Circulating osteoprotegerin is correlated with lipid profile, insulin sensitivity, adiponectin and sex steroids in an ageing male population

OBJECTIVE: Our purpose was to study the sex steroid-mediated changes in serum insulin and lipid concentrations in boys during puberty. DESIGN AND METHODS: We treated boys with constitutional delay of puberty either with testosterone plus placebo or with testosterone plus an aromatase inhibitor, letrozole, which inhibits the conversion of androgens to oestrogens. We demonstrated previously that during treatment with testosterone plus letrozole the increase in testosterone concentration was more than 5-fold higher than during treatment with testosterone plus placebo. The concentrations of 17beta-oestradiol, IGF-I and IGF-binding protein-3 increased during testosterone-plus-placebo treatment, but during testosterone-plus-letrozole treatment the concentrations remained unchanged. These divergent changes in the two groups enabled us to study the effects of sex steroids and GH on insulin sensitivity and lipid concentrations. RESULTS: The insulin concentration in the testosterone-plus-placebo-treated group did not change. In contrast, in the testosterone-plus-letrozole-treated group, the concentration decreased during letrozole treatment, indicating improved insulin sensitivity. Changes in insulin and IGF-I concentrations within 12 and 18 months were correlated. In the testosterone-plus-placebo-treated group, the high-density lipoprotein cholesterol concentration did not change but in the testosterone-plus-letrozole-treated group the concentration decreased. The concentrations of low-density lipoprotein cholesterol (LDL-cholesterol) and triglycerides did not change in either of the groups. CONCLUSIONS: The findings indicate that androgens do not directly alter insulin sensitivity in boys during puberty. In contrast, the observations suggest tight regulation of glucose--insulin homeostasis by GH in boys at this stage. Furthermore, our findings indicate that sex steroids do not significantly participate in the regulation of serum concentrations of LDL-cholesterol or triglycerides in boys during early and mid-puberty.

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A Moderate Low-Carbohydrate Low-Calorie Diet Improves Lipid Profile, Insulin Sensitivity and Adiponectin Expression in Rats

Nutrients ◽

10.3390/nu7064724 ◽

2015 ◽

Vol 7 (6) ◽

pp. 4724-4738 ◽

Cited By ~ 20

Author(s):

Jie-Hua Chen ◽

Caiqun Ouyang ◽

Qiang Ding ◽

Jia Song ◽

Wenhong Cao ◽

...

Keyword(s):

Insulin Sensitivity ◽

Lipid Profile ◽

Low Calorie ◽

Low Calorie Diet ◽

Low Carbohydrate ◽

Calorie Diet

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Erectile dysfunction – overview from a cardiovascular perspective

VASA ◽

10.1024/0301-1526/a000627 ◽

2017 ◽

Vol 46 (5) ◽

pp. 347-353 ◽

Cited By ~ 10

Author(s):

Frederic Baumann ◽

Deborah Hehli ◽

Vladimir Makaloski ◽

Martin Schumacher ◽

Heinz Schönhofen ◽

...

Keyword(s):

Risk Factors ◽

Erectile Dysfunction ◽

Cardiovascular Risk ◽

Endovascular Therapy ◽

Minimal Invasive ◽

Male Population ◽

Ageing Male ◽

The Common ◽

Diagnostics And Therapy

Abstract. Erectile dysfunction (ED) is an evolving health problem with growing incidence in the ageing male population with potentially predictive value for cardiovascular and other chronic diseases. ED shares the common cardiovascular risk factors. The aetiology of ED is numerous including neurogenic, psychogenic, arteriogenic, and venogenic reasons. The origin of arteriogenic ED is frequently atherosclerosis. Patients not adequately responding to conservative measures including oral medication are often referred to further vascular diagnostics and therapy. At present, the refinements in endovascular therapy allow for minimal-invasive revascularization of erection-related arteries. The role of endovascular therapy in the complex framework of the multifactorial causes of ED requires further scientific scrutiny.

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Sex Steroids Affect Triglyceride Handling, Glucose-Dependent Insulinotropic Polypeptide, and Insulin Sensitivity: A 1-week randomized clinical trial in healthy young men

Diabetes Care ◽

10.2337/dc10-0515 ◽

2010 ◽

Vol 33 (8) ◽

pp. 1831-1833 ◽

Cited By ~ 19

Author(s):

B. Lapauw ◽

M. Ouwens ◽

L. M. 't Hart ◽

B. Wuyts ◽

J. J. Holst ◽

...

