1.27-5.86). About 44% (n=1 062) of AYAs with HIV related cancers had not been tested for HIV, though they were very likely to have the disease. Conclusions: Cancer burden in AYAs living with HIV in South Africa could be reduced by screening young women for cervical cancer and vaccinating them against human papilloma virus (HPV) infection.


PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e102138 ◽  
Author(s):  
Jason J. Ong ◽  
Tim R. H. Read ◽  
Lenka A. Vodstrcil ◽  
Sandra Walker ◽  
Marcus Chen ◽  
...  

2019 ◽  
Vol 147 ◽  
Author(s):  
X. Liu ◽  
H. Lin ◽  
X. Chen ◽  
W. Shen ◽  
X. Ye ◽  
...  

AbstractThis study aims to investigate the prevalence and genotype distribution of anal human papillomavirus (HPV) infection among men with different sexual orientations with or without human immunodeficiency virus (HIV) in China. A cross-sectional study was conducted during 2016–2017 in Taizhou City, Zhejiang Province. Convenient sampling was used to recruit male participants from HIV voluntary counselling and testing clinics and Center for Disease Control and Prevention. A face-to-face questionnaire interview was administered and an anal-canal swab was collected for HPV genotyping. A total of 160 HIV-positive and 113 HIV-negative men participated in the study. The prevalence of any type HPV was 30.6% for heterosexual men, 74.1% for homosexual and 63.6% for bisexual men among HIV-positive participants, while the prevalence was 8.3%, 29.2% and 23.8% respectively among HIV-negatives. The most prevalent genotypes were HPV-58 (16.9%), HPV-6 (15.6%) and HPV-11 (15.0%) among HIV-positive men, and were HPV-16 (4.4%), HPV-52 (4.4%) and HPV-6 (3.5%) among HIV-negative men. Having ever had haemorrhoids and having ever seen blood on tissue after defaecation was associated with HPV infection. One-fourth of the HPV infections in this study population can be covered by the quadrivalent vaccine in market. The highly prevalent anal HPV infection among men especially HIV-infected men calls for close observation and further investigation for anal cancer prevention.


BMJ Open ◽  
2014 ◽  
Vol 4 (11) ◽  
pp. e004974 ◽  
Author(s):  
Ana L R Valadares ◽  
Aarão M Pinto-Neto ◽  
Debora de C Gomes ◽  
Walquíria C D'Avanzo ◽  
Alexandre S Moura ◽  
...  

Author(s):  
Blanche Cunégonde Omgba Etoundi ◽  
Lionel Fabrice Djomkam Youmsi ◽  
Danielle Émilie Mbock ◽  
Valère Cynthia Kayo Tayou ◽  
Martin Luther Koanga Mogtomo

Background: The increased nutritional needs associated with the initiation of antiretroviral therapy exposes HIV-positive patients to an uncontrolled diet. This places them at an increased risk for diabetes mellitus and highlights the role of nutritional habits in the development of diabetes mellitus amongst HIV patients. Aim: In this study, we sought to investigate the feeding habits and their effect on the occurrence of diabetes amongst HIV-positive patients at the Nylon District hospital. Materials and Methods: A hospital-based cross-sectional study was carried out over eight months. A total of 182 participants were randomly selected of which 134 were HIV-positive and 48 HIV-negative. Blood samples were collected after at least an eight-hour fast. Results: The prevalence of diabetes in the HIV-positive group was 19 % compared to 10 % in the HIV-negative group. The total cholesterol and triglyceride levels were higher in HIV-negative participants compared to HIV-positive participants. Consumption of dairy products more than once per day (OR= 0.71, 95 % CI: 0.27-1.89), vegetable consumption more than once per day (OR= 0.79, 95 % CI: 0.25-2.56), more than one meal per day (OR= 0.13 95% CI: 0.02-1.04), breakfast more than twice per week (OR= 0.91 95 % CI: 0.2-4.11), and practicing physical exercise (OR= 0.7 95 % CI: 0.28-1.78), reduced the odds of having diabetes in HIV positive participants. Conclusion: The HIV status has an impact on the occurrence of diabetes mellitus in these patients, and it is highly associated with the feeding habits and the lifestyle of these patients. Keywords: HIV, diabetes mellitus, feeding habits, lifestyle, lipid profile.


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