Anti‐acne vulgaris effects of chlorogenic acid by anti‐inflammatory activity and lipogenesis inhibition

2021 ◽  
Author(s):  
Jiao Luo ◽  
Weiyi He ◽  
Xuan Li ◽  
Xunmin Ji ◽  
Jiabang Liu
Keyword(s):  
Chlorogenic Acid ◽  
Acne Vulgaris ◽  
Inflammatory Activity ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-κB pathway inhibition: Contribution of chlorogenic acid

2013 ◽  
Vol 148 (1) ◽  
pp. 126-134 ◽  
Author(s):  
Vera Francisco ◽  
Gustavo Costa ◽  
Artur Figueirinha ◽  
Carla Marques ◽  
Paulo Pereira ◽  
...  
Keyword(s):  
Chlorogenic Acid ◽  
Nuclear Factor Κb ◽  
Inflammatory Activity ◽  
Nuclear Factor ◽  
Cymbopogon Citratus ◽  
Anti Inflammatory ◽  
Pathway Inhibition

scholarly journals Anti-inflammatory Activity and Phytochemical Profile of Galinsoga Parviflora Cav.

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2133 ◽  
Author(s):  
Elżbieta Studzińska-Sroka ◽  
Marlena Dudek-Makuch ◽  
Justyna Chanaj-Kaczmarek ◽  
Natasza Czepulis ◽  
Katarzyna Korybalska ◽  
...  
Keyword(s):  
Wound Healing ◽  
Endothelial Cells ◽  
Chlorogenic Acid ◽  
Cell Function ◽  
Complete Healing ◽  
Inflammatory Activity ◽  
Isolation And Identification ◽  
Endothelial Cell Function ◽  
Phytochemical Profile ◽  
Anti Inflammatory

The objective of this study was to evaluate the usefulness of a hydroalcoholic extract from Galinsoga parviflora herb (GP) in some aspects of the endothelial cell function necessary for anti-inflammatory activity and wound healing and relate these to the GP phytochemical profile. This study demonstrated that the GP extract caused a dose-dependent reduction of IL-6 secretion on IL-1β-stimulated endothelial cells. The IL-6 release was decreased to 33% ± 9% while this did not influence the IL-6 secretion without stimulation. Additionally, the GP extract exhibited an anti-hyaluronidase activity (IC50 = 0.47 mg/mL), which was evidently stronger than the positive control kaempferol (IC50 = 0.78 mg/mL) as well as a moderate and concentration-dependent, antioxidant activity. The results of the scratch assay showed that exposure of the endothelial cells to GP induced complete healing of the damage after 12 h of the study. The phytochemical profile of the extract was studied by using spectrophotometric (total amount of polyphenols and flavonoids) and UPLC (phenolic acids) methods. The main compound in the GP extract was a chlorogenic acid (2.00 ± 0.01 mg/g by UPLC). The total content of polyphenols was 98.30 ± 0.14 mg of chlorogenic acid equivalent/g of the dry herb and content of flavonoids amounted to 6.15 ± 0.41 mg quercetin equivalent/g of the dry herb. Moreover, the presence of flavonoids in G. parviflora was provided after their isolation and identification by spectroscopic methods. In conclusion, it demonstrated that application of GP in the treatment of skin lesions gives possibility of wound healing based on antioxidant, anti-inflammatory, and hyaluronidase-inhibiting activities of G. parviflora herb extract.

scholarly journals Administration of chlorogenic acid alleviates spinal cord injury via TLR4/NF‑κB and p38 signaling pathway anti‑inflammatory activity

2017 ◽  
Author(s):  
Dayong Chen ◽  
Dan Pan ◽  
Shaolong Tang ◽  
Zhihong Tan ◽  
Yanan Zhang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chlorogenic Acid ◽  
Signaling Pathway ◽  
Inflammatory Activity ◽  
Cord Injury ◽  
Anti Inflammatory

scholarly journals Antioxidant and Anti-Inflammatory activity of Chlorogenic Acid on Lead-Induced Fibroblast Cells

2019 ◽  
Vol 1374 ◽  
pp. 012006
Author(s):  
E Girsang ◽  
I N E Lister ◽  
C N Ginting ◽  
S L Nasution ◽  
S Suhartina ◽  
...  
Keyword(s):  
Chlorogenic Acid ◽  
Inflammatory Activity ◽  
Fibroblast Cells ◽  
Anti Inflammatory

scholarly journals Cecropia pachystachya: A Species with ExpressiveIn VivoTopical Anti-Inflammatory andIn VitroAntioxidant Effects

