Genetic Polymorphism of Head and Neck Cancers in African Populations: A Systematic Review

Objective Head and neck cancers are mostly composed of head and neck squamous cell carcinoma (HNSCC). The incidence and mortality of HNSCC are higher in countries with emerging health care systems, particularly Africa. Given that they are more genetically diverse, characterization of polymorphism in African HNSCC may result in the identification of distinct molecular targets as compared with the known HNSCC candidate genes. This study objective is to review the current evidence of genetic data on HNSCC among African populations as well as to demonstrate any distinctions as compared with known candidate genes and to appraise any research gaps. Data Sources Publications that interrogated susceptible gene polymorphisms to African-based populations with cancer were reviewed for this study. Review Methods Our search methodology was modeled after the Cochrane systematic review protocol, which included MeSH terms and keywords related to cancer, polymorphisms, and African countries. Results Seven articles studying 2 HNSCC cancer types in 3 of 54 African countries met the inclusion criteria. Thirteen polymorphisms from 10 genes were screened ( NOS3, CYP1A1, CYP2D6, NAT1, NAT2, NQO1, IL-10, IL-12, IL-8, COX2). All articles were screened for polymorphisms based on a polymerase chain reaction–based technique. All polymorphs suggested association to HNSCC, with 10 of 13 polymorphs demonstrating a statistically significant association. Conclusion Studies on known HNSCC candidate genes should be undertaken in Africa, particularly among sub-Saharan Africans. Importantly, these studies should be large scale with multiple HNC sites and with use of high-throughput methods.

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Consequences of the COVID-19 Syndemic for Nutritional Health: A Systematic Review

Nutrients ◽

10.3390/nu13041168 ◽

2021 ◽

Vol 13 (4) ◽

pp. 1168

Author(s):

Cristian Neira ◽

Rejane Godinho ◽

Fabio Rincón ◽

Rodrigo Mardones ◽

Janari Pedroso

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Preventive Measures ◽

Physical Contact ◽

Current Evidence ◽

Study Objective ◽

Eating Style ◽

Healthy Nutrition ◽

Meta Analyses ◽

The Impact

Confinement at home, quarantine, and social distancing are some measures adopted worldwide to prevent the spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2), which has been generating an important alteration in the routines and qualities of life of people. The impact on health is still being evaluated, and consequences in the nutritional field are not entirely clear. The study objective was to evaluate the current evidence about the impact that preventive measures of physical contact restriction causes in healthy nutrition. A systematic review was carried out according to the “Preferred Reporting Items for Systematic Reviews and Meta-Analyses” PRISMA Group and Cochrane method for rapid systematic reviews. Searching was performed in six electronic databases and evaluated articles published between 2010 and 2020, including among their participants adult subjects who had been exposed to the preventive measures of physical contact restriction. Seven studies met the selection criteria and reported an overall increase in food consumption, weight, Body Mass Index (BMI), and a change in eating style. Findings suggest that healthy nutrition is affected by preventive measures to restrict physical contact as a result of the COVID-19 syndemic.

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Predicting extracapsular spread of head and neck cancers using different imaging techniques: a systematic review and meta-analysis

International Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.ijom.2015.11.021 ◽

2016 ◽

Vol 45 (4) ◽

pp. 413-421 ◽

Cited By ~ 26

Author(s):

Z. Su ◽

Z. Duan ◽

W. Pan ◽

C. Wu ◽

Y. Jia ◽

...

Keyword(s):

Systematic Review ◽

Head And Neck ◽

Imaging Techniques ◽

Meta Analysis ◽

Head And Neck Cancers ◽

Extracapsular Spread

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P-52 The Effect of Prophylactic Low Level Laser Therapy on Oral Mucositis Following Chemoradiotherapy in Head and Neck Cancers: A Systematic Review

Oral Oncology ◽

10.1016/s1368-8375(21)00340-7 ◽

2021 ◽

Vol 118 ◽

pp. 8

Author(s):

Ahmed Subeh ◽

Hassan Baig ◽

Qaisar Khan ◽

Abdulaziz Alfailakawi

Keyword(s):

Systematic Review ◽

Head And Neck ◽

Laser Therapy ◽

Oral Mucositis ◽

Head And Neck Cancers ◽

Low Level Laser Therapy ◽

Low Level ◽

Low Level Laser ◽

Level Laser

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Systematic review and evidence synthesis of non-cervical human papillomavirus-related disease health system costs and quality of life estimates

Sexually Transmitted Infections ◽

10.1136/sextrans-2018-053606 ◽

2018 ◽

Vol 95 (1) ◽

pp. 28-35 ◽

Cited By ~ 2

Author(s):

Koh Jun Ong ◽

Marta Checchi ◽

Lorna Burns ◽

Charlotte Pavitt ◽

Maarten J Postma ◽

...

