scholarly journals E‐cigarettes and head and neck cancers: A systematic review of the current literature

2019 ◽  
Vol 44 (5) ◽  
pp. 749-756 ◽  
Author(s):  
Susanne Flach ◽  
Pavithran Maniam ◽  
Jaiganesh Manickavasagam
Keyword(s):  
Systematic Review ◽  
Head And Neck ◽  
Current Literature ◽  
Head And Neck Cancers

scholarly journals Systematic review and evidence synthesis of non-cervical human papillomavirus-related disease health system costs and quality of life estimates

2018 ◽  
Vol 95 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Koh Jun Ong ◽  
Marta Checchi ◽  
Lorna Burns ◽  
Charlotte Pavitt ◽  
Maarten J Postma ◽  
...  
Keyword(s):  
Systematic Review ◽  
Human Papillomavirus ◽  
Head And Neck ◽  
Anal Cancer ◽  
Penile Cancer ◽  
Vulvar Cancer ◽  
Head And Neck Cancers ◽  
Economic Evaluations ◽  
Anogenital Warts ◽  
Utility Elicitation

BackgroundMany economic evaluations of human papillomavirus vaccination should ideally consider multiple disease outcomes, including anogenital warts, respiratory papillomatosis and non-cervical cancers (eg, anal, oropharyngeal, penile, vulvar and vaginal cancers). However, published economic evaluations largely relied on estimates from single studies or informal rapid literature reviews.MethodsWe conducted a systematic review of articles up to June 2016 to identify costs and utility estimates admissible for an economic evaluation from a single-payer healthcare provider’s perspective. Meta-analyses were performed for studies that used same utility elicitation tools for similar diseases. Costs were adjusted to 2016/2017 US$.ResultsSixty-one papers (35 costs; 24 utilities; 2 costs and utilities) were selected from 10 742 initial records. Cost per case ranges were US$124–US$883 (anogenital warts), US$6912–US$52 579 (head and neck cancers), US$12 936–US$51 571 (anal cancer), US$17 524–34 258 (vaginal cancer), US$14 686–US$28 502 (vulvar cancer) and US$9975–US$27 629 (penile cancer). The total cost for 14 adult patients with recurrent respiratory papillomatosis was US$137 601 (one paper).Utility per warts episode ranged from 0.651 to 1 (12 papers, various utility elicitation methods), with pooled mean EQ-5D and EQ-VAS of 0.86 (95% CI 0.85 to 0.87) and 0.74 (95% CI 0.74 to 0.75), respectively. Fifteen papers reported utilities in head and neck cancers with range 0.29 (95% CI 0.0 to 0.76) to 0.94 (95% CI 0.3 to 1.0). Mean utility reported ranged from 0.5 (95% CI 0.4 to 0.61) to 0.65 (95% CI 0.45 to 0.75) (anal cancer), 0.59 (95% CI 0.54 to 0.64) (vaginal cancer), 0.65 (95% CI 0.60 to 0.70) (vulvar cancer) and 0.79 (95% CI 0.74 to 0.84) (penile cancer).ConclusionsDifferences in values reported from each paper reflect variations in cancer site, disease stages, study population, treatment modality/setting and utility elicitation methods used. As patient management changes over time, corresponding effects on both costs and utility need to be considered to ensure health economic assumptions are up-to-date and closely reflect the case mix of patients.

scholarly journals Genetic Polymorphism of Head and Neck Cancers in African Populations: A Systematic Review

OTO Open ◽  
2020 ◽  
Vol 4 (3) ◽  
pp. 2473974X2094220
Author(s):  
Eyituoyo Okoturo ◽  
Anslem Osasuyi ◽  
Taofiq Opaleye
Keyword(s):  
Systematic Review ◽  
Head And Neck ◽  
Candidate Genes ◽  
Head And Neck Cancers ◽  
Current Evidence ◽  
African Countries ◽  
Study Objective ◽  
Mesh Terms ◽  
Incidence And Mortality ◽  
African Populations

Objective Head and neck cancers are mostly composed of head and neck squamous cell carcinoma (HNSCC). The incidence and mortality of HNSCC are higher in countries with emerging health care systems, particularly Africa. Given that they are more genetically diverse, characterization of polymorphism in African HNSCC may result in the identification of distinct molecular targets as compared with the known HNSCC candidate genes. This study objective is to review the current evidence of genetic data on HNSCC among African populations as well as to demonstrate any distinctions as compared with known candidate genes and to appraise any research gaps. Data Sources Publications that interrogated susceptible gene polymorphisms to African-based populations with cancer were reviewed for this study. Review Methods Our search methodology was modeled after the Cochrane systematic review protocol, which included MeSH terms and keywords related to cancer, polymorphisms, and African countries. Results Seven articles studying 2 HNSCC cancer types in 3 of 54 African countries met the inclusion criteria. Thirteen polymorphisms from 10 genes were screened ( NOS3, CYP1A1, CYP2D6, NAT1, NAT2, NQO1, IL-10, IL-12, IL-8, COX2). All articles were screened for polymorphisms based on a polymerase chain reaction–based technique. All polymorphs suggested association to HNSCC, with 10 of 13 polymorphs demonstrating a statistically significant association. Conclusion Studies on known HNSCC candidate genes should be undertaken in Africa, particularly among sub-Saharan Africans. Importantly, these studies should be large scale with multiple HNC sites and with use of high-throughput methods.

SBRT for Primary Head and Neck Cancers: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 108 (3) ◽  
pp. e834
Author(s):  
N. Malik ◽  
M. Kim ◽  
H. Chen ◽  
I. Poon ◽  
Z.A. Husain ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck ◽  
Meta Analysis ◽  
Head And Neck Cancers

scholarly journals Hyperthermia and radiotherapy in the management of head and neck cancers: A systematic review and meta-analysis

2015 ◽  
Vol 32 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Niloy R. Datta ◽  
Susanne Rogers ◽  
Silvia Gómez Ordóñez ◽  
Emsad Puric ◽  
Stephan Bodis
Keyword(s):  
Systematic Review ◽  
Head And Neck ◽  
Meta Analysis ◽  
Head And Neck Cancers

scholarly journals Systematic review and meta-analysis of radiotherapy in various head and neck cancers: Comparing photons, carbon-ions and protons

2011 ◽  
Vol 37 (3) ◽  
pp. 185-201 ◽  
Author(s):  
Bram L.T. Ramaekers ◽  
Madelon Pijls-Johannesma ◽  
Manuela A. Joore ◽  
Piet van den Ende ◽  
Johannes A. Langendijk ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck ◽  
Meta Analysis ◽  
Head And Neck Cancers ◽  
Carbon Ions
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