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Natália Ramos Pacheco ◽  
Nícolas de Castro Campos Pinto ◽  
Josiane Mello da Silva ◽  
Renata de Freitas Mendes ◽  
Juliana de Carvalho da Costa ◽  
...  
Keyword(s):  
Chlorogenic Acid ◽  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Reducing Power ◽  
Inflammatory Activity ◽  
Histopathological Analysis ◽  
Croton Oil ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Cecropia pachystachyais a species traditionally used in Brazil to treat inflammation. This work aims to evaluate the topical anti-inflammatory and antioxidant activities of the methanolic extract ofC. pachystachya(CPM) and to perform its chemical fingerprint by HPLC-DAD. The topical anti-inflammatory activity was evaluated using the mouse models of acute ear inflammation induced by croton oil, arachidonic acid, capsaicin, EPP, phenol, and chronic inflammation induced by multiple application of croton oil. Thein vitroantioxidant effect of CPM was investigated using DPPH, reducing power,β-carotene bleaching, and TBARS assays. HPLC analysis was performed to quantify the antioxidant phenolics orientin, isoorientin, and chlorogenic acid previously identified in CPM. CPM exhibited significant anti-inflammatory effect in the acute models, in some cases comparable to the reference drugs. Histopathological analysis showed a moderate chronic skin anti-inflammatory effect with decrease in vasodilation, edema, cell infiltration, and epidermal hyperproliferation. It also showed strongin vitroantioxidant activity. The contents of orientin, isoorientin, and chlorogenic acid were 66.5 ± 1.8, 118.8 ± 0.7, and 5.4 ± 0.2 µg/mg extract, respectively. The topical anti-inflammatory activity of CPM could be based on its antioxidant properties, although other effects are probably involved, including COX inhibition and other mechanisms.

scholarly journals Anti-Inflammatory Properties, Bioaccessibility and Intestinal Absorption of Sea Fennel (Crithmum maritimum) Extract Encapsulated in Soy Phosphatidylcholine Liposomes

Nutrients ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 210
Author(s):  
Ailén Alemán ◽  
Daniel Marín-Peñalver ◽  
Pilar Fernández de Palencia ◽  
María del Carmen Gómez-Guillén ◽  
Pilar Montero
Keyword(s):  
Chlorogenic Acid ◽  
Cell Monolayer ◽  
Inflammatory Activity ◽  
Polyphenolic Compound ◽  
Gastrointestinal Digestion ◽  
Phosphatidylcholine Liposomes ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Inflammatory Effect

A sea fennel (Crithmum maritimum) aqueous extract was prepared and loaded into soybean phosphatidylcholine liposomes. Both the free extract (FE), and the empty (L) and loaded (L-FE) liposomes were shown to be non-cytotoxic to THP-1 and Caco-2 cells. The anti-inflammatory effect was tested on THP-1 cells differentiated into macrophages. FE showed anti-inflammatory activity, revealed by the induced secretion of IL-10 cytokines in macrophages that were subsequently stimulated with LPS. Also, a decrease in TNF-α production by L was observed, evidencing that liposomes reduced the pro-inflammatory mediators’ secretion. The liposomes (L) showed protective anti-inflammatory activity and also were able to downregulate the inflammation. Furthermore, L-FE were also found to downregulate the inflammation response, as they were able to decrease TNF-α secretion in macrophages previously exposed to LPS. The simulated in vitro gastrointestinal digestion (GID) of FE diminished the chlorogenic acid content (the main polyphenolic compound of the extract) by 40%, while in L-FE, the amount of this phenolic compound increased with respect to the undigested liposomes. The amount of bioaccessible chlorogenic, however, was similar for FE and L-FE. The percentage of chlorogenic acid absorbed through a Caco-2 cell monolayer after 3 h of incubation, was significantly similar for the extract and the liposomes (~1.5%), without finding significant differences once the extract and liposomes were digested.

scholarly journals Anti-inflammatory activity of cationic peptides: application to the treatment of acne vulgaris

2006 ◽  
Vol 257 (1) ◽  
pp. 1-6 ◽  
Author(s):  
M. Marta Guarna ◽  
Richard Coulson ◽  
Evelina Rubinchik
Keyword(s):  
Acne Vulgaris ◽  
Inflammatory Activity ◽  
Cationic Peptides ◽  
Anti Inflammatory
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