Keyword(s):

Systematic Review ◽

Human Papillomavirus ◽

Head And Neck ◽

Anal Cancer ◽

Penile Cancer ◽

Vulvar Cancer ◽

Head And Neck Cancers ◽

Economic Evaluations ◽

Anogenital Warts ◽

Utility Elicitation

BackgroundMany economic evaluations of human papillomavirus vaccination should ideally consider multiple disease outcomes, including anogenital warts, respiratory papillomatosis and non-cervical cancers (eg, anal, oropharyngeal, penile, vulvar and vaginal cancers). However, published economic evaluations largely relied on estimates from single studies or informal rapid literature reviews.MethodsWe conducted a systematic review of articles up to June 2016 to identify costs and utility estimates admissible for an economic evaluation from a single-payer healthcare provider’s perspective. Meta-analyses were performed for studies that used same utility elicitation tools for similar diseases. Costs were adjusted to 2016/2017 US$.ResultsSixty-one papers (35 costs; 24 utilities; 2 costs and utilities) were selected from 10 742 initial records. Cost per case ranges were US$124–US$883 (anogenital warts), US$6912–US$52 579 (head and neck cancers), US$12 936–US$51 571 (anal cancer), US$17 524–34 258 (vaginal cancer), US$14 686–US$28 502 (vulvar cancer) and US$9975–US$27 629 (penile cancer). The total cost for 14 adult patients with recurrent respiratory papillomatosis was US$137 601 (one paper).Utility per warts episode ranged from 0.651 to 1 (12 papers, various utility elicitation methods), with pooled mean EQ-5D and EQ-VAS of 0.86 (95% CI 0.85 to 0.87) and 0.74 (95% CI 0.74 to 0.75), respectively. Fifteen papers reported utilities in head and neck cancers with range 0.29 (95% CI 0.0 to 0.76) to 0.94 (95% CI 0.3 to 1.0). Mean utility reported ranged from 0.5 (95% CI 0.4 to 0.61) to 0.65 (95% CI 0.45 to 0.75) (anal cancer), 0.59 (95% CI 0.54 to 0.64) (vaginal cancer), 0.65 (95% CI 0.60 to 0.70) (vulvar cancer) and 0.79 (95% CI 0.74 to 0.84) (penile cancer).ConclusionsDifferences in values reported from each paper reflect variations in cancer site, disease stages, study population, treatment modality/setting and utility elicitation methods used. As patient management changes over time, corresponding effects on both costs and utility need to be considered to ensure health economic assumptions are up-to-date and closely reflect the case mix of patients.

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Incidence and Mortality of Acute Respiratory Distress Syndrome in Patients With Burns: A Systematic Review and Meta-Analysis

Frontiers in Medicine ◽

10.3389/fmed.2021.709642 ◽

2021 ◽

Vol 8 ◽

Author(s):

Baoli Wang ◽

Wei Chenru ◽

Yong Jiang ◽

Lunyang Hu ◽

He Fang ◽

...

Keyword(s):

Systematic Review ◽

Mechanical Ventilation ◽

Acute Respiratory Distress Syndrome ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Distress Syndrome ◽

Meta Analysis ◽

Inhalation Injury ◽

African Countries ◽

Incidence And Mortality

Objective: We conducted a systematic review and meta-analysis to comprehensively estimate the incidence and mortality of acute respiratory distress syndrome (ARDS) in overall and subgroups of patients with burns.Data sources: Pubmed, Embase, the Cochrane Library, CINAHL databases, and China National Knowledge Infrastructure database were searched until September 1, 2021.Study selection: Articles that report study data on incidence or mortality of ARDS in patients with burns were selected.Data extraction: Two researchers independently screened the literature, extracted data, and assessed the quality. We performed a meta-analysis of the incidence and mortality of ARDS in patients with burns using a random effects model, which made subgroup analysis according to the study type, inclusion (mechanical ventilation, minimal burn surface), definitions of ARDS, geographic location, mean age, burn severity, and inhalation injury. Primary outcomes were the incidence and mortality of burns patients with ARDS, and secondary outcomes were incidence for different subgroups.Data synthesis: Pooled weighted estimate of the incidence and mortality of ARDS in patients with burns was 0.24 [95% confidence interval (CI)0.2–0.28] and 0.31 [95% CI 0.18−0.44]. Incidences of ARDS were obviously higher in patients on mechanical ventilation (incidence = 0.37), diagnosed by Berlin definition (incidence = 0.35), and with over 50% inhalation injury proportion (incidence = 0.41) than in overall patients with burns. Patients with burns who came from western countries and with inhalation injury have a significantly higher incidence of ARDS compared with those who came from Asian/African countries (0.28 vs. 0.25) and without inhalation injury (0.41 vs. 0.24).Conclusion: This systematic review and meta-analysis revealed that the incidence of ARDS in patients with burns is 24% and that mortality is as high as 31%. The incidence rates are related to mechanical ventilation, location, and inhalation injury. The patients with burns from western countries and with inhalation injury have a significantly higher incidence than patients from Asian/African countries and without inhalation injury.Systematic Review Registration: identifier: CRD42021144888.

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