Keyword(s):

Clinical Trial ◽

Insulin Sensitivity ◽

Randomized Clinical Trial ◽

Sex Steroids ◽

Young Men

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Altered insulin sensitivity, insulin secretion and lipid profile in non-diabetic prostate carcinoma

Acta Physiologica Hungarica ◽

10.1556/aphysiol.95.2008.1.7 ◽

2008 ◽

Vol 95 (1) ◽

pp. 97-105 ◽

Cited By ~ 11

Author(s):

H. Nandeesha ◽

B. Koner ◽

L. Dorairajan

Keyword(s):

Insulin Secretion ◽

Insulin Sensitivity ◽

Lipid Profile ◽

Prostate Carcinoma ◽

Altered Insulin Sensitivity

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Lactiplantibacillus plantarum WJL administration during pregnancy and lactation improves lipid profile, insulin sensitivity and gut microbiota diversity in dyslipidemic dams and protects male offspring against cardiovascular dysfunction in later life

Food & Function ◽

10.1039/d0fo01718c ◽

2020 ◽

Vol 11 (10) ◽

pp. 8939-8950

Author(s):

Keyth Sulamitta de Lima Guimarães ◽

Valdir de Andrade Braga ◽

Sylvana I. S. Rendeiro de Noronha ◽

Whyara Karoline Almeida da Costa ◽

Kassem Makki ◽

...

Keyword(s):

Insulin Sensitivity ◽

Gut Microbiota ◽

Lipid Profile ◽

Later Life ◽

Male Offspring ◽

Cardiovascular Dysfunction ◽

Pregnancy And Lactation ◽

Microbiota Diversity

Lactiplantibacillus plantarum WJL administration during pregnancy and lactation improves gut microbiota diversity.

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Intense electroacupuncture normalizes insulin sensitivity, increases muscle GLUT4 content, and improves lipid profile in a rat model of polycystic ovary syndrome

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.00323.2010 ◽

2010 ◽

Vol 299 (4) ◽

pp. E551-E559 ◽

Cited By ~ 48

Author(s):

Julia Johansson ◽

Yi Feng ◽

Ruijin Shao ◽

Malin Lönn ◽

Håkan Billig ◽

...

Keyword(s):

Skeletal Muscle ◽

Insulin Sensitivity ◽

Polycystic Ovary Syndrome ◽

Lipid Profile ◽

Muscle Protein ◽

Polycystic Ovary ◽

Low Frequency ◽

Density Lipoprotein ◽

Female Rats ◽

Ovary Syndrome

Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism and insulin resistance, possibly reflecting defects in skeletal muscle and adipocyte insulin signaling. Low-frequency (2 Hz) electroacupuncture (EA) increases insulin sensitivity in female rats with dihydrotestosterone (DHT)-induced PCOS, but the mechanism is unclear. We hypothesized that low-frequency EA regulates mediators involved in skeletal muscle glucose uptake and metabolism and alters the lipid profile in rats with DHT-induced PCOS. To test this hypothesis, we implanted in prepubescent female rats 90-day continuous-release pellets containing DHT (PCOS). At 70 days of age, the rats were randomly subdivided into two groups: one received low-frequency EA (evoking muscle twitches) for 20–25 min five times/wk for 4–5 wk; the other did not. Controls were implanted with pellets containing vehicle only. All three groups were otherwise handled similarly. Lipid profile was measured in fasting blood samples. Insulin sensitivity was determined by euglycemic hyperinsulinemic clamp, soleus muscle protein expression of glucose transporter 4 (GLUT4), and phosphorylated and nonphosphorylated Akt, and Akt substrate of 160 kDa was determined by Western blot analysis and GLUT4 location by immunofluorescence staining. PCOS EA rats had normalized insulin sensitivity, lower levels of total high-density lipoprotein and low-density lipoprotein cholesterol, and increased expression of GLUT4 in different compartments of skeletal muscle compared with PCOS rats. Total weight and body composition did not differ in the groups. Thus, in rats with DHT-induced PCOS, low-frequency EA has systemic and local effects involving intracellular signaling pathways in muscle that may, at least in part, account for the marked improved insulin sensitivity.

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