A secretory multifunctional serine protease, DegP ofPlasmodium falciparum, plays an important role in thermo-oxidative stress, parasite growth and development

FEBS Journal ◽  
2014 ◽  
Vol 281 (6) ◽  
pp. 1679-1699 ◽  
Author(s):  
Shweta Sharma ◽  
Mohit Jadli ◽  
Anu Singh ◽  
Kavita Arora ◽  
Pawan Malhotra
Keyword(s):  
Oxidative Stress ◽  
Serine Protease ◽  
Growth And Development ◽  
Parasite Growth ◽  
Ofplasmodium Falciparum

Relapsing fever spirochaetes produce a serine protease that provides resistance to oxidative stress and killing by neutrophils

2006 ◽  
Vol 60 (3) ◽  
pp. 710-722 ◽  
Author(s):  
Cyril Guyard ◽  
James M. Battisti ◽  
Sandra J. Raffel ◽  
Merry E. Schrumpf ◽  
Adeline R. Whitney ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Serine Protease ◽  
Relapsing Fever

Exploring the Potentials of Antioxidants in Retarding Ageing

2017 ◽  
pp. 166-195 ◽  
Author(s):  
Minu Kesheri ◽  
Swarna Kanchan ◽  
Rajeshwar P. Sinha
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Growth And Development ◽  
Aging Process ◽  
Reactive Oxygen ◽  
Normal Growth ◽  
Antioxidant Defenses ◽  
Oxygen Species ◽  
Biotic Stresses ◽  
Living Organisms

In retrospect to the rise in the occurrence of ageing related disorders and the everlasting desire to overcome ageing, exploring the causes, mechanisms and therapies to curb ageing becomes relevant. Reactive Oxygen Species (ROS) are commonly generated during normal growth and development. However abiotic and biotic stresses enhance the level of ROS which in turn pose the threat of oxidative stress. Ability to perceive ROS and to speedily commence antioxidant defenses is crucial for the survival as well as longevity of living cells. Therefore living organisms are bestowed with antioxidants to combat the damages caused by oxidative stress. This chapter aims to elucidate an overview of the process of ageing, generation and enhancement of reactive oxygen species, damages incurred by oxidative stress, its amelioration strategies, therapeutic and biotechnological potentials of antioxidants and various sources of bioactive compounds significant in retardation of aging process.

A review of ascorbic acid potentialities against oxidative stress induced in plants

2011 ◽  
Vol 28 (2) ◽  
pp. 97-111 ◽  
Author(s):  
Taqi Khan ◽  
Mohd Mazid ◽  
Firoz Mohammad
Keyword(s):  
Oxidative Stress ◽  
Ascorbic Acid ◽  
Plant Growth ◽  
Growth And Development ◽  
Crop Production ◽  
Ultra Violet ◽  
Environmental Stresses ◽  
Plant Growth And Development ◽  
Cellular Mechanisms ◽  
Oxidative Stresses

A review of ascorbic acid potentialities against oxidative stress induced in plantsAscorbic acid (AA) currently holds a significant position in plant physiology, mainly due to its possession of antioxidant and cellular reductant etc.properties and its diverse roles in plant growth and development and the regulation of a broad spectrum of plant cellular mechanisms against environmental stresses. Some researchers suggest that endogenous AA has been implicated in the promotion of plant growth and development by involvement in a complex and enigmatic array of phytohormone-regulated signalling networks that ties together different environmental stresses. As it is evident from the present review, recent progress on AA potentiality in the tolerance of plants to environmental stresses has been impressive. Indeed, AA plays an important role in resistance to oxidative stresses such as heavy metal, saline, ultra-violet etc. Rapidly increasing evidence indicates that AA is centrally involved in several physiological processes but there has been much disagreement regarding the mechanism(s) by which AA reduces the damaging effects of such stresses in plants. Perhaps the role of AA in mediating tolerance to abiotic stress (e.g. UV, salinity and temperature, etc.) will lead to a greater research focus in the near future. In addition, AA might provide a suitably attractive target for the enhancement of crop production.

Changes in the Distribution of Type II Transmembrane Serine Protease, TMPRSS2 and in Paracellular Permeability in IPEC-J2 Cells Exposed to Oxidative Stress

Inflammation ◽  
2014 ◽  
Vol 38 (2) ◽  
pp. 775-783 ◽  
Author(s):  
Erzsebet Paszti-Gere ◽  
Reka Fanni Barna ◽  
Csaba Kovago ◽  
Ipoly Szauder ◽  
Gabriella Ujhelyi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Serine Protease ◽  
Paracellular Permeability ◽  
Type Ii ◽  
Transmembrane Serine Protease

scholarly journals Chickpea Ferritin CaFer1 Participates in Oxidative Stress Response and Promotes Growth and Development

