PCSK9 inhibitor therapy: A systematic review and meta‐analysis of metabolic and cardiovascular outcomes in patients with diabetes

2019 ◽  
Vol 21 (4) ◽  
pp. 903-908 ◽  
Author(s):  
Matteo Monami ◽  
Giorgio Sesti ◽  
Edoardo Mannucci
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Cardiovascular Outcomes ◽  
Inhibitor Therapy ◽  
Pcsk9 Inhibitor ◽  
Patients With Diabetes

Effects of wearable technology on patients with diabetes: A systematic review and meta-analysis (Preprint)

2020 ◽  
Author(s):  
Dongjun Wu ◽  
Nicholas Buys ◽  
Guandong Xu ◽  
Jing Sun
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Relapse Prevention ◽  
Diabetes Management ◽  
Meta Analysis ◽  
Intervention Group ◽  
Wearable Technologies ◽  
Patients With Diabetes ◽  
Hba1c Levels

UNSTRUCTURED Aims: This systematic review and meta-analysis aimed to evaluate the effects of wearable technologies on HbA1c, blood pressure, body mass index (BMI), and fastening blood glucose (FBG) in patients with diabetes. Methods: We searched PubMed, Scopus, Embase, the Cochrane database, and the Chinese CNKI database from last 15 years until August 2021. The quality of the 16 included studies was assessed using the PEDro scale, and random effect models were used to estimate outcomes, with I2 used for heterogeneity testing. Results: A significant reduction in HbA1c (-0.475% [95% CI -0.692 to -0.257, P<0.001]) was found following telemonitoring. However, the results of the meta-analysis did not show significant changes in blood pressure, BMI, and glucose, in the intervention group (P>0.05), although the effect size for systolic blood pressure (0.389) and diastolic blood pressure may indicate a significant effect. Subgroup analysis revealed statistically significant effects of wearable technologies on HbA1c when supported by dietetic interventions (P<0.001), medication monitoring (P<0.001), and relapse prevention (P<0.001). Online messages and telephone interventions significantly affected HbA1c levels (P<0.001). Trials with additional online face-to-face interventions showed greater reductions in HbA1c levels. Remote interventions including dietetic advice (P<0.001), medication (P<0.001), and relapse prevention (P<0.001) during telemonitoring showed a significant effect on HbA1c, particularly in patients attending ten or more intervention sessions (P<0.001). Conclusion: Wearable technologies can improve diabetes management by simplifying self-monitoring, allowing patients to upload their live measurement results frequently and thereby improving the quality of telemedicine. Wearable technologies also facilitate remote medication management, dietetic interventions, and relapse prevention.

scholarly journals PCV40 Cardiovascular Outcomes Associated with Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis

2021 ◽  
Vol 24 ◽  
pp. S74
Author(s):  
H. Alkofide ◽  
R. Almesned ◽  
L. Alnoghaimshi ◽  
Z. Alkherb ◽  
G. Alhindi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Cardiovascular Outcomes

scholarly journals Effect of omega-3 fatty acids on cardiovascular outcomes: A systematic review and meta-analysis

2021 ◽  
pp. 100997
Author(s):  
Safi U. Khan ◽  
Ahmad N. Lone ◽  
Muhammad Shahzeb Khan ◽  
Salim S. Virani ◽  
Roger S. Blumenthal ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fatty Acids ◽  
Meta Analysis ◽  
Cardiovascular Outcomes ◽  
Omega 3 Fatty Acids ◽  
Omega 3

Abstract 20: The Effect of Resistance Training on Survival and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 11 (suppl_1) ◽  
Author(s):  
Farzane Saeidifard ◽  
Jose R Medina Inojosa ◽  
Colin P West ◽  
Thomas P Olson ◽  
Virend K Somers ◽  
...  
Keyword(s):  
Systematic Review ◽  
Heart Disease ◽  
Resistance Training ◽  
Subgroup Analysis ◽  
Cancer Mortality ◽  
Meta Analysis ◽  
Cardiovascular Outcomes ◽  
Risk Of Bias ◽  
Cochrane Central Register ◽  
All Cause Mortality

Background: This is the first systematic review and meta-analysis to investigate the effect of resistance training (RT) on survival and other cardiovascular outcomes including ischemic heart disease events and stroke. Methods: An experienced librarian searched databases up to September 25 th , 2017, for randomized trials and cohort studies that evaluated the effect of RT on survival and cardiovascular events in the general population. The databases included Ovid MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus. Two investigators conducted the screening process independently and in duplicate. Cochrane tools were used to assess the risk of bias in clinical trials and observational studies. We calculated hazard ratios and 95% confidence intervals using RevMan and fixed and random effect models and had a subgroup analysis based on doses of RT and for the combination of RT and aerobic exercise (AE) vs no exercise. Results: The search identified 1429 studies from which 10 (one randomized trial) met the inclusion criteria, including 338,254 participants with a mean follow up of 8.14 years. The meta-analysis showed that RT, in comparison with no exercises, is associated with 24% lower all-cause mortality and 48% lower mortality when combined with AE. Based on subgroup analysis, performing 1-2 sessions of RT/week is associated with lower all-cause mortality by 28% (HR 0.72, 95% CI 0.66-0.78) whereas > 5 sessions of RT/week has no association with all-cause mortality (HR 0.99, 95% CI 0.76-1.31). Further, RT alone or combined with AE is associated with lower CV mortality compared to no exercise (Figures). Finally, RT alone also showed a borderline association with lower all-cancer mortality. Heterogeneity was present for several comparisons, and subsequent analysis will explore sources of this variability. Using study design-specific Cochrane risk of bias tools, no major sources of bias were identified in the included studies. One cohort study looked at the effect of RT on coronary heart disease events and found 23% risk reduction in men, while no study specifically assessed the effect of RT on cerebrovascular outcomes. Conclusion: RT is associated with lower all-cause, CV and all-cancer mortality. RT appears to have an additive effect when combined with AE.

Sign in / Sign up

Export Citation Format

Share Document