Chronic polypharmacy at all age: a population‐based drug utilization study

Author(s):  
Jordan Guillot ◽  
Sandy Maumus‐Robert ◽  
Antoine Pariente ◽  
Julien Bezin

2018 ◽  
Vol 11 ◽  
pp. 175628481877794 ◽  
Author(s):  
Óskar Ö. Hálfdánarson ◽  
Anton Pottegård ◽  
Einar S. Björnsson ◽  
Sigrún H. Lund ◽  
Margret H. Ogmundsdottir ◽  
...  

Background: The use of proton-pump inhibitors (PPIs) has grown worldwide, and there are concerns about increased unsubstantiated long-term use. The aim of the study was to describe the real-world use of PPIs over the past decade in an entire national population. Methods: This was a nationwide population-based drug-utilization study. Patterns of outpatient PPI use among adults in Iceland between 2003 and 2015 were investigated, including annual incidence and prevalence, duration of use, and dose of tablet used (lower versus higher), as well as the proportion of PPI use attributable to gastroprotection. Results: We observed 1,372,790 prescription fills over the entire study period, of which 95% were for higher-dose PPIs. Annual incidence remained stable across time (3.3–4.1 per 100 persons per year), while the annual prevalence increased from 8.5 per 100 persons to 15.5 per 100 persons. Prevalence increased with patient age and was higher among women than men. Duration of treatment increased with patients’ age (36% of users over 80 years remained on treatment after 1 year compared with 13% of users aged 19–39 years), and was longer among those initiating on a higher dose compared with a lower dose. The proportion of PPI users concurrently using nonsteroidal anti-inflammatory drugs decreased over the study period, while the proportion concurrently using acetylsalicylic acid, oral anticoagulants, or platelet inhibitors increased. Conclusions: In this nationwide study, a considerable increase in overall outpatient use of PPIs over a 13-year period was observed, particularly among older adults. Patients were increasingly treated for longer durations than recommended by clinical guidelines and mainly with higher doses.



2019 ◽  
Vol 11 (3) ◽  
pp. 25-29
Author(s):  
Suyog S Chopade ◽  
◽  
Rahul P Bhavsar ◽  
Devendra R Chaudhari ◽  
Bapurao M Bite ◽  
...  


Author(s):  
Helene K. Jensen ◽  
Lotte Rasmussen ◽  
Kari Furu ◽  
Øystein Karlstad ◽  
Marie Linder ◽  
...  


Rheumatology ◽  
2014 ◽  
Vol 54 (5) ◽  
pp. 860-867 ◽  
Author(s):  
Nicholas Wilson ◽  
Lidia Sanchez-Riera ◽  
Rosa Morros ◽  
Adolfo Diez-Perez ◽  
M. Kassim Javaid ◽  
...  


2014 ◽  
Vol 3 (27) ◽  
pp. 7614-7624
Author(s):  
Mohammed Waseem Ahmed ◽  
Prashant Dass ◽  
Rameez Ahmed ◽  
Michell Gulabani


Author(s):  
Saumya Ramadas ◽  
M. B. Sujatha ◽  
M. A. Andrews ◽  
Sanalkumar K. B.

Background: Hypertension is a major independent risk factor for coronary artery disease, congestive heart failure, stroke, chronic kidney disease and peripheral vascular diseases if left untreated. Drug utilization study of antihypertensive drugs and the study on prevalence of blood pressure control would help in reducing the burden of the disease and health expenditure.Methods: The study was conducted in the Outpatient Department of Medicine in Government Medical College, Thrissur. Patients aged 18yrs or above diagnosed with hypertension, on antihypertensive drugs were enrolled in the study. Patients suffering from secondary hypertension and acutely ill were excluded. Patients were enrolled after taking an informed consent. Demographic data, present treatment for hypertension, associated co- morbid conditions if any, and treatment of the same were recorded. BP was recorded, and cost of treatment was calculated using CIMS.Results: A total of 250 patients were included in the study. Mono therapy was used in 64.8% patients and combination therapy in 35.2%. Overall drug utilization pattern showed that CCBs (42.8%) were most commonly prescribed, followed by ACEIs (32.4%) and ARBs (29.2%). Most commonly prescribed combination therapy was ACE I + BB (29.3%), followed by ARB + CCB (21.3%). Mean cost of antihypertensive drug therapy was 3057.8 Rs / yr. Recommended target BP was achieved in 49.6% of patients.Conclusions: The prescription pattern of antihypertensive drug was in accordance to the JNC-VIII guidelines. The blood pressure target was achieved only in less than 50% of patients.



2016 ◽  
Vol 49 (04) ◽  
pp. 155-161 ◽  
Author(s):  
O. Schjerning ◽  
A. Pottegård ◽  
P. Damkier ◽  
M. Rosenzweig ◽  
J. Nielsen


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