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Shaista Parveen ◽  
Deepti Bhushan Gupta ◽  
Suchismita Dass ◽  
Amit Kumar ◽  
Aarti Pandey ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Growth And Development ◽  
Oxidative Stress Response

scholarly journals The Role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the Spotlight

2020 ◽  
Vol 21 (5) ◽  
pp. 1775 ◽  
Author(s):  
Brooke Armistead ◽  
Leena Kadam ◽  
Sascha Drewlo ◽  
Hamid-Reza Kohan-Ghadr
Keyword(s):  
Oxidative Stress ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Growth And Development ◽  
Protein Family ◽  
Growth Restriction ◽  
Placental Development ◽  
Critical Organ ◽  
And Oxidative Stress

The NFκB protein family regulates numerous pathways within the cell—including inflammation, hypoxia, angiogenesis and oxidative stress—all of which are implicated in placental development. The placenta is a critical organ that develops during pregnancy that primarily functions to supply and transport the nutrients required for fetal growth and development. Abnormal placental development can be observed in numerous disorders during pregnancy, including fetal growth restriction, miscarriage, and preeclampsia (PE). NFκB is highly expressed in the placentas of women with PE, however its contributions to the syndrome are not fully understood. In this review we discuss the molecular actions and related pathways of NFκB in the placenta and highlight areas of research that need attention

scholarly journals Identification of Triticum durum genotypes showing increased tolerance to oxidative stress

2020 ◽  
Vol 75 (1) ◽  
pp. 43-65
Author(s):  
JUSTYNA LEŚNIOWSKA-NOWAK ◽  
MAGDALENA SOZONIUK ◽  
MAGDALENA KAWĘCKA ◽  
KORNELIA MAGA ◽  
MAŁGORZATA MROZEK
Keyword(s):  
Oxidative Stress ◽  
Durum Wheat ◽  
Root System ◽  
Growth And Development ◽  
Triticum Durum ◽  
Methyl Viologen ◽  
System Development ◽  
Abiotic Factors ◽  
Root System Development ◽  
Different Types

Oxidative stress can significantly impair the plants growth and development. It can be triggered by various biotic and abiotic factors. The study analyzed durum wheat genotypes aiming at identifying the forms characterized by increased tolerance to stress induced by methyl viologen (paraquat). The presence of paraquat in the medium caused the majority of analyzed forms to reduce the weight and length of the shoot part of seedling. In addition, inhibition of the root system development compared to control forms was observed. In some of the forms studied, oxidative stress caused chlorosis. Six different types of responses to oxidative stress were found. Most genotypes (58.8%) showed a reduction in seedling weight and length, irrespective of the paraquat concentration used. Nine genotypes resistant to stressor (CYP, MEX × 2, ETH, FRA, ITA, POL, SUN, TUN) were identified, which constituted 6.1% of the examined forms.

scholarly journals Suppression of Schistosoma japonicum Acetylcholinesterase Affects Parasite Growth and Development

2018 ◽  
Vol 19 (8) ◽  
pp. 2426 ◽  
Author(s):  
Hong You ◽  
Chang Liu ◽  
Xiaofeng Du ◽  
Sujeevi Nawaratna ◽  
Vanessa Rivera ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Schistosoma Japonicum ◽  
Growth And Development ◽  
Parasite Growth ◽  
Schistosomiasis Japonica ◽  
Drug Candidate ◽  
Control Group ◽  
Male Worm ◽  
Cytokine Analysis ◽  
Cholinergic Signaling

To further investigate the importance of Schistosoma japonicum acetylcholinesterase (SjAChE) in cholinergic signaling for parasite growth and development, we used RNA interference (RNAi) to knock-down its expression in adults and eggs in vitro. This resulted in its reduced transcription but also expression of other important genes involved both in cholinergic signaling and glucose uptake were impacted substantially. Significant decreases in AChE protein expression, AChE enzymatic activity, and glucose uptake were observed in the SjAChE-knockdown parasites compared with luciferase controls. In vaccine/challenge experiments, we found that immunization of mice with recombinant SjAChE (rSjAChE) expressed in Escherichia coli elicited reductions in male worm numbers (33%), liver granuloma density (41%), and reduced numbers of mature intestinal eggs (73%) in the vaccinated group compared with the control group. These results indicate AChE plays an important role in the metabolism of male worms, and impacts indirectly on female fecundity leading to increased numbers of immature eggs being released and reduced sizes of liver granulomas. Furthermore, cytokine analysis showed that immunization of mice with rSjAChE elicited a predominantly Th1-type immune response characterized by increased production of IFNγ in splenic CD4+ T cells of vaccinated mice. The study confirms the potential of SjAChE as a vaccine/drug candidate against zoonotic schistosomiasis japonica.

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